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The map label for this gene is lly [H]

Identifier: 145294541

GI number: 145294541

Start: 549294

End: 551150

Strand: Direct

Name: lly [H]

Synonym: cgR_0493

Alternate gene names: 145294541

Gene position: 549294-551150 (Clockwise)

Preceding gene: 145294540

Following gene: 145294542

Centisome position: 16.57

GC content: 54.98

Gene sequence:

>1857_bases
ATGCGTACATCCATTGCCACTGTTTGTTTGTCCGGAACTCTTGCTGAAAAGCTGCGCGCAGCTGCAGATGCTGGATTTGA
TGGTGTGGAAATCTTCGAGCAGGACTTGGTGGTTTCCCCGCATTCGGCAGAGCAGATTCGTCAGCGGGCTCAGGATTTGG
GATTAACCCTGGATCTGTTCCAGCCGTTTCGAGATTTCGAAGGTGTGGAAGAAGAGCAGTTTCTGAAGAATCTGCACCGC
TTGGAAGAGAAGTTCAAGCTGATGAACAGGCTTGGCATTGAGATGATCTTGTTGTGTTCCAATGTGGGCACCGCGACCAT
CAATGATGATGACCTTTTCGTGGAGCAGTTGCATCGTGCAGCAGATTTGGCTGAGAAGTACAACGTCAAGATTGCTTATG
AAGCGTTGGCGTGGGGCAAGTTTGTCAATGATTTTGAGCATGCGCATGCACTTGTGGAGAAGGTGAATCACAAGGCGCTG
GGAACCTGCTTGGATACGTTCCATATTCTTTCCCGTGGTTGGGAAACCGACGAGGTGGAAAACATCCCGGCGGAGAAGAT
CTTCTTTGTTCAGTTGGCGGATGCACCGAAGCTGAGCATGGACATTTTGTCCTGGTCGCGTCACCACCGTGTTTTCCCTG
GTGAAGGCGATTTCGATCTGGTGAAATTCATGGTTCATCTGGCCAAGACGGGTTATGATGGCCCGATTTCTTTGGAGATC
TTCAACGATTCCTTCCGCAAGGCCGAGGTTGGTCGCACCGCGATTGATGGGTTGCGTTCTTTGCGTTGGTTGGAAGATCA
GACCTGGCATGCGCTAAATGCTGAGGATCGTCCAAGCGCACTAGAGCTGCGTGCACTTCCTGAGGTCGCGGAACCTGAAG
GCGTTGATTTCATTGAGATCGCCACTGGACGTTTGGGTGAGACCATTCGGGTTCTTCATCAATTGGGTTTCCGCTTGGGT
GGTCATCACTGCAGTAAGCAGGATTACCAGGTATGGACCCAGGGCGATGTGCGCATTGTGGTGTGTGATCGTGGGGCCAC
CGGGGCTCCAACCACGATCTCTGCGATGGGCTTTGACACCCCTGATCCAGAAGCCGCGCATGCCCGTGCGGAATTGCTGC
GGGCTCAGACAATTGATCGTCCCCACATCGAGGGTGAAGTTGACCTTAAAGGTGTGTACGCGCCGGATGGGGTGGAGCTG
TTTTTCGCGGGGCCGAGCCCCGATGGAATGCCCGAGTGGCTGCCGGAATTCGGCGTCGAAAAGCAAGAAGCTGGTCTCAT
TGAAGCCATCGACCACGTCAATTTCGCCCAGCCATGGCAACATTTTGATGAGGCAGTGCTGTTTTACACCGCGCTGATGG
CGTTAGAGACTGTGCGTGAGGATGAGTTCCCGAGCCCAATTGGTTTGGTGCGCAATCAGGTGATGCGTTCGCCGAATGAT
GCGGTGCGGTTGCTGCTCAGCGTGGCGCCGGAGGACGGTGAGCAGGGAGATTTCCTCAACGCGGCCTACCCGGAGCACAT
TGCGTTGGCCACGGCGGACATCGTGGCGGTGGCTGAACGTGCGCGCAAACGAGGCCTGGATTTCTTGCCCGTCCCAGAGA
ATTACTACGACGATGTGCAGGCGCGTTTTGATTTGCCGCAGGAATTCTTGGACACACTCAAGGAAAACCACCTGCTTTAC
GACTGCGACGAGAACGGCGAATTCCTCCACTTTTACACCCGCACGTTGGGCACGCTGTTCTTCGAAGTGGTGGAACGCCG
CGGCGGTTTTGCAGGTTGGGGCGAAACAAACGCTCCGGTGCGGTTAGCGGCGCAGTATCGTGAGGTGCGGGACCTCGAGC
GGGGAATCCCCAACTAG

Upstream 100 bases:

>100_bases
GTGGTGAGGCCGCAGACCTGGCAGCCGCAAACAAAGCCTCCGAGGCCCAACTCGCGGCTAAGTAAAATCACGTAACCAAA
GAAAAGGACTCTTTGACCAC

Downstream 100 bases:

>100_bases
CATCCCGAACTAGCCCCCCCAACAACAATTAGAAAAGGAACCTAAAATGCTTGGAAAAATTCTCCTCCTCAACGGCCCAA
ACCTGAACATGCTGGGCAAA

Product: hypothetical protein

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase; Legiolysin [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MRTSIATVCLSGTLAEKLRAAADAGFDGVEIFEQDLVVSPHSAEQIRQRAQDLGLTLDLFQPFRDFEGVEEEQFLKNLHR
LEEKFKLMNRLGIEMILLCSNVGTATINDDDLFVEQLHRAADLAEKYNVKIAYEALAWGKFVNDFEHAHALVEKVNHKAL
GTCLDTFHILSRGWETDEVENIPAEKIFFVQLADAPKLSMDILSWSRHHRVFPGEGDFDLVKFMVHLAKTGYDGPISLEI
FNDSFRKAEVGRTAIDGLRSLRWLEDQTWHALNAEDRPSALELRALPEVAEPEGVDFIEIATGRLGETIRVLHQLGFRLG
GHHCSKQDYQVWTQGDVRIVVCDRGATGAPTTISAMGFDTPDPEAAHARAELLRAQTIDRPHIEGEVDLKGVYAPDGVEL
FFAGPSPDGMPEWLPEFGVEKQEAGLIEAIDHVNFAQPWQHFDEAVLFYTALMALETVREDEFPSPIGLVRNQVMRSPND
AVRLLLSVAPEDGEQGDFLNAAYPEHIALATADIVAVAERARKRGLDFLPVPENYYDDVQARFDLPQEFLDTLKENHLLY
DCDENGEFLHFYTRTLGTLFFEVVERRGGFAGWGETNAPVRLAAQYREVRDLERGIPN

Sequences:

>Translated_618_residues
MRTSIATVCLSGTLAEKLRAAADAGFDGVEIFEQDLVVSPHSAEQIRQRAQDLGLTLDLFQPFRDFEGVEEEQFLKNLHR
LEEKFKLMNRLGIEMILLCSNVGTATINDDDLFVEQLHRAADLAEKYNVKIAYEALAWGKFVNDFEHAHALVEKVNHKAL
GTCLDTFHILSRGWETDEVENIPAEKIFFVQLADAPKLSMDILSWSRHHRVFPGEGDFDLVKFMVHLAKTGYDGPISLEI
FNDSFRKAEVGRTAIDGLRSLRWLEDQTWHALNAEDRPSALELRALPEVAEPEGVDFIEIATGRLGETIRVLHQLGFRLG
GHHCSKQDYQVWTQGDVRIVVCDRGATGAPTTISAMGFDTPDPEAAHARAELLRAQTIDRPHIEGEVDLKGVYAPDGVEL
FFAGPSPDGMPEWLPEFGVEKQEAGLIEAIDHVNFAQPWQHFDEAVLFYTALMALETVREDEFPSPIGLVRNQVMRSPND
AVRLLLSVAPEDGEQGDFLNAAYPEHIALATADIVAVAERARKRGLDFLPVPENYYDDVQARFDLPQEFLDTLKENHLLY
DCDENGEFLHFYTRTLGTLFFEVVERRGGFAGWGETNAPVRLAAQYREVRDLERGIPN
>Mature_618_residues
MRTSIATVCLSGTLAEKLRAAADAGFDGVEIFEQDLVVSPHSAEQIRQRAQDLGLTLDLFQPFRDFEGVEEEQFLKNLHR
LEEKFKLMNRLGIEMILLCSNVGTATINDDDLFVEQLHRAADLAEKYNVKIAYEALAWGKFVNDFEHAHALVEKVNHKAL
GTCLDTFHILSRGWETDEVENIPAEKIFFVQLADAPKLSMDILSWSRHHRVFPGEGDFDLVKFMVHLAKTGYDGPISLEI
FNDSFRKAEVGRTAIDGLRSLRWLEDQTWHALNAEDRPSALELRALPEVAEPEGVDFIEIATGRLGETIRVLHQLGFRLG
GHHCSKQDYQVWTQGDVRIVVCDRGATGAPTTISAMGFDTPDPEAAHARAELLRAQTIDRPHIEGEVDLKGVYAPDGVEL
FFAGPSPDGMPEWLPEFGVEKQEAGLIEAIDHVNFAQPWQHFDEAVLFYTALMALETVREDEFPSPIGLVRNQVMRSPND
AVRLLLSVAPEDGEQGDFLNAAYPEHIALATADIVAVAERARKRGLDFLPVPENYYDDVQARFDLPQEFLDTLKENHLLY
DCDENGEFLHFYTRTLGTLFFEVVERRGGFAGWGETNAPVRLAAQYREVRDLERGIPN

Specific function: Catalyzes the transformation of p-hydroxyphenylpyruvate into HGA. Has hemolytic and brown pigment production activity [H]

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=211, Percent_Identity=27.9620853080569, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4504477, Length=211, Percent_Identity=27.9620853080569, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555220, Length=228, Percent_Identity=25.8771929824561, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356105, Length=203, Percent_Identity=26.1083743842365, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24667510, Length=203, Percent_Identity=26.1083743842365, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 69522; Mature: 69522

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSIATVCLSGTLAEKLRAAADAGFDGVEIFEQDLVVSPHSAEQIRQRAQDLGLTLDLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEECCCCHHHHHHHHHHCCCCHHHH
QPFRDFEGVEEEQFLKNLHRLEEKFKLMNRLGIEMILLCSNVGTATINDDDLFVEQLHRA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCHHHHHHHHHHH
ADLAEKYNVKIAYEALAWGKFVNDFEHAHALVEKVNHKALGTCLDTFHILSRGWETDEVE
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
NIPAEKIFFVQLADAPKLSMDILSWSRHHRVFPGEGDFDLVKFMVHLAKTGYDGPISLEI
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
FNDSFRKAEVGRTAIDGLRSLRWLEDQTWHALNAEDRPSALELRALPEVAEPEGVDFIEI
ECCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCCCCCCCCCCCEEEE
ATGRLGETIRVLHQLGFRLGGHHCSKQDYQVWTQGDVRIVVCDRGATGAPTTISAMGFDT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCEEEECCCCC
PDPEAAHARAELLRAQTIDRPHIEGEVDLKGVYAPDGVELFFAGPSPDGMPEWLPEFGVE
CCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCCC
KQEAGLIEAIDHVNFAQPWQHFDEAVLFYTALMALETVREDEFPSPIGLVRNQVMRSPND
HHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
AVRLLLSVAPEDGEQGDFLNAAYPEHIALATADIVAVAERARKRGLDFLPVPENYYDDVQ
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ARFDLPQEFLDTLKENHLLYDCDENGEFLHFYTRTLGTLFFEVVERRGGFAGWGETNAPV
HHHCCCHHHHHHHHHCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
RLAAQYREVRDLERGIPN
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTSIATVCLSGTLAEKLRAAADAGFDGVEIFEQDLVVSPHSAEQIRQRAQDLGLTLDLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEECCCCHHHHHHHHHHCCCCHHHH
QPFRDFEGVEEEQFLKNLHRLEEKFKLMNRLGIEMILLCSNVGTATINDDDLFVEQLHRA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCHHHHHHHHHHH
ADLAEKYNVKIAYEALAWGKFVNDFEHAHALVEKVNHKALGTCLDTFHILSRGWETDEVE
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
NIPAEKIFFVQLADAPKLSMDILSWSRHHRVFPGEGDFDLVKFMVHLAKTGYDGPISLEI
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
FNDSFRKAEVGRTAIDGLRSLRWLEDQTWHALNAEDRPSALELRALPEVAEPEGVDFIEI
ECCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHCCCCCCCCCCCCEEEE
ATGRLGETIRVLHQLGFRLGGHHCSKQDYQVWTQGDVRIVVCDRGATGAPTTISAMGFDT
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCEEEECCCCC
PDPEAAHARAELLRAQTIDRPHIEGEVDLKGVYAPDGVELFFAGPSPDGMPEWLPEFGVE
CCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCCC
KQEAGLIEAIDHVNFAQPWQHFDEAVLFYTALMALETVREDEFPSPIGLVRNQVMRSPND
HHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
AVRLLLSVAPEDGEQGDFLNAAYPEHIALATADIVAVAERARKRGLDFLPVPENYYDDVQ
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ARFDLPQEFLDTLKENHLLYDCDENGEFLHFYTRTLGTLFFEVVERRGGFAGWGETNAPV
HHHCCCHHHHHHHHHCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
RLAAQYREVRDLERGIPN
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA