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The map label for this gene is cvrA [H]

Identifier: 145299809

GI number: 145299809

Start: 3114294

End: 3116021

Strand: Direct

Name: cvrA [H]

Synonym: ASA_2890

Alternate gene names: 145299809

Gene position: 3114294-3116021 (Clockwise)

Preceding gene: 145299808

Following gene: 145299810

Centisome position: 66.23

GC content: 62.73

Gene sequence:

>1728_bases
TTGGATGCCGTCACCATCAACAGTTTCTTTTTAGTCGCGGCCTTGTTGGTGGGAGCCAGTGTCCTGTTGAGCGCGCTCTC
CTCTCGCCTTGGTATCCCCATTTTGGTGATATTTCTCGCGGTCGGCATGCTGGCCGGGGAAGATGGGCCGGGGGGCATTC
ACTTCGCTGACTACTCGGTCGCCTATCTGGTGGGCAACCTGGCGCTCGCCATCATATTGCTCGACGGCGGCATGCGTACC
CGGGTTTCTTCTTTTCGGGTCGCACTCTGGCCAGCGCTCTCGCTGGCAACCGTCGGCGTGGCCATCACCACAGGGCTGAC
CGGTCTGGCCGCCGCCTGGTTGTTCGACCTCAATCTGATGCAGGGCATGCTGATCGGCGCCATCGTCGGCTCCACCGATG
CGGCGGCTGTTTTCTCCCTGCTCGGCGGGCGCAGCCTCAACGAGCGGGTCAGTGCCACCCTGGAGATAGAGTCCGGCAGC
AACGACCCCATGGCGGTGTTTCTCACCGTCACCCTGATCGAAATTCTTGCCACCAACCAACAGGGGCTGGACTGGTTCTT
CCTGCTGCTGCAACTGGGCAAGCAGTTTGGCCTCGGTGCCGGCATAGGTCTGGGCGGCGGCTGGCTGTTGTGGAAACTCA
TCAACAGCGCCAGGCTGGCTCCGGGCCTCTATCCCCTGCTGACCGTCAGTGGTGGCCTGCTCATCTTCGCCCTCACCACG
GCCATCGGAGGCAGCGGCATACTCGCCATCTATCTCACCGGCCTGCTGCTCGGCAACCTCTCCCTGCGCAGTCGCAGTAC
CACGCTGTCGGTACTCGATGGCCTGACCTGGCTCAGCCAGATCGGCATGTTCCTGGTGCTGGGACTGCTGGCCTCCCCCC
ACAAGCTGCTGCCCATCGCCCTGCCGGCGCTGGCACTCGCCGCCTGGATGATACTGTTTGCCCGTCCCGTCTCTGTCTGG
ATTGGCCTCTTGCCGTTCAAGAACTTCGCCCCCCGCGAGCGCTGGTTCATCTCCTGGGTGGGGCTGCGCGGCGCCGTGCC
CATCATACTGGCGGTCTTCCCCATGATGGCCGGGCTGCCCAACGCCCAGCTCTACTTCAATGTCGCCTTCTTCGTGGTGC
TGGTCTCCCTCATACTGCAAGGCAGCTCGCTGCCGCTGGCATCAAAGCTGGCCAGGGTTGAGGTACCGGCACCGCCGTCA
CCCATCAACCGATCCGGGCTTGAGATAGATCTGGACAGCCAGTGGGAGACCTTCGTCTACCGCCTCAGCGCCGAGAAGTG
GTGCATCGGCTCGCCCCTGCGGGATCTGCGCATGCCCAAGGGTACCCGCATCTGCGCCCTGTTCCGGGATCAGGAGTTGC
TGCACCCCTCGGGCAGTACCTGCCTGCAATCCAATGACATCCTCTGCGTCATAGGACACGAGCGAGATTTGCCGGCTCTC
GGCCAGCTGTTCAGTCAGGCTCCTGAGCAGGATCTGGGTCCGCGCTTCTTCGGTGACTTCCTGCTGGAGGCGGCCGCCAA
TATGGTGGACCTGGCTCCGCTCTACGGGCTGGATGTGAGCGAGGTGGCGGATCAGACACTTGGCGATTTTCTTGCCGACC
AGTTGGGCGATAATCTGGTAGTCGGCGATCAGGTCGAATGGCAGGGCCTGATCTGGACAGTGGCCGAAATGGAAGAGGGC
AAGCCCCGCAAGATAGGGGTGCGCTTTCAGGAAGAAGACCCGGTCTGA

Upstream 100 bases:

>100_bases
AATGTAAAAAACTGCAAATAAATGCACAATTAAGCCACACCGCGCCCAACAAACTGCATATAATGTGCCTGTTTTGCATT
TTGACAGAAGGAGTTCGCCA

Downstream 100 bases:

>100_bases
CGCACATCGTCTGACCCGCCTTTGCGAGCAGGGAGTTCATTATGCCTTACCAAACCGAGTTGTCTGGCCTGCAACCCCCT
TTTCCCAATCTGGGATTGAT

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MDAVTINSFFLVAALLVGASVLLSALSSRLGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRT
RVSSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGS
NDPMAVFLTVTLIEILATNQQGLDWFFLLLQLGKQFGLGAGIGLGGGWLLWKLINSARLAPGLYPLLTVSGGLLIFALTT
AIGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAAWMILFARPVSVW
IGLLPFKNFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPS
PINRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRDLRMPKGTRICALFRDQELLHPSGSTCLQSNDILCVIGHERDLPAL
GQLFSQAPEQDLGPRFFGDFLLEAAANMVDLAPLYGLDVSEVADQTLGDFLADQLGDNLVVGDQVEWQGLIWTVAEMEEG
KPRKIGVRFQEEDPV

Sequences:

>Translated_575_residues
MDAVTINSFFLVAALLVGASVLLSALSSRLGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRT
RVSSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGS
NDPMAVFLTVTLIEILATNQQGLDWFFLLLQLGKQFGLGAGIGLGGGWLLWKLINSARLAPGLYPLLTVSGGLLIFALTT
AIGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAAWMILFARPVSVW
IGLLPFKNFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPS
PINRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRDLRMPKGTRICALFRDQELLHPSGSTCLQSNDILCVIGHERDLPAL
GQLFSQAPEQDLGPRFFGDFLLEAAANMVDLAPLYGLDVSEVADQTLGDFLADQLGDNLVVGDQVEWQGLIWTVAEMEEG
KPRKIGVRFQEEDPV
>Mature_575_residues
MDAVTINSFFLVAALLVGASVLLSALSSRLGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRT
RVSSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGS
NDPMAVFLTVTLIEILATNQQGLDWFFLLLQLGKQFGLGAGIGLGGGWLLWKLINSARLAPGLYPLLTVSGGLLIFALTT
AIGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAAWMILFARPVSVW
IGLLPFKNFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPS
PINRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRDLRMPKGTRICALFRDQELLHPSGSTCLQSNDILCVIGHERDLPAL
GQLFSQAPEQDLGPRFFGDFLLEAAANMVDLAPLYGLDVSEVADQTLGDFLADQLGDNLVVGDQVEWQGLIWTVAEMEEG
KPRKIGVRFQEEDPV

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=576, Percent_Identity=66.3194444444444, Blast_Score=673, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61459; Mature: 61459

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVTINSFFLVAALLVGASVLLSALSSRLGIPILVIFLAVGMLAGEDGPGGIHFADYSV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECHHHH
AYLVGNLALAIILLDGGMRTRVSSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLM
HHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVFLTVTLIEILATNQ
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHCCC
QGLDWFFLLLQLGKQFGLGAGIGLGGGWLLWKLINSARLAPGLYPLLTVSGGLLIFALTT
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHH
AIGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIA
HCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LPALALAAWMILFARPVSVWIGLLPFKNFAPRERWFISWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHCCC
NAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPSPINRSGLEIDLDSQWETFVY
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEECCCCCCCCCCCCCEEEECCCCCEEHE
RLSAEKWCIGSPLRDLRMPKGTRICALFRDQELLHPSGSTCLQSNDILCVIGHERDLPAL
EECCCCEECCCCHHHHCCCCCCEEEEEECCCHHCCCCCCCEEECCCEEEEECCCCCCHHH
GQLFSQAPEQDLGPRFFGDFLLEAAANMVDLAPLYGLDVSEVADQTLGDFLADQLGDNLV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
VGDQVEWQGLIWTVAEMEEGKPRKIGVRFQEEDPV
ECCCCCCCEEEEEEEHHCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MDAVTINSFFLVAALLVGASVLLSALSSRLGIPILVIFLAVGMLAGEDGPGGIHFADYSV
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECHHHH
AYLVGNLALAIILLDGGMRTRVSSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLM
HHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVFLTVTLIEILATNQ
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHCCC
QGLDWFFLLLQLGKQFGLGAGIGLGGGWLLWKLINSARLAPGLYPLLTVSGGLLIFALTT
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHH
AIGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIA
HCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LPALALAAWMILFARPVSVWIGLLPFKNFAPRERWFISWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHCCC
NAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPSPINRSGLEIDLDSQWETFVY
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEECCCCCCCCCCCCCEEEECCCCCEEHE
RLSAEKWCIGSPLRDLRMPKGTRICALFRDQELLHPSGSTCLQSNDILCVIGHERDLPAL
EECCCCEECCCCHHHHCCCCCCEEEEEECCCHHCCCCCCCEEECCCEEEEECCCCCCHHH
GQLFSQAPEQDLGPRFFGDFLLEAAANMVDLAPLYGLDVSEVADQTLGDFLADQLGDNLV
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
VGDQVEWQGLIWTVAEMEEGKPRKIGVRFQEEDPV
ECCCCCCCEEEEEEEHHCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA