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The map label for this gene is mutS2 [H]

Identifier: 146300662

GI number: 146300662

Start: 3454929

End: 3457094

Strand: Direct

Name: mutS2 [H]

Synonym: Fjoh_2913

Alternate gene names: 146300662

Gene position: 3454929-3457094 (Clockwise)

Preceding gene: 146300660

Following gene: 146300663

Centisome position: 56.67

GC content: 32.13

Gene sequence:

>2166_bases
ATGATTAGTATTACCGAAAAAACATTACAAGACTTACAATTTCCAACCGTACTTGAAACCATTTCAGATGGATGCAATAC
CGATATTGGAAAAGAAAAAGCTTTACAAATAAAACCATTTAGAAATAAAGAAGAATTAATACAGTCGCTGATGCAGACTT
CAGAATATGTTTCTTCTTTTCAAAATAATAACGCAATTCCAAATCACGGATTTGATGCCATAACTCATGAAATTAAATTT
CTGGCTATTCAAGACAGCTTTCTTGAAGTAGGAAGTTTTAGAAAAATTGCAAATCTTGGTGCAACAACAAATGTCTTATT
AAATTTCCTGAAAAAGTTTGATGATTATTATCCAAACTTAAATGTAAGAGCTTCAAGAGTAGAATTGACCAAAGACATCA
TAACAGCAATTGATGCCATTGTAGATAAATACGGAGAAATAAAAGACAACGCCTCTCCTGCTCTAGCCGGAATTCGTCAG
AACATGAATTTAGTTCGTGGCAAAGTAAATCAAAGTTTTGGTTTAGCGCTGACTCAATACAACGGCTTAGGATATCTGGA
TGATATAAAGGAAAGCTTTGTACAAAATCGTAGAGTTCTAGCAGTTTTAGCAATGTATCGCCGTAAAGTAAAAGGTTCTA
TTTTAGGAAGTTCGAAAACCGGAAGTATTGCTTATATAGAACCAGAAGCTACTTTAAAGTATTCTAGAGAATTAGCCAAT
TTAGAATACGAAGAAAAAGAAGAGATTACGCGAATATTAAAAAATTTATCAAACGTAATTCGTCCTTATCTTCCTTTGTT
AATCGAATATCAGGAGTTTTTAAGTGATATTGATGTAGTTGCTGGAAAAGCAAAATATGCTAATCGCATTAACGGAATTC
TTCCAGCAATAACAGAAGAAAGGCGATTATTTTTTAGAGAAGCGTATCATCCAATTTTGTATCTAAATAATAAACAGAAA
AAAGAAGTTACGCATCCGCAGACCATAGAGTTAAAACAAGAAAACAGAATTATTGTAATTTCTGGTCCAAATGCTGGAGG
AAAAACTATTTCGTTAAAAACGGTCGGTTTATTGCAATTAATGCTGCAATCTGGAATTTTGATTCCGGTTCACGAACGCA
GCGAGACTTTCTTATTTGACAGAATCCTGACTGACATTGGGGACAACCAATCTATTGAAAATCACTTAAGTACTTATAGT
TACCGATTAAAAAACATGAATTACTTTTTAAAGAAATGTAATAACAAAACCATGTTTTTAATTGACGAATTTGGTACAGG
TTCTGATCCCGAACTTGGTGGAGCTTTAGCTGAAATTTTCTTAGAAGAATTTTATCATCGAGAGGCATTCGGAATTATTA
CAACACATTATTCTAATTTAAAAATTCTAGCAAACGAATTACCATACGCAACAAATGCGAATATGATGTTCGATGAAAAA
TCACTTGAGCCAATGTACAAACTGGCTTTGGGTCAGGCTGGAAGTTCGTTTACTTTTGAAGTAGCTCAGAAAAATGGAAT
TCCGTTTGGATTGATCAATCGTGCGAAAAAGAAAATCGAAGTTGGAAAAGTTCGTTTTGACAAGACCATTGCAACACTTC
AAAAAGAGCGTTCAAAACTGGAAAAAACTTCTTTAAATTTAAAAGAAGAAGAAACCAGAGCTCGTGAAGAAAGTAAAAAG
ATGGAAAACATCAATACTAAAATTCAGCAGAAACTGGAAAGCTATCAAGAATTATACGACAGTAACCAGAAGATTATATA
TATAGGACAAAAAATTGATGATATAGCTGAAAAATATTTCAACAACAAAAACAAAAAAGAGCTTATTGGTGAATTTTTGA
AAATTGTTGAGATCGAAAACTCTAAACGTAAAAAAGCAACTCCGAAAGAAGCTAAAGCAAAAGTTGAAAAACAAAAAGAA
ATTATTGCCGAAGTACAAGTAAAAGTTGAAGAAATTCGAAAAGAGAAAAAAGAGAAGAAATTAAAGCCGGTTATTGAAAA
ACCAAAACCAATTTTAAAAGTTGGTGATCGAGTAAGAATGCTTGATGGAAGATCTGTTGGTAGTATTGATATAATTGAAA
AAAATAAAGCAACAGTAAATTATGGCCTATTTACCTCAAAAGTAAGTTTGGACGAATTGGAATTAGTAGAAGCTGTTAAA
AAATAA

Upstream 100 bases:

>100_bases
GTTAAAATCATATTTACACATAACAAAATTTAGACACGAACTAGTAGAATTCAATCATTATGTTTTTGTACTTTTGCGTG
TACTTTCTTAAAGAAATTAA

Downstream 100 bases:

>100_bases
GTTTTCTGGCTCAGTCGCAGTTTTTCAGACTTAAAAAATGCTCTAAAAAAACACAAAATTAAAATAAAGCGATTTAAGGA
GTTATTTTTTATTTTACACA

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MISITEKTLQDLQFPTVLETISDGCNTDIGKEKALQIKPFRNKEELIQSLMQTSEYVSSFQNNNAIPNHGFDAITHEIKF
LAIQDSFLEVGSFRKIANLGATTNVLLNFLKKFDDYYPNLNVRASRVELTKDIITAIDAIVDKYGEIKDNASPALAGIRQ
NMNLVRGKVNQSFGLALTQYNGLGYLDDIKESFVQNRRVLAVLAMYRRKVKGSILGSSKTGSIAYIEPEATLKYSRELAN
LEYEEKEEITRILKNLSNVIRPYLPLLIEYQEFLSDIDVVAGKAKYANRINGILPAITEERRLFFREAYHPILYLNNKQK
KEVTHPQTIELKQENRIIVISGPNAGGKTISLKTVGLLQLMLQSGILIPVHERSETFLFDRILTDIGDNQSIENHLSTYS
YRLKNMNYFLKKCNNKTMFLIDEFGTGSDPELGGALAEIFLEEFYHREAFGIITTHYSNLKILANELPYATNANMMFDEK
SLEPMYKLALGQAGSSFTFEVAQKNGIPFGLINRAKKKIEVGKVRFDKTIATLQKERSKLEKTSLNLKEEETRAREESKK
MENINTKIQQKLESYQELYDSNQKIIYIGQKIDDIAEKYFNNKNKKELIGEFLKIVEIENSKRKKATPKEAKAKVEKQKE
IIAEVQVKVEEIRKEKKEKKLKPVIEKPKPILKVGDRVRMLDGRSVGSIDIIEKNKATVNYGLFTSKVSLDELELVEAVK
K

Sequences:

>Translated_721_residues
MISITEKTLQDLQFPTVLETISDGCNTDIGKEKALQIKPFRNKEELIQSLMQTSEYVSSFQNNNAIPNHGFDAITHEIKF
LAIQDSFLEVGSFRKIANLGATTNVLLNFLKKFDDYYPNLNVRASRVELTKDIITAIDAIVDKYGEIKDNASPALAGIRQ
NMNLVRGKVNQSFGLALTQYNGLGYLDDIKESFVQNRRVLAVLAMYRRKVKGSILGSSKTGSIAYIEPEATLKYSRELAN
LEYEEKEEITRILKNLSNVIRPYLPLLIEYQEFLSDIDVVAGKAKYANRINGILPAITEERRLFFREAYHPILYLNNKQK
KEVTHPQTIELKQENRIIVISGPNAGGKTISLKTVGLLQLMLQSGILIPVHERSETFLFDRILTDIGDNQSIENHLSTYS
YRLKNMNYFLKKCNNKTMFLIDEFGTGSDPELGGALAEIFLEEFYHREAFGIITTHYSNLKILANELPYATNANMMFDEK
SLEPMYKLALGQAGSSFTFEVAQKNGIPFGLINRAKKKIEVGKVRFDKTIATLQKERSKLEKTSLNLKEEETRAREESKK
MENINTKIQQKLESYQELYDSNQKIIYIGQKIDDIAEKYFNNKNKKELIGEFLKIVEIENSKRKKATPKEAKAKVEKQKE
IIAEVQVKVEEIRKEKKEKKLKPVIEKPKPILKVGDRVRMLDGRSVGSIDIIEKNKATVNYGLFTSKVSLDELELVEAVK
K
>Mature_721_residues
MISITEKTLQDLQFPTVLETISDGCNTDIGKEKALQIKPFRNKEELIQSLMQTSEYVSSFQNNNAIPNHGFDAITHEIKF
LAIQDSFLEVGSFRKIANLGATTNVLLNFLKKFDDYYPNLNVRASRVELTKDIITAIDAIVDKYGEIKDNASPALAGIRQ
NMNLVRGKVNQSFGLALTQYNGLGYLDDIKESFVQNRRVLAVLAMYRRKVKGSILGSSKTGSIAYIEPEATLKYSRELAN
LEYEEKEEITRILKNLSNVIRPYLPLLIEYQEFLSDIDVVAGKAKYANRINGILPAITEERRLFFREAYHPILYLNNKQK
KEVTHPQTIELKQENRIIVISGPNAGGKTISLKTVGLLQLMLQSGILIPVHERSETFLFDRILTDIGDNQSIENHLSTYS
YRLKNMNYFLKKCNNKTMFLIDEFGTGSDPELGGALAEIFLEEFYHREAFGIITTHYSNLKILANELPYATNANMMFDEK
SLEPMYKLALGQAGSSFTFEVAQKNGIPFGLINRAKKKIEVGKVRFDKTIATLQKERSKLEKTSLNLKEEETRAREESKK
MENINTKIQQKLESYQELYDSNQKIIYIGQKIDDIAEKYFNNKNKKELIGEFLKIVEIENSKRKKATPKEAKAKVEKQKE
IIAEVQVKVEEIRKEKKEKKLKPVIEKPKPILKVGDRVRMLDGRSVGSIDIIEKNKATVNYGLFTSKVSLDELELVEAVK
K

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=272, Percent_Identity=26.4705882352941, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI4557761, Length=285, Percent_Identity=25.9649122807018, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI36949366, Length=243, Percent_Identity=26.7489711934156, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI26638666, Length=293, Percent_Identity=26.962457337884, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI4505253, Length=293, Percent_Identity=26.962457337884, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI26638664, Length=293, Percent_Identity=26.962457337884, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789089, Length=274, Percent_Identity=25.1824817518248, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17508445, Length=290, Percent_Identity=25.1724137931034, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17534743, Length=268, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=279, Percent_Identity=25.8064516129032, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=375, Percent_Identity=25.0666666666667, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=294, Percent_Identity=24.8299319727891, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320302, Length=220, Percent_Identity=30, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319935, Length=255, Percent_Identity=27.843137254902, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321109, Length=234, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321912, Length=256, Percent_Identity=20.703125, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24664545, Length=269, Percent_Identity=27.5092936802974, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24584320, Length=358, Percent_Identity=23.7430167597765, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 82252; Mature: 82252

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISITEKTLQDLQFPTVLETISDGCNTDIGKEKALQIKPFRNKEELIQSLMQTSEYVSSF
CCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
QNNNAIPNHGFDAITHEIKFLAIQDSFLEVGSFRKIANLGATTNVLLNFLKKFDDYYPNL
HCCCCCCCCCHHHHHHHEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
NVRASRVELTKDIITAIDAIVDKYGEIKDNASPALAGIRQNMNLVRGKVNQSFGLALTQY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
NGLGYLDDIKESFVQNRRVLAVLAMYRRKVKGSILGSSKTGSIAYIEPEATLKYSRELAN
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCHHHHHHHHHHC
LEYEEKEEITRILKNLSNVIRPYLPLLIEYQEFLSDIDVVAGKAKYANRINGILPAITEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHH
RRLFFREAYHPILYLNNKQKKEVTHPQTIELKQENRIIVISGPNAGGKTISLKTVGLLQL
HHHHHHHHCCCEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEHHHHHHHH
MLQSGILIPVHERSETFLFDRILTDIGDNQSIENHLSTYSYRLKNMNYFLKKCNNKTMFL
HHHCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IDEFGTGSDPELGGALAEIFLEEFYHREAFGIITTHYSNLKILANELPYATNANMMFDEK
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCCCCCCCCEEECCH
SLEPMYKLALGQAGSSFTFEVAQKNGIPFGLINRAKKKIEVGKVRFDKTIATLQKERSKL
HCCHHHHHHHCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKTSLNLKEEETRAREESKKMENINTKIQQKLESYQELYDSNQKIIYIGQKIDDIAEKYF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
NNKNKKELIGEFLKIVEIENSKRKKATPKEAKAKVEKQKEIIAEVQVKVEEIRKEKKEKK
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKPVIEKPKPILKVGDRVRMLDGRSVGSIDIIEKNKATVNYGLFTSKVSLDELELVEAVK
CCHHHHCCCHHHHCCCEEEEECCCCCCCEEEEECCCCEEEECEEECCCCHHHHHHHHHHC
K
C
>Mature Secondary Structure
MISITEKTLQDLQFPTVLETISDGCNTDIGKEKALQIKPFRNKEELIQSLMQTSEYVSSF
CCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
QNNNAIPNHGFDAITHEIKFLAIQDSFLEVGSFRKIANLGATTNVLLNFLKKFDDYYPNL
HCCCCCCCCCHHHHHHHEEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
NVRASRVELTKDIITAIDAIVDKYGEIKDNASPALAGIRQNMNLVRGKVNQSFGLALTQY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
NGLGYLDDIKESFVQNRRVLAVLAMYRRKVKGSILGSSKTGSIAYIEPEATLKYSRELAN
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCHHHHHHHHHHC
LEYEEKEEITRILKNLSNVIRPYLPLLIEYQEFLSDIDVVAGKAKYANRINGILPAITEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHH
RRLFFREAYHPILYLNNKQKKEVTHPQTIELKQENRIIVISGPNAGGKTISLKTVGLLQL
HHHHHHHHCCCEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEHHHHHHHH
MLQSGILIPVHERSETFLFDRILTDIGDNQSIENHLSTYSYRLKNMNYFLKKCNNKTMFL
HHHCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IDEFGTGSDPELGGALAEIFLEEFYHREAFGIITTHYSNLKILANELPYATNANMMFDEK
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCCCCCCCCCEEECCH
SLEPMYKLALGQAGSSFTFEVAQKNGIPFGLINRAKKKIEVGKVRFDKTIATLQKERSKL
HCCHHHHHHHCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKTSLNLKEEETRAREESKKMENINTKIQQKLESYQELYDSNQKIIYIGQKIDDIAEKYF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
NNKNKKELIGEFLKIVEIENSKRKKATPKEAKAKVEKQKEIIAEVQVKVEEIRKEKKEKK
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKPVIEKPKPILKVGDRVRMLDGRSVGSIDIIEKNKATVNYGLFTSKVSLDELELVEAVK
CCHHHHCCCHHHHCCCEEEEECCCCCCCEEEEECCCCEEEECEEECCCCHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA