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The map label for this gene is murB

Identifier: 145294515

GI number: 145294515

Start: 524875

End: 525981

Strand: Direct

Name: murB

Synonym: cgR_0470

Alternate gene names: 145294515

Gene position: 524875-525981 (Clockwise)

Preceding gene: 145294511

Following gene: 145294516

Centisome position: 15.84

GC content: 61.16

Gene sequence:

>1107_bases
GTGTTGGATTCATCGCTAGCCCAGGAAATCGCCGCGATCGACGGCGTCGAACTCGATTCGAAAGTCACTTTCGCCGATCT
GACGACCCTCCGCATCGGCGGAAAACCCCGCAGTGCCGTACGTTGCCAGACCACAGAGGCGCTGGTCAGCGCCATAAAAT
TGCTTGACGACGCCTCCCTCCCCCTCCTCATCGTCGGCGGCGGGTCCAATCTCGTCGTGGCCGACGGCGATCTGGATGTT
ATTGCCGTCATCATCGAAACCGACGACGTCTCCATCAACCTCACCGACGGTCTCCTCACCGCCGATGCAGGCGCCGTTTG
GGACGATGTTGTCCACCTTTCGGTGGATGCCGGCCTCGGTGGAATTGAATGCCTCTCCGGAATCCCCGGCTCCGCCGGCG
CCACCCCAGTCCAAAACGTGGGCGCCTACGGCACGGAAGTTTCCGATGTACTCACCCGCGTCCAGCTTCTCGACCGCACC
ACCCACCAAGTCTCCTGGGTCGACGCCTCCGAACTCGACCTTTCTTACCGATACTCCAATCTCAAATTCACCAACCGCGC
AGTCGTCTTGGCGATCGAACTCCAGCTCCTCACCGACGGATTGTCCGCGCCGCTACGTTTTGGTGAATTGGGACGTCGAT
TAGCGATCTCCGAGGCCGAACCCCACCCACGTCGCCCCGTCCGCATGGTCCGCGACGCCGTCTTAGAACTCCGTCGCGCC
AAAGGCATGGTCGTGGAACACACCGACCACGACACCTGGTCCGCCGGATCCTTCTTCACCAATCCAATCGTCGACCCAGC
CCTTGCCGACGCAGTCTTTGAAAAAGTCGGCGAACCCACCATGCCCCGCTTCCCAGCCGGCGATGGCAAAGAAAAACTCT
CCGCAGCCTGGCTCATCGAACGCGCCGGCTTCAAAAAGGGACACCCCGGCGCAGGCGCAAAAGCCTCCCTGAGCACCAAA
CACACCCTCGCACTCACCAACCGTGGCGACGCCCGCGCCTCCGACCTCGTCGCATTAGCCAAAGAAATCCGCGACGGAGT
CCTCGAAACCTTCGGCGTCACCCTCGTCCCAGAACCCGTCTGGATTGGAATTAGCATCGATGACTAA

Upstream 100 bases:

>100_bases
CTTCGGTGGTCAGTGCTTGGTGCACCTTGCCGACGGGCTGATTGATCGTAATGGTGTTTTCTGTACGCGTTGCCATGAGG
ATAAGACTACCGTTAGTGAG

Downstream 100 bases:

>100_bases
ATTCTCCAGCGTCCCTGGCACCGCCGCCCCACTGCACAGGGCGTTGGAAAATGCCGGGTACCCCTCTTTGGAATCCCTCG
ACGGTGTTCCCTACAAAACG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLDSSLAQEIAAIDGVELDSKVTFADLTTLRIGGKPRSAVRCQTTEALVSAIKLLDDASLPLLIVGGGSNLVVADGDLDV
IAVIIETDDVSINLTDGLLTADAGAVWDDVVHLSVDAGLGGIECLSGIPGSAGATPVQNVGAYGTEVSDVLTRVQLLDRT
THQVSWVDASELDLSYRYSNLKFTNRAVVLAIELQLLTDGLSAPLRFGELGRRLAISEAEPHPRRPVRMVRDAVLELRRA
KGMVVEHTDHDTWSAGSFFTNPIVDPALADAVFEKVGEPTMPRFPAGDGKEKLSAAWLIERAGFKKGHPGAGAKASLSTK
HTLALTNRGDARASDLVALAKEIRDGVLETFGVTLVPEPVWIGISIDD

Sequences:

>Translated_368_residues
MLDSSLAQEIAAIDGVELDSKVTFADLTTLRIGGKPRSAVRCQTTEALVSAIKLLDDASLPLLIVGGGSNLVVADGDLDV
IAVIIETDDVSINLTDGLLTADAGAVWDDVVHLSVDAGLGGIECLSGIPGSAGATPVQNVGAYGTEVSDVLTRVQLLDRT
THQVSWVDASELDLSYRYSNLKFTNRAVVLAIELQLLTDGLSAPLRFGELGRRLAISEAEPHPRRPVRMVRDAVLELRRA
KGMVVEHTDHDTWSAGSFFTNPIVDPALADAVFEKVGEPTMPRFPAGDGKEKLSAAWLIERAGFKKGHPGAGAKASLSTK
HTLALTNRGDARASDLVALAKEIRDGVLETFGVTLVPEPVWIGISIDD
>Mature_368_residues
MLDSSLAQEIAAIDGVELDSKVTFADLTTLRIGGKPRSAVRCQTTEALVSAIKLLDDASLPLLIVGGGSNLVVADGDLDV
IAVIIETDDVSINLTDGLLTADAGAVWDDVVHLSVDAGLGGIECLSGIPGSAGATPVQNVGAYGTEVSDVLTRVQLLDRT
THQVSWVDASELDLSYRYSNLKFTNRAVVLAIELQLLTDGLSAPLRFGELGRRLAISEAEPHPRRPVRMVRDAVLELRRA
KGMVVEHTDHDTWSAGSFFTNPIVDPALADAVFEKVGEPTMPRFPAGDGKEKLSAAWLIERAGFKKGHPGAGAKASLSTK
HTLALTNRGDARASDLVALAKEIRDGVLETFGVTLVPEPVWIGISIDD

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=341, Percent_Identity=31.0850439882698, Blast_Score=135, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_CORGB (A4QB37)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137336.1
- ProteinModelPortal:   A4QB37
- SMR:   A4QB37
- STRING:   A4QB37
- GeneID:   4994293
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0470
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   GAAPMQN
- ProtClustDB:   PRK13903
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 38999; Mature: 38999

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 177-177 ACT_SITE 257-257 ACT_SITE 358-358

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSSLAQEIAAIDGVELDSKVTFADLTTLRIGGKPRSAVRCQTTEALVSAIKLLDDASL
CCCHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCC
PLLIVGGGSNLVVADGDLDVIAVIIETDDVSINLTDGLLTADAGAVWDDVVHLSVDAGLG
CEEEEECCCEEEEECCCCEEEEEEEECCCEEEEEECCEEECCCCHHHHCEEEEEECCCCC
GIECLSGIPGSAGATPVQNVGAYGTEVSDVLTRVQLLDRTTHQVSWVDASELDLSYRYSN
HHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHCEEEEEECC
LKFTNRAVVLAIELQLLTDGLSAPLRFGELGRRLAISEAEPHPRRPVRMVRDAVLELRRA
EEECCCEEEEEEEEEEHHCCCCCCHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
KGMVVEHTDHDTWSAGSFFTNPIVDPALADAVFEKVGEPTMPRFPAGDGKEKLSAAWLIE
CCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RAGFKKGHPGAGAKASLSTKHTLALTNRGDARASDLVALAKEIRDGVLETFGVTLVPEPV
HCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCE
WIGISIDD
EEEEEECC
>Mature Secondary Structure
MLDSSLAQEIAAIDGVELDSKVTFADLTTLRIGGKPRSAVRCQTTEALVSAIKLLDDASL
CCCHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCC
PLLIVGGGSNLVVADGDLDVIAVIIETDDVSINLTDGLLTADAGAVWDDVVHLSVDAGLG
CEEEEECCCEEEEECCCCEEEEEEEECCCEEEEEECCEEECCCCHHHHCEEEEEECCCCC
GIECLSGIPGSAGATPVQNVGAYGTEVSDVLTRVQLLDRTTHQVSWVDASELDLSYRYSN
HHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHCEEEEEECC
LKFTNRAVVLAIELQLLTDGLSAPLRFGELGRRLAISEAEPHPRRPVRMVRDAVLELRRA
EEECCCEEEEEEEEEEHHCCCCCCHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
KGMVVEHTDHDTWSAGSFFTNPIVDPALADAVFEKVGEPTMPRFPAGDGKEKLSAAWLIE
CCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
RAGFKKGHPGAGAKASLSTKHTLALTNRGDARASDLVALAKEIRDGVLETFGVTLVPEPV
HCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCE
WIGISIDD
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA