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The map label for this gene is fadA [H]

Identifier: 138896596

GI number: 138896596

Start: 3056494

End: 3057666

Strand: Reverse

Name: fadA [H]

Synonym: GTNG_2959

Alternate gene names: 138896596

Gene position: 3057666-3056494 (Counterclockwise)

Preceding gene: 138896597

Following gene: 138896595

Centisome position: 86.12

GC content: 59.16

Gene sequence:

>1173_bases
GTGAGAGAAGCGGTGATTGTCGCAGGAGCGCGCACACCGGTCGGGAAAGCGAAAAAAGGGACGCTCGCTCATGTGCGGCC
GGATGATTTAGGAGCGCTTGTCGTCAAAGAAACGCTAAAACGAGCAGGAAACTATGACGGGAATATTGATGATTTAATTA
TCGGCTGCGCCATGCCGGAGGCGGAGCAAGGACTCAATGTCGCCCGCAACATCGGGGCGCTCGCCGGTCTGCCGTATACC
GTGCCGGCGATCACGATCAACCGGTATTGTTCGTCCGGTTTGCAGGCGATCGCCTATGCAGCTGAACGGGTGATGCTTGG
TCATTCCGATACGGTCATCGCCGGCGGGGTCGAATCGATGAGCATGGTCCCGATGATGGGTCATGTCGTCCGCCCGAATG
CCCGCTTGGCGGAAGAAGCGCCAGAATATTACATGTCGATGGGGCATACGGCCGAGCAAGTGGCGAAAAAGTACGGCGTC
AGCCGTGAGGACCAAGATGCGTTTGCTGTGCGCAGCCATCAGCGGGCGGCGAAAGCGCTGGCCGAGGGGAAATTTGATGA
GGAAATCGTACCGGTAGAAGTGACGGTGCGCAAAGTAGAAAACAACAAACTCGTCGAAGAGAAAGTGGTCTTTACGCAAG
ATGAAGGGGTGCGCCCGGACACGAACATGGAGACGCTCGCGAAACTGCGCCCGGCGTTTGCCGTCAACGGCACGGTCACG
GCGGGCAACGCGTCGCAAATGAGCGACGGGGCCGCGGCGGTGATGGTCATGGATCGCGAAAAAGCAGAATCGCTCGGCTT
GAAGCCGCTTGGCAAGTTTCGTTCGTTCGCCGTCGCCGGCGTGCCGCCGGAAGTGATGGGGATCGGTCCGGTCGCGGCTG
TGCCGAAAGCGTTGAAACTGGCCGGTCTTGAGCTGTCCGATATCGGCCTGATCGAGTTAAACGAAGCATTCGCGTCTCAA
TCGGTCCAAGTCATTCGCGAGCTTGGTCTCGATGAAGAGATCGTCAACGTCAACGGCGGGGCGATCGCGCTTGGCCATCC
GCTCGGCTGCACGGGCGCGAAGTTGACCTTGTCCTTGCTTTACGAAATGCGGCGCCGCAACGTCCAGTTCGGCATTGTCA
CGATGTGCATTGGCGGCGGCATGGGGGCCGCAGGCGTCTTTGAACTGCTGTGA

Upstream 100 bases:

>100_bases
TTGATCGGCGAGCCAAAGACGCAAGCGAGAATGCAACATATGCTTGTCAAAGGAAAACCGCTCCGCAACTAAGGCGGACG
AATGTTGAGGGGGGATTGGC

Downstream 100 bases:

>100_bases
TGTGAAGTCAATAGAAAATCCAGCGGGCGGCGCTGCCGCCCGGGTAATCACACGATAGTTGGAGGAGGAAAATAAACAAT
GGCAAAAACGGTCGAAAATG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MREAVIVAGARTPVGKAKKGTLAHVRPDDLGALVVKETLKRAGNYDGNIDDLIIGCAMPEAEQGLNVARNIGALAGLPYT
VPAITINRYCSSGLQAIAYAAERVMLGHSDTVIAGGVESMSMVPMMGHVVRPNARLAEEAPEYYMSMGHTAEQVAKKYGV
SREDQDAFAVRSHQRAAKALAEGKFDEEIVPVEVTVRKVENNKLVEEKVVFTQDEGVRPDTNMETLAKLRPAFAVNGTVT
AGNASQMSDGAAAVMVMDREKAESLGLKPLGKFRSFAVAGVPPEVMGIGPVAAVPKALKLAGLELSDIGLIELNEAFASQ
SVQVIRELGLDEEIVNVNGGAIALGHPLGCTGAKLTLSLLYEMRRRNVQFGIVTMCIGGGMGAAGVFELL

Sequences:

>Translated_390_residues
MREAVIVAGARTPVGKAKKGTLAHVRPDDLGALVVKETLKRAGNYDGNIDDLIIGCAMPEAEQGLNVARNIGALAGLPYT
VPAITINRYCSSGLQAIAYAAERVMLGHSDTVIAGGVESMSMVPMMGHVVRPNARLAEEAPEYYMSMGHTAEQVAKKYGV
SREDQDAFAVRSHQRAAKALAEGKFDEEIVPVEVTVRKVENNKLVEEKVVFTQDEGVRPDTNMETLAKLRPAFAVNGTVT
AGNASQMSDGAAAVMVMDREKAESLGLKPLGKFRSFAVAGVPPEVMGIGPVAAVPKALKLAGLELSDIGLIELNEAFASQ
SVQVIRELGLDEEIVNVNGGAIALGHPLGCTGAKLTLSLLYEMRRRNVQFGIVTMCIGGGMGAAGVFELL
>Mature_390_residues
MREAVIVAGARTPVGKAKKGTLAHVRPDDLGALVVKETLKRAGNYDGNIDDLIIGCAMPEAEQGLNVARNIGALAGLPYT
VPAITINRYCSSGLQAIAYAAERVMLGHSDTVIAGGVESMSMVPMMGHVVRPNARLAEEAPEYYMSMGHTAEQVAKKYGV
SREDQDAFAVRSHQRAAKALAEGKFDEEIVPVEVTVRKVENNKLVEEKVVFTQDEGVRPDTNMETLAKLRPAFAVNGTVT
AGNASQMSDGAAAVMVMDREKAESLGLKPLGKFRSFAVAGVPPEVMGIGPVAAVPKALKLAGLELSDIGLIELNEAFASQ
SVQVIRELGLDEEIVNVNGGAIALGHPLGCTGAKLTLSLLYEMRRRNVQFGIVTMCIGGGMGAAGVFELL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=389, Percent_Identity=47.5578406169666, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=42.6395939086294, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=38.25, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=35.1620947630923, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI4504327, Length=438, Percent_Identity=33.3333333333333, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI194353979, Length=387, Percent_Identity=34.1085271317829, Blast_Score=184, Evalue=9e-47,
Organism=Escherichia coli, GI48994986, Length=393, Percent_Identity=47.5826972010178, Blast_Score=340, Evalue=6e-95,
Organism=Escherichia coli, GI1787663, Length=407, Percent_Identity=46.6830466830467, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=44.4168734491315, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=43.0348258706468, Blast_Score=290, Evalue=8e-80,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=38.1861575178998, Blast_Score=228, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI133906874, Length=398, Percent_Identity=39.9497487437186, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=37.9746835443038, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=34.0852130325814, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=30.8390022675737, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=29.6675191815857, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=40.4580152671756, Blast_Score=276, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=36, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=42.6799007444169, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=39.8989898989899, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=35.8395989974937, Blast_Score=234, Evalue=8e-62,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=32.7146171693735, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41225; Mature: 41225

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVAGARTPVGKAKKGTLAHVRPDDLGALVVKETLKRAGNYDGNIDDLIIGCAMPE
CCCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHEEEECCCCC
AEQGLNVARNIGALAGLPYTVPAITINRYCSSGLQAIAYAAERVMLGHSDTVIAGGVESM
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHH
SMVPMMGHVVRPNARLAEEAPEYYMSMGHTAEQVAKKYGVSREDQDAFAVRSHQRAAKAL
HHHHHHHHEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
AEGKFDEEIVPVEVTVRKVENNKLVEEKVVFTQDEGVRPDTNMETLAKLRPAFAVNGTVT
HCCCCCCCEEEEEEEEEECCCCCCHHHHEEEECCCCCCCCCCHHHHHHHCCCEEECCEEE
AGNASQMSDGAAAVMVMDREKAESLGLKPLGKFRSFAVAGVPPEVMGIGPVAAVPKALKL
CCCHHHCCCCCEEEEEEECHHHHHCCCCCCHHHHHEEECCCCHHHHCCCCHHHHHHHHHH
AGLELSDIGLIELNEAFASQSVQVIRELGLDEEIVNVNGGAIALGHPLGCTGAKLTLSLL
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHH
YEMRRRNVQFGIVTMCIGGGMGAAGVFELL
HHHHHCCCCEEEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MREAVIVAGARTPVGKAKKGTLAHVRPDDLGALVVKETLKRAGNYDGNIDDLIIGCAMPE
CCCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHEEEECCCCC
AEQGLNVARNIGALAGLPYTVPAITINRYCSSGLQAIAYAAERVMLGHSDTVIAGGVESM
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHH
SMVPMMGHVVRPNARLAEEAPEYYMSMGHTAEQVAKKYGVSREDQDAFAVRSHQRAAKAL
HHHHHHHHEECCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
AEGKFDEEIVPVEVTVRKVENNKLVEEKVVFTQDEGVRPDTNMETLAKLRPAFAVNGTVT
HCCCCCCCEEEEEEEEEECCCCCCHHHHEEEECCCCCCCCCCHHHHHHHCCCEEECCEEE
AGNASQMSDGAAAVMVMDREKAESLGLKPLGKFRSFAVAGVPPEVMGIGPVAAVPKALKL
CCCHHHCCCCCEEEEEEECHHHHHCCCCCCHHHHHEEECCCCHHHHCCCCHHHHHHHHHH
AGLELSDIGLIELNEAFASQSVQVIRELGLDEEIVNVNGGAIALGHPLGCTGAKLTLSLL
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHH
YEMRRRNVQFGIVTMCIGGGMGAAGVFELL
HHHHHCCCCEEEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]