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The map label for this gene is hemD [H]

Identifier: 138896210

GI number: 138896210

Start: 2678566

End: 2679336

Strand: Reverse

Name: hemD [H]

Synonym: GTNG_2573

Alternate gene names: 138896210

Gene position: 2679336-2678566 (Counterclockwise)

Preceding gene: 138896211

Following gene: 138896209

Centisome position: 75.47

GC content: 57.46

Gene sequence:

>771_bases
ATGACCAATCGTGCGCTGGCTGGCAAGACAGTGCTTGTAACCCGTGACAAGGAGCAGGCGGCATCGTTTTCCGCCAAGCT
GCGCGACGCTGGTGCGGTGCCGATCGAAATCCCACTCATAGCTATCCGGCCAGCGGCGACACCGGAAGCGATTGCAGCGC
TCGCCGAACGGCTTGAGGAATACCGATGGCTCGTCTTGACGAGCGCGAACGCCATTCGCTTCTTTTTTCCGCACGTTTCG
TTGTCGCGGCCGTTGCCGAATATCGCTGTCGTCGGACGGAAGACGGCAGCTGCCCTCGCTGAGTACGGTGTTTCACCGGT
GCTCGTGCCGGATGATTTCACCGCTGAACGGCTCGCTGCCATGCTTGCACCGCGCTTGAAACAGGGCGAACGGGTGCTGT
TTGTCAAGGGGGACTTGGCGAGCCCGACGCTGCCTGAGGCGTTAAGAGAGGCTGGGGCAACAGTTGATGAGTTTATTGTG
TATCGCACCATGCCGGATACGAGCGGAGAAGAGCAGTTGTTGACACTGCTGCGCGAACGGAAGTTGGATGTACTCACTTT
GATGAGCCCATCAGCAGTCCGCAGCCTTGCCCGTCTTCTTGGCGGAGAAGCGAACGAGCTTCTCTCCGGAGTCACCGTCG
CCTGCATCGGACCGGTGACAAAAAAGGCAGCCGAGCAGGAAGGCATAGCAGTACATATTTGTCCAGCTGATTACACGGCT
GATGGTATAATGAAAGCGATGGAACAATATTTTTCCACGGAGGGACGATAA

Upstream 100 bases:

>100_bases
GCGCTGATCCGGAAGAGGTCGGCCGACAGGCAGCTGCCCTCCTGAGTGAGCAAGGGGCCAAAGAGCTGATCGAGCGCGTA
AAAAAGGAGCTGGGCAACTA

Downstream 100 bases:

>100_bases
ATGTCATTGTCATTTGACCGCCATCGTCGCCTGCGGCAAACAGCCGCCATTCGGGCGATGGTACGCGAGACGCATCTTCG
CGTTGATGATCTTATTTATC

Product: uroporphyrinogen III cosynthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTNRALAGKTVLVTRDKEQAASFSAKLRDAGAVPIEIPLIAIRPAATPEAIAALAERLEEYRWLVLTSANAIRFFFPHVS
LSRPLPNIAVVGRKTAAALAEYGVSPVLVPDDFTAERLAAMLAPRLKQGERVLFVKGDLASPTLPEALREAGATVDEFIV
YRTMPDTSGEEQLLTLLRERKLDVLTLMSPSAVRSLARLLGGEANELLSGVTVACIGPVTKKAAEQEGIAVHICPADYTA
DGIMKAMEQYFSTEGR

Sequences:

>Translated_256_residues
MTNRALAGKTVLVTRDKEQAASFSAKLRDAGAVPIEIPLIAIRPAATPEAIAALAERLEEYRWLVLTSANAIRFFFPHVS
LSRPLPNIAVVGRKTAAALAEYGVSPVLVPDDFTAERLAAMLAPRLKQGERVLFVKGDLASPTLPEALREAGATVDEFIV
YRTMPDTSGEEQLLTLLRERKLDVLTLMSPSAVRSLARLLGGEANELLSGVTVACIGPVTKKAAEQEGIAVHICPADYTA
DGIMKAMEQYFSTEGR
>Mature_255_residues
TNRALAGKTVLVTRDKEQAASFSAKLRDAGAVPIEIPLIAIRPAATPEAIAALAERLEEYRWLVLTSANAIRFFFPHVSL
SRPLPNIAVVGRKTAAALAEYGVSPVLVPDDFTAERLAAMLAPRLKQGERVLFVKGDLASPTLPEALREAGATVDEFIVY
RTMPDTSGEEQLLTLLRERKLDVLTLMSPSAVRSLARLLGGEANELLSGVTVACIGPVTKKAAEQEGIAVHICPADYTAD
GIMKAMEQYFSTEGR

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27555; Mature: 27424

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRALAGKTVLVTRDKEQAASFSAKLRDAGAVPIEIPLIAIRPAATPEAIAALAERLEE
CCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHH
YRWLVLTSANAIRFFFPHVSLSRPLPNIAVVGRKTAAALAEYGVSPVLVPDDFTAERLAA
CEEEEEECCCEEEEEECCCCCCCCCCCEEEECCHHHHHHHHHCCCCEEECCCCCHHHHHH
MLAPRLKQGERVLFVKGDLASPTLPEALREAGATVDEFIVYRTMPDTSGEEQLLTLLRER
HHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHEEEEEECCCCCCHHHHHHHHHHC
KLDVLTLMSPSAVRSLARLLGGEANELLSGVTVACIGPVTKKAAEQEGIAVHICPADYTA
CCCEEEECCCHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHHHHHCCCEEEEECCCCCH
DGIMKAMEQYFSTEGR
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TNRALAGKTVLVTRDKEQAASFSAKLRDAGAVPIEIPLIAIRPAATPEAIAALAERLEE
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHH
YRWLVLTSANAIRFFFPHVSLSRPLPNIAVVGRKTAAALAEYGVSPVLVPDDFTAERLAA
CEEEEEECCCEEEEEECCCCCCCCCCCEEEECCHHHHHHHHHCCCCEEECCCCCHHHHHH
MLAPRLKQGERVLFVKGDLASPTLPEALREAGATVDEFIVYRTMPDTSGEEQLLTLLRER
HHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCHHHEEEEEECCCCCCHHHHHHHHHHC
KLDVLTLMSPSAVRSLARLLGGEANELLSGVTVACIGPVTKKAAEQEGIAVHICPADYTA
CCCEEEECCCHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHHHHHCCCEEEEECCCCCH
DGIMKAMEQYFSTEGR
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]