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The map label for this gene is hisB [H]

Identifier: 138896661

GI number: 138896661

Start: 3119708

End: 3120295

Strand: Reverse

Name: hisB [H]

Synonym: GTNG_3024

Alternate gene names: 138896661

Gene position: 3120295-3119708 (Counterclockwise)

Preceding gene: 138896662

Following gene: 138896660

Centisome position: 87.89

GC content: 52.21

Gene sequence:

>588_bases
ATGGCGAGAGAAGCGACGATCGCAAGAACGACGAATGAGACAAGCATTCAGTTGTCGTTTTCGTTGGATGGTGAAGGGAA
GGCCGAGCTCGAGACGGGGGTGCCGTTTTTGACTCATATGCTCGATTTGTTTGCCAAACATGGACAGTTTGATTTGCGAG
TCGATGCGAAAGGTGATACGCATATTGACGATCACCATACGACTGAAGATATCGGCATTTGCCTCGGACAAGCGATTAAA
GAAGCGCTTGGCGACAAAAAAGGAATCAAGCGATACGGCAACGCGTTTGTGCCGATGGATGACGCGTTGGCGCAAGTCGT
CATCGATTTAAGCAACCGCCCGCATTTTGAGTTTCGCGGCGAATTTCCGGCGGCCAAAGTCGGCACGTTCGACGTCGAGC
TGGTTTATGAGTTTTTATGGAAGCTGGCGCTTGAGGCGCGGATGAACTTGCATGTCATCGTCCATTATGGACGCAATACG
CACCATATGATCGAAGCCGTGTTTAAAGCGCTTGGGCGGGCGCTCGATGAAGCGACGATGGTCGACCCGCGCGTCAAAGG
CGTCCCGTCGACAAAAGGCATGCTTTGA

Upstream 100 bases:

>100_bases
AACACGGCAAGGACATCGCTGCGTTTGCCCGCTTAGAGGGGCTGGAGGCGCATGCGCGCGCCATCGAGGTGCGGTTGAAA
AAAGAAAGAGGGGAACGATA

Downstream 100 bases:

>100_bases
CGCTGCGCTTGACGTACCATTGATGAAAGGAATGGGATGACGATGATCGGGGTAATCGATTATGGCATGGGCAACTTATA
TAGCGTCAGCAAAGCGCTCG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MAREATIARTTNETSIQLSFSLDGEGKAELETGVPFLTHMLDLFAKHGQFDLRVDAKGDTHIDDHHTTEDIGICLGQAIK
EALGDKKGIKRYGNAFVPMDDALAQVVIDLSNRPHFEFRGEFPAAKVGTFDVELVYEFLWKLALEARMNLHVIVHYGRNT
HHMIEAVFKALGRALDEATMVDPRVKGVPSTKGML

Sequences:

>Translated_195_residues
MAREATIARTTNETSIQLSFSLDGEGKAELETGVPFLTHMLDLFAKHGQFDLRVDAKGDTHIDDHHTTEDIGICLGQAIK
EALGDKKGIKRYGNAFVPMDDALAQVVIDLSNRPHFEFRGEFPAAKVGTFDVELVYEFLWKLALEARMNLHVIVHYGRNT
HHMIEAVFKALGRALDEATMVDPRVKGVPSTKGML
>Mature_194_residues
AREATIARTTNETSIQLSFSLDGEGKAELETGVPFLTHMLDLFAKHGQFDLRVDAKGDTHIDDHHTTEDIGICLGQAIKE
ALGDKKGIKRYGNAFVPMDDALAQVVIDLSNRPHFEFRGEFPAAKVGTFDVELVYEFLWKLALEARMNLHVIVHYGRNTH
HMIEAVFKALGRALDEATMVDPRVKGVPSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=45.1282051282051, Blast_Score=171, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=43.778801843318, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21688; Mature: 21557

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAREATIARTTNETSIQLSFSLDGEGKAELETGVPFLTHMLDLFAKHGQFDLRVDAKGDT
CCCCCCEEECCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCC
HIDDHHTTEDIGICLGQAIKEALGDKKGIKRYGNAFVPMDDALAQVVIDLSNRPHFEFRG
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECC
EFPAAKVGTFDVELVYEFLWKLALEARMNLHVIVHYGRNTHHMIEAVFKALGRALDEATM
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VDPRVKGVPSTKGML
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
AREATIARTTNETSIQLSFSLDGEGKAELETGVPFLTHMLDLFAKHGQFDLRVDAKGDT
CCCCCEEECCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCC
HIDDHHTTEDIGICLGQAIKEALGDKKGIKRYGNAFVPMDDALAQVVIDLSNRPHFEFRG
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECC
EFPAAKVGTFDVELVYEFLWKLALEARMNLHVIVHYGRNTHHMIEAVFKALGRALDEATM
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VDPRVKGVPSTKGML
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA