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The map label for this gene is arcA [H]

Identifier: 145299955

GI number: 145299955

Start: 3282484

End: 3283203

Strand: Direct

Name: arcA [H]

Synonym: ASA_3047

Alternate gene names: 145299955

Gene position: 3282484-3283203 (Clockwise)

Preceding gene: 145299952

Following gene: 145299956

Centisome position: 69.8

GC content: 56.11

Gene sequence:

>720_bases
ATGCAAACACCACACATTCTGATCGTCGAAGACGAACTGGTCACCCGCAATACCCTGAAAAGCATCTTCGAGGCCGAAGG
CTACGTTGTACTCGAGGCCAATAATGGCGACGAAATGCATCAAGCCCTCACTGCCCACACCATCAATCTGGTGATCATGG
ACATCAACCTGCCGGGCAAAAATGGCCTGCTGCTGGCGCGCGAGCTGCGTGAAGATGACAACATCGCCCTGATGTTCCTG
ACCGGTCGTGACAATGAAGTGGACAAGATCCTGGGTCTGGAAATCGGCGCCGATGATTACATCACCAAGCCGTTCAATCC
CCGTGAATTGACCATTCGTGCCCGCAATCTGCTGAGCCGCACCATGAATGTAGCCGCTGGCGGCGAAGAGAAGAAGCTGG
TTGAGCGCTACCTGTTCAACGGCTGGGCACTGGACATCAACAGCCGCGCACTGGTCAGCCCGGCTGGCGACATGTTCAAG
CTGCCCCGTTCAGAATTCCGTGCCATGCTGCACTTCTGCGAAAACCCGGGCCAGATCCAGACCCGTGCAGAACTGCTCAA
GAAGATGACAGGTCGTGAGCTCAAGCCCCATGACCGCACTGTGGATGTCACCATCCGCCGCATTCGCAAGCACTTCGAGA
GCGTCAACGACACACCTGAAATCATCGCCACCATCCATGGCGAAGGCTACCGTTTCTGTGGCGAGCTGGAGCAGGAATAA

Upstream 100 bases:

>100_bases
TTCATACCCAGGATGACGTAATAAATTTTCAGGACCGGTCGGGTAACGCCAAAGAGTGTTAAAATTTAGATAACTAACTG
ATAAGAATCTGGGAATACTC

Downstream 100 bases:

>100_bases
GCCCGTTTCGTCATTGCAGAGTGAGTTTACGAGGCGCCCATGGCGCCTTTTCTCTGCCTGATGTTTGCCATCGCCCAGCG
CAAACACAAAACAAAAAGCC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYVVLEANNGDEMHQALTAHTINLVIMDINLPGKNGLLLARELREDDNIALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNVAAGGEEKKLVERYLFNGWALDINSRALVSPAGDMFK
LPRSEFRAMLHFCENPGQIQTRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESVNDTPEIIATIHGEGYRFCGELEQE

Sequences:

>Translated_239_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYVVLEANNGDEMHQALTAHTINLVIMDINLPGKNGLLLARELREDDNIALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNVAAGGEEKKLVERYLFNGWALDINSRALVSPAGDMFK
LPRSEFRAMLHFCENPGQIQTRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESVNDTPEIIATIHGEGYRFCGELEQE
>Mature_239_residues
MQTPHILIVEDELVTRNTLKSIFEAEGYVVLEANNGDEMHQALTAHTINLVIMDINLPGKNGLLLARELREDDNIALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNVAAGGEEKKLVERYLFNGWALDINSRALVSPAGDMFK
LPRSEFRAMLHFCENPGQIQTRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESVNDTPEIIATIHGEGYRFCGELEQE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=84.8101265822785, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=39.4849785407725, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=34.6320346320346, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=33.0434782608696, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=32.9004329004329, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790860, Length=241, Percent_Identity=31.1203319502075, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=29.3859649122807, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=29.6943231441048, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI87082012, Length=231, Percent_Identity=31.6017316017316, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=31.5789473684211, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.8701298701299, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=28.3185840707965, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=30.4347826086957, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27196; Mature: 27196

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYVVLEANNGDEMHQALTAHTINLVIMDINLPGK
CCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHEEEEEEEEEEECCCC
NGLLLARELREDDNIALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEEEHCCCCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNVAAGGEEKKLVERYLFNGWALDINSRALVSPAGDMFKLPRSEFRAMLHFCENPGQIQ
HHHHCCCCHHHHHHHHHHHCCEEEEECCCEEECCCCHHHHCCHHHHHHHHHHHCCCCCCH
TRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESVNDTPEIIATIHGEGYRFCGELEQE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MQTPHILIVEDELVTRNTLKSIFEAEGYVVLEANNGDEMHQALTAHTINLVIMDINLPGK
CCCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHEEEEEEEEEEECCCC
NGLLLARELREDDNIALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEEEHCCCCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNVAAGGEEKKLVERYLFNGWALDINSRALVSPAGDMFKLPRSEFRAMLHFCENPGQIQ
HHHHCCCCHHHHHHHHHHHCCEEEEECCCEEECCCCHHHHCCHHHHHHHHHHHCCCCCCH
TRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESVNDTPEIIATIHGEGYRFCGELEQE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]