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The map label for this gene is mmgB [H]

Identifier: 138896971

GI number: 138896971

Start: 3448053

End: 3448904

Strand: Reverse

Name: mmgB [H]

Synonym: GTNG_3340

Alternate gene names: 138896971

Gene position: 3448904-3448053 (Counterclockwise)

Preceding gene: 138896972

Following gene: 138896970

Centisome position: 97.14

GC content: 51.76

Gene sequence:

>852_bases
ATGGACGTAAAAACAATCATGGTCGTCGGTGCCGGTCAAATGGGATCAGGTATTGCTCAAGTATGTGCTGTCGCCGGCTA
TGACGTACTTTTATATGACATTAGCGAAGCGCAATTGGATAAAGGAATCGCGAACATTGAAAAACTGCTCGCTCGCCAAG
TGGAAAAAGGGAAAATGGCGGCAGCGGACAAGGACGCGGCGCTGTCGCGGCTTTCCCGTTCCACCGACTTGCATGATGCC
ACCGACGCTGACCTTGTCATCGAAGCCGTTGTCGAAAACATGGATGTGAAAACGAAGCTGTTTGCCGAGTTGGACAAAAT
CGCCCGCCCGGAGACGATCTTAGCTTCCAATACGTCGTCACTTCCGATTACGGAAATCGCAGCGGCGACAAAGCGGCCAG
ACAAAGTAATCGGCATGCACTTTATGAACCCGGTGCCGGTCATGAAGCTAGTGGAAATTATCCGCGGGTTGGCGACGGCT
GATGAGGTATACGAGACGATCGAAGCGGTCACCCGGACGCTTGGCAAAGTACCGGTTGAAGTAAACGACTTTCCAGGCTT
TATTTCCAATCGTGTACTCATGCCGATGATTAACGAAGCGATTTACGCTTTGTACGAAGGAGTAGCAACAAAAGAGGCGA
TCGATGAAGTGATGAAACTTGGCATGAACCATCCGATGGGGCCGCTCACGCTCGCTGACTTTATCGGATTGGACACGTGC
TTATACATTATGGAAACGCTTCATGAAGGGTTCGGCGACGACAAGTACCGCCCGTGCCCGCTGTTGCGCAAATACGTCAA
GGCTGGTTGGCTTGGTCGCAAGACGGGGCGCGGATTTTACACGTACGAGTAA

Upstream 100 bases:

>100_bases
ATACCTATCGAGGTTGAAACGGCGGCATCGGCCGCCGGAAAACTAACGGATATCCTGCACGTTCATTTTTCAGAAATACA
CATAGATGGGGGATAAGAAC

Downstream 100 bases:

>100_bases
GTAGATAGAGGCAACATTGACAAACAACATGAAAAAGGGGGATGTCCCGTGCAATTTCGGTTTACGGAAGAACAAGAAAT
GATGCGGCAAATGGTGCGCG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MDVKTIMVVGAGQMGSGIAQVCAVAGYDVLLYDISEAQLDKGIANIEKLLARQVEKGKMAAADKDAALSRLSRSTDLHDA
TDADLVIEAVVENMDVKTKLFAELDKIARPETILASNTSSLPITEIAAATKRPDKVIGMHFMNPVPVMKLVEIIRGLATA
DEVYETIEAVTRTLGKVPVEVNDFPGFISNRVLMPMINEAIYALYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
LYIMETLHEGFGDDKYRPCPLLRKYVKAGWLGRKTGRGFYTYE

Sequences:

>Translated_283_residues
MDVKTIMVVGAGQMGSGIAQVCAVAGYDVLLYDISEAQLDKGIANIEKLLARQVEKGKMAAADKDAALSRLSRSTDLHDA
TDADLVIEAVVENMDVKTKLFAELDKIARPETILASNTSSLPITEIAAATKRPDKVIGMHFMNPVPVMKLVEIIRGLATA
DEVYETIEAVTRTLGKVPVEVNDFPGFISNRVLMPMINEAIYALYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
LYIMETLHEGFGDDKYRPCPLLRKYVKAGWLGRKTGRGFYTYE
>Mature_283_residues
MDVKTIMVVGAGQMGSGIAQVCAVAGYDVLLYDISEAQLDKGIANIEKLLARQVEKGKMAAADKDAALSRLSRSTDLHDA
TDADLVIEAVVENMDVKTKLFAELDKIARPETILASNTSSLPITEIAAATKRPDKVIGMHFMNPVPVMKLVEIIRGLATA
DEVYETIEAVTRTLGKVPVEVNDFPGFISNRVLMPMINEAIYALYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
LYIMETLHEGFGDDKYRPCPLLRKYVKAGWLGRKTGRGFYTYE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=47.0588235294118, Blast_Score=244, Evalue=4e-65,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=45.2768729641694, Blast_Score=237, Evalue=7e-63,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=40.2826855123675, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=34.3537414965986, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=34.1296928327645, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI115430219, Length=231, Percent_Identity=30.3030303030303, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=44.8763250883392, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1790281, Length=265, Percent_Identity=38.1132075471698, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=37.2093023255814, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=43.4027777777778, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17553560, Length=290, Percent_Identity=40.6896551724138, Blast_Score=227, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=41.1149825783972, Blast_Score=211, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=40.2826855123675, Blast_Score=186, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=40.2826855123675, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17508953, Length=283, Percent_Identity=40.2826855123675, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=38.5159010600707, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=30.9608540925267, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=30.1418439716312, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI115533614, Length=230, Percent_Identity=29.1304347826087, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193203623, Length=230, Percent_Identity=29.1304347826087, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=39.9293286219081, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=39.9293286219081, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=39.9293286219081, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=30.5084745762712, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129993, Length=227, Percent_Identity=28.1938325991189, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30977; Mature: 30977

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKTIMVVGAGQMGSGIAQVCAVAGYDVLLYDISEAQLDKGIANIEKLLARQVEKGKMA
CCCEEEEEEECCCCCHHHHHHHHHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHCCHH
AADKDAALSRLSRSTDLHDATDADLVIEAVVENMDVKTKLFAELDKIARPETILASNTSS
HCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCC
LPITEIAAATKRPDKVIGMHFMNPVPVMKLVEIIRGLATADEVYETIEAVTRTLGKVPVE
CCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VNDFPGFISNRVLMPMINEAIYALYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
ECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMETLHEGFGDDKYRPCPLLRKYVKAGWLGRKTGRGFYTYE
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDVKTIMVVGAGQMGSGIAQVCAVAGYDVLLYDISEAQLDKGIANIEKLLARQVEKGKMA
CCCEEEEEEECCCCCHHHHHHHHHHCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHCCHH
AADKDAALSRLSRSTDLHDATDADLVIEAVVENMDVKTKLFAELDKIARPETILASNTSS
HCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCC
LPITEIAAATKRPDKVIGMHFMNPVPVMKLVEIIRGLATADEVYETIEAVTRTLGKVPVE
CCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VNDFPGFISNRVLMPMINEAIYALYEGVATKEAIDEVMKLGMNHPMGPLTLADFIGLDTC
ECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LYIMETLHEGFGDDKYRPCPLLRKYVKAGWLGRKTGRGFYTYE
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]