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The map label for this gene is hmuU [H]

Identifier: 145296075

GI number: 145296075

Start: 2195582

End: 2196622

Strand: Reverse

Name: hmuU [H]

Synonym: cgR_1997

Alternate gene names: 145296075

Gene position: 2196622-2195582 (Counterclockwise)

Preceding gene: 145296076

Following gene: 145296074

Centisome position: 66.28

GC content: 53.7

Gene sequence:

>1041_bases
GTGCTGAAGAGAATTTTCCTCAACCCCTGGGTGGCTACCGCGTTGTCGGTAGTCATTTTGGGGTTTGTGGTGCTGTTTTC
AGGTTTTAGCGGTGTTATTGATTTAAGCCCCACAGCAGTGATTAGACATTTGAGTGGGCAGGACACGCTCACCCCTCGAG
ATCAGGCCATCTTCTTTGATATCCGGCTGCCTCGAATTATCGCTGGTGTCATTGTCGGAGCAACGCTGGCTATTTCTGGT
GCTGCTTACCAAGCGGTATTTAGAAACCCGCTGGCTGATCCTTATTTGTTGGGTGTGTCCGCAGGTTCTGGCCTTGGTGT
CACGGCAGTGATTGTTGGCGGTACCGTGCTGGGATTTTCTGCACCGAGCATCGGCGTGATTGGTGCAGCATTTGTAGGTG
GTGTTGCCGCAGTACTTGCCACGCTGATGGTGAGTCGGGGAGTAGGACAGGGATCATCAACCACCGTAGTTATTTTGGCC
GGCGTGGCGGTTGCTGCTTTTGCCAGTTCCATCCAGACCTATATTCAGCAACGACACATCGATACGGTGGCGCGCGTATA
TGTGTGGATGTTGGGCAATCTCAATGTCACCAACTGGATGTCGATCTTCATCGTGGCTGTGGTGGCGGGACTATGCGCGG
CCGTGATCATGTCCTGCGCCAGGTTGTTAGACGTGATGGCTGTTGGTGATGTGGAAGCCCGCACATTGGGCGTCGATCCA
GGCCTCGTACGCATTGGCATTGTCATCGTGGCAACCCTTGGTACAGCTGCAGTGGTATCCATTTCCGGTCTCATCGGGTT
TGTGGGCATCATTGTTCCGCACGCCCTGCGCCTAATTGTTGGCCCGGGGCATCGGATTTTACTGCCACTGTCTTTCGTAT
GGGGTGCCATTTTCCTCGTGTTGGCAGATACCGCAGGGCGAACATTGATGGCTCCTCAGGAACTTCCCGTGGGTGTGGTG
ACAGCTGCACTCGGCGCACCGTTCTTCTTATTTATTTTGCGCAGAACCAGCAGACAACGAGTTCCAAAAAGGAGTGCTTA
A

Upstream 100 bases:

>100_bases
CAGGTGGGGACCTCGCGTATCCCAGCTGGTGGAAGAAATCGCAGCGCAGTTGAATCAGCTTGCTTCTTCTGAAGCCGTGC
CGGCCGCTGCTTAAGTTTTC

Downstream 100 bases:

>100_bases
GTGGCGATCATTGAATGCGAAGACATCACGGTTCGCCACCCACATGCGCCCACACCTGCGGTTTCTGGGTTGAGCACCTT
TGTAGAACAAGGGGAATGGC

Product: hypothetical protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLKRIFLNPWVATALSVVILGFVVLFSGFSGVIDLSPTAVIRHLSGQDTLTPRDQAIFFDIRLPRIIAGVIVGATLAISG
AAYQAVFRNPLADPYLLGVSAGSGLGVTAVIVGGTVLGFSAPSIGVIGAAFVGGVAAVLATLMVSRGVGQGSSTTVVILA
GVAVAAFASSIQTYIQQRHIDTVARVYVWMLGNLNVTNWMSIFIVAVVAGLCAAVIMSCARLLDVMAVGDVEARTLGVDP
GLVRIGIVIVATLGTAAVVSISGLIGFVGIIVPHALRLIVGPGHRILLPLSFVWGAIFLVLADTAGRTLMAPQELPVGVV
TAALGAPFFLFILRRTSRQRVPKRSA

Sequences:

>Translated_346_residues
MLKRIFLNPWVATALSVVILGFVVLFSGFSGVIDLSPTAVIRHLSGQDTLTPRDQAIFFDIRLPRIIAGVIVGATLAISG
AAYQAVFRNPLADPYLLGVSAGSGLGVTAVIVGGTVLGFSAPSIGVIGAAFVGGVAAVLATLMVSRGVGQGSSTTVVILA
GVAVAAFASSIQTYIQQRHIDTVARVYVWMLGNLNVTNWMSIFIVAVVAGLCAAVIMSCARLLDVMAVGDVEARTLGVDP
GLVRIGIVIVATLGTAAVVSISGLIGFVGIIVPHALRLIVGPGHRILLPLSFVWGAIFLVLADTAGRTLMAPQELPVGVV
TAALGAPFFLFILRRTSRQRVPKRSA
>Mature_346_residues
MLKRIFLNPWVATALSVVILGFVVLFSGFSGVIDLSPTAVIRHLSGQDTLTPRDQAIFFDIRLPRIIAGVIVGATLAISG
AAYQAVFRNPLADPYLLGVSAGSGLGVTAVIVGGTVLGFSAPSIGVIGAAFVGGVAAVLATLMVSRGVGQGSSTTVVILA
GVAVAAFASSIQTYIQQRHIDTVARVYVWMLGNLNVTNWMSIFIVAVVAGLCAAVIMSCARLLDVMAVGDVEARTLGVDP
GLVRIGIVIVATLGTAAVVSISGLIGFVGIIVPHALRLIVGPGHRILLPLSFVWGAIFLVLADTAGRTLMAPQELPVGVV
TAALGAPFFLFILRRTSRQRVPKRSA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=303, Percent_Identity=36.3036303630363, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790740, Length=283, Percent_Identity=35.3356890459364, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790741, Length=283, Percent_Identity=31.095406360424, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786805, Length=309, Percent_Identity=33.0097087378641, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786347, Length=283, Percent_Identity=31.095406360424, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786804, Length=328, Percent_Identity=30.4878048780488, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35771; Mature: 35771

Theoretical pI: Translated: 11.43; Mature: 11.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRIFLNPWVATALSVVILGFVVLFSGFSGVIDLSPTAVIRHLSGQDTLTPRDQAIFFD
CCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHCCCCCCCCCCCCEEEEE
IRLPRIIAGVIVGATLAISGAAYQAVFRNPLADPYLLGVSAGSGLGVTAVIVGGTVLGFS
EEHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCEEEECC
APSIGVIGAAFVGGVAAVLATLMVSRGVGQGSSTTVVILAGVAVAAFASSIQTYIQQRHI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
DTVARVYVWMLGNLNVTNWMSIFIVAVVAGLCAAVIMSCARLLDVMAVGDVEARTLGVDP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
GLVRIGIVIVATLGTAAVVSISGLIGFVGIIVPHALRLIVGPGHRILLPLSFVWGAIFLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
LADTAGRTLMAPQELPVGVVTAALGAPFFLFILRRTSRQRVPKRSA
HHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKRIFLNPWVATALSVVILGFVVLFSGFSGVIDLSPTAVIRHLSGQDTLTPRDQAIFFD
CCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHCCCCCCCCCCCCEEEEE
IRLPRIIAGVIVGATLAISGAAYQAVFRNPLADPYLLGVSAGSGLGVTAVIVGGTVLGFS
EEHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCEEEECC
APSIGVIGAAFVGGVAAVLATLMVSRGVGQGSSTTVVILAGVAVAAFASSIQTYIQQRHI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
DTVARVYVWMLGNLNVTNWMSIFIVAVVAGLCAAVIMSCARLLDVMAVGDVEARTLGVDP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCC
GLVRIGIVIVATLGTAAVVSISGLIGFVGIIVPHALRLIVGPGHRILLPLSFVWGAIFLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
LADTAGRTLMAPQELPVGVVTAALGAPFFLFILRRTSRQRVPKRSA
HHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]