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The map label for this gene is hemC [H]

Identifier: 138896211

GI number: 138896211

Start: 2679336

End: 2680265

Strand: Reverse

Name: hemC [H]

Synonym: GTNG_2574

Alternate gene names: 138896211

Gene position: 2680265-2679336 (Counterclockwise)

Preceding gene: 138896212

Following gene: 138896210

Centisome position: 75.49

GC content: 56.77

Gene sequence:

>930_bases
ATGCGAAACATCGTCGTTGGCTCGCGGCGCAGCAAGCTTGCTTTGACTCAGACGAACTGGGTCATTAACGAATTGAAGCG
GCTCGGGGCGCCGTTTACGTTTGAGGTAAAAGAAATCGTCACGAAAGGAGATCGCGTGCTCGATGTCACGCTCTCCAAAG
TAGGAGGCAAAGGGCTGTTTGTGAAAGAAATTGAGCATGAAATGCTGACCGGCGGCATCGATATGGCCGTCCACAGTATG
AAAGACATGCCGGCAGTACTGCCGAGCGGATTGGTGATCGGCTCGGTTCCGCGGCGTGAGGATGTGCGTGATGTGCTCGT
CAGCAAGGGGAATCTGTCGCTTTCCGATTTGCCAAGCGGGGCGGTCATCGGTACGAGCAGTCTGCGCCGCTCGGCACAGT
TGCTCGCCTATCGGCCGGATGTGACGATCAAATGGATCCGCGGCAACATTGACACAAGGCTGGCGAAGCTGAAAAACGAA
GATTATGACGCCATCGTGCTGGCGGCTGCCGGCTTGGCGCGTATGGGCTGGAGCGATGACGTGATCAGCGAATATTTGTC
GCCGGATGTGTGCGTCCCGGCGGTTGGCCAAGGAGCGCTTGCTGTCGAATGCCGTGAAGATGATGTGGAGTTGCGCGAGT
GGCTGAGCCGTCTGAATGATGAACAGACGGAACGAGCAGTTCGGGCGGAGCGCGCCTTTTTGCAGCAGATGGAAGGTGGA
TGCCAAGTGCCGATTGCCGGCTATGCGGAAGTGAAGGAGGGAATGGTGCATCTTACTGCGCTTGTTGCCTCCCCAGACGG
CAAAGAGAAATACAAAGAAATCGTCATTGGCGCTGATCCGGAAGAGGTCGGCCGACAGGCAGCTGCCCTCCTGAGTGAGC
AAGGGGCCAAAGAGCTGATCGAGCGCGTAAAAAAGGAGCTGGGCAACTAA

Upstream 100 bases:

>100_bases
ATGGAATATCGGTTCATTTTTATTTTTGCTTATCAACTTTTTCTTGTTTGGCAGTTTGTCAGAATTCCATTTTTGGTATG
CGTAATTGAGGAGGAGCGAA

Downstream 100 bases:

>100_bases
TGACCAATCGTGCGCTGGCTGGCAAGACAGTGCTTGTAACCCGTGACAAGGAGCAGGCGGCATCGTTTTCCGCCAAGCTG
CGCGACGCTGGTGCGGTGCC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRNIVVGSRRSKLALTQTNWVINELKRLGAPFTFEVKEIVTKGDRVLDVTLSKVGGKGLFVKEIEHEMLTGGIDMAVHSM
KDMPAVLPSGLVIGSVPRREDVRDVLVSKGNLSLSDLPSGAVIGTSSLRRSAQLLAYRPDVTIKWIRGNIDTRLAKLKNE
DYDAIVLAAAGLARMGWSDDVISEYLSPDVCVPAVGQGALAVECREDDVELREWLSRLNDEQTERAVRAERAFLQQMEGG
CQVPIAGYAEVKEGMVHLTALVASPDGKEKYKEIVIGADPEEVGRQAAALLSEQGAKELIERVKKELGN

Sequences:

>Translated_309_residues
MRNIVVGSRRSKLALTQTNWVINELKRLGAPFTFEVKEIVTKGDRVLDVTLSKVGGKGLFVKEIEHEMLTGGIDMAVHSM
KDMPAVLPSGLVIGSVPRREDVRDVLVSKGNLSLSDLPSGAVIGTSSLRRSAQLLAYRPDVTIKWIRGNIDTRLAKLKNE
DYDAIVLAAAGLARMGWSDDVISEYLSPDVCVPAVGQGALAVECREDDVELREWLSRLNDEQTERAVRAERAFLQQMEGG
CQVPIAGYAEVKEGMVHLTALVASPDGKEKYKEIVIGADPEEVGRQAAALLSEQGAKELIERVKKELGN
>Mature_309_residues
MRNIVVGSRRSKLALTQTNWVINELKRLGAPFTFEVKEIVTKGDRVLDVTLSKVGGKGLFVKEIEHEMLTGGIDMAVHSM
KDMPAVLPSGLVIGSVPRREDVRDVLVSKGNLSLSDLPSGAVIGTSSLRRSAQLLAYRPDVTIKWIRGNIDTRLAKLKNE
DYDAIVLAAAGLARMGWSDDVISEYLSPDVCVPAVGQGALAVECREDDVELREWLSRLNDEQTERAVRAERAFLQQMEGG
CQVPIAGYAEVKEGMVHLTALVASPDGKEKYKEIVIGADPEEVGRQAAALLSEQGAKELIERVKKELGN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=279, Percent_Identity=44.4444444444444, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI66933009, Length=279, Percent_Identity=44.4444444444444, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI48994974, Length=300, Percent_Identity=47.3333333333333, Blast_Score=258, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=35.4430379746835, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20130425, Length=254, Percent_Identity=48.0314960629921, Blast_Score=227, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33730; Mature: 33730

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIVVGSRRSKLALTQTNWVINELKRLGAPFTFEVKEIVTKGDRVLDVTLSKVGGKGLF
CCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEHHHHHHHCCCEEEEEEHHHCCCCCCH
VKEIEHEMLTGGIDMAVHSMKDMPAVLPSGLVIGSVPRREDVRDVLVSKGNLSLSDLPSG
HHHHHHHHHHCCHHHHHHHHHHCHHHCCCCCEECCCCCHHHHHHHHHCCCCCCHHCCCCC
AVIGTSSLRRSAQLLAYRPDVTIKWIRGNIDTRLAKLKNEDYDAIVLAAAGLARMGWSDD
CEEEHHHHHHHHHHEEECCCCEEEEEECCHHHHHHHHCCCCCCEEEEEHHHHHHCCCCHH
VISEYLSPDVCVPAVGQGALAVECREDDVELREWLSRLNDEQTERAVRAERAFLQQMEGG
HHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC
CQVPIAGYAEVKEGMVHLTALVASPDGKEKYKEIVIGADPEEVGRQAAALLSEQGAKELI
CCCCCCCHHHHHHHHHEEHHEEECCCCHHHHHHEEECCCHHHHHHHHHHHHHHCCHHHHH
ERVKKELGN
HHHHHHHCC
>Mature Secondary Structure
MRNIVVGSRRSKLALTQTNWVINELKRLGAPFTFEVKEIVTKGDRVLDVTLSKVGGKGLF
CCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEHHHHHHHCCCEEEEEEHHHCCCCCCH
VKEIEHEMLTGGIDMAVHSMKDMPAVLPSGLVIGSVPRREDVRDVLVSKGNLSLSDLPSG
HHHHHHHHHHCCHHHHHHHHHHCHHHCCCCCEECCCCCHHHHHHHHHCCCCCCHHCCCCC
AVIGTSSLRRSAQLLAYRPDVTIKWIRGNIDTRLAKLKNEDYDAIVLAAAGLARMGWSDD
CEEEHHHHHHHHHHEEECCCCEEEEEECCHHHHHHHHCCCCCCEEEEEHHHHHHCCCCHH
VISEYLSPDVCVPAVGQGALAVECREDDVELREWLSRLNDEQTERAVRAERAFLQQMEGG
HHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC
CQVPIAGYAEVKEGMVHLTALVASPDGKEKYKEIVIGADPEEVGRQAAALLSEQGAKELI
CCCCCCCHHHHHHHHHEEHHEEECCCCHHHHHHEEECCCHHHHHHHHHHHHHHCCHHHHH
ERVKKELGN
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA