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The map label for this gene is pyrE [H]

Identifier: 146300359

GI number: 146300359

Start: 3098808

End: 3099452

Strand: Reverse

Name: pyrE [H]

Synonym: Fjoh_2604

Alternate gene names: 146300359

Gene position: 3099452-3098808 (Counterclockwise)

Preceding gene: 146300366

Following gene: 146300358

Centisome position: 50.84

GC content: 38.14

Gene sequence:

>645_bases
ATGATTTTTAATAAAGATACTGCCGAAAAAACAGCTGAATTGCTTTTGCAAATAAATGCAATTAAATTGAATCCAGAAAA
TCCTTTTACATGGGCTTCTGGATGGAAATCTCCTATTTATTGTGATAATAGGTTAATTCTTTCATTTCCCAGCATTAGAA
ACTACGTTCGCGACGAGTTTGCGAAGAACATCGAAAAACAATTTGGAAAGCCTGATGTCATTGCCGGTGTTGCCACTGGA
GCCATTGGAGTTGGGATTTTGGTTGCCGAAAGCCTAGGACTTCCATTCGTATACGTACGTCCGGAACCAAAAAAACACGG
AAGACAAAACCAAGTTGAAGGTTTTTTACAAAAAGGACAAAATGTTGTCGTGGTTGAAGATTTAATCAGCACCGGAAAAA
GCAGTTTATTAGCTGTAGAAGCTTTAAGAAACGAAGGTGCCAACATTAAAGGAATGGCTGCCGTTTTTACTTATGGTTTT
GGCGTTGCCGAAGAAAACTTCAAAGAAGCTAATGTTGATTTATTCACATTAAGCAACTACGAAAATCTATTAGATTTAGC
CGTTCAAAAACAATACATCACAGAAGACCAGCAGTCTACATTACAAGAATGGAGCGTAAGCCCATCGACTTGGGGACAGG
AATAA

Upstream 100 bases:

>100_bases
AATACTCTCCAACAAGAACAATTGGAAATCTGTTTCTTTCGAGATTTCATTTGTCAAAAAAAGTGGTTTGTCGTTTACAA
AAACTTTATACATTTGTACT

Downstream 100 bases:

>100_bases
GATTTTAGATTTTAGATTGTTGATTGTTGATTGTTGATTTTCTAAAAATCGCTCTGCTCTTTTTGGATTTTGGAGTTTAT
TTAAAGTTTCAACTTTGCGA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MIFNKDTAEKTAELLLQINAIKLNPENPFTWASGWKSPIYCDNRLILSFPSIRNYVRDEFAKNIEKQFGKPDVIAGVATG
AIGVGILVAESLGLPFVYVRPEPKKHGRQNQVEGFLQKGQNVVVVEDLISTGKSSLLAVEALRNEGANIKGMAAVFTYGF
GVAEENFKEANVDLFTLSNYENLLDLAVQKQYITEDQQSTLQEWSVSPSTWGQE

Sequences:

>Translated_214_residues
MIFNKDTAEKTAELLLQINAIKLNPENPFTWASGWKSPIYCDNRLILSFPSIRNYVRDEFAKNIEKQFGKPDVIAGVATG
AIGVGILVAESLGLPFVYVRPEPKKHGRQNQVEGFLQKGQNVVVVEDLISTGKSSLLAVEALRNEGANIKGMAAVFTYGF
GVAEENFKEANVDLFTLSNYENLLDLAVQKQYITEDQQSTLQEWSVSPSTWGQE
>Mature_214_residues
MIFNKDTAEKTAELLLQINAIKLNPENPFTWASGWKSPIYCDNRLILSFPSIRNYVRDEFAKNIEKQFGKPDVIAGVATG
AIGVGILVAESLGLPFVYVRPEPKKHGRQNQVEGFLQKGQNVVVVEDLISTGKSSLLAVEALRNEGANIKGMAAVFTYGF
GVAEENFKEANVDLFTLSNYENLLDLAVQKQYITEDQQSTLQEWSVSPSTWGQE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=165, Percent_Identity=24.8484848484848, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508631, Length=180, Percent_Identity=30, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17933654, Length=143, Percent_Identity=31.4685314685315, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 23746; Mature: 23746

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFNKDTAEKTAELLLQINAIKLNPENPFTWASGWKSPIYCDNRLILSFPSIRNYVRDEF
CCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCEEECCEEEEECHHHHHHHHHHH
AKNIEKQFGKPDVIAGVATGAIGVGILVAESLGLPFVYVRPEPKKHGRQNQVEGFLQKGQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHCCCHHHHHHHHHCCC
NVVVVEDLISTGKSSLLAVEALRNEGANIKGMAAVFTYGFGVAEENFKEANVDLFTLSNY
CEEEEHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHCCEEEEEECCH
ENLLDLAVQKQYITEDQQSTLQEWSVSPSTWGQE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIFNKDTAEKTAELLLQINAIKLNPENPFTWASGWKSPIYCDNRLILSFPSIRNYVRDEF
CCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCEEECCEEEEECHHHHHHHHHHH
AKNIEKQFGKPDVIAGVATGAIGVGILVAESLGLPFVYVRPEPKKHGRQNQVEGFLQKGQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHCCCHHHHHHHHHCCC
NVVVVEDLISTGKSSLLAVEALRNEGANIKGMAAVFTYGFGVAEENFKEANVDLFTLSNY
CEEEEHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHCCEEEEEECCH
ENLLDLAVQKQYITEDQQSTLQEWSVSPSTWGQE
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA