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The map label for this gene is mutS [H]

Identifier: 146300459

GI number: 146300459

Start: 3222522

End: 3224294

Strand: Direct

Name: mutS [H]

Synonym: Fjoh_2709

Alternate gene names: 146300459

Gene position: 3222522-3224294 (Clockwise)

Preceding gene: 146300458

Following gene: 146300460

Centisome position: 52.86

GC content: 29.72

Gene sequence:

>1773_bases
ATGGAAGTATATTTAAGCAAGGTCAGACAGTATTCAAAAATATTTACTCAAATCAACAAAAGATACAACAGCATAAGTCT
TTTAAGACTTTTAAGCATATTTTTTTGTTTGTTTATGTTGTTTTACTACATCAAAACCAATGAAGCTTTATATGTCTTAT
TTGCTTTTTTATTTTTTGTTGGTTTTCTTTTTTTAATGAGAATCCATTCAAAACTTTCTTTCCAGAAAGAATTGACAAAA
GCTGTTTTAAAAATTAATGAAGACGAAATAGCATATTTAAAAAGAGAAAAACTCCCTTTTGAAAACGGAATTGAATTTAA
TGATTTTCATCATCCTTATGCTTACGATTTAGATATTTTTGGAGAGCATTCCTTATTCCAAAATTTAAACAGAACAGCCA
CTTTTATTGGTAAAAAAACATTAGCGAATAAATTATTAAATCTATTTTCTAATGAAACAATTCTTGAAAATCAGGAAGCC
ATAAACGAACTAAAAGCTAAAATAGACTGGCGTCAGGATTTTGAAGCTCTTGCAATTGTCAGTACTGACAGTAAGAATTC
GTATGACTCATTAATTCATTGGATTTCATTTAAAAATAATTCTTTATCTAAAGTTTTAATTGCACTGTCAATTATTCTTC
CAACTCTATTTTTTGGTTTTGTAATTGCTTATTTTATCACTTCAAAAGCAATTATTCTTTCCTATGTAACTTATATTTTT
ATTTTCAATTTAATCGTTTTGGGAAGATCACTAAAGCGAATTCAATCTGAAATTGCCAAAGCAGATAATATCGACAAAAC
CATAAAACAATATAGTTTATTGGTTAAGAAAATTGAACTTGAAAAATTTGAATCTAAAAAGCTGATTGAACTGCAAAAAC
AACTGGTTTCTAAAAATGCTTCTGCTAGTTCTCATTTAAAACAGCTGTCAGAATTATTTTCAAGAATGGAGACTATCAAC
AATTTTGTTACTGCGACTTTGTTTAACGGATCTTTTTTGTTTAACCTGCACGTTTTAAAGGCTCTTTTAAAATGGAAAGA
CAATTACGCACATGAACTTGAAAAATGGATTAATATAATTGGCGAATTTGAAGCTTTAAATAGTTTAGCAAATCTATCGT
ATAATAACCCTGATTTTGTTTTTCCTGAAATCAATTCACAATATAAAATTGGGTTTGAAAACTTAAGTCATCCTTTATTA
AATCCGACGACCAGAGTAGGCAATGACACCTATTTTTATCCTCAGTCATTTATGATTTTAACCGGATCGAATATGTCTGG
AAAAAGTACTTTTTTGAGAAGCTTAGGTATAAATATGGTTTTAGGCGGAATTGGTTCAGTTGTTTGTGCTTCAAAAGCTA
ACATACATCCACTTCCAGTTTTAGTTTCAATGCGATTATCTGATTCTTTAGCAGATAGTGAGTCATATTTCTTTGCAGAA
ATTAAACGTTTAAAACAAATTATGGATGCTCTTGAAGAAGGCCCTGCTTTTGTTTTATTAGATGAAATTTTAAGAGGAAC
AAACTCTGATGATAAACGTAACGGCACTATTGAAGTAGTCAAAAAAGTAATTGCTAAAAATGCGATTGGAGCTATTGCAA
CGCATGATATAGAAGTCTGTTTGACCACAAACGAATATCCGGATATTTTAACCAATCAATGTTTTGAAGTAGAAATTCAA
AATAACGAACTGCATTTTGATTATAAACTTCGCAGCGGCATCTGCCAGAATAGAAGCGCTACCTTCCTGATGCAGAAAAT
GGGAGTTATTTAG

Upstream 100 bases:

>100_bases
TATTCCAGTATTGATAATGCATGAGAATTAAATTCTGCTGTAAATGAATAGCTTTTTTGAAAGTGTAAAACCTATATTTG
TATTTCATTAAATTTTAAAA

Downstream 100 bases:

>100_bases
AATCTTAGAATTTAGATTTTAGAATTTAGAATTTAGATTTTAGAATTTAGATTTTAGAATTTAGATTTTTAAAAAAAGGC
CAAAAGAGTAATTATTATTC

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MEVYLSKVRQYSKIFTQINKRYNSISLLRLLSIFFCLFMLFYYIKTNEALYVLFAFLFFVGFLFLMRIHSKLSFQKELTK
AVLKINEDEIAYLKREKLPFENGIEFNDFHHPYAYDLDIFGEHSLFQNLNRTATFIGKKTLANKLLNLFSNETILENQEA
INELKAKIDWRQDFEALAIVSTDSKNSYDSLIHWISFKNNSLSKVLIALSIILPTLFFGFVIAYFITSKAIILSYVTYIF
IFNLIVLGRSLKRIQSEIAKADNIDKTIKQYSLLVKKIELEKFESKKLIELQKQLVSKNASASSHLKQLSELFSRMETIN
NFVTATLFNGSFLFNLHVLKALLKWKDNYAHELEKWINIIGEFEALNSLANLSYNNPDFVFPEINSQYKIGFENLSHPLL
NPTTRVGNDTYFYPQSFMILTGSNMSGKSTFLRSLGINMVLGGIGSVVCASKANIHPLPVLVSMRLSDSLADSESYFFAE
IKRLKQIMDALEEGPAFVLLDEILRGTNSDDKRNGTIEVVKKVIAKNAIGAIATHDIEVCLTTNEYPDILTNQCFEVEIQ
NNELHFDYKLRSGICQNRSATFLMQKMGVI

Sequences:

>Translated_590_residues
MEVYLSKVRQYSKIFTQINKRYNSISLLRLLSIFFCLFMLFYYIKTNEALYVLFAFLFFVGFLFLMRIHSKLSFQKELTK
AVLKINEDEIAYLKREKLPFENGIEFNDFHHPYAYDLDIFGEHSLFQNLNRTATFIGKKTLANKLLNLFSNETILENQEA
INELKAKIDWRQDFEALAIVSTDSKNSYDSLIHWISFKNNSLSKVLIALSIILPTLFFGFVIAYFITSKAIILSYVTYIF
IFNLIVLGRSLKRIQSEIAKADNIDKTIKQYSLLVKKIELEKFESKKLIELQKQLVSKNASASSHLKQLSELFSRMETIN
NFVTATLFNGSFLFNLHVLKALLKWKDNYAHELEKWINIIGEFEALNSLANLSYNNPDFVFPEINSQYKIGFENLSHPLL
NPTTRVGNDTYFYPQSFMILTGSNMSGKSTFLRSLGINMVLGGIGSVVCASKANIHPLPVLVSMRLSDSLADSESYFFAE
IKRLKQIMDALEEGPAFVLLDEILRGTNSDDKRNGTIEVVKKVIAKNAIGAIATHDIEVCLTTNEYPDILTNQCFEVEIQ
NNELHFDYKLRSGICQNRSATFLMQKMGVI
>Mature_590_residues
MEVYLSKVRQYSKIFTQINKRYNSISLLRLLSIFFCLFMLFYYIKTNEALYVLFAFLFFVGFLFLMRIHSKLSFQKELTK
AVLKINEDEIAYLKREKLPFENGIEFNDFHHPYAYDLDIFGEHSLFQNLNRTATFIGKKTLANKLLNLFSNETILENQEA
INELKAKIDWRQDFEALAIVSTDSKNSYDSLIHWISFKNNSLSKVLIALSIILPTLFFGFVIAYFITSKAIILSYVTYIF
IFNLIVLGRSLKRIQSEIAKADNIDKTIKQYSLLVKKIELEKFESKKLIELQKQLVSKNASASSHLKQLSELFSRMETIN
NFVTATLFNGSFLFNLHVLKALLKWKDNYAHELEKWINIIGEFEALNSLANLSYNNPDFVFPEINSQYKIGFENLSHPLL
NPTTRVGNDTYFYPQSFMILTGSNMSGKSTFLRSLGINMVLGGIGSVVCASKANIHPLPVLVSMRLSDSLADSESYFFAE
IKRLKQIMDALEEGPAFVLLDEILRGTNSDDKRNGTIEVVKKVIAKNAIGAIATHDIEVCLTTNEYPDILTNQCFEVEIQ
NNELHFDYKLRSGICQNRSATFLMQKMGVI

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=212, Percent_Identity=27.8301886792453, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI4557761, Length=261, Percent_Identity=25.2873563218391, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1789089, Length=164, Percent_Identity=29.8780487804878, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508445, Length=193, Percent_Identity=29.5336787564767, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=272, Percent_Identity=28.3088235294118, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321912, Length=263, Percent_Identity=25.0950570342205, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 67747; Mature: 67747

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVYLSKVRQYSKIFTQINKRYNSISLLRLLSIFFCLFMLFYYIKTNEALYVLFAFLFFV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GFLFLMRIHSKLSFQKELTKAVLKINEDEIAYLKREKLPFENGIEFNDFHHPYAYDLDIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECEEC
GEHSLFQNLNRTATFIGKKTLANKLLNLFSNETILENQEAINELKAKIDWRQDFEALAIV
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCHHHCCCEEEEE
STDSKNSYDSLIHWISFKNNSLSKVLIALSIILPTLFFGFVIAYFITSKAIILSYVTYIF
ECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFNLIVLGRSLKRIQSEIAKADNIDKTIKQYSLLVKKIELEKFESKKLIELQKQLVSKNA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
SASSHLKQLSELFSRMETINNFVTATLFNGSFLFNLHVLKALLKWKDNYAHELEKWINII
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GEFEALNSLANLSYNNPDFVFPEINSQYKIGFENLSHPLLNPTTRVGNDTYFYPQSFMIL
HHHHHHHHHHCCCCCCCCEEECCCCCCEEECHHHCCCCCCCCCCCCCCCEEECCCEEEEE
TGSNMSGKSTFLRSLGINMVLGGIGSVVCASKANIHPLPVLVSMRLSDSLADSESYFFAE
ECCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
IKRLKQIMDALEEGPAFVLLDEILRGTNSDDKRNGTIEVVKKVIAKNAIGAIATHDIEVC
HHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCEEEE
LTTNEYPDILTNQCFEVEIQNNELHFDYKLRSGICQNRSATFLMQKMGVI
EECCCCCHHHCCCEEEEEEECCEEEEEEEHHCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MEVYLSKVRQYSKIFTQINKRYNSISLLRLLSIFFCLFMLFYYIKTNEALYVLFAFLFFV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GFLFLMRIHSKLSFQKELTKAVLKINEDEIAYLKREKLPFENGIEFNDFHHPYAYDLDIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECEEC
GEHSLFQNLNRTATFIGKKTLANKLLNLFSNETILENQEAINELKAKIDWRQDFEALAIV
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHCCHHHCCCEEEEE
STDSKNSYDSLIHWISFKNNSLSKVLIALSIILPTLFFGFVIAYFITSKAIILSYVTYIF
ECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFNLIVLGRSLKRIQSEIAKADNIDKTIKQYSLLVKKIELEKFESKKLIELQKQLVSKNA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
SASSHLKQLSELFSRMETINNFVTATLFNGSFLFNLHVLKALLKWKDNYAHELEKWINII
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GEFEALNSLANLSYNNPDFVFPEINSQYKIGFENLSHPLLNPTTRVGNDTYFYPQSFMIL
HHHHHHHHHHCCCCCCCCEEECCCCCCEEECHHHCCCCCCCCCCCCCCCEEECCCEEEEE
TGSNMSGKSTFLRSLGINMVLGGIGSVVCASKANIHPLPVLVSMRLSDSLADSESYFFAE
ECCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
IKRLKQIMDALEEGPAFVLLDEILRGTNSDDKRNGTIEVVKKVIAKNAIGAIATHDIEVC
HHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCEEEE
LTTNEYPDILTNQCFEVEIQNNELHFDYKLRSGICQNRSATFLMQKMGVI
EECCCCCHHHCCCEEEEEEECCEEEEEEEHHCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA