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The map label for this gene is pcoA [H]

Identifier: 146300823

GI number: 146300823

Start: 3647739

End: 3650354

Strand: Direct

Name: pcoA [H]

Synonym: Fjoh_3078

Alternate gene names: 146300823

Gene position: 3647739-3650354 (Clockwise)

Preceding gene: 146300822

Following gene: 146300824

Centisome position: 59.83

GC content: 40.25

Gene sequence:

>2616_bases
ATGAAAAACATACTTATAATACTCGTATTTATCATGCTTCCTGTCCTGATTCAAGCCCAGGATATGAAAATGGCAATAGA
TAAAAAGTCTGTCAAAGAAGAGTCGAATCCTGCTACCTATACTTGTCCAATGCATCCCGATATCCATGAATCCAAACCAG
GAAAATGCCCAAAATGCGGCATGGCATTAGTGAAAGAAAAGTCTAAAATCACTAAGCCGAAGGCAGCTGCAAAACCTAAA
ACTGTAACTGCTGTTAAAGAGGAAATGCCTAAAAAGGCTAAATCTTCCTCTGCGGATAAGATCAATATGCATCAGGCGCA
TAATAAGACAAACATGGAAAAGAAAACAGCGAGCCCCCCAGTAAAAAAAATGATGGTAAATGATGAGCCACCTAAAGTTG
TAAGGTACGATTTATATGTTCGCGATACGGTGGTAAATTTCTCAGGGAAATCAAAAAGAGCGATAGCGGTAAATGGCCAG
ATACCAATGCCTACATTAACCTTTACAGAAGGTGATACCGCAGAAATTTATGTTCATAATGAACTTGACGAAGAAACGTC
ATTACACTGGCATGGTTTGTTTCTACCCAATAAAGAAGACGGTGTGCCTAACCTTACCCAAATGCCGATAAAAGCACACA
GTACCTACAAATATTCTTTTCCCATCAGGCAGCATGGGACCCATTGGTACCATAGCCATTCTGGTTTGCAGGAACAAATA
GGAATGTACGGTTCTTTTGTGATGAACAAACGAAGCTCCGATCCAAACTTCAGGGCAGGGATAGATGACCTACCGACAAT
TCCGATTGTGCTGAGCGAATGGACCGATATCGACCCGGAGAACGTTCATAGAATGCTGCATAATGCCTCCGATTGGTTTG
CAATAAAAAAAGGCACGACCCAAAGTTATGGCGAAGCTATAAAACAAGGCTATTTAAAAACCAAGGTCCTCAATGAGTGG
AAGCGTATGAACGCTATGGATGTAAGCGATGTCTATTATGAGAAATTTTTAATTAATGGGAAAAACGAAAGCCAGCTTTC
GCAGTTCAAAGCCGGTGATAAGGTAAGATTACGCGTCTCTAATGGCGGTGCATCCAGTAATTTTTGGCTTACCTATGCCG
GAGGCAAAATTACAGTAGTGGCCAGTGATGGTAATGATGTTGAGCCTGTTGAAGTAGACCGTCTACTTATTGCAGTTTCT
GAAACTTATGACCTTGTTTTAAGCATTCCGGCAGAAAATACATCTTATGAGTTTTTGGCAACACCAGAAGACCGGACAAA
ATCGGCGTCCCTCTACATTGGAAATGGCATCAAACAGCTCACCTCCCCTTTACCCAAACTGAAATACTTTGAAGGGATGC
AAATGATGAACGATATGATGAAAATGAACGGAGACCTAAATGATATGGGGATGAAGATGTCGCTGAATCAGATGGATATG
AACTCGGTAATGTATCCTGAAATTACAGGCCCACAAACAAAAGGAAGTAAAGACATGCCAATGGAGATGGACAAAGAAGA
AACCAAATTGGATACCCCTGATAAAATGCACGACATGCACAATATGGAAAATAAGTACAATGCCAATGCTCTTGCCGATA
TTGTGACATTAAATTATGCGATGCTAAAATCTCCAACAAGCACGGCATTGTCAAAAGATGCTCCAGTGAGGGAGCTCAAA
TTCGAGCTTACCGGAAATATGAATCGCTATGTGTGGAGCCTGGATAACAAGGTCGTTTCCGAAGCTGATAAAATCCTGAT
CAAGAAAGGAGAAATTTTACGTATCGTCCTGCATAATAATTCAATGATGCGCCATCCAATGCATTTGCATGGCCATGATT
TCAGGGTCATCAATGGGCAAGGTGATTTTGCGCCTTTGAAAAATATCATCGACATCATGCCAATGGAAACAGATACTATT
GAATTCGCCGCAAGCGAAGATGGCGGCGACTGGTTTTTCCACTGTCATATTCTCTACCATATGATGGCTGGTATGGGCAG
AATTTTTTCTTATGAAAATTCACCTCCAAATCCAGAAATACCAAACCCTAAACTGGCTCAACGAAAATTGTTTGCTGACG
ACAGAAAATTCCACTTTATGGCAGAAAATGATTTTGCCACCAATGGAAATGACGGTGAAGCAATGTATCAAAGTACACGC
TGGAGCATTGGAACCGAATGGAGGTTAGGATACAATGACATGCATGGTTATGAAACAGAAACACATATTGGTCGATATAT
TGGAAAAATGCAATGGTTAATGCCTTTTATAGGATTTGACTGGAGATATAGAAGAATGGGAGAAGATATACAAGAAAATA
ATCTTTTTGGACAAACCAATACTAAGGATAAACGTGCAGTGGTAAGTCTAGGGGTTAACTACATCCTACCTATGTTAATA
GTAGCACAAGCTGAAGTTTTTACCGATGGTAAAGTCAGATTACAATTTGAACGTAAAGACATTCCCGTTTCTAAACGGCT
TAGAATGAATTTGATGTGGAATACAGACAAGGAATATATGGCAGGACTACGCTATATAATTACCAGATGGGGTTCTTTGT
CTTCACACTATGACAGTGATATGGGCTTTGGTGCAGGATTTATTTTAAATTACTAG

Upstream 100 bases:

>100_bases
GGACATTATAAAAGCACAACAAACTGAAATTGCACAGATGAAGGCCAAGTTAAATGAGATGGAAAAAAAATAATAGAACA
CTATTCTTTAAAAAAGCAAT

Downstream 100 bases:

>100_bases
CTTATAAGTACAATAGTAAATTATTGTAAGACCAAATTCTAGAATTAAGATTAATCGGTTAATATTGAAGGATATCAATT
TTTTTAAATTGTCTTTCATT

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 871; Mature: 871

Protein sequence:

>871_residues
MKNILIILVFIMLPVLIQAQDMKMAIDKKSVKEESNPATYTCPMHPDIHESKPGKCPKCGMALVKEKSKITKPKAAAKPK
TVTAVKEEMPKKAKSSSADKINMHQAHNKTNMEKKTASPPVKKMMVNDEPPKVVRYDLYVRDTVVNFSGKSKRAIAVNGQ
IPMPTLTFTEGDTAEIYVHNELDEETSLHWHGLFLPNKEDGVPNLTQMPIKAHSTYKYSFPIRQHGTHWYHSHSGLQEQI
GMYGSFVMNKRSSDPNFRAGIDDLPTIPIVLSEWTDIDPENVHRMLHNASDWFAIKKGTTQSYGEAIKQGYLKTKVLNEW
KRMNAMDVSDVYYEKFLINGKNESQLSQFKAGDKVRLRVSNGGASSNFWLTYAGGKITVVASDGNDVEPVEVDRLLIAVS
ETYDLVLSIPAENTSYEFLATPEDRTKSASLYIGNGIKQLTSPLPKLKYFEGMQMMNDMMKMNGDLNDMGMKMSLNQMDM
NSVMYPEITGPQTKGSKDMPMEMDKEETKLDTPDKMHDMHNMENKYNANALADIVTLNYAMLKSPTSTALSKDAPVRELK
FELTGNMNRYVWSLDNKVVSEADKILIKKGEILRIVLHNNSMMRHPMHLHGHDFRVINGQGDFAPLKNIIDIMPMETDTI
EFAASEDGGDWFFHCHILYHMMAGMGRIFSYENSPPNPEIPNPKLAQRKLFADDRKFHFMAENDFATNGNDGEAMYQSTR
WSIGTEWRLGYNDMHGYETETHIGRYIGKMQWLMPFIGFDWRYRRMGEDIQENNLFGQTNTKDKRAVVSLGVNYILPMLI
VAQAEVFTDGKVRLQFERKDIPVSKRLRMNLMWNTDKEYMAGLRYIITRWGSLSSHYDSDMGFGAGFILNY

Sequences:

>Translated_871_residues
MKNILIILVFIMLPVLIQAQDMKMAIDKKSVKEESNPATYTCPMHPDIHESKPGKCPKCGMALVKEKSKITKPKAAAKPK
TVTAVKEEMPKKAKSSSADKINMHQAHNKTNMEKKTASPPVKKMMVNDEPPKVVRYDLYVRDTVVNFSGKSKRAIAVNGQ
IPMPTLTFTEGDTAEIYVHNELDEETSLHWHGLFLPNKEDGVPNLTQMPIKAHSTYKYSFPIRQHGTHWYHSHSGLQEQI
GMYGSFVMNKRSSDPNFRAGIDDLPTIPIVLSEWTDIDPENVHRMLHNASDWFAIKKGTTQSYGEAIKQGYLKTKVLNEW
KRMNAMDVSDVYYEKFLINGKNESQLSQFKAGDKVRLRVSNGGASSNFWLTYAGGKITVVASDGNDVEPVEVDRLLIAVS
ETYDLVLSIPAENTSYEFLATPEDRTKSASLYIGNGIKQLTSPLPKLKYFEGMQMMNDMMKMNGDLNDMGMKMSLNQMDM
NSVMYPEITGPQTKGSKDMPMEMDKEETKLDTPDKMHDMHNMENKYNANALADIVTLNYAMLKSPTSTALSKDAPVRELK
FELTGNMNRYVWSLDNKVVSEADKILIKKGEILRIVLHNNSMMRHPMHLHGHDFRVINGQGDFAPLKNIIDIMPMETDTI
EFAASEDGGDWFFHCHILYHMMAGMGRIFSYENSPPNPEIPNPKLAQRKLFADDRKFHFMAENDFATNGNDGEAMYQSTR
WSIGTEWRLGYNDMHGYETETHIGRYIGKMQWLMPFIGFDWRYRRMGEDIQENNLFGQTNTKDKRAVVSLGVNYILPMLI
VAQAEVFTDGKVRLQFERKDIPVSKRLRMNLMWNTDKEYMAGLRYIITRWGSLSSHYDSDMGFGAGFILNY
>Mature_871_residues
MKNILIILVFIMLPVLIQAQDMKMAIDKKSVKEESNPATYTCPMHPDIHESKPGKCPKCGMALVKEKSKITKPKAAAKPK
TVTAVKEEMPKKAKSSSADKINMHQAHNKTNMEKKTASPPVKKMMVNDEPPKVVRYDLYVRDTVVNFSGKSKRAIAVNGQ
IPMPTLTFTEGDTAEIYVHNELDEETSLHWHGLFLPNKEDGVPNLTQMPIKAHSTYKYSFPIRQHGTHWYHSHSGLQEQI
GMYGSFVMNKRSSDPNFRAGIDDLPTIPIVLSEWTDIDPENVHRMLHNASDWFAIKKGTTQSYGEAIKQGYLKTKVLNEW
KRMNAMDVSDVYYEKFLINGKNESQLSQFKAGDKVRLRVSNGGASSNFWLTYAGGKITVVASDGNDVEPVEVDRLLIAVS
ETYDLVLSIPAENTSYEFLATPEDRTKSASLYIGNGIKQLTSPLPKLKYFEGMQMMNDMMKMNGDLNDMGMKMSLNQMDM
NSVMYPEITGPQTKGSKDMPMEMDKEETKLDTPDKMHDMHNMENKYNANALADIVTLNYAMLKSPTSTALSKDAPVRELK
FELTGNMNRYVWSLDNKVVSEADKILIKKGEILRIVLHNNSMMRHPMHLHGHDFRVINGQGDFAPLKNIIDIMPMETDTI
EFAASEDGGDWFFHCHILYHMMAGMGRIFSYENSPPNPEIPNPKLAQRKLFADDRKFHFMAENDFATNGNDGEAMYQSTR
WSIGTEWRLGYNDMHGYETETHIGRYIGKMQWLMPFIGFDWRYRRMGEDIQENNLFGQTNTKDKRAVVSLGVNYILPMLI
VAQAEVFTDGKVRLQFERKDIPVSKRLRMNLMWNTDKEYMAGLRYIITRWGSLSSHYDSDMGFGAGFILNY

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323703, Length=555, Percent_Identity=25.2252252252252, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320714, Length=298, Percent_Identity=25.8389261744966, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321067, Length=107, Percent_Identity=42.0560747663551, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574104, Length=616, Percent_Identity=22.8896103896104, Blast_Score=120, Evalue=5e-27,
Organism=Drosophila melanogaster, GI221330000, Length=584, Percent_Identity=25, Blast_Score=113, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18859919, Length=273, Percent_Identity=28.9377289377289, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24650186, Length=303, Percent_Identity=25.0825082508251, Blast_Score=104, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281360167, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585842, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221329998, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=2e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 99289; Mature: 99289

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILIILVFIMLPVLIQAQDMKMAIDKKSVKEESNPATYTCPMHPDIHESKPGKCPKCG
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHH
MALVKEKSKITKPKAAAKPKTVTAVKEEMPKKAKSSSADKINMHQAHNKTNMEKKTASPP
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCEEEHHHHCCCCCCCHHCCCCC
VKKMMVNDEPPKVVRYDLYVRDTVVNFSGKSKRAIAVNGQIPMPTLTFTEGDTAEIYVHN
HHHHCCCCCCCCEEEEEEEEEEEEEECCCCCCEEEEECCCCCCCEEEECCCCEEEEEEEC
ELDEETSLHWHGLFLPNKEDGVPNLTQMPIKAHSTYKYSFPIRQHGTHWYHSHSGLQEQI
CCCCCCCEEEEEEECCCCCCCCCCCEECCEEECCEEEEECCHHHCCCEEEECCCCHHHHH
GMYGSFVMNKRSSDPNFRAGIDDLPTIPIVLSEWTDIDPENVHRMLHNASDWFAIKKGTT
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCC
QSYGEAIKQGYLKTKVLNEWKRMNAMDVSDVYYEKFLINGKNESQLSQFKAGDKVRLRVS
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCHHHHHHHCCCCEEEEEEE
NGGASSNFWLTYAGGKITVVASDGNDVEPVEVDRLLIAVSETYDLVLSIPAENTSYEFLA
CCCCCCCEEEEEECCEEEEEECCCCCCCCEEECEEEEEEECCEEEEEECCCCCCCEEEEE
TPEDRTKSASLYIGNGIKQLTSPLPKLKYFEGMQMMNDMMKMNGDLNDMGMKMSLNQMDM
CCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
NSVMYPEITGPQTKGSKDMPMEMDKEETKLDTPDKMHDMHNMENKYNANALADIVTLNYA
CCEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLKSPTSTALSKDAPVRELKFELTGNMNRYVWSLDNKVVSEADKILIKKGEILRIVLHNN
HHCCCCHHHHCCCCCHHHEEEEECCCCCEEEEECCHHHHHHHHHEEEECCCEEEEEEECC
SMMRHPMHLHGHDFRVINGQGDFAPLKNIIDIMPMETDTIEFAASEDGGDWFFHCHILYH
CHHCCCCEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHHHH
MMAGMGRIFSYENSPPNPEIPNPKLAQRKLFADDRKFHFMAENDFATNGNDGEAMYQSTR
HHHCCHHEEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHCC
WSIGTEWRLGYNDMHGYETETHIGRYIGKMQWLMPFIGFDWRYRRMGEDIQENNLFGQTN
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCCC
TKDKRAVVSLGVNYILPMLIVAQAEVFTDGKVRLQFERKDIPVSKRLRMNLMWNTDKEYM
CCCHHHHHHHCHHHHHHHHHHHHHHEECCCEEEEEEECCCCCCCCCEEEEEEECCCHHHH
AGLRYIITRWGSLSSHYDSDMGFGAGFILNY
HHHHHHHHHCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MKNILIILVFIMLPVLIQAQDMKMAIDKKSVKEESNPATYTCPMHPDIHESKPGKCPKCG
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCHHH
MALVKEKSKITKPKAAAKPKTVTAVKEEMPKKAKSSSADKINMHQAHNKTNMEKKTASPP
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCEEEHHHHCCCCCCCHHCCCCC
VKKMMVNDEPPKVVRYDLYVRDTVVNFSGKSKRAIAVNGQIPMPTLTFTEGDTAEIYVHN
HHHHCCCCCCCCEEEEEEEEEEEEEECCCCCCEEEEECCCCCCCEEEECCCCEEEEEEEC
ELDEETSLHWHGLFLPNKEDGVPNLTQMPIKAHSTYKYSFPIRQHGTHWYHSHSGLQEQI
CCCCCCCEEEEEEECCCCCCCCCCCEECCEEECCEEEEECCHHHCCCEEEECCCCHHHHH
GMYGSFVMNKRSSDPNFRAGIDDLPTIPIVLSEWTDIDPENVHRMLHNASDWFAIKKGTT
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCC
QSYGEAIKQGYLKTKVLNEWKRMNAMDVSDVYYEKFLINGKNESQLSQFKAGDKVRLRVS
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCHHHHHHHCCCCEEEEEEE
NGGASSNFWLTYAGGKITVVASDGNDVEPVEVDRLLIAVSETYDLVLSIPAENTSYEFLA
CCCCCCCEEEEEECCEEEEEECCCCCCCCEEECEEEEEEECCEEEEEECCCCCCCEEEEE
TPEDRTKSASLYIGNGIKQLTSPLPKLKYFEGMQMMNDMMKMNGDLNDMGMKMSLNQMDM
CCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
NSVMYPEITGPQTKGSKDMPMEMDKEETKLDTPDKMHDMHNMENKYNANALADIVTLNYA
CCEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLKSPTSTALSKDAPVRELKFELTGNMNRYVWSLDNKVVSEADKILIKKGEILRIVLHNN
HHCCCCHHHHCCCCCHHHEEEEECCCCCEEEEECCHHHHHHHHHEEEECCCEEEEEEECC
SMMRHPMHLHGHDFRVINGQGDFAPLKNIIDIMPMETDTIEFAASEDGGDWFFHCHILYH
CHHCCCCEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHHHH
MMAGMGRIFSYENSPPNPEIPNPKLAQRKLFADDRKFHFMAENDFATNGNDGEAMYQSTR
HHHCCHHEEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHCC
WSIGTEWRLGYNDMHGYETETHIGRYIGKMQWLMPFIGFDWRYRRMGEDIQENNLFGQTN
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCCC
TKDKRAVVSLGVNYILPMLIVAQAEVFTDGKVRLQFERKDIPVSKRLRMNLMWNTDKEYM
CCCHHHHHHHCHHHHHHHHHHHHHHEECCCEEEEEEECCCCCCCCCEEEEEEECCCHHHH
AGLRYIITRWGSLSSHYDSDMGFGAGFILNY
HHHHHHHHHCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]