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The map label for this gene is acdA [H]

Identifier: 138896969

GI number: 138896969

Start: 3445670

End: 3446812

Strand: Reverse

Name: acdA [H]

Synonym: GTNG_3338

Alternate gene names: 138896969

Gene position: 3446812-3445670 (Counterclockwise)

Preceding gene: 138896970

Following gene: 138896968

Centisome position: 97.08

GC content: 53.63

Gene sequence:

>1143_bases
ATGAATTTTCAATTGAGCGAAGAACATGAAATGTTGCGGAAAATGGTGCGTGAATTTGCCGAAAACGAAGTGGCGCCTAC
GGCCGCTGAGCGTGATGAGGAAGAGCGGTTTGACCGCAGCATTTTCAACAAAATGGCCGAACTTGGCTTAACGGGCATCC
CGTGGCCGGAAGAGTATGGCGGCATCGGCAGCGACTATTTGGCGTATGTCATTGCGGTCGAAGAGTTGTCGCGTGTCTGT
GCCTCGACCGGGGTGACGCTCTCCGCCCATATTTCGCTTGCAAGCTGGCCGATTTATAAGTTCGGCACGGAAGAGCAAAA
GCAGAAGTATTTGCGCGCTTTGGCAACCGGGGAAAAGCTCGGAGCATACGGGCTGTCCGAGCCGGGAGCAGGGTCTGATG
TCGCCTCGATGAAAACGCGTGCCATCAAAGACGGCGACCATTACGTGTTAAACGGTTCGAAAGTATGGATCACGAACGGC
GGCGAGGCAGAGATTTACGTCGTCTTTGCCGTCACTGATCCGGAAAAGCGGCATAAAGGGATCAGCGCCTTTATCGTCGA
AAAAGGGACGCCGGGCTTTTCAATCGGCAAAAAAGAAAAGAAACTTGGCATCCGTTCGTCGCCGACGACTGAGCTCATTT
TTGAAGATTGCCGTATCCCGAAAGAAAACTTGCTCGGTCAAGAAGGGGAAGGGTTTAAGATCGCGATGATGACGTTAGAC
GGCGGCCGCAACGGCATCGCCGCCCAAGCGGTCGGCATCGCTCAAGGAGCGCTGGATGCCGCTGTGGACTACGCGAAACA
GCGCGTCCAATTCGGTAAACCGATCGCTGAACAGCAAGGGGTTTCCTTTAAGCTCGCCGACATGGCGACAGCCATTGAAG
CGGCTCGGCTGTTGACATACCAAGCGGCATGGCTCGAGTCAAACGGCTTGCCATACGGCAAGGCATCGGCGATGGCAAAA
CTGTTTGCCGGCGACACGGCGATGAAAGTGACTGTCGATGCGGTGCAAATCTTTGGCGGCAACGGTTATACGAAAGACTA
TCCAGTTGAACGGTTTATGCGCGATGCGAAAATTACGCAAATTTACGAAGGGACACAAGAAATTCAGCGCCTCGTTATTT
CGCGGATGTTGACGCGCGATTAA

Upstream 100 bases:

>100_bases
ACGAGCGAAATCCAGCGGATTGTCATTAGCAAGCAACTGACCAAACAGTAATCAAAACAAGGGGAAGAGGATTTTTTATA
GAAAACGGGGGAATGAAGCG

Downstream 100 bases:

>100_bases
TGATAGCAGCGCTTGAACGTTTGAATCGCAGCAGCCGTTTCAAGGATCACGCTCTATGTGCTGCTGCGAGGGGGATCTTC
GTGATTTCGGGGACGTGCCG

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MNFQLSEEHEMLRKMVREFAENEVAPTAAERDEEERFDRSIFNKMAELGLTGIPWPEEYGGIGSDYLAYVIAVEELSRVC
ASTGVTLSAHISLASWPIYKFGTEEQKQKYLRALATGEKLGAYGLSEPGAGSDVASMKTRAIKDGDHYVLNGSKVWITNG
GEAEIYVVFAVTDPEKRHKGISAFIVEKGTPGFSIGKKEKKLGIRSSPTTELIFEDCRIPKENLLGQEGEGFKIAMMTLD
GGRNGIAAQAVGIAQGALDAAVDYAKQRVQFGKPIAEQQGVSFKLADMATAIEAARLLTYQAAWLESNGLPYGKASAMAK
LFAGDTAMKVTVDAVQIFGGNGYTKDYPVERFMRDAKITQIYEGTQEIQRLVISRMLTRD

Sequences:

>Translated_380_residues
MNFQLSEEHEMLRKMVREFAENEVAPTAAERDEEERFDRSIFNKMAELGLTGIPWPEEYGGIGSDYLAYVIAVEELSRVC
ASTGVTLSAHISLASWPIYKFGTEEQKQKYLRALATGEKLGAYGLSEPGAGSDVASMKTRAIKDGDHYVLNGSKVWITNG
GEAEIYVVFAVTDPEKRHKGISAFIVEKGTPGFSIGKKEKKLGIRSSPTTELIFEDCRIPKENLLGQEGEGFKIAMMTLD
GGRNGIAAQAVGIAQGALDAAVDYAKQRVQFGKPIAEQQGVSFKLADMATAIEAARLLTYQAAWLESNGLPYGKASAMAK
LFAGDTAMKVTVDAVQIFGGNGYTKDYPVERFMRDAKITQIYEGTQEIQRLVISRMLTRD
>Mature_380_residues
MNFQLSEEHEMLRKMVREFAENEVAPTAAERDEEERFDRSIFNKMAELGLTGIPWPEEYGGIGSDYLAYVIAVEELSRVC
ASTGVTLSAHISLASWPIYKFGTEEQKQKYLRALATGEKLGAYGLSEPGAGSDVASMKTRAIKDGDHYVLNGSKVWITNG
GEAEIYVVFAVTDPEKRHKGISAFIVEKGTPGFSIGKKEKKLGIRSSPTTELIFEDCRIPKENLLGQEGEGFKIAMMTLD
GGRNGIAAQAVGIAQGALDAAVDYAKQRVQFGKPIAEQQGVSFKLADMATAIEAARLLTYQAAWLESNGLPYGKASAMAK
LFAGDTAMKVTVDAVQIFGGNGYTKDYPVERFMRDAKITQIYEGTQEIQRLVISRMLTRD

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=55.4089709762533, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=45.8445040214477, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=44.1798941798942, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=44.1798941798942, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI226958412, Length=382, Percent_Identity=44.2408376963351, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=44.2970822281167, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI226958414, Length=352, Percent_Identity=44.8863636363636, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=43.3048433048433, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI4557235, Length=379, Percent_Identity=39.5778364116095, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI76496475, Length=379, Percent_Identity=39.5778364116095, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=36.8421052631579, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=34.6560846560847, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=34.4262295081967, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI48976061, Length=320, Percent_Identity=32.1875, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI211971008, Length=320, Percent_Identity=32.1875, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI38505218, Length=295, Percent_Identity=31.5254237288136, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI218563752, Length=271, Percent_Identity=27.3062730627306, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=33.2467532467532, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=30.5263157894737, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082384, Length=285, Percent_Identity=28.7719298245614, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081702, Length=311, Percent_Identity=27.0096463022508, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=45.1871657754011, Blast_Score=333, Evalue=6e-92,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=47.244094488189, Blast_Score=330, Evalue=9e-91,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=44.7368421052632, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=46.09375, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=42.3592493297587, Blast_Score=320, Evalue=7e-88,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=43.6842105263158, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=41.9525065963061, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71990804, Length=319, Percent_Identity=45.141065830721, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71985184, Length=371, Percent_Identity=40.1617250673854, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=34.6560846560847, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=44.2982456140351, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71985192, Length=304, Percent_Identity=42.1052631578947, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17505929, Length=378, Percent_Identity=31.2169312169312, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=37.1747211895911, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=31.5508021390374, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=34.0163934426229, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=28.8194444444444, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=31.25, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=278, Percent_Identity=28.4172661870504, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=278, Percent_Identity=28.4172661870504, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=55.6756756756757, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=48.6702127659575, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=43.3510638297872, Blast_Score=328, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=46.1741424802111, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=44.0104166666667, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI281363737, Length=363, Percent_Identity=40.771349862259, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=33.245382585752, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45550141, Length=313, Percent_Identity=26.1980830670927, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221473076, Length=313, Percent_Identity=26.1980830670927, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281365206, Length=308, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585193, Length=308, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585195, Length=308, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585191, Length=308, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41629; Mature: 41629

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQLSEEHEMLRKMVREFAENEVAPTAAERDEEERFDRSIFNKMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAVEELSRVCASTGVTLSAHISLASWPIYKFGTEEQKQKYLRALATGEKL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEECCCHHHHHHHHHHHHCCCHH
GAYGLSEPGAGSDVASMKTRAIKDGDHYVLNGSKVWITNGGEAEIYVVFAVTDPEKRHKG
CCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCEEEEECCCCEEEEEEEEECCCHHHHCC
ISAFIVEKGTPGFSIGKKEKKLGIRSSPTTELIFEDCRIPKENLLGQEGEGFKIAMMTLD
CEEEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCEEEEEEEEC
GGRNGIAAQAVGIAQGALDAAVDYAKQRVQFGKPIAEQQGVSFKLADMATAIEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHHHHHHHHHH
QAAWLESNGLPYGKASAMAKLFAGDTAMKVTVDAVQIFGGNGYTKDYPVERFMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTRD
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFQLSEEHEMLRKMVREFAENEVAPTAAERDEEERFDRSIFNKMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAVEELSRVCASTGVTLSAHISLASWPIYKFGTEEQKQKYLRALATGEKL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEECCCHHHHHHHHHHHHCCCHH
GAYGLSEPGAGSDVASMKTRAIKDGDHYVLNGSKVWITNGGEAEIYVVFAVTDPEKRHKG
CCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCEEEEECCCCEEEEEEEEECCCHHHHCC
ISAFIVEKGTPGFSIGKKEKKLGIRSSPTTELIFEDCRIPKENLLGQEGEGFKIAMMTLD
CEEEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCEEEEEEEEC
GGRNGIAAQAVGIAQGALDAAVDYAKQRVQFGKPIAEQQGVSFKLADMATAIEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHHHHHHHHHH
QAAWLESNGLPYGKASAMAKLFAGDTAMKVTVDAVQIFGGNGYTKDYPVERFMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTRD
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]