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The map label for this gene is hisD [H]

Identifier: 138896662

GI number: 138896662

Start: 3120295

End: 3121620

Strand: Reverse

Name: hisD [H]

Synonym: GTNG_3025

Alternate gene names: 138896662

Gene position: 3121620-3120295 (Counterclockwise)

Preceding gene: 138896663

Following gene: 138896661

Centisome position: 87.93

GC content: 57.84

Gene sequence:

>1326_bases
ATGGACGAAAACCGATGGACGTCACAGAAAGGGGAGCGAACGATGAAAATCGAACGGGTGCAAGGAGGCGTCTCGCTAAG
GCGCACGATTGAAAGCGGGACGGACGAGCAGCGACGAGCGGTGCTCGACATTATCGCCGCAGTGCGCGCCCGCGGTGACG
CGGCGTTGAAAGAGTATACAGAACAGTTTGACGGCGTCAAGTTGGAGACGCTTCAGGTGACGGAGGAAGAAATGAAGCGG
GCTCATGCGGCGCTGAGCCCGGAGATGCTGGCAGTCATCCGTGAAGCGGCGACGAACATTCGCGACTATCATGAGCGGCA
AAAGCGCCAATCATGGTGGATGACGAAAGAAGATGGCACGATTCTCGGGCAAAAGGTGACGCCGCTTGACGCGGTCGGGC
TGTATGTTCCAGGAGGGACAGCCGCCTATCCGTCGTCCGTGCTCATGAACGTCATCCCTGCGCAAGTGGCGGGCGTGAAG
CGGATTGTCATTGCCTCTCCTCCGAATGCGGACGGCTCGCTTCCTGACGGGGTGCTGGCCGCGGCGTATGAGCTGGGAGT
GACGGAAGTTTACAAAGTGGGCGGTGCGCAGGCGATCGCCGCTCTTGCTTATGGAACGGAAACGATTCGGCCGGTCGATA
AAATTTTCGGGCCGGGCAACATTTATGTGGCGTTGGCGAAACGGGAAGTGTTTGGACATGTGGCGATCGACATGATCGCC
GGGCCGAGCGAAATTGTCGTATTGGCTGATGAGACAGCCTATGCGGATGAAATTGCTGCTGACTTGTTGTCACAGGCCGA
GCATGATGTACGGGCGTCGGCCATTTTAGTGACGCCCTCGATGAAACTCGCCTTGGCGGTGGCAAGTGAGGTGGAACGGC
AGTTGGAGACGCTGCCGCGTCGTGAGATTGCCCAAGCGGCGTTAGAAACCTACGGTGCCATTTATGTGACCGAGACGCTT
GATGAGGCGGTTGATGTGGTCAATGAGCTGGCGCCCGAGCATTTGGAAGTGATGACGGCAGAACCGATGGCGCTATTAGG
GAAGCTACGCCATGCCGGGGCAATGTTTTTTGGCCGTTTCAGCTCCGAGCCGGTTGGTGACTATTTTGCAGGGCCAAACC
ATGTGCTGCCGACGAACGGGACGGCGAGATTCTCAAGCGGCTTGAGCGTCGATGAGTTTGTGAAAAAATCGAGCGTGATC
GTTTACAGTGAGGCCGCGCTCCGTGAACACGGCAAGGACATCGCTGCGTTTGCCCGCTTAGAGGGGCTGGAGGCGCATGC
GCGCGCCATCGAGGTGCGGTTGAAAAAAGAAAGAGGGGAACGATAA

Upstream 100 bases:

>100_bases
AAAGGGGAACCGGGCGGTTTCCCATGAATGGATTGGTAGAGATTCGGGACTGGTGTTGCCGAATGGTGGAGCGGCGTTGA
CAGCGCTGAAAAGGTTGCCA

Downstream 100 bases:

>100_bases
TGGCGAGAGAAGCGACGATCGCAAGAACGACGAATGAGACAAGCATTCAGTTGTCGTTTTCGTTGGATGGTGAAGGGAAG
GCCGAGCTCGAGACGGGGGT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MDENRWTSQKGERTMKIERVQGGVSLRRTIESGTDEQRRAVLDIIAAVRARGDAALKEYTEQFDGVKLETLQVTEEEMKR
AHAALSPEMLAVIREAATNIRDYHERQKRQSWWMTKEDGTILGQKVTPLDAVGLYVPGGTAAYPSSVLMNVIPAQVAGVK
RIVIASPPNADGSLPDGVLAAAYELGVTEVYKVGGAQAIAALAYGTETIRPVDKIFGPGNIYVALAKREVFGHVAIDMIA
GPSEIVVLADETAYADEIAADLLSQAEHDVRASAILVTPSMKLALAVASEVERQLETLPRREIAQAALETYGAIYVTETL
DEAVDVVNELAPEHLEVMTAEPMALLGKLRHAGAMFFGRFSSEPVGDYFAGPNHVLPTNGTARFSSGLSVDEFVKKSSVI
VYSEAALREHGKDIAAFARLEGLEAHARAIEVRLKKERGER

Sequences:

>Translated_441_residues
MDENRWTSQKGERTMKIERVQGGVSLRRTIESGTDEQRRAVLDIIAAVRARGDAALKEYTEQFDGVKLETLQVTEEEMKR
AHAALSPEMLAVIREAATNIRDYHERQKRQSWWMTKEDGTILGQKVTPLDAVGLYVPGGTAAYPSSVLMNVIPAQVAGVK
RIVIASPPNADGSLPDGVLAAAYELGVTEVYKVGGAQAIAALAYGTETIRPVDKIFGPGNIYVALAKREVFGHVAIDMIA
GPSEIVVLADETAYADEIAADLLSQAEHDVRASAILVTPSMKLALAVASEVERQLETLPRREIAQAALETYGAIYVTETL
DEAVDVVNELAPEHLEVMTAEPMALLGKLRHAGAMFFGRFSSEPVGDYFAGPNHVLPTNGTARFSSGLSVDEFVKKSSVI
VYSEAALREHGKDIAAFARLEGLEAHARAIEVRLKKERGER
>Mature_441_residues
MDENRWTSQKGERTMKIERVQGGVSLRRTIESGTDEQRRAVLDIIAAVRARGDAALKEYTEQFDGVKLETLQVTEEEMKR
AHAALSPEMLAVIREAATNIRDYHERQKRQSWWMTKEDGTILGQKVTPLDAVGLYVPGGTAAYPSSVLMNVIPAQVAGVK
RIVIASPPNADGSLPDGVLAAAYELGVTEVYKVGGAQAIAALAYGTETIRPVDKIFGPGNIYVALAKREVFGHVAIDMIA
GPSEIVVLADETAYADEIAADLLSQAEHDVRASAILVTPSMKLALAVASEVERQLETLPRREIAQAALETYGAIYVTETL
DEAVDVVNELAPEHLEVMTAEPMALLGKLRHAGAMFFGRFSSEPVGDYFAGPNHVLPTNGTARFSSGLSVDEFVKKSSVI
VYSEAALREHGKDIAAFARLEGLEAHARAIEVRLKKERGER

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=433, Percent_Identity=41.3394919168591, Blast_Score=301, Evalue=8e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=39.0476190476191, Blast_Score=268, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47863; Mature: 47863

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDENRWTSQKGERTMKIERVQGGVSLRRTIESGTDEQRRAVLDIIAAVRARGDAALKEYT
CCCCCCCCCCCCCCEEHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
EQFDGVKLETLQVTEEEMKRAHAALSPEMLAVIREAATNIRDYHERQKRQSWWMTKEDGT
HHHCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCC
ILGQKVTPLDAVGLYVPGGTAAYPSSVLMNVIPAQVAGVKRIVIASPPNADGSLPDGVLA
EECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH
AAYELGVTEVYKVGGAQAIAALAYGTETIRPVDKIFGPGNIYVALAKREVFGHVAIDMIA
HHHHHCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHEEEC
GPSEIVVLADETAYADEIAADLLSQAEHDVRASAILVTPSMKLALAVASEVERQLETLPR
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCH
REIAQAALETYGAIYVTETLDEAVDVVNELAPEHLEVMTAEPMALLGKLRHAGAMFFGRF
HHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
SSEPVGDYFAGPNHVLPTNGTARFSSGLSVDEFVKKSSVIVYSEAALREHGKDIAAFARL
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHCCEEEEEHHHHHHCCCHHHHHHHH
EGLEAHARAIEVRLKKERGER
HCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDENRWTSQKGERTMKIERVQGGVSLRRTIESGTDEQRRAVLDIIAAVRARGDAALKEYT
CCCCCCCCCCCCCCEEHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
EQFDGVKLETLQVTEEEMKRAHAALSPEMLAVIREAATNIRDYHERQKRQSWWMTKEDGT
HHHCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCC
ILGQKVTPLDAVGLYVPGGTAAYPSSVLMNVIPAQVAGVKRIVIASPPNADGSLPDGVLA
EECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH
AAYELGVTEVYKVGGAQAIAALAYGTETIRPVDKIFGPGNIYVALAKREVFGHVAIDMIA
HHHHHCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHEEEC
GPSEIVVLADETAYADEIAADLLSQAEHDVRASAILVTPSMKLALAVASEVERQLETLPR
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHCCH
REIAQAALETYGAIYVTETLDEAVDVVNELAPEHLEVMTAEPMALLGKLRHAGAMFFGRF
HHHHHHHHHHHCCEEEHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
SSEPVGDYFAGPNHVLPTNGTARFSSGLSVDEFVKKSSVIVYSEAALREHGKDIAAFARL
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHCCEEEEEHHHHHHCCCHHHHHHHH
EGLEAHARAIEVRLKKERGER
HCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA