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The map label for this gene is mdh [H]

Identifier: 145299780

GI number: 145299780

Start: 3080291

End: 3081484

Strand: Direct

Name: mdh [H]

Synonym: ASA_2860

Alternate gene names: 145299780

Gene position: 3080291-3081484 (Clockwise)

Preceding gene: 145299779

Following gene: 145299783

Centisome position: 65.5

GC content: 66.16

Gene sequence:

>1194_bases
ATGAACAACATGAGTCGCTATTACGATTTCTTCTGTCCGGTCAAACTGATAGCGGGCGAGCAGGCGCTGGAACAGCTGGC
TGGCGAATTGGCGGGTCTGGGGGCACGCCGTCCGCTGCTGCTCACTGACAAGGGGGTCAGCGGCACAGGGCTCGCCACCC
TGCTGGCCAATGTGCTGGCCGAGGGGGAGCTGCCGGTCGCCGACATCTGGGACGAGATCCCGGCCGACTCCTCCACCGCC
GTGGTGGAGCGGATCGCGGCCCGCTATCGGGAGCTCGAATGCGACAGCCTGGTGGCGCTGGGCGGCGGCTCCGTCATCGA
CACCGCCAAGGCGGTCAACATCCTCGCCTCCATGGGCGGGGATCGGCTGCTGGATTACGCCGGAGCAGGCTGTCTGACCC
GGCCCCTGCAGCCACTGGCGGTGGTGCCCACCACGGCAGGTACGGGATCCGAGGTGACGCTGGTGGCGGTGATCAAGGAT
GAGGCGAGCGGGCGCAAAGTGCCCTTCACCTCCCCCTTCCTGCTGCCCCAGCTGGCGGTGCTGGATCCGCGCCTCACTCA
GGGCTTGCCCCTCAACATCACGGCCGCCACCGCCATGGATGCCATGACCCACGCCATCGAGGCCTTCATCGGCAATGCCA
AGAATCCGGTCAGCGACGCCCTGGCCCTGATGGCGATAGAGAAAATTGCCAACGCCTTGCCCAAGGTGCTGCAAAGCCCG
CAAGACAAGCAGCTGCGGCTGCAACTGGCGGAAGGATCCACCCTGGCGGGGATGGCGTTTTCCAACTCCATGGTGGGGTT
GGTGCATGCCCTCGGCCACAGCCTGGGGGCCCGCTGTCACCTGCCCCACGGTCTGTGCATGAACCTCTTCCTGCCGACCG
TGCTCGACTACAACCGCCCGGGCATAGACCCTGAGCTGGCCCGCCTGCTGCTGCCCCTGGTCGGTGCCGAGCGCTTTGCG
GCAACCCCGGCCACAGAACAGGCACAAGCAAGCATTCAGGCACTGTGCGCCCTGCGCGATAGCCTGTGGCAGGCGGTGAA
GCTGCCGCGCACCTTGCGTGAAGCGGGCGTCACCGACAAGGGGTTGCTGCCCGAGATCCGGGATCTCGCCATCAATGACG
GCGCCCTGCTCTATAACCGCAAGGATGCCGACCGGGCTCAACTGCTCGACCTGCTGGAACGGGCGTGGGAGTAA

Upstream 100 bases:

>100_bases
TCATAGCGCGGCCGCTGCTGCGCCACTATCCGAACCCGCGCAACAAGCTGACGCGTGCCTGCCACATCTACCTGGGTCTG
CTGACCGGCTGAATAAAAGG

Downstream 100 bases:

>100_bases
TCTGGCTGGAGGCCCCGCATCGCGGGGCCCTCAGTTACCAGCGGATGGTGGCACCGGCGCCGTAGTTGCCGCTCTCTTCA
GGCGTTTTTTCGCGCCAGAT

Product: alcohol dehydrogenase IV

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNNMSRYYDFFCPVKLIAGEQALEQLAGELAGLGARRPLLLTDKGVSGTGLATLLANVLAEGELPVADIWDEIPADSSTA
VVERIAARYRELECDSLVALGGGSVIDTAKAVNILASMGGDRLLDYAGAGCLTRPLQPLAVVPTTAGTGSEVTLVAVIKD
EASGRKVPFTSPFLLPQLAVLDPRLTQGLPLNITAATAMDAMTHAIEAFIGNAKNPVSDALALMAIEKIANALPKVLQSP
QDKQLRLQLAEGSTLAGMAFSNSMVGLVHALGHSLGARCHLPHGLCMNLFLPTVLDYNRPGIDPELARLLLPLVGAERFA
ATPATEQAQASIQALCALRDSLWQAVKLPRTLREAGVTDKGLLPEIRDLAINDGALLYNRKDADRAQLLDLLERAWE

Sequences:

>Translated_397_residues
MNNMSRYYDFFCPVKLIAGEQALEQLAGELAGLGARRPLLLTDKGVSGTGLATLLANVLAEGELPVADIWDEIPADSSTA
VVERIAARYRELECDSLVALGGGSVIDTAKAVNILASMGGDRLLDYAGAGCLTRPLQPLAVVPTTAGTGSEVTLVAVIKD
EASGRKVPFTSPFLLPQLAVLDPRLTQGLPLNITAATAMDAMTHAIEAFIGNAKNPVSDALALMAIEKIANALPKVLQSP
QDKQLRLQLAEGSTLAGMAFSNSMVGLVHALGHSLGARCHLPHGLCMNLFLPTVLDYNRPGIDPELARLLLPLVGAERFA
ATPATEQAQASIQALCALRDSLWQAVKLPRTLREAGVTDKGLLPEIRDLAINDGALLYNRKDADRAQLLDLLERAWE
>Mature_397_residues
MNNMSRYYDFFCPVKLIAGEQALEQLAGELAGLGARRPLLLTDKGVSGTGLATLLANVLAEGELPVADIWDEIPADSSTA
VVERIAARYRELECDSLVALGGGSVIDTAKAVNILASMGGDRLLDYAGAGCLTRPLQPLAVVPTTAGTGSEVTLVAVIKD
EASGRKVPFTSPFLLPQLAVLDPRLTQGLPLNITAATAMDAMTHAIEAFIGNAKNPVSDALALMAIEKIANALPKVLQSP
QDKQLRLQLAEGSTLAGMAFSNSMVGLVHALGHSLGARCHLPHGLCMNLFLPTVLDYNRPGIDPELARLLLPLVGAERFA
ATPATEQAQASIQALCALRDSLWQAVKLPRTLREAGVTDKGLLPEIRDLAINDGALLYNRKDADRAQLLDLLERAWE

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=320, Percent_Identity=28.75, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI48994951, Length=351, Percent_Identity=34.4729344729345, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI87082107, Length=297, Percent_Identity=36.7003367003367, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1789163, Length=381, Percent_Identity=32.8083989501312, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1787493, Length=361, Percent_Identity=27.9778393351801, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789386, Length=281, Percent_Identity=28.1138790035587, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537053, Length=443, Percent_Identity=26.410835214447, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321181, Length=397, Percent_Identity=34.5088161209068, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24657991, Length=412, Percent_Identity=29.126213592233, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 42118; Mature: 42118

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNMSRYYDFFCPVKLIAGEQALEQLAGELAGLGARRPLLLTDKGVSGTGLATLLANVLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHH
EGELPVADIWDEIPADSSTAVVERIAARYRELECDSLVALGGGSVIDTAKAVNILASMGG
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCC
DRLLDYAGAGCLTRPLQPLAVVPTTAGTGSEVTLVAVIKDEASGRKVPFTSPFLLPQLAV
HHHHHHCCCCHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHH
LDPRLTQGLPLNITAATAMDAMTHAIEAFIGNAKNPVSDALALMAIEKIANALPKVLQSP
CCCHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
QDKQLRLQLAEGSTLAGMAFSNSMVGLVHALGHSLGARCHLPHGLCMNLFLPTVLDYNRP
CCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHCCCCC
GIDPELARLLLPLVGAERFAATPATEQAQASIQALCALRDSLWQAVKLPRTLREAGVTDK
CCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GLLPEIRDLAINDGALLYNRKDADRAQLLDLLERAWE
CCCCHHHHHEECCCEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNNMSRYYDFFCPVKLIAGEQALEQLAGELAGLGARRPLLLTDKGVSGTGLATLLANVLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHH
EGELPVADIWDEIPADSSTAVVERIAARYRELECDSLVALGGGSVIDTAKAVNILASMGG
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCC
DRLLDYAGAGCLTRPLQPLAVVPTTAGTGSEVTLVAVIKDEASGRKVPFTSPFLLPQLAV
HHHHHHCCCCHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHH
LDPRLTQGLPLNITAATAMDAMTHAIEAFIGNAKNPVSDALALMAIEKIANALPKVLQSP
CCCHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
QDKQLRLQLAEGSTLAGMAFSNSMVGLVHALGHSLGARCHLPHGLCMNLFLPTVLDYNRP
CCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHCCCCC
GIDPELARLLLPLVGAERFAATPATEQAQASIQALCALRDSLWQAVKLPRTLREAGVTDK
CCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GLLPEIRDLAINDGALLYNRKDADRAQLLDLLERAWE
CCCCHHHHHEECCCEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]