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The map label for this gene is hom [H]

Identifier: 138896551

GI number: 138896551

Start: 3018974

End: 3020272

Strand: Reverse

Name: hom [H]

Synonym: GTNG_2914

Alternate gene names: 138896551

Gene position: 3020272-3018974 (Counterclockwise)

Preceding gene: 138896552

Following gene: 138896550

Centisome position: 85.07

GC content: 50.58

Gene sequence:

>1299_bases
ATGGAAAAGCCAATTTTTGTTGGATTATTAGGATTAGGAACGGTCGGAAGCGGTGTAGTCAAAATTATTGAAAACCACCA
AGAAAAATTGATTCACCAAGTCGGTTGTCCGGTGAAGGTGAAAAAAATCCTCGTTCGTGACGTGCAGAAACCGCGCGAGG
TTGCCGTCGATTCGGCGTTGTTGACGACGAGCGCTGCGGATGTAATTGATGATCCGGATATTGATGTCATTATTGAAGTG
ATGGGCGGCATTGAGGAGACAAAGGAACTGTTGTTGCGGGCGCTGCGCCAAGGAAAACATGTGGTGACGGCGAACAAAGA
TTTAATGGCTGTTTACGGTTCGGAATTGCTTCGGGTGGCAGCTGAACACCATTGCGATTTGTTTTACGAAGCGAGCGTCG
CCGGCGGCATTCCGATTTTGCGCAGCTTGGTCGACGGGTTGGCGTCGGACCGAATCACGAAGATGATGGGAATTGTCAAC
GGAACGACCAACTACATTTTAACGAAAATGTCGCAAAACGGTGCTTCCTATCAGGAAGTGCTGGCGGAAGCGCAGGCGCT
CGGGTTCGCCGAAGCCGACCCGACATCGGACGTCGAAGGGCTTGATGCGGCACGGAAAATGGCGATTTTAGCCCGCCTTG
GCTTTTCGATGGACATCGACTTGGACGATGTGCAAGTTAAGGGCATTACTCATGTAACGGAAGAAGATTTAAATTATGGG
AAGCGGCTCGGTTATACGATGAAGCTCATCGGCATCGCCCAGCGTAATGGCAACAAGGTGGAAGTGAGCGTCCAACCGAC
GTTTCTTCCTGATTCTCATCCACTCGCTTCCGTCCATAATGAATATAACGCTGTCTATGTGTACGGAGAGGCAGTCGGGG
AAACGATGTTTTACGGACCGGGGGCTGGCAGCTTGCCGACGGCGACGGCAGTCGTCTCTGACTTGGTGGCGGTAATGAAA
AACATGCGCCTTGGCGTCAACGGCCATTATGCCGTCGCGCCGCAATATGAAAAACAGTTGAAAGCACCGGCGGAAATTTT
CTCGAAATACTTCTTGCGCATTCATGTCAAAGACCAAGTCGGCGCGTTTGCCAAAATTACGACGCTGTTTTCCGAGCGCG
GGGTGAGCTTCGAGAAAATTTTGCAATTGCCGTTGAAAGAAAACGGCTTGGCGGAAATCGTGATTGTGACACACGACGCC
TCGCAGCAAGACTATGAAGACATTTTACAGCAGTTAAGCGATTTAGAAATCGTCGAGCGGGTGCAAAGCTCGTATCGGGT
GGAAGGAGAGAAACGGTAA

Upstream 100 bases:

>100_bases
CATCGTAAAAATTTTCATTGCCAAATGGCAGATCGTCTTTTATAATGTCTACTATAAAAATACAGATGTCTACTGTACGT
AAACAGAAGGGGCGGTAAGG

Downstream 100 bases:

>100_bases
TGGCATGGAAAGGGCTGCTTGACGCCTACGGTGACTTTTTGCCGCTGACAGAAGCAACGCCAAGACTATCACTTTGCGAA
GGGAATACGCCGCTCATCCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MEKPIFVGLLGLGTVGSGVVKIIENHQEKLIHQVGCPVKVKKILVRDVQKPREVAVDSALLTTSAADVIDDPDIDVIIEV
MGGIEETKELLLRALRQGKHVVTANKDLMAVYGSELLRVAAEHHCDLFYEASVAGGIPILRSLVDGLASDRITKMMGIVN
GTTNYILTKMSQNGASYQEVLAEAQALGFAEADPTSDVEGLDAARKMAILARLGFSMDIDLDDVQVKGITHVTEEDLNYG
KRLGYTMKLIGIAQRNGNKVEVSVQPTFLPDSHPLASVHNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMK
NMRLGVNGHYAVAPQYEKQLKAPAEIFSKYFLRIHVKDQVGAFAKITTLFSERGVSFEKILQLPLKENGLAEIVIVTHDA
SQQDYEDILQQLSDLEIVERVQSSYRVEGEKR

Sequences:

>Translated_432_residues
MEKPIFVGLLGLGTVGSGVVKIIENHQEKLIHQVGCPVKVKKILVRDVQKPREVAVDSALLTTSAADVIDDPDIDVIIEV
MGGIEETKELLLRALRQGKHVVTANKDLMAVYGSELLRVAAEHHCDLFYEASVAGGIPILRSLVDGLASDRITKMMGIVN
GTTNYILTKMSQNGASYQEVLAEAQALGFAEADPTSDVEGLDAARKMAILARLGFSMDIDLDDVQVKGITHVTEEDLNYG
KRLGYTMKLIGIAQRNGNKVEVSVQPTFLPDSHPLASVHNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMK
NMRLGVNGHYAVAPQYEKQLKAPAEIFSKYFLRIHVKDQVGAFAKITTLFSERGVSFEKILQLPLKENGLAEIVIVTHDA
SQQDYEDILQQLSDLEIVERVQSSYRVEGEKR
>Mature_432_residues
MEKPIFVGLLGLGTVGSGVVKIIENHQEKLIHQVGCPVKVKKILVRDVQKPREVAVDSALLTTSAADVIDDPDIDVIIEV
MGGIEETKELLLRALRQGKHVVTANKDLMAVYGSELLRVAAEHHCDLFYEASVAGGIPILRSLVDGLASDRITKMMGIVN
GTTNYILTKMSQNGASYQEVLAEAQALGFAEADPTSDVEGLDAARKMAILARLGFSMDIDLDDVQVKGITHVTEEDLNYG
KRLGYTMKLIGIAQRNGNKVEVSVQPTFLPDSHPLASVHNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMK
NMRLGVNGHYAVAPQYEKQLKAPAEIFSKYFLRIHVKDQVGAFAKITTLFSERGVSFEKILQLPLKENGLAEIVIVTHDA
SQQDYEDILQQLSDLEIVERVQSSYRVEGEKR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=267, Percent_Identity=29.2134831460674, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790376, Length=362, Percent_Identity=24.3093922651934, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=92, Percent_Identity=35.8695652173913, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47180; Mature: 47180

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPIFVGLLGLGTVGSGVVKIIENHQEKLIHQVGCPVKVKKILVRDVQKPREVAVDSAL
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
LTTSAADVIDDPDIDVIIEVMGGIEETKELLLRALRQGKHVVTANKDLMAVYGSELLRVA
HHCCCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHH
AEHHCDLFYEASVAGGIPILRSLVDGLASDRITKMMGIVNGTTNYILTKMSQNGASYQEV
HHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHH
LAEAQALGFAEADPTSDVEGLDAARKMAILARLGFSMDIDLDDVQVKGITHVTEEDLNYG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHH
KRLGYTMKLIGIAQRNGNKVEVSVQPTFLPDSHPLASVHNEYNAVYVYGEAVGETMFYGP
HHCCCEEEEEEEEECCCCEEEEEEECEECCCCCCHHHHCCCCCEEEEEECHHCCEEEECC
GAGSLPTATAVVSDLVAVMKNMRLGVNGHYAVAPQYEKQLKAPAEIFSKYFLRIHVKDQV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHCCCHHHHHHHHHEEEEEHHHH
GAFAKITTLFSERGVSFEKILQLPLKENGLAEIVIVTHDASQQDYEDILQQLSDLEIVER
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VQSSYRVEGEKR
HHHHHCCCCCCC
>Mature Secondary Structure
MEKPIFVGLLGLGTVGSGVVKIIENHQEKLIHQVGCPVKVKKILVRDVQKPREVAVDSAL
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
LTTSAADVIDDPDIDVIIEVMGGIEETKELLLRALRQGKHVVTANKDLMAVYGSELLRVA
HHCCCHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHH
AEHHCDLFYEASVAGGIPILRSLVDGLASDRITKMMGIVNGTTNYILTKMSQNGASYQEV
HHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHH
LAEAQALGFAEADPTSDVEGLDAARKMAILARLGFSMDIDLDDVQVKGITHVTEEDLNYG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHH
KRLGYTMKLIGIAQRNGNKVEVSVQPTFLPDSHPLASVHNEYNAVYVYGEAVGETMFYGP
HHCCCEEEEEEEEECCCCEEEEEEECEECCCCCCHHHHCCCCCEEEEEECHHCCEEEECC
GAGSLPTATAVVSDLVAVMKNMRLGVNGHYAVAPQYEKQLKAPAEIFSKYFLRIHVKDQV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHCCCHHHHHHHHHEEEEEHHHH
GAFAKITTLFSERGVSFEKILQLPLKENGLAEIVIVTHDASQQDYEDILQQLSDLEIVER
CHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
VQSSYRVEGEKR
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]