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The map label for this gene is hemL [H]

Identifier: 138896208

GI number: 138896208

Start: 2676286

End: 2677575

Strand: Reverse

Name: hemL [H]

Synonym: GTNG_2571

Alternate gene names: 138896208

Gene position: 2677575-2676286 (Counterclockwise)

Preceding gene: 138896209

Following gene: 138896207

Centisome position: 75.42

GC content: 53.41

Gene sequence:

>1290_bases
GTGCGAAGTTATGAACGGTCGAAAGCGGCTTATGAAGAAGCAGTGACATTAATGCCAGGTGGGGTAAACAGCCCGGTTCG
CGCCTTCAAATCGGTCGGGATGACGCCGATTTTTATGGCGCGCGGCCAAGGTGCGAAAATTTACGATATTGACGGCAACG
AATATATCGATTATGTGTTGTCATGGGGACCGCTCATTTTAGGGCATGCCGATCCACAAGTTGTTGAAGCGTTAAAACGG
GTAGCCGAACAAGGGACGAGCTTCGGCGCTCCGACGTTGCTTGAGAACGAGTTGGCCAAACTCGTGATCGAGCGGGTGCC
TTCCGTCGAGATCGTACGAATGGTCAACTCCGGAACGGAAGCAACGATGAGCGCCCTCCGTTTGGCGCGTGGCTACACGA
AGCGCAACAAAATCATCAAGTTTGAAGGCAGCTACCATGGTCATGGTGATTCGTTGCTTATTAAAGCTGGCTCCGGTGTG
GCGACGCTCGGCTTACCGGATAGTCCAGGCGTACCGCAATCAGTCGCTCAGCATACCATCACCGTTCCGTACAATGATTT
GGACAGCGTGCGCTATGCATTTGAGCGGTTTGGTGAAGACATTGCGGCGGTGATTGTCGAGCCGGTAGCCGGCAATATGG
GCGTTGTTCCGCCAGTCCCTGGCTTTTTGGAAGGGCTGCGCGACGTGACAAAACAATACGGCGCTCTATTGATTTTTGAC
GAGGTGATGACCGGATTCCGTGTCGATTACCATTGTGCACAAGGGTATTACGGCGTTGAACCGGATTTGACGTGCCTCGG
CAAAGTGATCGGCGGCGGCCTGCCGGTTGGAGCGTATGGCGGTAAAGCAGAAATTATGGAGCAAGTTGCACCGAGCGGGC
CGGTGTATCAGGCCGGTACGTTGTCCGGCAACCCGCTTGCCATGACAGCCGGTTATGAAACGCTTCGCCAACTGACACCG
GAAACGTATAAAGAGTTTCGTCGGAAGGCAGCGCGCCTTGAAGAAGGGCTGCATCAAGCTGCCGAAAAATATGAGATTCC
GCATACCATCAACCGCGCTGGATCGATGATTGGCTTTTTCTTTACGAACGAGCCGGTCATCAATTACGAGACGGCAAAAA
CGTCGGATTTGGAACTGTTTGCCGCCTATTACCGGGAGATGGCGAACGAAGGCATTTTCTTGCCGCCGTCACAATTTGAA
GGGCTGTTTTTGTCGACTGCTCATAGCGATGAAGACATTGAATATACGATCGCCGCTGCCGAGCGGGTATTTGCTCGTCT
GCGCGGCTAA

Upstream 100 bases:

>100_bases
AATGCTGACAGGAATGAAGCGAGCCGGCGCTGATTTAATCATCACATATTTTGCGAAAGATGTTGCTCGCTGGCTGGCTG
AATAGAGAGGGGGCGGAATC

Downstream 100 bases:

>100_bases
ATCCATCGGGCTGCTGTATGGGCAGCCCGATTTTTTTATCATACCGCCTCTTTTCCGTTCATACAATGGATAATGTCATA
GAAACTATTTGTCGAGGGGA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2 [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MRSYERSKAAYEEAVTLMPGGVNSPVRAFKSVGMTPIFMARGQGAKIYDIDGNEYIDYVLSWGPLILGHADPQVVEALKR
VAEQGTSFGAPTLLENELAKLVIERVPSVEIVRMVNSGTEATMSALRLARGYTKRNKIIKFEGSYHGHGDSLLIKAGSGV
ATLGLPDSPGVPQSVAQHTITVPYNDLDSVRYAFERFGEDIAAVIVEPVAGNMGVVPPVPGFLEGLRDVTKQYGALLIFD
EVMTGFRVDYHCAQGYYGVEPDLTCLGKVIGGGLPVGAYGGKAEIMEQVAPSGPVYQAGTLSGNPLAMTAGYETLRQLTP
ETYKEFRRKAARLEEGLHQAAEKYEIPHTINRAGSMIGFFFTNEPVINYETAKTSDLELFAAYYREMANEGIFLPPSQFE
GLFLSTAHSDEDIEYTIAAAERVFARLRG

Sequences:

>Translated_429_residues
MRSYERSKAAYEEAVTLMPGGVNSPVRAFKSVGMTPIFMARGQGAKIYDIDGNEYIDYVLSWGPLILGHADPQVVEALKR
VAEQGTSFGAPTLLENELAKLVIERVPSVEIVRMVNSGTEATMSALRLARGYTKRNKIIKFEGSYHGHGDSLLIKAGSGV
ATLGLPDSPGVPQSVAQHTITVPYNDLDSVRYAFERFGEDIAAVIVEPVAGNMGVVPPVPGFLEGLRDVTKQYGALLIFD
EVMTGFRVDYHCAQGYYGVEPDLTCLGKVIGGGLPVGAYGGKAEIMEQVAPSGPVYQAGTLSGNPLAMTAGYETLRQLTP
ETYKEFRRKAARLEEGLHQAAEKYEIPHTINRAGSMIGFFFTNEPVINYETAKTSDLELFAAYYREMANEGIFLPPSQFE
GLFLSTAHSDEDIEYTIAAAERVFARLRG
>Mature_429_residues
MRSYERSKAAYEEAVTLMPGGVNSPVRAFKSVGMTPIFMARGQGAKIYDIDGNEYIDYVLSWGPLILGHADPQVVEALKR
VAEQGTSFGAPTLLENELAKLVIERVPSVEIVRMVNSGTEATMSALRLARGYTKRNKIIKFEGSYHGHGDSLLIKAGSGV
ATLGLPDSPGVPQSVAQHTITVPYNDLDSVRYAFERFGEDIAAVIVEPVAGNMGVVPPVPGFLEGLRDVTKQYGALLIFD
EVMTGFRVDYHCAQGYYGVEPDLTCLGKVIGGGLPVGAYGGKAEIMEQVAPSGPVYQAGTLSGNPLAMTAGYETLRQLTP
ETYKEFRRKAARLEEGLHQAAEKYEIPHTINRAGSMIGFFFTNEPVINYETAKTSDLELFAAYYREMANEGIFLPPSQFE
GLFLSTAHSDEDIEYTIAAAERVFARLRG

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=303, Percent_Identity=31.3531353135314, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI13994255, Length=361, Percent_Identity=26.0387811634349, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24119277, Length=380, Percent_Identity=27.3684210526316, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI284507298, Length=222, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1786349, Length=424, Percent_Identity=58.0188679245283, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1789759, Length=332, Percent_Identity=33.433734939759, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789016, Length=361, Percent_Identity=31.8559556786704, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788044, Length=365, Percent_Identity=31.5068493150685, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI145693181, Length=308, Percent_Identity=32.7922077922078, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1787560, Length=348, Percent_Identity=30.1724137931034, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786991, Length=289, Percent_Identity=28.719723183391, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=307, Percent_Identity=30.2931596091205, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=383, Percent_Identity=28.1984334203655, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=147, Percent_Identity=38.0952380952381, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=321, Percent_Identity=28.9719626168224, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=354, Percent_Identity=29.3785310734463, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356575, Length=321, Percent_Identity=29.2834890965732, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357415, Length=305, Percent_Identity=27.5409836065574, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46689; Mature: 46689

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSYERSKAAYEEAVTLMPGGVNSPVRAFKSVGMTPIFMARGQGAKIYDIDGNEYIDYVL
CCCCHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHH
SWGPLILGHADPQVVEALKRVAEQGTSFGAPTLLENELAKLVIERVPSVEIVRMVNSGTE
HCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCHH
ATMSALRLARGYTKRNKIIKFEGSYHGHGDSLLIKAGSGVATLGLPDSPGVPQSVAQHTI
HHHHHHHHHHCHHHCCCEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHCEE
TVPYNDLDSVRYAFERFGEDIAAVIVEPVAGNMGVVPPVPGFLEGLRDVTKQYGALLIFD
ECCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEH
EVMTGFRVDYHCAQGYYGVEPDLTCLGKVIGGGLPVGAYGGKAEIMEQVAPSGPVYQAGT
HHHHCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCC
LSGNPLAMTAGYETLRQLTPETYKEFRRKAARLEEGLHQAAEKYEIPHTINRAGSMIGFF
CCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEE
FTNEPVINYETAKTSDLELFAAYYREMANEGIFLPPSQFEGLFLSTAHSDEDIEYTIAAA
EECCCEEEECCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCEEHHHHH
ERVFARLRG
HHHHHHHCC
>Mature Secondary Structure
MRSYERSKAAYEEAVTLMPGGVNSPVRAFKSVGMTPIFMARGQGAKIYDIDGNEYIDYVL
CCCCHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHH
SWGPLILGHADPQVVEALKRVAEQGTSFGAPTLLENELAKLVIERVPSVEIVRMVNSGTE
HCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCHH
ATMSALRLARGYTKRNKIIKFEGSYHGHGDSLLIKAGSGVATLGLPDSPGVPQSVAQHTI
HHHHHHHHHHCHHHCCCEEEECCCCCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHCEE
TVPYNDLDSVRYAFERFGEDIAAVIVEPVAGNMGVVPPVPGFLEGLRDVTKQYGALLIFD
ECCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEH
EVMTGFRVDYHCAQGYYGVEPDLTCLGKVIGGGLPVGAYGGKAEIMEQVAPSGPVYQAGT
HHHHCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCC
LSGNPLAMTAGYETLRQLTPETYKEFRRKAARLEEGLHQAAEKYEIPHTINRAGSMIGFF
CCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEE
FTNEPVINYETAKTSDLELFAAYYREMANEGIFLPPSQFEGLFLSTAHSDEDIEYTIAAA
EECCCEEEECCCCCCHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCCEEHHHHH
ERVFARLRG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA