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The map label for this gene is gyrA [H]

Identifier: 146300339

GI number: 146300339

Start: 3075678

End: 3078317

Strand: Direct

Name: gyrA [H]

Synonym: Fjoh_2584

Alternate gene names: 146300339

Gene position: 3075678-3078317 (Clockwise)

Preceding gene: 146300335

Following gene: 146300340

Centisome position: 50.45

GC content: 35.76

Gene sequence:

>2640_bases
ATGTCTGAAGGAGAAAAGTTAATTCCTATTAACATTGAAGATGAAATGAAATCAGCTTACATCGATTATTCGATGTCAGT
AATTGTATCGAGAGCGCTTCCTGATGTTAGAGATGGCTTGAAACCAGTACATCGAAGAGTACTTTATGGAATGTATGATT
TAGGTGTAACTTCAAGATCTGCCCATAAAAAATCTGCGAGAATTGTGGGAGAGGTTCTGGGTAAGTACCACCCGCATGGA
GATACTTCTGTTTATGATGCAATGGTGCGTATGGCACAGGAATGGAGTATGCGTTATTTATTAGTGGATGGTCAGGGTAA
CTTTGGGTCTGTTGATGGTGACAGTCCGGCAGCGATGCGTTATACTGAGGCCAGAATGCGCAAAATTTCAGAAGAAATTA
TGGCAGATATCGAAAAAGAAACAGTTGATTTTCAATTGAACTTTGACGATACAATATATGAACCAAAAGTAATGCCTACA
AGAGTTCCTACTTTATTAGTAAATGGAGCTACCGGTATTGCAGTTGGTATGGCAACTAATATGCCGCCACACAATTTAAC
AGAAGTAATCAATGGTACTTTAGCTTATCTTGATAATAATGATATCGAAGTAGATGAGTTAATGACTCACATTAAAGCTC
CTGATTTCCCAACGGGAGGTATCATTTACGGTTACGAAGGTGTTCGTGAAGCTTTTAAAACAGGTAGAGGACGTATTGTA
ATGCGTGCTAAAGTTGGTTTTGAAGAAGTTGAAGGAAGAGAATCTATCATCGTTACCGAAATTCCATATCAGGTTAACAA
AGCCGAAATGATTAAACGTACGGCAGATTTAGTTAACGAGAAAAAAATTGAAGGTATTGCTAATATCCGTGATGAATCGG
ATAGAAATGGTATGCGTATCGTTTATATCCTAAAACGTGACGCTACACCAAACGTAGTTTTAAATACCTTATATAAGTAT
ACTCAATTACAATCTTCTTTTAGTGTAAATAATATTGCATTAGTAAAAGGACGTCCTCAATTATTGAATCTAAAAGATAT
GATTCACTATTTTATTGAGCACCGTCATGATGTAGTAGTAAGAAGAACGCAGTTTGAATTGCGTAAAGCAGAAGAAAGAG
CGCATATTTTAGAAGGTTTAATTATCGCTTCTGATAATATTGACGAAGTAATTGCGTTAATTAGAGGGTCTAAAAACACA
GATGAAGCAAGAGAGAAATTAATCGAAAGATTTAAATTGTCAGATATTCAGGCTCGTGCAATTGTTGAAATGCGTCTGCG
TCAGTTAACAGGTCTGGAGCAGGACAAATTAAGAGCTGAGTATGATGAATTGATGAAATTAATCGAGCATTTAAAAGCTT
TACTTGCAGATGTTAATCTTAGAATTGACTTGATTAAAGAAGAACTTACTGAAATTCGTGATAAATACGGAGACGATCGT
CGTTCTCAAATCGAATATTCTGGTGGAGATGTAAGCATCGAAGATTTAATTGCCGATGAAAATGTAGTAATTACAATTTC
ACATGCAGGTTATATTAAGCGTACAAACTTATCAGAATACAAAACTCAGAATAGAGGAGGAGTTGGTCAAAAAAGTGCAG
GAACAAGAGATCAGGATTTCTTAGAGCATATGTTCGTTGCAACAAACCACCAGTACATGATGTTCTTTACTCAAAAAGGA
AAATGTTTCTGGATGCGTGTTTATGAAATTCCGGAAGGAAGTAAAACGGCAAAAGGAAGAGCGATTCAAAACCTTATCAA
TATCGAAAGTGATGATAAAGTAAAAGCTTTCATTTGTACACAAGATTTAAAAGACAAAGATTATATCAATACTCATAACC
TTGTAATGGTAACAAAACAAGGACAGGTTAAGAAAACTTCTTTAGAGAAATACTCTAAACCTCGTGCTAATGGAGTTGCT
GCTATTACTATTAAAGAAGGAGATGAATTGCTTGAAGCAAAATTAACCGACGGAGAAAGTCAAATTATCCTGGCAGTTAA
ATCTGGTAAATTGGTTCGTTTTGAAGAAACAAAAACACGTCCGATGGGAAGAACAGCTTCTGGAGTTCGTGGAATTACTT
TAAAAGACGATACTGATGAAGTAATTGGTATGGTTACTGTTGGTAAAAATGATGTCGCTGATTCTCAAATTTTAGTTGTA
ACTGAAAACGGATACGGAAAACGTACAAAATTAGTTGATGATGATGGTGAAGACGTTTACAGAATTACAAACCGTGGCGG
TAAAGGAGTTAAAACCTTAAATATTACAGATAAAACAGGAAAACTGATTTCTATTAATGCTGTAACAGATTCAGATGATT
TAATGATTATCAACAAATCTGGATTGACAATTAGAATGGCAATTGAGGATTTACGTGTTATGGGACGTGCTACTCAAGGT
GTTAGATTGATTAACCTGAAAGGAAAAGATTCTATTGCGGCTGTTACAAAAGTAATGAAAGATGACGCCGAAGAAGTTGT
AGTTGACGAAGATGGTAACGTTGTAGAATCTGCTATTGAAAGAGTTAAACCGGATCTTGATGAAGTTCTTGAAGATGATG
GAACTGCTGACGATGACGATGACGACTCTGATGATGTAGTTGAAGATGAAGACGATTCAGAAGAAGAATCTGAGGAATAA

Upstream 100 bases:

>100_bases
AAATCATTTAAATAAGTGTAAGGAAATAGCTGAAAAAATTTTAAAAAAACGTATCTTGGCACGCTTTGAAACTAATATAA
TTATTTAAACATAACAACTT

Downstream 100 bases:

>100_bases
ATTTAAATTAGTCCACAAGAAAATTAAATTAAATATACAAATTGAACATTATGAAAAGTAAATATGTTATACTAGCATCA
GCATTACTGATTTCTGTAGC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 879; Mature: 878

Protein sequence:

>879_residues
MSEGEKLIPINIEDEMKSAYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMYDLGVTSRSAHKKSARIVGEVLGKYHPHG
DTSVYDAMVRMAQEWSMRYLLVDGQGNFGSVDGDSPAAMRYTEARMRKISEEIMADIEKETVDFQLNFDDTIYEPKVMPT
RVPTLLVNGATGIAVGMATNMPPHNLTEVINGTLAYLDNNDIEVDELMTHIKAPDFPTGGIIYGYEGVREAFKTGRGRIV
MRAKVGFEEVEGRESIIVTEIPYQVNKAEMIKRTADLVNEKKIEGIANIRDESDRNGMRIVYILKRDATPNVVLNTLYKY
TQLQSSFSVNNIALVKGRPQLLNLKDMIHYFIEHRHDVVVRRTQFELRKAEERAHILEGLIIASDNIDEVIALIRGSKNT
DEAREKLIERFKLSDIQARAIVEMRLRQLTGLEQDKLRAEYDELMKLIEHLKALLADVNLRIDLIKEELTEIRDKYGDDR
RSQIEYSGGDVSIEDLIADENVVITISHAGYIKRTNLSEYKTQNRGGVGQKSAGTRDQDFLEHMFVATNHQYMMFFTQKG
KCFWMRVYEIPEGSKTAKGRAIQNLINIESDDKVKAFICTQDLKDKDYINTHNLVMVTKQGQVKKTSLEKYSKPRANGVA
AITIKEGDELLEAKLTDGESQIILAVKSGKLVRFEETKTRPMGRTASGVRGITLKDDTDEVIGMVTVGKNDVADSQILVV
TENGYGKRTKLVDDDGEDVYRITNRGGKGVKTLNITDKTGKLISINAVTDSDDLMIINKSGLTIRMAIEDLRVMGRATQG
VRLINLKGKDSIAAVTKVMKDDAEEVVVDEDGNVVESAIERVKPDLDEVLEDDGTADDDDDDSDDVVEDEDDSEEESEE

Sequences:

>Translated_879_residues
MSEGEKLIPINIEDEMKSAYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMYDLGVTSRSAHKKSARIVGEVLGKYHPHG
DTSVYDAMVRMAQEWSMRYLLVDGQGNFGSVDGDSPAAMRYTEARMRKISEEIMADIEKETVDFQLNFDDTIYEPKVMPT
RVPTLLVNGATGIAVGMATNMPPHNLTEVINGTLAYLDNNDIEVDELMTHIKAPDFPTGGIIYGYEGVREAFKTGRGRIV
MRAKVGFEEVEGRESIIVTEIPYQVNKAEMIKRTADLVNEKKIEGIANIRDESDRNGMRIVYILKRDATPNVVLNTLYKY
TQLQSSFSVNNIALVKGRPQLLNLKDMIHYFIEHRHDVVVRRTQFELRKAEERAHILEGLIIASDNIDEVIALIRGSKNT
DEAREKLIERFKLSDIQARAIVEMRLRQLTGLEQDKLRAEYDELMKLIEHLKALLADVNLRIDLIKEELTEIRDKYGDDR
RSQIEYSGGDVSIEDLIADENVVITISHAGYIKRTNLSEYKTQNRGGVGQKSAGTRDQDFLEHMFVATNHQYMMFFTQKG
KCFWMRVYEIPEGSKTAKGRAIQNLINIESDDKVKAFICTQDLKDKDYINTHNLVMVTKQGQVKKTSLEKYSKPRANGVA
AITIKEGDELLEAKLTDGESQIILAVKSGKLVRFEETKTRPMGRTASGVRGITLKDDTDEVIGMVTVGKNDVADSQILVV
TENGYGKRTKLVDDDGEDVYRITNRGGKGVKTLNITDKTGKLISINAVTDSDDLMIINKSGLTIRMAIEDLRVMGRATQG
VRLINLKGKDSIAAVTKVMKDDAEEVVVDEDGNVVESAIERVKPDLDEVLEDDGTADDDDDDSDDVVEDEDDSEEESEE
>Mature_878_residues
SEGEKLIPINIEDEMKSAYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMYDLGVTSRSAHKKSARIVGEVLGKYHPHGD
TSVYDAMVRMAQEWSMRYLLVDGQGNFGSVDGDSPAAMRYTEARMRKISEEIMADIEKETVDFQLNFDDTIYEPKVMPTR
VPTLLVNGATGIAVGMATNMPPHNLTEVINGTLAYLDNNDIEVDELMTHIKAPDFPTGGIIYGYEGVREAFKTGRGRIVM
RAKVGFEEVEGRESIIVTEIPYQVNKAEMIKRTADLVNEKKIEGIANIRDESDRNGMRIVYILKRDATPNVVLNTLYKYT
QLQSSFSVNNIALVKGRPQLLNLKDMIHYFIEHRHDVVVRRTQFELRKAEERAHILEGLIIASDNIDEVIALIRGSKNTD
EAREKLIERFKLSDIQARAIVEMRLRQLTGLEQDKLRAEYDELMKLIEHLKALLADVNLRIDLIKEELTEIRDKYGDDRR
SQIEYSGGDVSIEDLIADENVVITISHAGYIKRTNLSEYKTQNRGGVGQKSAGTRDQDFLEHMFVATNHQYMMFFTQKGK
CFWMRVYEIPEGSKTAKGRAIQNLINIESDDKVKAFICTQDLKDKDYINTHNLVMVTKQGQVKKTSLEKYSKPRANGVAA
ITIKEGDELLEAKLTDGESQIILAVKSGKLVRFEETKTRPMGRTASGVRGITLKDDTDEVIGMVTVGKNDVADSQILVVT
ENGYGKRTKLVDDDGEDVYRITNRGGKGVKTLNITDKTGKLISINAVTDSDDLMIINKSGLTIRMAIEDLRVMGRATQGV
RLINLKGKDSIAAVTKVMKDDAEEVVVDEDGNVVESAIERVKPDLDEVLEDDGTADDDDDDSDDVVEDEDDSEEESEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=317, Percent_Identity=22.397476340694, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1788562, Length=907, Percent_Identity=46.3065049614112, Blast_Score=811, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=666, Percent_Identity=35.8858858858859, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6324241, Length=257, Percent_Identity=28.0155642023346, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR010235
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; PF08780 NTase_sub_bind [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98778; Mature: 98646

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGEKLIPINIEDEMKSAYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMYDLGVTSRS
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
AHKKSARIVGEVLGKYHPHGDTSVYDAMVRMAQEWSMRYLLVDGQGNFGSVDGDSPAAMR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHH
YTEARMRKISEEIMADIEKETVDFQLNFDDTIYEPKVMPTRVPTLLVNGATGIAVGMATN
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
MPPHNLTEVINGTLAYLDNNDIEVDELMTHIKAPDFPTGGIIYGYEGVREAFKTGRGRIV
CCCHHHHHHHCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCEEE
MRAKVGFEEVEGRESIIVTEIPYQVNKAEMIKRTADLVNEKKIEGIANIRDESDRNGMRI
EEEECCHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
VYILKRDATPNVVLNTLYKYTQLQSSFSVNNIALVKGRPQLLNLKDMIHYFIEHRHDVVV
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHHHHHHHCCCCEEE
RRTQFELRKAEERAHILEGLIIASDNIDEVIALIRGSKNTDEAREKLIERFKLSDIQARA
EHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHH
IVEMRLRQLTGLEQDKLRAEYDELMKLIEHLKALLADVNLRIDLIKEELTEIRDKYGDDR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCC
RSQIEYSGGDVSIEDLIADENVVITISHAGYIKRTNLSEYKTQNRGGVGQKSAGTRDQDF
HHEEEECCCCEEHHHHCCCCCEEEEEECCCEEEECCCHHHHHCCCCCCCCCCCCCCHHHH
LEHMFVATNHQYMMFFTQKGKCFWMRVYEIPEGSKTAKGRAIQNLINIESDDKVKAFICT
HHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEEEE
QDLKDKDYINTHNLVMVTKQGQVKKTSLEKYSKPRANGVAAITIKEGDELLEAKLTDGES
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCC
QIILAVKSGKLVRFEETKTRPMGRTASGVRGITLKDDTDEVIGMVTVGKNDVADSQILVV
EEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCEEEEE
TENGYGKRTKLVDDDGEDVYRITNRGGKGVKTLNITDKTGKLISINAVTDSDDLMIINKS
EECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECC
GLTIRMAIEDLRVMGRATQGVRLINLKGKDSIAAVTKVMKDDAEEVVVDEDGNVVESAIE
CCEEEEEHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
RVKPDLDEVLEDDGTADDDDDDSDDVVEDEDDSEEESEE
HHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEGEKLIPINIEDEMKSAYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMYDLGVTSRS
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
AHKKSARIVGEVLGKYHPHGDTSVYDAMVRMAQEWSMRYLLVDGQGNFGSVDGDSPAAMR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHH
YTEARMRKISEEIMADIEKETVDFQLNFDDTIYEPKVMPTRVPTLLVNGATGIAVGMATN
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
MPPHNLTEVINGTLAYLDNNDIEVDELMTHIKAPDFPTGGIIYGYEGVREAFKTGRGRIV
CCCHHHHHHHCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCCEEE
MRAKVGFEEVEGRESIIVTEIPYQVNKAEMIKRTADLVNEKKIEGIANIRDESDRNGMRI
EEEECCHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
VYILKRDATPNVVLNTLYKYTQLQSSFSVNNIALVKGRPQLLNLKDMIHYFIEHRHDVVV
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHHHHHHHCCCCEEE
RRTQFELRKAEERAHILEGLIIASDNIDEVIALIRGSKNTDEAREKLIERFKLSDIQARA
EHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHH
IVEMRLRQLTGLEQDKLRAEYDELMKLIEHLKALLADVNLRIDLIKEELTEIRDKYGDDR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCC
RSQIEYSGGDVSIEDLIADENVVITISHAGYIKRTNLSEYKTQNRGGVGQKSAGTRDQDF
HHEEEECCCCEEHHHHCCCCCEEEEEECCCEEEECCCHHHHHCCCCCCCCCCCCCCHHHH
LEHMFVATNHQYMMFFTQKGKCFWMRVYEIPEGSKTAKGRAIQNLINIESDDKVKAFICT
HHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEEEE
QDLKDKDYINTHNLVMVTKQGQVKKTSLEKYSKPRANGVAAITIKEGDELLEAKLTDGES
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCC
QIILAVKSGKLVRFEETKTRPMGRTASGVRGITLKDDTDEVIGMVTVGKNDVADSQILVV
EEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCEEEEE
TENGYGKRTKLVDDDGEDVYRITNRGGKGVKTLNITDKTGKLISINAVTDSDDLMIINKS
EECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECC
GLTIRMAIEDLRVMGRATQGVRLINLKGKDSIAAVTKVMKDDAEEVVVDEDGNVVESAIE
CCEEEEEHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
RVKPDLDEVLEDDGTADDDDDDSDDVVEDEDDSEEESEE
HHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10427704; 11058132 [H]