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The map label for this gene is mutM

Identifier: 145296036

GI number: 145296036

Start: 2153991

End: 2154851

Strand: Reverse

Name: mutM

Synonym: cgR_1958

Alternate gene names: 145296036

Gene position: 2154851-2153991 (Counterclockwise)

Preceding gene: 145296037

Following gene: 145296035

Centisome position: 65.02

GC content: 53.31

Gene sequence:

>861_bases
GTGCCTGAACTGCCTGAAGTTGAGGTGGTGCGCCGCGGTTTAGAAGATCATATGGTCGGCCACACCATCGTGTCCGCCAC
AGTGCTCCACCCGCGCGCAGCCCGCAATCAACTCGGTGGTGGCCCCGAAATCGAGGCCAACATCGCAGGGCTTAGGGTCA
GCGCTGCCAAGCGACGCGGCAAATTCCTCTGGCTTGAGCTTATCGACGCACCCTCCGGCGAAACCCGTCCCGATTTAGGG
CTACTGGTTCACCTTGGGATGAGTGGACAAATGCTCATCAAAGAACCAGATGCACCAATTAGTCCACACCTTCGAGCCAA
AATCGAGCTAGATAATGGCGATGAAGTGTGGTTTGTTGATCAACGCACCTTCGGTTATTGGTGGCTCGGCGACCTAGTTG
ATGGAGTACCCGAACGCGTCTCTCACATTGCCACAGATGTATTGGATGAGTCTGCTGATTTCTCTGCGATTGCGCGGAAT
TTGAAATCTCGGAAATCGGAGATCAAACGCCTCCTGCTTAACCAGGAGATCGTCTCCGGCATCGGAAATATCTATGCCGA
TGAAATGCTCTGGCAAGCAAAAATTCACCCATTGCAACGTGCCGACCGACTGTCCCTAGCCCGCTTGGAAGAACTTCTTC
AAGCTGGCAAAGACGTGATGACCAAAGCACTTGCTCAAGGTGGCACCTCTTTCGACGCACTCTATGTCAACGTCAATGGA
AACTCCGGCTATTTTTCATTATCACTTAATGCTTATGGCCAAACAGGGGAGCCCTGTGGACGCTGTGGCACACAGATCGT
CCGGGAAAACTTCATGAACCGTGGATCTCACTACTGCCCAAACTGCCAGAAGCGGCGCTAG

Upstream 100 bases:

>100_bases
ACGTTGGAAGGTGAAGAAATGGGTCGGGGAGAAGGCCCGAACAAGAAGCTGGCCGAGCAGGAAGCAGCGCGCCAGGCATT
CCGAAAGCTTCGGGAGTCCC

Downstream 100 bases:

>100_bases
CTGATGAGCAAAGCTTTTGATGCAACCAAAGTGCGCAAAGCTGTGCTCACCGTCGCGCTGCTTAACTTCGCTTATTTCTT
TGTAGAGTTCTTTATTGCAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRGKFLWLELIDAPSGETRPDLG
LLVHLGMSGQMLIKEPDAPISPHLRAKIELDNGDEVWFVDQRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARN
LKSRKSEIKRLLLNQEIVSGIGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
NSGYFSLSLNAYGQTGEPCGRCGTQIVRENFMNRGSHYCPNCQKRR

Sequences:

>Translated_286_residues
MPELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRGKFLWLELIDAPSGETRPDLG
LLVHLGMSGQMLIKEPDAPISPHLRAKIELDNGDEVWFVDQRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARN
LKSRKSEIKRLLLNQEIVSGIGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
NSGYFSLSLNAYGQTGEPCGRCGTQIVRENFMNRGSHYCPNCQKRR
>Mature_285_residues
PELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRGKFLWLELIDAPSGETRPDLGL
LVHLGMSGQMLIKEPDAPISPHLRAKIELDNGDEVWFVDQRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARNL
KSRKSEIKRLLLNQEIVSGIGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNGN
SGYFSLSLNAYGQTGEPCGRCGTQIVRENFMNRGSHYCPNCQKRR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=284, Percent_Identity=36.2676056338028, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786932, Length=292, Percent_Identity=23.6301369863014, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_CORGB (A4QFD9)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138857.1
- ProteinModelPortal:   A4QFD9
- SMR:   A4QFD9
- STRING:   A4QFD9
- GeneID:   4992154
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1958
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31693; Mature: 31561

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 274-274 BINDING 103-103 BINDING 122-122 BINDING 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRG
CCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCEEEHHHHHCC
KFLWLELIDAPSGETRPDLGLLVHLGMSGQMLIKEPDAPISPHLRAKIELDNGDEVWFVD
CEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEE
QRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARNLKSRKSEIKRLLLNQEIVSG
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
NSGYFSLSLNAYGQTGEPCGRCGTQIVRENFMNRGSHYCPNCQKRR
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLEDHMVGHTIVSATVLHPRAARNQLGGGPEIEANIAGLRVSAAKRRG
CCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCEEEHHHHHCC
KFLWLELIDAPSGETRPDLGLLVHLGMSGQMLIKEPDAPISPHLRAKIELDNGDEVWFVD
CEEEEEEEECCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEEE
QRTFGYWWLGDLVDGVPERVSHIATDVLDESADFSAIARNLKSRKSEIKRLLLNQEIVSG
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGNIYADEMLWQAKIHPLQRADRLSLARLEELLQAGKDVMTKALAQGGTSFDALYVNVNG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
NSGYFSLSLNAYGQTGEPCGRCGTQIVRENFMNRGSHYCPNCQKRR
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA