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The map label for this gene is thrC [H]

Identifier: 138896550

GI number: 138896550

Start: 3017913

End: 3018974

Strand: Reverse

Name: thrC [H]

Synonym: GTNG_2913

Alternate gene names: 138896550

Gene position: 3018974-3017913 (Counterclockwise)

Preceding gene: 138896551

Following gene: 138896549

Centisome position: 85.03

GC content: 57.34

Gene sequence:

>1062_bases
ATGGCATGGAAAGGGCTGCTTGACGCCTACGGTGACTTTTTGCCGCTGACAGAAGCAACGCCAAGACTATCACTTTGCGA
AGGGAATACGCCGCTCATCCCGCTGCCGCGTCTGTCGGAAGAGCTCGGCATTACGTTATACGTCAAGGTGGAAGGAGCGA
ACCCGACCGGTTCGTTTAAAGACCGCGGCATGGTGATGGCGGTGGCGAAGGCGAAAGAGGAAGGAAGCCATACGATCATT
TGTGCATCGACCGGCAATACGTCCGCTTCCGCCGCCGCGTATGCCGCACGCGCCGGGATGCGCTGCCTTGTCGTCATCCC
GAATGGGAAAATCGCGCTCGGCAAACTAGCACAAGCCGCCATGTACGGAGCGGAGATTTTTGCGATTGAAGGCAACTTTG
ACGAAGCGCTCAGTATGGTGCGTCGGCTGAGTGAAACAGCGCCGATCACGCTGGTGAACTCGGTCAACCCGTACCGCATT
GAAGGGCAAAAAACGGCAGCGTTTGAAGTGTGCGACCAGCTTGGACGCGCGCCGGACGTGCTCGCCATCCCGGTTGGCAA
TGCGGGCAACATTACGGCCTATTGGAAAGGGTTTAAGGAGTATCATGAAGCAAAAGGAACGGGACTGCCGCAAATGCGCG
GTTTTGAAGCGGAAGGAGCAGCGGCAATTGTCCGCAATCAAGTGATTGAACAGCCGGAAACGATTGCGACGGCAATTCGC
ATCGGCAACCCGGCGAGCTGGCAGAAAGCGGTCCAAGCGGCGAACGAATCGCGTGGAAAAATCGATGAAGTGAGCGATGA
GGAAATTTTAGCAGCTTACAAACGGCTCGCGCGGACAGAAGGCATTTTTGCCGAGCCGGCGTCATGCGCCGCCATCGCCG
GAGTGATCAAACAGCGCGAGCGGAATGAAATCGAGCGCGGCAGCCTCGTTGTCGCGGTTCTCACCGGCAACGGCTTGAAA
GACCCGGCCGTCGCCCTCGATACCGCAGCGATTGAACCGATCGTGCTGCCGAACGATGAACAAGTCGTGCTGGAGCATTT
GCAAGGGGTTGTTCATACATGA

Upstream 100 bases:

>100_bases
CCTCGCAGCAAGACTATGAAGACATTTTACAGCAGTTAAGCGATTTAGAAATCGTCGAGCGGGTGCAAAGCTCGTATCGG
GTGGAAGGAGAGAAACGGTA

Downstream 100 bases:

>100_bases
AAGAAGATGAGATGTTAAAAATCGTCGTTCCGGGAAGTACGGCGAACTTAGGGCCCGGCTTCGATTCGGTTGGGCTCGCC
GTCTCCCGTTACTTAACGCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MAWKGLLDAYGDFLPLTEATPRLSLCEGNTPLIPLPRLSEELGITLYVKVEGANPTGSFKDRGMVMAVAKAKEEGSHTII
CASTGNTSASAAAYAARAGMRCLVVIPNGKIALGKLAQAAMYGAEIFAIEGNFDEALSMVRRLSETAPITLVNSVNPYRI
EGQKTAAFEVCDQLGRAPDVLAIPVGNAGNITAYWKGFKEYHEAKGTGLPQMRGFEAEGAAAIVRNQVIEQPETIATAIR
IGNPASWQKAVQAANESRGKIDEVSDEEILAAYKRLARTEGIFAEPASCAAIAGVIKQRERNEIERGSLVVAVLTGNGLK
DPAVALDTAAIEPIVLPNDEQVVLEHLQGVVHT

Sequences:

>Translated_353_residues
MAWKGLLDAYGDFLPLTEATPRLSLCEGNTPLIPLPRLSEELGITLYVKVEGANPTGSFKDRGMVMAVAKAKEEGSHTII
CASTGNTSASAAAYAARAGMRCLVVIPNGKIALGKLAQAAMYGAEIFAIEGNFDEALSMVRRLSETAPITLVNSVNPYRI
EGQKTAAFEVCDQLGRAPDVLAIPVGNAGNITAYWKGFKEYHEAKGTGLPQMRGFEAEGAAAIVRNQVIEQPETIATAIR
IGNPASWQKAVQAANESRGKIDEVSDEEILAAYKRLARTEGIFAEPASCAAIAGVIKQRERNEIERGSLVVAVLTGNGLK
DPAVALDTAAIEPIVLPNDEQVVLEHLQGVVHT
>Mature_352_residues
AWKGLLDAYGDFLPLTEATPRLSLCEGNTPLIPLPRLSEELGITLYVKVEGANPTGSFKDRGMVMAVAKAKEEGSHTIIC
ASTGNTSASAAAYAARAGMRCLVVIPNGKIALGKLAQAAMYGAEIFAIEGNFDEALSMVRRLSETAPITLVNSVNPYRIE
GQKTAAFEVCDQLGRAPDVLAIPVGNAGNITAYWKGFKEYHEAKGTGLPQMRGFEAEGAAAIVRNQVIEQPETIATAIRI
GNPASWQKAVQAANESRGKIDEVSDEEILAAYKRLARTEGIFAEPASCAAIAGVIKQRERNEIERGSLVVAVLTGNGLKD
PAVALDTAAIEPIVLPNDEQVVLEHLQGVVHT

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI33469958, Length=273, Percent_Identity=26.7399267399267, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790207, Length=295, Percent_Identity=28.8135593220339, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=25, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=27.6872964169381, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24643623, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129101, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37493; Mature: 37362

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWKGLLDAYGDFLPLTEATPRLSLCEGNTPLIPLPRLSEELGITLYVKVEGANPTGSFK
CCCHHHHHHHCCCEECCCCCCCEEEECCCCCEEECCCCHHHCCEEEEEEEECCCCCCCCC
DRGMVMAVAKAKEEGSHTIICASTGNTSASAAAYAARAGMRCLVVIPNGKIALGKLAQAA
CCCEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHH
MYGAEIFAIEGNFDEALSMVRRLSETAPITLVNSVNPYRIEGQKTAAFEVCDQLGRAPDV
HCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCCCE
LAIPVGNAGNITAYWKGFKEYHEAKGTGLPQMRGFEAEGAAAIVRNQVIEQPETIATAIR
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHEE
IGNPASWQKAVQAANESRGKIDEVSDEEILAAYKRLARTEGIFAEPASCAAIAGVIKQRE
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RNEIERGSLVVAVLTGNGLKDPAVALDTAAIEPIVLPNDEQVVLEHLQGVVHT
HCCCCCCCEEEEEEECCCCCCCCCEEHHHCCCCEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AWKGLLDAYGDFLPLTEATPRLSLCEGNTPLIPLPRLSEELGITLYVKVEGANPTGSFK
CCHHHHHHHCCCEECCCCCCCEEEECCCCCEEECCCCHHHCCEEEEEEEECCCCCCCCC
DRGMVMAVAKAKEEGSHTIICASTGNTSASAAAYAARAGMRCLVVIPNGKIALGKLAQAA
CCCEEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHH
MYGAEIFAIEGNFDEALSMVRRLSETAPITLVNSVNPYRIEGQKTAAFEVCDQLGRAPDV
HCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCCCE
LAIPVGNAGNITAYWKGFKEYHEAKGTGLPQMRGFEAEGAAAIVRNQVIEQPETIATAIR
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHEE
IGNPASWQKAVQAANESRGKIDEVSDEEILAAYKRLARTEGIFAEPASCAAIAGVIKQRE
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RNEIERGSLVVAVLTGNGLKDPAVALDTAAIEPIVLPNDEQVVLEHLQGVVHT
HCCCCCCCEEEEEEECCCCCCCCCEEHHHCCCCEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]