Click here to switch to the map view.

The map label for this gene is polC [H]

Identifier: 146300607

GI number: 146300607

Start: 3389998

End: 3390594

Strand: Direct

Name: polC [H]

Synonym: Fjoh_2858

Alternate gene names: 146300607

Gene position: 3389998-3390594 (Clockwise)

Preceding gene: 146300605

Following gene: 146300615

Centisome position: 55.6

GC content: 32.5

Gene sequence:

>597_bases
ATGCTAGACTGGATTAAAAACATTAACAAGGATTATCCGGAATTCTGGAAAGAATACTTGACAAAATTAGAAGCAAAACC
CAGCAAATTTGTGGTTTTGTCTACTGAAACTTCTGGCTTAAATCCTAACAAAGATGTTATTTTGTCTCTTGGCGCTTTTT
CAGTCATAGATGACAGCATTATAATTAAGGAGAATTTTGAAGCCGTTTTACTGCAGTACAAATTCTTAGAAGACAATGGT
CTTTCTAACGAATTTATTATTGAGAGTAAAATGACAAAAATGCCCGAAGCTGAGGCCTTAGAAGCTTTTATTAACTTCTT
GGGAAATGCTGTTTTGGTTGGTCATCATATTAATTTTGATATTGAAATGCTTAATGCTGCTTTAGAAAGATTGGATTGCG
GCAGGTTAAAAAATGAAGCGCTTGATATTGACGTTATGTACAGAAAATTAACTGACATTAACGACAAACAGTTTTCTTTA
AACGATTTATGCGAAATTTACAAAATTCCAAAAAGTGACAGAAATTCTTCTGCCGAAGATGCTTATAAAATTGGTCTTCT
GTTCTTAAAACTAAAATCGCGTTTGGGAATTAAATAA

Upstream 100 bases:

>100_bases
CTAAAACAGACAAAGAGAAGTTAAAAAATGCTTTGACCCCGATGAAAGACCTTGAGGAACTAATTAAGAGTAAATTTCAA
CTTACACAATTCTCATAAAT

Downstream 100 bases:

>100_bases
AAAATATCAATTTGCAGGACTTCGACTTCGCTCAGTCTGGCATAAATTGTAAACATAAAAAAAGCCTCTTAATTTTTAAG
AGGCTTTTTTATTTATTTAT

Product: exonuclease, RNase T and DNA polymerase III

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MLDWIKNINKDYPEFWKEYLTKLEAKPSKFVVLSTETSGLNPNKDVILSLGAFSVIDDSIIIKENFEAVLLQYKFLEDNG
LSNEFIIESKMTKMPEAEALEAFINFLGNAVLVGHHINFDIEMLNAALERLDCGRLKNEALDIDVMYRKLTDINDKQFSL
NDLCEIYKIPKSDRNSSAEDAYKIGLLFLKLKSRLGIK

Sequences:

>Translated_198_residues
MLDWIKNINKDYPEFWKEYLTKLEAKPSKFVVLSTETSGLNPNKDVILSLGAFSVIDDSIIIKENFEAVLLQYKFLEDNG
LSNEFIIESKMTKMPEAEALEAFINFLGNAVLVGHHINFDIEMLNAALERLDCGRLKNEALDIDVMYRKLTDINDKQFSL
NDLCEIYKIPKSDRNSSAEDAYKIGLLFLKLKSRLGIK
>Mature_198_residues
MLDWIKNINKDYPEFWKEYLTKLEAKPSKFVVLSTETSGLNPNKDVILSLGAFSVIDDSIIIKENFEAVLLQYKFLEDNG
LSNEFIIESKMTKMPEAEALEAFINFLGNAVLVGHHINFDIEMLNAALERLDCGRLKNEALDIDVMYRKLTDINDKQFSL
NDLCEIYKIPKSDRNSSAEDAYKIGLLFLKLKSRLGIK

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 22676; Mature: 22676

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDWIKNINKDYPEFWKEYLTKLEAKPSKFVVLSTETSGLNPNKDVILSLGAFSVIDDSI
CCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECCCHHHHCCCE
IIKENFEAVLLQYKFLEDNGLSNEFIIESKMTKMPEAEALEAFINFLGNAVLVGHHINFD
EEECCHHEEHHHHEECCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHCCEEEEEEECCCH
IEMLNAALERLDCGRLKNEALDIDVMYRKLTDINDKQFSLNDLCEIYKIPKSDRNSSAED
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHH
AYKIGLLFLKLKSRLGIK
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDWIKNINKDYPEFWKEYLTKLEAKPSKFVVLSTETSGLNPNKDVILSLGAFSVIDDSI
CCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECCCHHHHCCCE
IIKENFEAVLLQYKFLEDNGLSNEFIIESKMTKMPEAEALEAFINFLGNAVLVGHHINFD
EEECCHHEEHHHHEECCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHCCEEEEEEECCCH
IEMLNAALERLDCGRLKNEALDIDVMYRKLTDINDKQFSLNDLCEIYKIPKSDRNSSAED
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHH
AYKIGLLFLKLKSRLGIK
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]