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The map label for this gene is hisC

Identifier: 145296063

GI number: 145296063

Start: 2182164

End: 2183264

Strand: Reverse

Name: hisC

Synonym: cgR_1985

Alternate gene names: 145296063

Gene position: 2183264-2182164 (Counterclockwise)

Preceding gene: 145296064

Following gene: 145296062

Centisome position: 65.88

GC content: 54.77

Gene sequence:

>1101_bases
ATGACCAAAATTACTTTGAGCGATTTGCCATTGCGTGAAGAACTGCGCGGTGAGCACGCTTACGGCGCACCCCAGCTCAA
CGTTGATATTCGCCTCAACACCAACGAAAACCCTTACCCACCGTCAGAGGCATTGGTCGCTGACTTGGTTGCCACCGTGG
ATAAGATCGCCACCGAGCTGAACCGCTACCCAGAGCGCGATGCTGTGGAACTGCGTGATGAGTTGGCTGCGTACATCACC
AAGCAAACCGGCGTGGCTGTCACCAGGGATAACCTGTGGGCTGCCAATGGTTCCAATGAAATTCTGCAGCAGCTGCTGCA
GGCATTTGGTGGACCTGGACGCACCGCGTTGGGATTCCAACCCAGCTATTCCATGCACCCAATTTTGGCTAAAGGCACTC
ACACTGAATTCATTGCGGTGTCCCGAGGTGCTGATTTCCGCATCGATATGGATGTGGCGCTGGAAGAAATTCGTGCAAAG
CAGCCTGACATTGTTTTTGTCACCACCCCGAACAACCCGACCGGTGATGTGACCTCGCTGGACGATATTGAGCGCATCAT
CAACGTTGCCCCAGGCATCGTGATCGTGGATGAAGCTTATGCGGAATTCTCCCCATCACCTTCAGCAACCACTCTTCTGG
AGAAGTACCCAACCAAGCTGGTGGTGTCCCGCACCATGAGTAAGGCTTTTGATTTCGCAGGTGGACGCCTCGGCTACTTC
GTGGCGAACCCAGCGTTTATCGACGCCGTGATGCTAGTCCGCCTTCCGTATCATCTTTCAGCGCTGAGCCAAGCAGCCGC
AATCGTAGCGCTGCGTCACTCCGCTGACACGCTGGGAACCGTCGAAAAGCTCTCTGTAGAGCGTGTTCGCGTGGCAGCAC
GCTTGGAGGAACTGGGCTACGCTGTGGTTCCAAGTGAGTCCAACTTTGTGTTCTTTGGAGATTTCTCCGATCAGCACGCG
GCATGGCAGGCATTTTTGGATAGGGGAGTGCTCATCCGCGATGTGGGAATCGCCGGGCACTTGCGCACTACCATTGGTGT
GCCTGAGGAAAATGATGCGTTTTTGGACGCAGCTGCAGAGATCATCAAGCTGAACCTGTAA

Upstream 100 bases:

>100_bases
TTGTCATCAACTTTGCCAACGCCGAAGATCTTCCAGCGCACGGCGAAGCAATCCGTGCACGCTTTGAAAACCTCCCCACC
ACCGACGAGGCCTAAGAAAA

Downstream 100 bases:

>100_bases
GAGAGAAGAATTTTTCATGACTGTCGCACCAAGAATTGGTACCGCAACCCGCACCACCAGCGAATCCGACATCACCGTCG
AGATCAACCTGGACGGCACC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATELNRYPERDAVELRDELAAYIT
KQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAK
QPDIVFVTTPNNPTGDVTSLDDIERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGYAVVPSESNFVFFGDFSDQHA
AWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAEIIKLNL

Sequences:

>Translated_366_residues
MTKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATELNRYPERDAVELRDELAAYIT
KQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAK
QPDIVFVTTPNNPTGDVTSLDDIERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGYAVVPSESNFVFFGDFSDQHA
AWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAEIIKLNL
>Mature_365_residues
TKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATELNRYPERDAVELRDELAAYITK
QTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAKQ
PDIVFVTTPNNPTGDVTSLDDIERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYFV
ANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGYAVVPSESNFVFFGDFSDQHAA
WQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAEIIKLNL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=378, Percent_Identity=30.4232804232804, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788722, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=362, Percent_Identity=29.5580110497238, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_CORGB (A4QFG6)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138884.1
- ProteinModelPortal:   A4QFG6
- SMR:   A4QFG6
- STRING:   A4QFG6
- GeneID:   4993041
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1985
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   GRTAIGF
- ProtClustDB:   PRK03317
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39933; Mature: 39802

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATEL
CCEEECCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
NRYPERDAVELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQ
HHCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCHHHHHHHHHHHCCCCCCEECCC
PSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAKQPDIVFVTTPNNPTGDVTSL
CCCCCCCEEECCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCH
DDIERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
HHHHHHHHHCCCEEEEECHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGY
EECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCE
AVVPSESNFVFFGDFSDQHAAWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAE
EEECCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCHHHEECCCCCCCHHHHHHHH
IIKLNL
HHEECC
>Mature Secondary Structure 
TKITLSDLPLREELRGEHAYGAPQLNVDIRLNTNENPYPPSEALVADLVATVDKIATEL
CEEECCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
NRYPERDAVELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQ
HHCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEECCCCHHHHHHHHHHHCCCCCCEECCC
PSYSMHPILAKGTHTEFIAVSRGADFRIDMDVALEEIRAKQPDIVFVTTPNNPTGDVTSL
CCCCCCCEEECCCCCEEEEEECCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCCH
DDIERIINVAPGIVIVDEAYAEFSPSPSATTLLEKYPTKLVVSRTMSKAFDFAGGRLGYF
HHHHHHHHHCCCEEEEECHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEE
VANPAFIDAVMLVRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVERVRVAARLEELGY
EECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCE
AVVPSESNFVFFGDFSDQHAAWQAFLDRGVLIRDVGIAGHLRTTIGVPEENDAFLDAAAE
EEECCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCHHHEECCCCCCCHHHHHHHH
IIKLNL
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA