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The map label for this gene is gabT [H]

Identifier: 145299929

GI number: 145299929

Start: 3254673

End: 3255977

Strand: Direct

Name: gabT [H]

Synonym: ASA_3021

Alternate gene names: 145299929

Gene position: 3254673-3255977 (Clockwise)

Preceding gene: 145299928

Following gene: 145299930

Centisome position: 69.21

GC content: 63.91

Gene sequence:

>1305_bases
ATGAGTCATTCAGATAGCCATGCAGACAACAACCGGGCCTGGCAGGCCCGCGGTGAAGCGGCCGTGGTCAACGGCGTCGG
CACCCTGCTGCCGGTGTTTATCGACAAGACTCTCAACGCCGAGCTATGGGACGTGGAGGGCAATCGCTACATCGACTTTG
CCTCCGGCATCGCCGTGCTCAACACGGGCCACAACCACCCCAAAGTGGTGGCGGCGGTGCGTGAACAGCTCGAAAAATTC
AGCCACACCTGCTTTCAGGTGACCCCCTACCCCGGCTATATCGAGCTTGCCGAGAAGCTCAACGCCCTGGTGCCCGGCCC
GACGCCAAAACGCACCCTGTTTCTCTCCACCGGCGCCGAGGCGGTGGAAAACGCCATCAAGATAGCCCGCGCCCACACGG
GCCGCAGCGGCACCATCGCATTCAAGGGGGGCTTCCACGGTCGCACCATGATGGGGATGGCGCTCACCGGCAAGGTAGTG
CCCTACAAAACGGGTTTCGGCCCCTTCCCGGGGGAGGTCTATCACCTGCCCTTCCCGAGCGATTACCTGGGGGTGAGCGA
GGCCGATGCCCTGGCCGCACTGGATCTCTGCTTCAGCTCGGATATAGAACCGGCCCGGGTGGCAGCCATCATTCTCGAAC
CCGTGCAGGGTGAAGGGGGTTTCTACTCCGCCTCTCCCAGCTTTATGCAGAGCCTGCGCAAGCTGTGCGATCAGCACGGC
ATAGTGCTCATCTGTGACGAGATCCAGAGCGGTTTCTGTCGCACCGGCAAAACCTTTGCCACTGAATACAGCGGCATAGA
ACCAGACATCATGACGCTCGCCAAGAGTCTGGCCGGTGGCTTCCCTCTCTCGGCCGTGGTGGGCAAGGCGGCCATCATGA
ACGCTGCCAAGCCGGGCGGTCTGGGGGGCACTTATGCGGGTTCCCCCATCGCCTGCGCCGCCGCCCTAGCGGTGCTCGAG
GTGATCGAAGAGGAACAACTCAACCAGAAAGCCCTGGCTCAGGGGGCGCAGATCAAGGCTCGCCTGCATCAGCTGGCCGA
GGGTTTTGACTGCATCGGCGACATTCGCGGCCCCGGCGCCATGGTGGCCATGGAACTGGTCAAGGGTCGGGATGCCAGCC
AGCCTGACCCGGACCTCACCAAACGGCTGGTGGCCGAGGCCGGCAAACGCGGGCTTGTGCTGCTCTCCTGCGGCGTGCGG
GCCAACGTCATCCGCTTCCTGGCGCCCCTTACCGCCACTCCGGCCTTGATCGAGGAAGGGCTGGCTCTGCTGGAACAGGC
GCTCACCGCCGCCAGTCAGGGCTAG

Upstream 100 bases:

>100_bases
GCCTTTGCAGGCATACCATCATGAAAAGGACCAAGTGAGCGCTCCCGGTTGGGAGGCTCGCCACATTGAGACAGGGGCCA
AGGCCTCTCAGGGAGGAAAG

Downstream 100 bases:

>100_bases
ATCCACCCGGTTTCATCGGTCATGGCGAAAAATACCGTGAGATAACCCCAGGCCGCCCATCGCGGACGGCCTGCTCATAC
GGTATCATCCCCGCCCCAAA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSHSDSHADNNRAWQARGEAAVVNGVGTLLPVFIDKTLNAELWDVEGNRYIDFASGIAVLNTGHNHPKVVAAVREQLEKF
SHTCFQVTPYPGYIELAEKLNALVPGPTPKRTLFLSTGAEAVENAIKIARAHTGRSGTIAFKGGFHGRTMMGMALTGKVV
PYKTGFGPFPGEVYHLPFPSDYLGVSEADALAALDLCFSSDIEPARVAAIILEPVQGEGGFYSASPSFMQSLRKLCDQHG
IVLICDEIQSGFCRTGKTFATEYSGIEPDIMTLAKSLAGGFPLSAVVGKAAIMNAAKPGGLGGTYAGSPIACAAALAVLE
VIEEEQLNQKALAQGAQIKARLHQLAEGFDCIGDIRGPGAMVAMELVKGRDASQPDPDLTKRLVAEAGKRGLVLLSCGVR
ANVIRFLAPLTATPALIEEGLALLEQALTAASQG

Sequences:

>Translated_434_residues
MSHSDSHADNNRAWQARGEAAVVNGVGTLLPVFIDKTLNAELWDVEGNRYIDFASGIAVLNTGHNHPKVVAAVREQLEKF
SHTCFQVTPYPGYIELAEKLNALVPGPTPKRTLFLSTGAEAVENAIKIARAHTGRSGTIAFKGGFHGRTMMGMALTGKVV
PYKTGFGPFPGEVYHLPFPSDYLGVSEADALAALDLCFSSDIEPARVAAIILEPVQGEGGFYSASPSFMQSLRKLCDQHG
IVLICDEIQSGFCRTGKTFATEYSGIEPDIMTLAKSLAGGFPLSAVVGKAAIMNAAKPGGLGGTYAGSPIACAAALAVLE
VIEEEQLNQKALAQGAQIKARLHQLAEGFDCIGDIRGPGAMVAMELVKGRDASQPDPDLTKRLVAEAGKRGLVLLSCGVR
ANVIRFLAPLTATPALIEEGLALLEQALTAASQG
>Mature_433_residues
SHSDSHADNNRAWQARGEAAVVNGVGTLLPVFIDKTLNAELWDVEGNRYIDFASGIAVLNTGHNHPKVVAAVREQLEKFS
HTCFQVTPYPGYIELAEKLNALVPGPTPKRTLFLSTGAEAVENAIKIARAHTGRSGTIAFKGGFHGRTMMGMALTGKVVP
YKTGFGPFPGEVYHLPFPSDYLGVSEADALAALDLCFSSDIEPARVAAIILEPVQGEGGFYSASPSFMQSLRKLCDQHGI
VLICDEIQSGFCRTGKTFATEYSGIEPDIMTLAKSLAGGFPLSAVVGKAAIMNAAKPGGLGGTYAGSPIACAAALAVLEV
IEEEQLNQKALAQGAQIKARLHQLAEGFDCIGDIRGPGAMVAMELVKGRDASQPDPDLTKRLVAEAGKRGLVLLSCGVRA
NVIRFLAPLTATPALIEEGLALLEQALTAASQG

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=32.1951219512195, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=32, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=31.3846153846154, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI37574042, Length=425, Percent_Identity=28, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI24119277, Length=414, Percent_Identity=27.2946859903382, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI226442709, Length=393, Percent_Identity=28.498727735369, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI226442705, Length=425, Percent_Identity=27.2941176470588, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI188536080, Length=409, Percent_Identity=28.1173594132029, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679950, Length=409, Percent_Identity=28.1173594132029, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679946, Length=409, Percent_Identity=28.1173594132029, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=55.5294117647059, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=54.5238095238095, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1789759, Length=409, Percent_Identity=34.4743276283619, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1788044, Length=388, Percent_Identity=35.5670103092784, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=34.7368421052632, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1786349, Length=306, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1786991, Length=381, Percent_Identity=31.2335958005249, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=29.9270072992701, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=424, Percent_Identity=29.4811320754717, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=29.5081967213115, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=229, Percent_Identity=32.7510917030568, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=443, Percent_Identity=25.9593679458239, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=32.2115384615385, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=30.7142857142857, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324386, Length=374, Percent_Identity=27.0053475935829, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=384, Percent_Identity=25.78125, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21357415, Length=411, Percent_Identity=32.1167883211679, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=32.2429906542056, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=32.1678321678322, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=32.541567695962, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281366494, Length=381, Percent_Identity=26.7716535433071, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667139, Length=381, Percent_Identity=26.7716535433071, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667143, Length=381, Percent_Identity=26.7716535433071, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45699; Mature: 45568

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSDSHADNNRAWQARGEAAVVNGVGTLLPVFIDKTLNAELWDVEGNRYIDFASGIAVL
CCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCEEEEECCCEEEE
NTGHNHPKVVAAVREQLEKFSHTCFQVTPYPGYIELAEKLNALVPGPTPKRTLFLSTGAE
ECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCHH
AVENAIKIARAHTGRSGTIAFKGGFHGRTMMGMALTGKVVPYKTGFGPFPGEVYHLPFPS
HHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCEEEECCCCCCCCCCEEECCCCC
DYLGVSEADALAALDLCFSSDIEPARVAAIILEPVQGEGGFYSASPSFMQSLRKLCDQHG
CCCCCCHHHHHHHHHHHHCCCCCHHHEEEEEEEECCCCCCEECCCHHHHHHHHHHHHHCC
IVLICDEIQSGFCRTGKTFATEYSGIEPDIMTLAKSLAGGFPLSAVVGKAAIMNAAKPGG
EEEEECCHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
LGGTYAGSPIACAAALAVLEVIEEEQLNQKALAQGAQIKARLHQLAEGFDCIGDIRGPGA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHH
MVAMELVKGRDASQPDPDLTKRLVAEAGKRGLVLLSCGVRANVIRFLAPLTATPALIEEG
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHH
LALLEQALTAASQG
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SHSDSHADNNRAWQARGEAAVVNGVGTLLPVFIDKTLNAELWDVEGNRYIDFASGIAVL
CCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCEEEEECCCEEEE
NTGHNHPKVVAAVREQLEKFSHTCFQVTPYPGYIELAEKLNALVPGPTPKRTLFLSTGAE
ECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCHH
AVENAIKIARAHTGRSGTIAFKGGFHGRTMMGMALTGKVVPYKTGFGPFPGEVYHLPFPS
HHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCEEEECCCCCCCCCCEEECCCCC
DYLGVSEADALAALDLCFSSDIEPARVAAIILEPVQGEGGFYSASPSFMQSLRKLCDQHG
CCCCCCHHHHHHHHHHHHCCCCCHHHEEEEEEEECCCCCCEECCCHHHHHHHHHHHHHCC
IVLICDEIQSGFCRTGKTFATEYSGIEPDIMTLAKSLAGGFPLSAVVGKAAIMNAAKPGG
EEEEECCHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
LGGTYAGSPIACAAALAVLEVIEEEQLNQKALAQGAQIKARLHQLAEGFDCIGDIRGPGA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHH
MVAMELVKGRDASQPDPDLTKRLVAEAGKRGLVLLSCGVRANVIRFLAPLTATPALIEEG
HHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHH
LALLEQALTAASQG
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]