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The map label for this gene is hemB [H]

Identifier: 138896209

GI number: 138896209

Start: 2677591

End: 2678565

Strand: Reverse

Name: hemB [H]

Synonym: GTNG_2572

Alternate gene names: 138896209

Gene position: 2678565-2677591 (Counterclockwise)

Preceding gene: 138896210

Following gene: 138896208

Centisome position: 75.45

GC content: 52.41

Gene sequence:

>975_bases
ATGTCATTGTCATTTGACCGCCATCGTCGCCTGCGGCAAACAGCCGCCATTCGGGCGATGGTACGCGAGACGCATCTTCG
CGTTGATGATCTTATTTATCCGCTGTTTGTCGTCGAAGGAAGCGGCATTCGCCGCGAAGTGCCATCGATGCCTGGGGTAT
ACCATTTATCGCTTGATCGTCTAACGGAAGAAATCGATGAAATCGCGAAGCTTGGCATCCGGGCGGTCATGGTGTTTGGT
GTGCCGGACGAAAAAGATGAAGTCGGTTCGCAGGCGTATTGCGAAACTGGGATCGTCCAGCGAGCAATCCGGCAAATCAA
GGCTGAACGTTCGGAGATGGTCGTCATTGCCGATACATGTTTATGCGAATATACGAGCCATGGTCATTGCGGCGTCGTCG
AAAATGAGCAAGTACTCAACGACCCGTCGCTCGAGTTGCTCGTCAAAACGGCAGTGAGCCAAGCGCAAGCTGGTGCCGAC
ATCATCGCACCGTCGAACATGATGGACGGGTTTGTCGCCGCCATTCGCCATGGGCTTGATGAAGCGGGGTTTGAGAACGT
GCCGATCATGTCCTATGCAATTAAGTACGCCTCGGCATTTTACGGCCCGTTCCGCGATGCAGCGGACAGCGCACCGCAAT
TTGGCGACCGGAAAACGTACCAAATGGATCCGGCCAATCGTCTTGAGGCGTTTCGCGAGGCAGAATCCGATATAAAAGAA
GGCGCTGATTTCTTAATGGTCAAACCGGCGCTTGCCTATATGGACATTATTCGCGACATCAAAAACCGGTTTCCGCTTCC
GCTTGTTGCCTATAACGTGAGCGGTGAGTATTCGATGGTGAAAGCGGCAGCGCAAAACGGTTGGATTGACGAAAAATCAG
TTGTGATGGAAATGCTGACAGGAATGAAGCGAGCCGGCGCTGATTTAATCATCACATATTTTGCGAAAGATGTTGCTCGC
TGGCTGGCTGAATAG

Upstream 100 bases:

>100_bases
CGAGCAGGAAGGCATAGCAGTACATATTTGTCCAGCTGATTACACGGCTGATGGTATAATGAAAGCGATGGAACAATATT
TTTCCACGGAGGGACGATAA

Downstream 100 bases:

>100_bases
AGAGGGGGCGGAATCGTGCGAAGTTATGAACGGTCGAAAGCGGCTTATGAAGAAGCAGTGACATTAATGCCAGGTGGGGT
AAACAGCCCGGTTCGCGCCT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSLSFDRHRRLRQTAAIRAMVRETHLRVDDLIYPLFVVEGSGIRREVPSMPGVYHLSLDRLTEEIDEIAKLGIRAVMVFG
VPDEKDEVGSQAYCETGIVQRAIRQIKAERSEMVVIADTCLCEYTSHGHCGVVENEQVLNDPSLELLVKTAVSQAQAGAD
IIAPSNMMDGFVAAIRHGLDEAGFENVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDIKE
GADFLMVKPALAYMDIIRDIKNRFPLPLVAYNVSGEYSMVKAAAQNGWIDEKSVVMEMLTGMKRAGADLIITYFAKDVAR
WLAE

Sequences:

>Translated_324_residues
MSLSFDRHRRLRQTAAIRAMVRETHLRVDDLIYPLFVVEGSGIRREVPSMPGVYHLSLDRLTEEIDEIAKLGIRAVMVFG
VPDEKDEVGSQAYCETGIVQRAIRQIKAERSEMVVIADTCLCEYTSHGHCGVVENEQVLNDPSLELLVKTAVSQAQAGAD
IIAPSNMMDGFVAAIRHGLDEAGFENVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDIKE
GADFLMVKPALAYMDIIRDIKNRFPLPLVAYNVSGEYSMVKAAAQNGWIDEKSVVMEMLTGMKRAGADLIITYFAKDVAR
WLAE
>Mature_323_residues
SLSFDRHRRLRQTAAIRAMVRETHLRVDDLIYPLFVVEGSGIRREVPSMPGVYHLSLDRLTEEIDEIAKLGIRAVMVFGV
PDEKDEVGSQAYCETGIVQRAIRQIKAERSEMVVIADTCLCEYTSHGHCGVVENEQVLNDPSLELLVKTAVSQAQAGADI
IAPSNMMDGFVAAIRHGLDEAGFENVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDIKEG
ADFLMVKPALAYMDIIRDIKNRFPLPLVAYNVSGEYSMVKAAAQNGWIDEKSVVMEMLTGMKRAGADLIITYFAKDVARW
LAE

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=45.0980392156863, Blast_Score=272, Evalue=4e-73,
Organism=Escherichia coli, GI87081728, Length=313, Percent_Identity=55.591054313099, Blast_Score=323, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6321398, Length=323, Percent_Identity=42.4148606811146, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21358291, Length=288, Percent_Identity=42.3611111111111, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36098; Mature: 35967

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSFDRHRRLRQTAAIRAMVRETHLRVDDLIYPLFVVEGSGIRREVPSMPGVYHLSLDR
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEECCCCHHHCCCCCCEEEEEHHH
LTEEIDEIAKLGIRAVMVFGVPDEKDEVGSQAYCETGIVQRAIRQIKAERSEMVVIADTC
HHHHHHHHHHHHHHEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHH
LCEYTSHGHCGVVENEQVLNDPSLELLVKTAVSQAQAGADIIAPSNMMDGFVAAIRHGLD
HHHCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCHH
EAGFENVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDIKE
HCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHC
GADFLMVKPALAYMDIIRDIKNRFPLPLVAYNVSGEYSMVKAAAQNGWIDEKSVVMEMLT
CCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
GMKRAGADLIITYFAKDVARWLAE
HHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLSFDRHRRLRQTAAIRAMVRETHLRVDDLIYPLFVVEGSGIRREVPSMPGVYHLSLDR
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEECCCCHHHCCCCCCEEEEEHHH
LTEEIDEIAKLGIRAVMVFGVPDEKDEVGSQAYCETGIVQRAIRQIKAERSEMVVIADTC
HHHHHHHHHHHHHHEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHH
LCEYTSHGHCGVVENEQVLNDPSLELLVKTAVSQAQAGADIIAPSNMMDGFVAAIRHGLD
HHHCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCHH
EAGFENVPIMSYAIKYASAFYGPFRDAADSAPQFGDRKTYQMDPANRLEAFREAESDIKE
HCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHC
GADFLMVKPALAYMDIIRDIKNRFPLPLVAYNVSGEYSMVKAAAQNGWIDEKSVVMEMLT
CCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
GMKRAGADLIITYFAKDVARWLAE
HHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]