Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 145299977

GI number: 145299977

Start: 3307952

End: 3309733

Strand: Direct

Name: ggt [H]

Synonym: ASA_3071

Alternate gene names: 145299977

Gene position: 3307952-3309733 (Clockwise)

Preceding gene: 145299976

Following gene: 145299978

Centisome position: 70.35

GC content: 66.16

Gene sequence:

>1782_bases
ATGTTGCTCAAACCCGCAGGGCTGGCCGTTGCCTTCGCCCTCCTGGCCGGTTGCGCCAGTGACAAGGGCTTTCACTATGC
CCCGCCCCCCCAGACCCTGATCGCCCCGGAAGCCGCCAGCGGCTGGACAGATAAACAGGGCTGGCAGGGCCATGGCTTCA
TGGTGGCTGCGGCCAATCCGCTGGCAGTGGATGCGGGCTACCAGATCATCCGGGCGGGCGGCAGCGCCGTGGATGCCGCC
ATCGCCGTGCAACTGGTACTGACCCTGGTGGAGCCGCAATCCTCCGGTATCGGTGGCGGCTCCCTGCTGCTGGTATGGGA
TGGCAGCAAGGTTGCGGCTGTAGATGGTCGCGAGACGGCCCCTGCCGCCGCCACGGATCAGCTGTTCATGAAGGATGGCA
AGCCCATGGCCTTCTATGACGGCGTGGTGGGCGGTCGCTCGGTCGGCGCGCCTGGCACAGTGCGGGCGCTGGCGCTGGCC
CATCAGCGCTATGGCAAGCTGCCCTGGGCTGCGCTGTTCGAGCCCGCCATCACCCTCGCGGAGCAGGGGTTTGTCATCAG
CCCGCGCCTCGCCACCCTGCTGGCAAAAGACCCCTATCTCGCCAAAGACCCGGATGCCCGCGCCTACTTCTATCTGCCCG
ACGGCACACCAAGGCCTGCCGGCAGCACGCTCACCAACCCGGCACTGGCCAAGGTGTTGCGCACCCTGGCCACACAGGGG
GCGGATGCCTTCTATCAGGGGCCGCTGGCCCAGGCCATGGTAGCCAAGGTGCGCCAGCATCCCACCAATCCCGGTGTGCT
GGCGGCGGCCGATCTGGCCAGCTATCGCGCCAAACTGCGCGACGGCCTCTGCTTTGACTACCGCCAGAGCCAGATCTGCG
GCTTCCCGACCCCCTCCTCCGGCACCATAGCCCTGGGACAGATATTCGGCATGCTGGAGAGCCGCGACATGGCGGCCCTC
AAACCTGTGACGACGCCAGAAGGTCAGCTTGCCGCGTCAAGCGATGCCATCCATCTCTACAGCGAGGCGGCGCGGCTCGC
CTTCGCCGATCGCAACCAGTATGTGGCAGACAGCGATTTTGTCAGCGTGCCGGTCAAGGGGCTGCTGGACAAGGGCTATC
TGGCCGAGCGGAGCAAGCTTGTCGGCGAGCGCTCCATGGGGATCGCCCAGCCCGGTATGCCGCCGCTGGCACTGGCTCGC
GGCAAGGATGCGACCCCCGAGCTCCCCTCCACCAGCCATGTCTCCATCGTCGACAAGGCGGGCATGGCGGTCTCCATGAC
CAGTTCCATCGAGGATGGTTTCGGTTCGCGGCTGATGGTCAACGGCTACCTGCTCAACAACCAGCTCACCGATTTTTCCT
TCACCTCTGTGGATGCCGCCGGTCTGCCGGTGGCGAACCGGGTCGAGCCTGGCAAACGGCCACGCTCCTCCATGTCCCCC
CTGCTGGTGTTTGACAAGCCAAGCGGCGAGCTGACCATCACGCTGGGCTCGCCGGGGGGCTCCGCCATCATCAACTACGT
GGGCAAGACGCTGCTCGGCACCCAGGATTGGGGGCTGAACCTGCAGCAGGCCATCAATCTGCCCAACTTCGGCAGCCGCA
ACGGCCCCACCGAGCTGGAGCTTGGGCGCACACCGGAGAGCGTGGTCGAGGGATTGAAAGCGAGAGGCCACGAAGTGGTA
CTGAGCGAGCAGACATCGGGTCTGCAAGGGGTCGAGCGCAATGCCGGCGGCTGGTTCGGCGCCGCCGATCCGAGGCGAGA
AGGCATTGCCAAGGGCGAATGA

Upstream 100 bases:

>100_bases
TAAATGAGTAAGGTATTGATCTGGTTCAACAACTTGAGCAACCAGTTCCAATCGTGACATAGTCGTCCTTCGCGCTCATA
AAACAGACAAGGAGAGTGTC

Downstream 100 bases:

>100_bases
GTGCCAGCGTATCTTCACCAAGGCGACCTCAGGGTCGCCTTGGTGCTTGTGGCGTCCTGGCACCCACCTATACAGGGAAA
ATCATCAACGATGAATTATT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MLLKPAGLAVAFALLAGCASDKGFHYAPPPQTLIAPEAASGWTDKQGWQGHGFMVAAANPLAVDAGYQIIRAGGSAVDAA
IAVQLVLTLVEPQSSGIGGGSLLLVWDGSKVAAVDGRETAPAAATDQLFMKDGKPMAFYDGVVGGRSVGAPGTVRALALA
HQRYGKLPWAALFEPAITLAEQGFVISPRLATLLAKDPYLAKDPDARAYFYLPDGTPRPAGSTLTNPALAKVLRTLATQG
ADAFYQGPLAQAMVAKVRQHPTNPGVLAAADLASYRAKLRDGLCFDYRQSQICGFPTPSSGTIALGQIFGMLESRDMAAL
KPVTTPEGQLAASSDAIHLYSEAARLAFADRNQYVADSDFVSVPVKGLLDKGYLAERSKLVGERSMGIAQPGMPPLALAR
GKDATPELPSTSHVSIVDKAGMAVSMTSSIEDGFGSRLMVNGYLLNNQLTDFSFTSVDAAGLPVANRVEPGKRPRSSMSP
LLVFDKPSGELTITLGSPGGSAIINYVGKTLLGTQDWGLNLQQAINLPNFGSRNGPTELELGRTPESVVEGLKARGHEVV
LSEQTSGLQGVERNAGGWFGAADPRREGIAKGE

Sequences:

>Translated_593_residues
MLLKPAGLAVAFALLAGCASDKGFHYAPPPQTLIAPEAASGWTDKQGWQGHGFMVAAANPLAVDAGYQIIRAGGSAVDAA
IAVQLVLTLVEPQSSGIGGGSLLLVWDGSKVAAVDGRETAPAAATDQLFMKDGKPMAFYDGVVGGRSVGAPGTVRALALA
HQRYGKLPWAALFEPAITLAEQGFVISPRLATLLAKDPYLAKDPDARAYFYLPDGTPRPAGSTLTNPALAKVLRTLATQG
ADAFYQGPLAQAMVAKVRQHPTNPGVLAAADLASYRAKLRDGLCFDYRQSQICGFPTPSSGTIALGQIFGMLESRDMAAL
KPVTTPEGQLAASSDAIHLYSEAARLAFADRNQYVADSDFVSVPVKGLLDKGYLAERSKLVGERSMGIAQPGMPPLALAR
GKDATPELPSTSHVSIVDKAGMAVSMTSSIEDGFGSRLMVNGYLLNNQLTDFSFTSVDAAGLPVANRVEPGKRPRSSMSP
LLVFDKPSGELTITLGSPGGSAIINYVGKTLLGTQDWGLNLQQAINLPNFGSRNGPTELELGRTPESVVEGLKARGHEVV
LSEQTSGLQGVERNAGGWFGAADPRREGIAKGE
>Mature_593_residues
MLLKPAGLAVAFALLAGCASDKGFHYAPPPQTLIAPEAASGWTDKQGWQGHGFMVAAANPLAVDAGYQIIRAGGSAVDAA
IAVQLVLTLVEPQSSGIGGGSLLLVWDGSKVAAVDGRETAPAAATDQLFMKDGKPMAFYDGVVGGRSVGAPGTVRALALA
HQRYGKLPWAALFEPAITLAEQGFVISPRLATLLAKDPYLAKDPDARAYFYLPDGTPRPAGSTLTNPALAKVLRTLATQG
ADAFYQGPLAQAMVAKVRQHPTNPGVLAAADLASYRAKLRDGLCFDYRQSQICGFPTPSSGTIALGQIFGMLESRDMAAL
KPVTTPEGQLAASSDAIHLYSEAARLAFADRNQYVADSDFVSVPVKGLLDKGYLAERSKLVGERSMGIAQPGMPPLALAR
GKDATPELPSTSHVSIVDKAGMAVSMTSSIEDGFGSRLMVNGYLLNNQLTDFSFTSVDAAGLPVANRVEPGKRPRSSMSP
LLVFDKPSGELTITLGSPGGSAIINYVGKTLLGTQDWGLNLQQAINLPNFGSRNGPTELELGRTPESVVEGLKARGHEVV
LSEQTSGLQGVERNAGGWFGAADPRREGIAKGE

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=546, Percent_Identity=31.5018315018315, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI73915090, Length=546, Percent_Identity=31.5018315018315, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI73915096, Length=546, Percent_Identity=31.5018315018315, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI73915094, Length=546, Percent_Identity=31.5018315018315, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI113429324, Length=545, Percent_Identity=30.2752293577982, Blast_Score=209, Evalue=8e-54,
Organism=Homo sapiens, GI113429326, Length=552, Percent_Identity=30.0724637681159, Blast_Score=202, Evalue=9e-52,
Organism=Homo sapiens, GI153266885, Length=559, Percent_Identity=29.3381037567084, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI153266901, Length=560, Percent_Identity=28.75, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI109148539, Length=560, Percent_Identity=30.5357142857143, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI153266907, Length=557, Percent_Identity=28.1867145421903, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI30581157, Length=201, Percent_Identity=31.8407960199005, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI30581155, Length=201, Percent_Identity=31.8407960199005, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI218505805, Length=201, Percent_Identity=28.8557213930348, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI171543825, Length=191, Percent_Identity=31.9371727748691, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI310124095, Length=204, Percent_Identity=28.921568627451, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1789856, Length=549, Percent_Identity=35.5191256830601, Blast_Score=283, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17542894, Length=546, Percent_Identity=30.2197802197802, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI72000294, Length=558, Percent_Identity=29.0322580645161, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI212646519, Length=558, Percent_Identity=29.0322580645161, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193208247, Length=563, Percent_Identity=29.8401420959147, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI193208245, Length=563, Percent_Identity=29.8401420959147, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17506189, Length=558, Percent_Identity=27.2401433691756, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17564448, Length=435, Percent_Identity=27.1264367816092, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI72001497, Length=409, Percent_Identity=23.7163814180929, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI72001495, Length=231, Percent_Identity=25.5411255411255, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=538, Percent_Identity=25.6505576208178, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI161077880, Length=572, Percent_Identity=31.1188811188811, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI45551474, Length=572, Percent_Identity=31.1188811188811, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24642670, Length=572, Percent_Identity=31.1188811188811, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24642666, Length=572, Percent_Identity=31.1188811188811, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI161077878, Length=572, Percent_Identity=31.1188811188811, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI18859893, Length=508, Percent_Identity=30.9055118110236, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI161077496, Length=514, Percent_Identity=26.0700389105058, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI18859741, Length=508, Percent_Identity=27.9527559055118, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61965; Mature: 61965

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKPAGLAVAFALLAGCASDKGFHYAPPPQTLIAPEAASGWTDKQGWQGHGFMVAAANP
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEECCC
LAVDAGYQIIRAGGSAVDAAIAVQLVLTLVEPQSSGIGGGSLLLVWDGSKVAAVDGRETA
EEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEECCCCCC
PAAATDQLFMKDGKPMAFYDGVVGGRSVGAPGTVRALALAHQRYGKLPWAALFEPAITLA
CCCCCCHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EQGFVISPRLATLLAKDPYLAKDPDARAYFYLPDGTPRPAGSTLTNPALAKVLRTLATQG
CCCEEECCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
ADAFYQGPLAQAMVAKVRQHPTNPGVLAAADLASYRAKLRDGLCFDYRQSQICGFPTPSS
CCHHHCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCC
GTIALGQIFGMLESRDMAALKPVTTPEGQLAASSDAIHLYSEAARLAFADRNQYVADSDF
CCEEHHHHHHHHHCCCCHHCCCCCCCCCCEECCCCCEEHHHHHHHHEEECCCCEECCCCE
VSVPVKGLLDKGYLAERSKLVGERSMGIAQPGMPPLALARGKDATPELPSTSHVSIVDKA
EECCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECC
GMAVSMTSSIEDGFGSRLMVNGYLLNNQLTDFSFTSVDAAGLPVANRVEPGKRPRSSMSP
CCEEEECCHHCCCCCCEEEEEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCC
LLVFDKPSGELTITLGSPGGSAIINYVGKTLLGTQDWGLNLQQAINLPNFGSRNGPTELE
EEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCEEE
LGRTPESVVEGLKARGHEVVLSEQTSGLQGVERNAGGWFGAADPRREGIAKGE
ECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MLLKPAGLAVAFALLAGCASDKGFHYAPPPQTLIAPEAASGWTDKQGWQGHGFMVAAANP
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEECCC
LAVDAGYQIIRAGGSAVDAAIAVQLVLTLVEPQSSGIGGGSLLLVWDGSKVAAVDGRETA
EEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEECCCCCC
PAAATDQLFMKDGKPMAFYDGVVGGRSVGAPGTVRALALAHQRYGKLPWAALFEPAITLA
CCCCCCHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EQGFVISPRLATLLAKDPYLAKDPDARAYFYLPDGTPRPAGSTLTNPALAKVLRTLATQG
CCCEEECCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
ADAFYQGPLAQAMVAKVRQHPTNPGVLAAADLASYRAKLRDGLCFDYRQSQICGFPTPSS
CCHHHCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCC
GTIALGQIFGMLESRDMAALKPVTTPEGQLAASSDAIHLYSEAARLAFADRNQYVADSDF
CCEEHHHHHHHHHCCCCHHCCCCCCCCCCEECCCCCEEHHHHHHHHEEECCCCEECCCCE
VSVPVKGLLDKGYLAERSKLVGERSMGIAQPGMPPLALARGKDATPELPSTSHVSIVDKA
EECCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECC
GMAVSMTSSIEDGFGSRLMVNGYLLNNQLTDFSFTSVDAAGLPVANRVEPGKRPRSSMSP
CCEEEECCHHCCCCCCEEEEEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCC
LLVFDKPSGELTITLGSPGGSAIINYVGKTLLGTQDWGLNLQQAINLPNFGSRNGPTELE
EEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCEEE
LGRTPESVVEGLKARGHEVVLSEQTSGLQGVERNAGGWFGAADPRREGIAKGE
ECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]