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The map label for this gene is hisB [H]

Identifier: 145296062

GI number: 145296062

Start: 2181539

End: 2182147

Strand: Reverse

Name: hisB [H]

Synonym: cgR_1984

Alternate gene names: 145296062

Gene position: 2182147-2181539 (Counterclockwise)

Preceding gene: 145296063

Following gene: 145296061

Centisome position: 65.84

GC content: 57.14

Gene sequence:

>609_bases
ATGACTGTCGCACCAAGAATTGGTACCGCAACCCGCACCACCAGCGAATCCGACATCACCGTCGAGATCAACCTGGACGG
CACCGGCAAAGTAGATATCGATACCGGCCTGCCATTTTTCGACCACATGCTCACTGCATTCGGCGTGCACGGCAGTTTTG
ATCTGAAAGTCCATGCCAAGGGCGACATCGAGATCGACGCACACCACACCGTGGAAGATACCGCCATTGTGCTCGGCCAA
GCACTCCTTGACGCTATTGGCGACAAGAAAGGCATCCGCCGTTTCGCATCCTGCCAGCTGCCCATGGATGAGGCATTAGT
GGAGTCCGTGGTGGATATCTCCGGTCGCCCATACTTCGTGATCTCCGGCGAACCAGACCACATGATCACCTCCGTGATCG
GTGGACACTACGCAACCGTGATCAACGAGCACTTCTTTGAAACCCTCGCGCTCAACTCCCGAATCACCCTCCACGTGATC
TGCCACTACGGCCGCGACCCTCACCACATCACCGAAGCAGAATACAAGGCTGTTGCCCGTGCGCTGCGCGGTGCCGTAGA
GATGGATCCTCGTCAAACAGGAATCCCATCCACCAAGGGAGCGCTCTAG

Upstream 100 bases:

>100_bases
CACTTGCGCACTACCATTGGTGTGCCTGAGGAAAATGATGCGTTTTTGGACGCAGCTGCAGAGATCATCAAGCTGAACCT
GTAAGAGAGAAGAATTTTTC

Downstream 100 bases:

>100_bases
ACATGAACTCTTCTCCCATCTCTGATATGGTCACTGCGACTGTGCAGAACGAACCAGATGCGGGGGACCGATGGTTTATT
TATGGTCTTTTCATCATCGC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MTVAPRIGTATRTTSESDITVEINLDGTGKVDIDTGLPFFDHMLTAFGVHGSFDLKVHAKGDIEIDAHHTVEDTAIVLGQ
ALLDAIGDKKGIRRFASCQLPMDEALVESVVDISGRPYFVISGEPDHMITSVIGGHYATVINEHFFETLALNSRITLHVI
CHYGRDPHHITEAEYKAVARALRGAVEMDPRQTGIPSTKGAL

Sequences:

>Translated_202_residues
MTVAPRIGTATRTTSESDITVEINLDGTGKVDIDTGLPFFDHMLTAFGVHGSFDLKVHAKGDIEIDAHHTVEDTAIVLGQ
ALLDAIGDKKGIRRFASCQLPMDEALVESVVDISGRPYFVISGEPDHMITSVIGGHYATVINEHFFETLALNSRITLHVI
CHYGRDPHHITEAEYKAVARALRGAVEMDPRQTGIPSTKGAL
>Mature_201_residues
TVAPRIGTATRTTSESDITVEINLDGTGKVDIDTGLPFFDHMLTAFGVHGSFDLKVHAKGDIEIDAHHTVEDTAIVLGQA
LLDAIGDKKGIRRFASCQLPMDEALVESVVDISGRPYFVISGEPDHMITSVIGGHYATVINEHFFETLALNSRITLHVIC
HYGRDPHHITEAEYKAVARALRGAVEMDPRQTGIPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=202, Percent_Identity=42.0792079207921, Blast_Score=150, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324776, Length=174, Percent_Identity=43.1034482758621, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21914; Mature: 21783

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAPRIGTATRTTSESDITVEINLDGTGKVDIDTGLPFFDHMLTAFGVHGSFDLKVHAK
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEEEC
GDIEIDAHHTVEDTAIVLGQALLDAIGDKKGIRRFASCQLPMDEALVESVVDISGRPYFV
CCEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEE
ISGEPDHMITSVIGGHYATVINEHFFETLALNSRITLHVICHYGRDPHHITEAEYKAVAR
ECCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
ALRGAVEMDPRQTGIPSTKGAL
HHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVAPRIGTATRTTSESDITVEINLDGTGKVDIDTGLPFFDHMLTAFGVHGSFDLKVHAK
CCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEEEC
GDIEIDAHHTVEDTAIVLGQALLDAIGDKKGIRRFASCQLPMDEALVESVVDISGRPYFV
CCEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEE
ISGEPDHMITSVIGGHYATVINEHFFETLALNSRITLHVICHYGRDPHHITEAEYKAVAR
ECCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
ALRGAVEMDPRQTGIPSTKGAL
HHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]