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The map label for this gene is puuP [H]

Identifier: 145299931

GI number: 145299931

Start: 3257960

End: 3259309

Strand: Direct

Name: puuP [H]

Synonym: ASA_3023

Alternate gene names: 145299931

Gene position: 3257960-3259309 (Clockwise)

Preceding gene: 145299930

Following gene: 145299932

Centisome position: 69.28

GC content: 60.44

Gene sequence:

>1350_bases
ATGAGCCAGCAACCCGTTCGTCTGAAGAAAACCCTCAGCATGTGGCAGGTGGTGGTGATGGGCCTTGCCTATCTGACCCC
CATGGCCGTGTTCGATACCTTCGCCATCGTCGGTGACATTACCGAAGGTCGGGTCGCCACTGCCTATCTGCTGGCGCTGG
GCGGCATACTGCTGACCGCGTTCAGCTACGGCCATCTGGTGCGCAAGTTCCCCTCTGCGGGCTCTGCCTATACCTATGCC
CAGAAGGTGTTCAACCCCTACATCGGTTTCATGGTGGGCTGGTCTTCCCTGCTCGACTATATGTTCATGCCGATGATCAA
TATCCTGCTGGCCAAGATCTACCTGACCGCCATGTTCCCCGGAGTTGATCCCTGGATTTTCATCTTCGGTCTGGTGACTG
TGATGACCTTCCTCAACCTGCGCGGCATCAACCTGGTAGCCAACTTCAATGGCCTGATCGTGGTGATCCAGCTGGCCATC
ATCACCCTTTTCATCGGTCTGATGGGCTGGGGCATCTACCAGGGTGAGGGCGCAGCGACCCTGATGAGCAGCCGGCCGTT
CCACTTCGAATCCGCCAGCGTGGTGCCGCTCTTTACCGGTGCGACCATCCTCTGCTTCTCCTTCCTCGGCTTCGACGGCC
TGAGCTCGCTCAGTGAAGAGACCCCGAACGCTGGCAAGGTGATACCGCGTGCCATCGTGCTGACCGCCCTCATTGGCGGC
GTCATCTTCGTGGTGGTCTCCTACTGCCTGCAGCTCTATTTCCCGGATCTGGCCCGCTTCAAGGAGCCCGATGCCGTGCT
GCCCGAGATTGCCCTCTACGTCGGCGGCGCCTTCTTCCAGAGCGTGGTACTGGTGTGTACCACTGTGGCGGTACTGGCCT
CCGGCATGGCGGCGCACGCAGGCGTGTCCCGCATCCTCTACGTCATGGGGCGCGATCGCATGATACCGGAGCGGGTGTTT
GGCTACATCCATCCGAAATACCGGACGCCGGCCATCAACGTGCTGATGGTGGGCTGTCTCGCCCTCTCCGCCGTGTCGTT
TGATCTCGACACAGCGCTGGCGCTGGTGAACTTCGGTGCCCTGGTGGCCTTCACCTTCGTCAACTTGTCGGTCATAGGCC
AGTTCTGGGTACGCGAGAAGCGCAACAAGAGCATCAAGGATCACCTGCTCTACCTGCTGCTGCCGCTGCTCGGCGCCGCC
ACTATCGGTGCGCTCTGGATCAACCTGGAGCAGAGCTCCCTGGAGCTGGGCCTGATCTGGGCGGGTCTCGGGGTCACCTA
TCTGTTCCTGCGTCTGGCGGTGTTCCGTATTCCCTTCCGTCAGTACGAAGAGACGGCCGACTCCCAATAA

Upstream 100 bases:

>100_bases
CGTCTGTGGTTTGCATACCGATGTTGTGAGTACGCGAGAACCCGGTCCCATGGCCTCAAGCCATTCCACTTCCTGCCGCC
CGTGCAAGGAGGAAGCCTGA

Downstream 100 bases:

>100_bases
GGGAGCGCGCTACACAGCAAAAAAGCAGAAGGGGAGCCATGGCTCCCCTTCTTGTTATCCGGCCCTCTGTGCAGCCTTGT
CATCAAACCATCATAAAAGT

Product: amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSQQPVRLKKTLSMWQVVVMGLAYLTPMAVFDTFAIVGDITEGRVATAYLLALGGILLTAFSYGHLVRKFPSAGSAYTYA
QKVFNPYIGFMVGWSSLLDYMFMPMINILLAKIYLTAMFPGVDPWIFIFGLVTVMTFLNLRGINLVANFNGLIVVIQLAI
ITLFIGLMGWGIYQGEGAATLMSSRPFHFESASVVPLFTGATILCFSFLGFDGLSSLSEETPNAGKVIPRAIVLTALIGG
VIFVVVSYCLQLYFPDLARFKEPDAVLPEIALYVGGAFFQSVVLVCTTVAVLASGMAAHAGVSRILYVMGRDRMIPERVF
GYIHPKYRTPAINVLMVGCLALSAVSFDLDTALALVNFGALVAFTFVNLSVIGQFWVREKRNKSIKDHLLYLLLPLLGAA
TIGALWINLEQSSLELGLIWAGLGVTYLFLRLAVFRIPFRQYEETADSQ

Sequences:

>Translated_449_residues
MSQQPVRLKKTLSMWQVVVMGLAYLTPMAVFDTFAIVGDITEGRVATAYLLALGGILLTAFSYGHLVRKFPSAGSAYTYA
QKVFNPYIGFMVGWSSLLDYMFMPMINILLAKIYLTAMFPGVDPWIFIFGLVTVMTFLNLRGINLVANFNGLIVVIQLAI
ITLFIGLMGWGIYQGEGAATLMSSRPFHFESASVVPLFTGATILCFSFLGFDGLSSLSEETPNAGKVIPRAIVLTALIGG
VIFVVVSYCLQLYFPDLARFKEPDAVLPEIALYVGGAFFQSVVLVCTTVAVLASGMAAHAGVSRILYVMGRDRMIPERVF
GYIHPKYRTPAINVLMVGCLALSAVSFDLDTALALVNFGALVAFTFVNLSVIGQFWVREKRNKSIKDHLLYLLLPLLGAA
TIGALWINLEQSSLELGLIWAGLGVTYLFLRLAVFRIPFRQYEETADSQ
>Mature_448_residues
SQQPVRLKKTLSMWQVVVMGLAYLTPMAVFDTFAIVGDITEGRVATAYLLALGGILLTAFSYGHLVRKFPSAGSAYTYAQ
KVFNPYIGFMVGWSSLLDYMFMPMINILLAKIYLTAMFPGVDPWIFIFGLVTVMTFLNLRGINLVANFNGLIVVIQLAII
TLFIGLMGWGIYQGEGAATLMSSRPFHFESASVVPLFTGATILCFSFLGFDGLSSLSEETPNAGKVIPRAIVLTALIGGV
IFVVVSYCLQLYFPDLARFKEPDAVLPEIALYVGGAFFQSVVLVCTTVAVLASGMAAHAGVSRILYVMGRDRMIPERVFG
YIHPKYRTPAINVLMVGCLALSAVSFDLDTALALVNFGALVAFTFVNLSVIGQFWVREKRNKSIKDHLLYLLLPLLGAAT
IGALWINLEQSSLELGLIWAGLGVTYLFLRLAVFRIPFRQYEETADSQ

Specific function: Imports putrescine [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=23.0588235294118, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI114326544, Length=203, Percent_Identity=29.064039408867, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI114326550, Length=203, Percent_Identity=29.064039408867, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI186910308, Length=425, Percent_Identity=22.8235294117647, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI186910306, Length=425, Percent_Identity=22.8235294117647, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI186910304, Length=425, Percent_Identity=22.8235294117647, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI115648063, Length=422, Percent_Identity=23.4597156398104, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI115648022, Length=422, Percent_Identity=23.4597156398104, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI258614005, Length=412, Percent_Identity=22.8155339805825, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI258614003, Length=412, Percent_Identity=22.8155339805825, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87081869, Length=452, Percent_Identity=61.5044247787611, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI87082023, Length=441, Percent_Identity=62.1315192743764, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI87082250, Length=346, Percent_Identity=23.121387283237, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788480, Length=273, Percent_Identity=24.9084249084249, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=390, Percent_Identity=24.3589743589744, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17533459, Length=411, Percent_Identity=25.0608272506083, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=406, Percent_Identity=22.6600985221675, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24667468, Length=386, Percent_Identity=23.3160621761658, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI221512776, Length=408, Percent_Identity=22.0588235294118, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666159, Length=408, Percent_Identity=22.0588235294118, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24668806, Length=410, Percent_Identity=22.6829268292683, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356285, Length=410, Percent_Identity=22.6829268292683, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24668802, Length=410, Percent_Identity=22.6829268292683, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281366235, Length=402, Percent_Identity=23.134328358209, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007820, Length=402, Percent_Identity=23.134328358209, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007818, Length=402, Percent_Identity=23.134328358209, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI85725152, Length=402, Percent_Identity=23.134328358209, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077963, Length=329, Percent_Identity=23.1003039513678, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49217; Mature: 49086

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00267 TACHYKININ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCHHHHHHCCCCC
>Mature Secondary Structure 
SQQPVRLKKTLSMWQVVVMGLAYLTPMAVFDTFAIVGDITEGRVATAYLLALGGILLTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FSYGHLVRKFPSAGSAYTYAQKVFNPYIGFMVGWSSLLDYMFMPMINILLAKIYLTAMFP
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVDPWIFIFGLVTVMTFLNLRGINLVANFNGLIVVIQLAIITLFIGLMGWGIYQGEGAAT
CCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LMSSRPFHFESASVVPLFTGATILCFSFLGFDGLSSLSEETPNAGKVIPRAIVLTALIGG
HHCCCCCCCCCCCCEEHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VIFVVVSYCLQLYFPDLARFKEPDAVLPEIALYVGGAFFQSVVLVCTTVAVLASGMAAHA
HHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
GVSRILYVMGRDRMIPERVFGYIHPKYRTPAINVLMVGCLALSAVSFDLDTALALVNFGA
HHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAFTFVNLSVIGQFWVREKRNKSIKDHLLYLLLPLLGAATIGALWINLEQSSLELGLIW
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHH
AGLGVTYLFLRLAVFRIPFRQYEETADSQ
HHHHHHHHHHHHHHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]