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The map label for this gene is hbd [H]

Identifier: 145294707

GI number: 145294707

Start: 712430

End: 713281

Strand: Direct

Name: hbd [H]

Synonym: cgR_0655

Alternate gene names: 145294707

Gene position: 712430-713281 (Clockwise)

Preceding gene: 145294706

Following gene: 145294709

Centisome position: 21.5

GC content: 54.93

Gene sequence:

>852_bases
ATGTCTAGTGAAATCACAGTGCCAAACAAAGTTGGTGTGCTCGGTGGCGGTCGCATGGGTGGAGGCATTGCGCACTCTTT
CCTTGCTGCTGGCGCGGAAGTGGTGGTCGTTGATATCAATGACGCTGCGGTGGAGGCTGCCAAGGAGCGGATTACAAAAG
ATATTGAAGGTTCCATCAAACGGGGAGCCGCGGGAACTGTTGAAGAGTGGTCTTCCCGGTTGAGTTTCTCCGTAGATCAT
TCCGCGTTTGCTGGCTTGGAGCTTGTCGTTGAGGCGGTTCCTGAGTCTTTTGAGTTGAAGACCAACGCGTTTGCCCAGAT
CAGCGCCCATGCTCCTGAAGCTGTGATCGCCACCAATACCTCATCTTTATCGGTATCTGATTTGGCTGCCACTGTGAATA
ATCAGGTCATTGGTCTGCACTTTTTCAACCCGGTGCCAGCATCCAATTTGGTGGAAATTGTGGTGGCTACCCAAACTCCG
CAGGATCTGGTTGAGGTAGCTCGTGGTTGGGTCGAAGCCCTGGGCAAGACACCCATCGTGGTGAAGGATTCCCCAGGTTT
CGCGTCGTCACGCTTGGGCGTGGTTATTGCTCTCGAGGCGATTCGCATGGTGGAGGAGGGAGTGGCCAGCCCCAAGGATA
TCGATAACGCCATGGTGTTGGGCTATAAATTCCCCATCGGTCCACTGGAGCTGACCGATATTGTGGGCCTTGATGTGCGC
TTAGGCATTGCCGAGTACTTGGAGTCCACGCTGGGTGCTAACTTCACGCCGCCACAGTTGATGCGCGACATGGTTGCGCG
CGGGGAACTGGGCCGCAAGTCGGGTAAAGGCTTCTACGACTACAGCGCCTAA

Upstream 100 bases:

>100_bases
CAGGCGATTCTCTTTGAATCTGAAGCGAAGTTTGATCGCATGCAAGCATTTCTCGACCGCAAGAAGAGCAAGTAAAAAGA
ACAGGTAAGGAACTTAAAAT

Downstream 100 bases:

>100_bases
GCTCGCTTATCGACGATTGCGTTCGTAATTCTGGCAGTACACAACCTTTTGCCTGCGTCATCATGAAGAACTACTTCGTG
GCTCGTCAGGGTCCGCCCGA

Product: hypothetical protein

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSSEITVPNKVGVLGGGRMGGGIAHSFLAAGAEVVVVDINDAAVEAAKERITKDIEGSIKRGAAGTVEEWSSRLSFSVDH
SAFAGLELVVEAVPESFELKTNAFAQISAHAPEAVIATNTSSLSVSDLAATVNNQVIGLHFFNPVPASNLVEIVVATQTP
QDLVEVARGWVEALGKTPIVVKDSPGFASSRLGVVIALEAIRMVEEGVASPKDIDNAMVLGYKFPIGPLELTDIVGLDVR
LGIAEYLESTLGANFTPPQLMRDMVARGELGRKSGKGFYDYSA

Sequences:

>Translated_283_residues
MSSEITVPNKVGVLGGGRMGGGIAHSFLAAGAEVVVVDINDAAVEAAKERITKDIEGSIKRGAAGTVEEWSSRLSFSVDH
SAFAGLELVVEAVPESFELKTNAFAQISAHAPEAVIATNTSSLSVSDLAATVNNQVIGLHFFNPVPASNLVEIVVATQTP
QDLVEVARGWVEALGKTPIVVKDSPGFASSRLGVVIALEAIRMVEEGVASPKDIDNAMVLGYKFPIGPLELTDIVGLDVR
LGIAEYLESTLGANFTPPQLMRDMVARGELGRKSGKGFYDYSA
>Mature_282_residues
SSEITVPNKVGVLGGGRMGGGIAHSFLAAGAEVVVVDINDAAVEAAKERITKDIEGSIKRGAAGTVEEWSSRLSFSVDHS
AFAGLELVVEAVPESFELKTNAFAQISAHAPEAVIATNTSSLSVSDLAATVNNQVIGLHFFNPVPASNLVEIVVATQTPQ
DLVEVARGWVEALGKTPIVVKDSPGFASSRLGVVIALEAIRMVEEGVASPKDIDNAMVLGYKFPIGPLELTDIVGLDVRL
GIAEYLESTLGANFTPPQLMRDMVARGELGRKSGKGFYDYSA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=38.5964912280702, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI20127408, Length=279, Percent_Identity=35.84229390681, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=36.4238410596026, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=31.2925170068027, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=31.2925170068027, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI115430219, Length=234, Percent_Identity=35.042735042735, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787661, Length=286, Percent_Identity=37.4125874125874, Blast_Score=170, Evalue=8e-44,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=36.4341085271318, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790281, Length=298, Percent_Identity=30.2013422818792, Blast_Score=117, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17549919, Length=296, Percent_Identity=36.8243243243243, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=35.5400696864112, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=36.5853658536585, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25144276, Length=280, Percent_Identity=34.6428571428571, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508951, Length=280, Percent_Identity=34.6428571428571, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=280, Percent_Identity=34.6428571428571, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17558304, Length=280, Percent_Identity=33.5714285714286, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=32.3943661971831, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71985930, Length=283, Percent_Identity=29.6819787985866, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19921000, Length=278, Percent_Identity=36.3309352517986, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583077, Length=278, Percent_Identity=36.3309352517986, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24583079, Length=278, Percent_Identity=36.3309352517986, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45549573, Length=251, Percent_Identity=29.8804780876494, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129993, Length=253, Percent_Identity=28.4584980237154, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 29678; Mature: 29547

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEITVPNKVGVLGGGRMGGGIAHSFLAAGAEVVVVDINDAAVEAAKERITKDIEGSIK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
RGAAGTVEEWSSRLSFSVDHSAFAGLELVVEAVPESFELKTNAFAQISAHAPEAVIATNT
CCCCCCHHHHHHHCEEEECHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEEEECC
SSLSVSDLAATVNNQVIGLHFFNPVPASNLVEIVVATQTPQDLVEVARGWVEALGKTPIV
CCCCHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEE
VKDSPGFASSRLGVVIALEAIRMVEEGVASPKDIDNAMVLGYKFPIGPLELTDIVGLDVR
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEHHHHCCCHHH
LGIAEYLESTLGANFTPPQLMRDMVARGELGRKSGKGFYDYSA
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSEITVPNKVGVLGGGRMGGGIAHSFLAAGAEVVVVDINDAAVEAAKERITKDIEGSIK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
RGAAGTVEEWSSRLSFSVDHSAFAGLELVVEAVPESFELKTNAFAQISAHAPEAVIATNT
CCCCCCHHHHHHHCEEEECHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEEEECC
SSLSVSDLAATVNNQVIGLHFFNPVPASNLVEIVVATQTPQDLVEVARGWVEALGKTPIV
CCCCHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEE
VKDSPGFASSRLGVVIALEAIRMVEEGVASPKDIDNAMVLGYKFPIGPLELTDIVGLDVR
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEHHHHCCCHHH
LGIAEYLESTLGANFTPPQLMRDMVARGELGRKSGKGFYDYSA
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]