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The map label for this gene is dxs [H]

Identifier: 145295806

GI number: 145295806

Start: 1922515

End: 1924413

Strand: Reverse

Name: dxs [H]

Synonym: cgR_1731

Alternate gene names: 145295806

Gene position: 1924413-1922515 (Counterclockwise)

Preceding gene: 145295807

Following gene: 145295803

Centisome position: 58.07

GC content: 53.03

Gene sequence:

>1899_bases
ATGGGAATTCTGAACAGTATTTCAACACCTGCTGACTTAAAGGCCCTTAATGATGAGGATTTGGACGCTCTTGCCAAAGA
AATCCGAACTTTCCTGGTCGATAAAGTCGCAGCAACTGGTGGCCACTTAGGTCCAAATTTGGGCGTAGTGGAATTAACCA
TCGGTCTTCATCGAGTTTTCGATTCGCCTCAAGACCCGATCATCTTTGATACTTCTCACCAGTCCTATGTGCATAAGATC
CTGACGGGTCGCGCTAAAGATTTTGATTCTTTGCGTCAAAAAGATGGCCTTTCTGGTTACACCTGCCGTGCTGAAAGTGA
GCACGATTGGACTGAGTCTTCGCATGCTTCGGCGGCCTTGTCTTATGCGGATGGTTTGTCCAAAGCCAAGCAGCTGGATG
GCGATACCACGCATAGTGTCGTTGCTGTCGTTGGTGATGGCGCTCTAACTGGCGGCATGTGTTGGGAAGCATTGAACAAC
ATTGCTGCTGGTAAAGACCGCAAAGTTGTTGTCGTAGTCAATGACAATGGCCGGAGTTATTCTCCAACCATCGGCGGATT
TGCGGAAAACCTTGCGGGCCTTCGCATGCAGCCTTTCTATGATCGCTTCATGGAAAAGGGCAAGACATCCCTGAAATCCA
TGGGGTGGGTAGGGGAGCGTACTTTTGAAGCGCTCCATGCATTTAAAGAAGGTGTGAAGAGCACCGTCATTCCCACCGAA
ATGTTCCCTGAACTGGGCATGAAATACGTGGGTCCGGTTGATGGACATAACCAAAAAGCTGTCGACAATGCGCTGAAATA
CGCTCATGATTATGATGGCCCCATCATCGTGCACATGGTCACCGAAAAGGGTCGTGGTTACGCGCCTGCTGAGCAGGATT
TGGACGAATTGATGCACTCCACGGGCGTCATCGATCCGCTCACAGGAGCTCCTAAATCTGCATCAAAGCCTGGTTGGACC
TCTGTGTTCAGCGATGAGCTGGTCAAGATTGGTGCGCAGAATGAAAACGTTGTTGCCATCACCGCCGCGATGGCAGGTCC
TACCGGTCTGTCCAAGTTCGAAGCCAATTTCCCCAACCGATTCTTTGATGTCGGCATTGCTGAGCAGCACGCGGTAACTT
CTGCCGCAGGCCTCGCATTGGGTGGAAAACACCCTGTGGTGGCTATTTACTCCACGTTCTTGAACCGCGCTTTTGATCAG
CTGCTCATGGATGTGGGCATGCTCAACCAGCCTGTTACTTTGGTGCTTGATCGCTCAGGTGTCACGGGTTCGGATGGAGC
GAGCCACAATGGCGTCTGGGATATGGCGCTGACCTCGATCGTTCCAGGCGTGCAGGTGGCGGCACCACGTGATGAGGATT
CCTTGCGTGAGCTGCTCAATGAGGCTATTTCCATCGATGATGGCCCCACAGTTGTGCGTTTCCCCAAGGGCGACTTGCCA
ACTCCAATTGTTGCTATCGACACCCTCGAAGACGGCGTTGATGTCCTCGCATATGAAGATGCCACTGAAGACGATGCTCC
CTCAGTCTTGATTGTTGCAGTGGGCGAGCGCGCAACTGTCGCACTTGAGGTTGCTTCCAGGATTACACAGCACGGCGTGA
ACGTCACGGTTGTTGACCCCCGCTGGATTGTCCCAATCCCGCAGTCCTTGGTCGCGCTGTCTGATGATCATGACCTCGTG
ATCACCATCGAAGACGGCGTCATCCACGGCGGCGTGGGATCCTTGCTCTCTGATGCGCTTAACGCCTCTGAGGTGGATAC
CCCTCGCCGACAAATCGCCGTGCCCCAGAAGTACCTGGATCACGCGTCCCGAAGTGAAGTGTTCGCCGATTATGGCCTCG
ACGCCGACGGCATTGAAACCACTGTTGTTGGATGGCTGGATTCCCTGTTCGGGGAATAA

Upstream 100 bases:

>100_bases
GTAGGTGCACATTTGTTTTGTCACCTGCACAAAAGTGTCGCCAGCCCGATACTTGTACAACCGTCCGCATCCGAGAAGCA
AAGGTGTCTGACTCGCGCCA

Downstream 100 bases:

>100_bases
AATCCTGCTTATCGACGCCGCCCTACACCGAAGCCCGCAGCCTGAGCCGCGGGCTTTAGGTTTAGAGCTTCAGCAAATTG
GCAGACAGAATCGGAAAAGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MGILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVFDSPQDPIIFDTSHQSYVHKI
LTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAALSYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNN
IAAGKDRKVVVVVNDNGRSYSPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHSTGVIDPLTGAPKSASKPGWT
SVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNRFFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQ
LLMDVGMLNQPVTLVLDRSGVTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
TPIVAIDTLEDGVDVLAYEDATEDDAPSVLIVAVGERATVALEVASRITQHGVNVTVVDPRWIVPIPQSLVALSDDHDLV
ITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLDHASRSEVFADYGLDADGIETTVVGWLDSLFGE

Sequences:

>Translated_632_residues
MGILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVFDSPQDPIIFDTSHQSYVHKI
LTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAALSYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNN
IAAGKDRKVVVVVNDNGRSYSPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHSTGVIDPLTGAPKSASKPGWT
SVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNRFFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQ
LLMDVGMLNQPVTLVLDRSGVTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
TPIVAIDTLEDGVDVLAYEDATEDDAPSVLIVAVGERATVALEVASRITQHGVNVTVVDPRWIVPIPQSLVALSDDHDLV
ITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLDHASRSEVFADYGLDADGIETTVVGWLDSLFGE
>Mature_631_residues
GILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVFDSPQDPIIFDTSHQSYVHKIL
TGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAALSYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNNI
AAGKDRKVVVVVNDNGRSYSPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTEM
FPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHSTGVIDPLTGAPKSASKPGWTS
VFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNRFFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQL
LMDVGMLNQPVTLVLDRSGVTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLPT
PIVAIDTLEDGVDVLAYEDATEDDAPSVLIVAVGERATVALEVASRITQHGVNVTVVDPRWIVPIPQSLVALSDDHDLVI
TIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLDHASRSEVFADYGLDADGIETTVVGWLDSLFGE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=522, Percent_Identity=22.9885057471264, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4507521, Length=522, Percent_Identity=22.9885057471264, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI133778974, Length=300, Percent_Identity=29, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI225637463, Length=259, Percent_Identity=24.7104247104247, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI225637461, Length=259, Percent_Identity=24.7104247104247, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI225637459, Length=259, Percent_Identity=24.7104247104247, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786622, Length=628, Percent_Identity=36.7834394904459, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17539652, Length=481, Percent_Identity=25.1559251559252, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24645119, Length=469, Percent_Identity=25.1599147121535, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551847, Length=469, Percent_Identity=25.1599147121535, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45550715, Length=469, Percent_Identity=25.1599147121535, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24666278, Length=507, Percent_Identity=24.2603550295858, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67458; Mature: 67327

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVF
CCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHH
DSPQDPIIFDTSHQSYVHKILTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAAL
CCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHH
SYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNNIAAGKDRKVVVVVNDNGRSY
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
SPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHS
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
TGVIDPLTGAPKSASKPGWTSVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCCCHHHHCCCCCH
FFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQLLMDVGMLNQPVTLVLDRSG
HEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
VTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCC
TPIVAIDTLEDGVDVLAYEDATEDDAPSVLIVAVGERATVALEVASRITQHGVNVTVVDP
CCEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECC
RWIVPIPQSLVALSDDHDLVITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLD
EEEECCCHHHEEECCCCCEEEEEECCEEECCHHHHHHHHCCCCCCCCCHHHHCCCHHHHC
HASRSEVFADYGLDADGIETTVVGWLDSLFGE
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GILNSISTPADLKALNDEDLDALAKEIRTFLVDKVAATGGHLGPNLGVVELTIGLHRVF
CCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHH
DSPQDPIIFDTSHQSYVHKILTGRAKDFDSLRQKDGLSGYTCRAESEHDWTESSHASAAL
CCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHH
SYADGLSKAKQLDGDTTHSVVAVVGDGALTGGMCWEALNNIAAGKDRKVVVVVNDNGRSY
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
SPTIGGFAENLAGLRMQPFYDRFMEKGKTSLKSMGWVGERTFEALHAFKEGVKSTVIPTE
CCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
MFPELGMKYVGPVDGHNQKAVDNALKYAHDYDGPIIVHMVTEKGRGYAPAEQDLDELMHS
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
TGVIDPLTGAPKSASKPGWTSVFSDELVKIGAQNENVVAITAAMAGPTGLSKFEANFPNR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCCCHHHHCCCCCH
FFDVGIAEQHAVTSAAGLALGGKHPVVAIYSTFLNRAFDQLLMDVGMLNQPVTLVLDRSG
HEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
VTGSDGASHNGVWDMALTSIVPGVQVAAPRDEDSLRELLNEAISIDDGPTVVRFPKGDLP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCC
TPIVAIDTLEDGVDVLAYEDATEDDAPSVLIVAVGERATVALEVASRITQHGVNVTVVDP
CCEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECC
RWIVPIPQSLVALSDDHDLVITIEDGVIHGGVGSLLSDALNASEVDTPRRQIAVPQKYLD
EEEECCCHHHEEECCCCCEEEEEECCEEECCHHHHHHHHCCCCCCCCCHHHHCCCHHHHC
HASRSEVFADYGLDADGIETTVVGWLDSLFGE
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]