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The map label for this gene is hisI

Identifier: 145296055

GI number: 145296055

Start: 2175590

End: 2175946

Strand: Reverse

Name: hisI

Synonym: cgR_1977

Alternate gene names: 145296055

Gene position: 2175946-2175590 (Counterclockwise)

Preceding gene: 145296056

Following gene: 145296054

Centisome position: 65.66

GC content: 56.3

Gene sequence:

>357_bases
ATGAGTGACAATCCACAAGAGTATGAGCTGGATTGGGACGTCGAAAAGCGATTAAAGCTTAACGACGCCGGCCTGGTGCC
GGCAATCGTCCAGGCCGACGGGACCAACGAGGTCCTCATGATGGCCTGGATGGATACCCACGCGCTAGCCTATACTTTGG
CGACCCGCCGTGGAACCTATTTTTCTAGGTCCCGCAACGAGTACTGGATCAAGGGCCTGACCTCTGGAAACGTCCAAGAA
GTCACCGGAGTTGCCCTCGACTGCGACGGCGACACCGTCCTTCTGACCGTGAAACAAACCGGCGGTGCGTGCCACACTGG
TGCCCACACATGTTTCGACAATGACGTTTTGCTGTAA

Upstream 100 bases:

>100_bases
GCGCCAACGCAGTGCTTGCCGCGACCATTTTCCACTTCCGCGAAGTAACCATCGCCGAAGTAAAGGGAGCCATTAAAGAT
GCAGGATTTGAGGTGCGGAA

Downstream 100 bases:

>100_bases
AAGCAACAACGATTAAGGGAGAAGTCTTATGAAGCCACGCGTGCTGTCAGCATTAGGCATTGGAGCTGGCGCCCTGGTTG
TCTGGATCAGCTCACGCATG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 118; Mature: 117

Protein sequence:

>118_residues
MSDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTYFSRSRNEYWIKGLTSGNVQE
VTGVALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL

Sequences:

>Translated_118_residues
MSDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTYFSRSRNEYWIKGLTSGNVQE
VTGVALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL
>Mature_117_residues
SDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTYFSRSRNEYWIKGLTSGNVQEV
TGVALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=112, Percent_Identity=41.0714285714286, Blast_Score=92, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=90, Percent_Identity=38.8888888888889, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_CORGB (A4QFF8)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138876.1
- ProteinModelPortal:   A4QFF8
- SMR:   A4QFF8
- STRING:   A4QFF8
- GeneID:   4994337
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1977
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13027; Mature: 12896

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTY
CCCCCCCEEECCCCCCEEEECCCCCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCCCE
FSRSRNEYWIKGLTSGNVQEVTGVALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL
EECCCCCEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SDNPQEYELDWDVEKRLKLNDAGLVPAIVQADGTNEVLMMAWMDTHALAYTLATRRGTY
CCCCCCEEECCCCCCEEEECCCCCCEEEEECCCCCCEEEEEEECCCEEEEEEECCCCCE
FSRSRNEYWIKGLTSGNVQEVTGVALDCDGDTVLLTVKQTGGACHTGAHTCFDNDVLL
EECCCCCEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA