Click here to switch to the map view.

The map label for this gene is gpmA

Identifier: 145294519

GI number: 145294519

Start: 530270

End: 531016

Strand: Direct

Name: gpmA

Synonym: cgR_0474

Alternate gene names: 145294519

Gene position: 530270-531016 (Clockwise)

Preceding gene: 145294518

Following gene: 145294520

Centisome position: 16.0

GC content: 58.37

Gene sequence:

>747_bases
ATGACTAACGGAAAATTGATTCTTCTTCGTCACGGTCAGAGCGAATGGAACGCATCCAACCAGTTCACTGGATGGGTCGA
CGTCAATCTGACCGAACAGGGTGAGGCTGAGGCCAAGCGCGGAGGCGAACTCCTCGTCGAGGCAGGCGTCCTCCCAGGCG
TTGTATACACCTCCTTGCTGCGTCGCGCGATCCGCACCGCAAACATCGCACTGAACGCTGCAGACCGCCACTGGATCCCA
GTGATCCGCGACTGGCGCCTCAACGAGCGTCACTACGGTGCTCTGCAGGGCCTCGACAAGGCTGCAACCAAGGAAAAGTA
CGGCGACGACCAGTTCATGGAATGGCGCCGCTCCTACGACACCCCACCACCAGAGCTCGCGGATGACGCAGAGTACTCCC
AGGCAAATGACCCTCGTTACGCGGACCTCGACGTAGTTCCACGCACCGAATGCCTCAAGGACGTTGTGGTTCGTTTTGTT
CCTTACTTCGAGGAAGAAATCCTGCCACGCGCAAAGAAGGGCGAAACCGTCCTCATCGCAGCACACGGCAACTCCCTGCG
TGCACTGGTTAAGCACCTTGACGGCATCTCCGATGCTGATATCGCAGAGCTCAACATCCCAACCGGCATCCCACTGGTCT
ACGAAATCGCCGAAGACGGTTCCGTAGTAAACCCAGGCGGCACCTACCTCGATCCTGAGGCAGCAGCAGCCGGCGCAGCA
GCAGTAGCAAACCAGGGTAATAAGTAG

Upstream 100 bases:

>100_bases
GCTGTACAACGACGCTATTGCCAACGAAAACGTCGACGGTGAAACGCATCACGGCTAAGTAAACGCGCGTCTTGGAACAT
AAAGTGGCAAACTAGTACCT

Downstream 100 bases:

>100_bases
CTATTTGTAGGTGAGCACTCTTCTTGCTTTCGTATTGGGCGTGGTCCTCATGGGCCTCGCCCTACCTGCGTATACGAAAA
TTAAAGATCGGATGCGTCGC

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTNGKLILLRHGQSEWNASNQFTGWVDVNLTEQGEAEAKRGGELLVEAGVLPGVVYTSLLRRAIRTANIALNAADRHWIP
VIRDWRLNERHYGALQGLDKAATKEKYGDDQFMEWRRSYDTPPPELADDAEYSQANDPRYADLDVVPRTECLKDVVVRFV
PYFEEEILPRAKKGETVLIAAHGNSLRALVKHLDGISDADIAELNIPTGIPLVYEIAEDGSVVNPGGTYLDPEAAAAGAA
AVANQGNK

Sequences:

>Translated_248_residues
MTNGKLILLRHGQSEWNASNQFTGWVDVNLTEQGEAEAKRGGELLVEAGVLPGVVYTSLLRRAIRTANIALNAADRHWIP
VIRDWRLNERHYGALQGLDKAATKEKYGDDQFMEWRRSYDTPPPELADDAEYSQANDPRYADLDVVPRTECLKDVVVRFV
PYFEEEILPRAKKGETVLIAAHGNSLRALVKHLDGISDADIAELNIPTGIPLVYEIAEDGSVVNPGGTYLDPEAAAAGAA
AVANQGNK
>Mature_247_residues
TNGKLILLRHGQSEWNASNQFTGWVDVNLTEQGEAEAKRGGELLVEAGVLPGVVYTSLLRRAIRTANIALNAADRHWIPV
IRDWRLNERHYGALQGLDKAATKEKYGDDQFMEWRRSYDTPPPELADDAEYSQANDPRYADLDVVPRTECLKDVVVRFVP
YFEEEILPRAKKGETVLIAAHGNSLRALVKHLDGISDADIAELNIPTGIPLVYEIAEDGSVVNPGGTYLDPEAAAAGAAA
VANQGNK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=251, Percent_Identity=47.808764940239, Blast_Score=245, Evalue=2e-65,
Organism=Homo sapiens, GI4505753, Length=251, Percent_Identity=49.800796812749, Blast_Score=239, Evalue=1e-63,
Organism=Homo sapiens, GI71274132, Length=251, Percent_Identity=47.4103585657371, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI4502445, Length=252, Percent_Identity=44.4444444444444, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI40353764, Length=252, Percent_Identity=44.4444444444444, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI310129614, Length=165, Percent_Identity=49.6969696969697, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1786970, Length=221, Percent_Identity=56.1085972850679, Blast_Score=253, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=61.7886178861789, Blast_Score=280, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324516, Length=293, Percent_Identity=36.1774744027304, Blast_Score=164, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6320183, Length=295, Percent_Identity=34.5762711864407, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24646216, Length=248, Percent_Identity=47.1774193548387, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI85725270, Length=248, Percent_Identity=46.3709677419355, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI85725272, Length=248, Percent_Identity=46.3709677419355, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24650981, Length=248, Percent_Identity=46.3709677419355, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI28571815, Length=251, Percent_Identity=35.8565737051793, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI28571817, Length=251, Percent_Identity=35.8565737051793, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24648979, Length=249, Percent_Identity=36.144578313253, Blast_Score=151, Evalue=4e-37,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_CORGB (A4QB41)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137340.1
- ProteinModelPortal:   A4QB41
- SMR:   A4QB41
- STRING:   A4QB41
- GeneID:   4992057
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0474
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14120
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 27246; Mature: 27115

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 11-11 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNGKLILLRHGQSEWNASNQFTGWVDVNLTEQGEAEAKRGGELLVEAGVLPGVVYTSLL
CCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCHHHHCCCEEEEECCCCCHHHHHHHH
RRAIRTANIALNAADRHWIPVIRDWRLNERHYGALQGLDKAATKEKYGDDQFMEWRRSYD
HHHHHHHHEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
TPPPELADDAEYSQANDPRYADLDVVPRTECLKDVVVRFVPYFEEEILPRAKKGETVLIA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHGNSLRALVKHLDGISDADIAELNIPTGIPLVYEIAEDGSVVNPGGTYLDPEAAAAGAA
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEECCCCCEECCHHHHHHHH
AVANQGNK
HHHCCCCC
>Mature Secondary Structure 
TNGKLILLRHGQSEWNASNQFTGWVDVNLTEQGEAEAKRGGELLVEAGVLPGVVYTSLL
CCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCHHHHCCCEEEEECCCCCHHHHHHHH
RRAIRTANIALNAADRHWIPVIRDWRLNERHYGALQGLDKAATKEKYGDDQFMEWRRSYD
HHHHHHHHEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
TPPPELADDAEYSQANDPRYADLDVVPRTECLKDVVVRFVPYFEEEILPRAKKGETVLIA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHGNSLRALVKHLDGISDADIAELNIPTGIPLVYEIAEDGSVVNPGGTYLDPEAAAAGAA
ECCCHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEECCCCCEECCHHHHHHHH
AVANQGNK
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA