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The map label for this gene is rsbRA [H]

Identifier: 146300882

GI number: 146300882

Start: 3726390

End: 3727241

Strand: Reverse

Name: rsbRA [H]

Synonym: Fjoh_3137

Alternate gene names: 146300882

Gene position: 3727241-3726390 (Counterclockwise)

Preceding gene: 146300883

Following gene: 146300881

Centisome position: 61.13

GC content: 39.91

Gene sequence:

>852_bases
ATGAATATCCAAATATCACAACAAATGCAGAACAATCTCCTGGGAAGCTTGAAAGAGCACCAAAACAAATTATTGACCAC
ATGGTCTCAGCTTTTACAAGCAAACGGATCTACTGATGGAGCAACAGAAGAAGAAGAATCAAAGGAGTTCGCCGCTCTTT
TTCTAGATGCTTTACAGCATTCAAACGGAAATACTGAATCACACGAATTCGAAAAAGTTCATGACCTGTTAATCGGAATT
TCAAGTTCGAGAGGCAGACGTGGTTTTTCTCCCCGCGAAAATGCACAATATCTGATTGCTTTTAAAGAAGCAGCTTCTAA
AATTCTTTCAGAAACAGCATCTGATTCTACAGAATTATACAACGCTAATTTGCAATTATCTACGCTGCTGGATAACATGA
CAATCTTAACTTTTGAATCGTACATGAAAGGACGTGAAGATGTCATTTCAAGACAGATTGACGAGATTAGTGAAATTTCG
ACACCGGTTATCCGTGTTTGGGATGGTGTTGTGGCACTTCCTATTATAGGAACCCTTGACAGTTCCAGAACACAGGTGGT
AATGGAAAATCTTTTGCAGCAAATTGTAGATACAGGCAGTTCTATTGCCATACTTGACATTTCAGGTGTGCCGGCGGTAG
ATTCACTGGTAGCACAGCATCTTATAAAAACGGTGAGTGCAACGAGATTAATGGGAGCAGAGTGCATAATCAGCGGTATT
CGCCCTGAAATTGCACAGACTGTGGTGCATTTAGGAATAGATCTTACTGGAATTATTACAAAAGCTTCGCTTGCAAGCGC
TCTTCAAACAGCCTTTGAAATGTTACAGCTTACGGTTGTGAAAAGAAAATAA

Upstream 100 bases:

>100_bases
AAAAAAAATCCGATTATTGATTAAAGAATAAAGTGATGTTTTTTTTACAAGTTTTTTCTGAATTTAAAGAGTTTTGCTAA
TATTAATTGTCTACATTTAC

Downstream 100 bases:

>100_bases
CGAATTAAGATTACTGACATGGAAAGAATTCCAATACTCAAGATGGGAGATTTTCTGCTGGTTACCATACAGGTTGATTT
GTATGACCAATTGGCTGAAA

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MNIQISQQMQNNLLGSLKEHQNKLLTTWSQLLQANGSTDGATEEEESKEFAALFLDALQHSNGNTESHEFEKVHDLLIGI
SSSRGRRGFSPRENAQYLIAFKEAASKILSETASDSTELYNANLQLSTLLDNMTILTFESYMKGREDVISRQIDEISEIS
TPVIRVWDGVVALPIIGTLDSSRTQVVMENLLQQIVDTGSSIAILDISGVPAVDSLVAQHLIKTVSATRLMGAECIISGI
RPEIAQTVVHLGIDLTGIITKASLASALQTAFEMLQLTVVKRK

Sequences:

>Translated_283_residues
MNIQISQQMQNNLLGSLKEHQNKLLTTWSQLLQANGSTDGATEEEESKEFAALFLDALQHSNGNTESHEFEKVHDLLIGI
SSSRGRRGFSPRENAQYLIAFKEAASKILSETASDSTELYNANLQLSTLLDNMTILTFESYMKGREDVISRQIDEISEIS
TPVIRVWDGVVALPIIGTLDSSRTQVVMENLLQQIVDTGSSIAILDISGVPAVDSLVAQHLIKTVSATRLMGAECIISGI
RPEIAQTVVHLGIDLTGIITKASLASALQTAFEMLQLTVVKRK
>Mature_283_residues
MNIQISQQMQNNLLGSLKEHQNKLLTTWSQLLQANGSTDGATEEEESKEFAALFLDALQHSNGNTESHEFEKVHDLLIGI
SSSRGRRGFSPRENAQYLIAFKEAASKILSETASDSTELYNANLQLSTLLDNMTILTFESYMKGREDVISRQIDEISEIS
TPVIRVWDGVVALPIIGTLDSSRTQVVMENLLQQIVDTGSSIAILDISGVPAVDSLVAQHLIKTVSATRLMGAECIISGI
RPEIAQTVVHLGIDLTGIITKASLASALQTAFEMLQLTVVKRK

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 30939; Mature: 30939

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQISQQMQNNLLGSLKEHQNKLLTTWSQLLQANGSTDGATEEEESKEFAALFLDALQH
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
SNGNTESHEFEKVHDLLIGISSSRGRRGFSPRENAQYLIAFKEAASKILSETASDSTELY
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHH
NANLQLSTLLDNMTILTFESYMKGREDVISRQIDEISEISTPVIRVWDGVVALPIIGTLD
CCCCHHHHHHHCHHHEEHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCC
SSRTQVVMENLLQQIVDTGSSIAILDISGVPAVDSLVAQHLIKTVSATRLMGAECIISGI
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPEIAQTVVHLGIDLTGIITKASLASALQTAFEMLQLTVVKRK
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIQISQQMQNNLLGSLKEHQNKLLTTWSQLLQANGSTDGATEEEESKEFAALFLDALQH
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
SNGNTESHEFEKVHDLLIGISSSRGRRGFSPRENAQYLIAFKEAASKILSETASDSTELY
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHH
NANLQLSTLLDNMTILTFESYMKGREDVISRQIDEISEISTPVIRVWDGVVALPIIGTLD
CCCCHHHHHHHCHHHEEHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCC
SSRTQVVMENLLQQIVDTGSSIAILDISGVPAVDSLVAQHLIKTVSATRLMGAECIISGI
CHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPEIAQTVVHLGIDLTGIITKASLASALQTAFEMLQLTVVKRK
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]