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The map label for this gene is comC [H]

Identifier: 138896192

GI number: 138896192

Start: 2655788

End: 2656534

Strand: Reverse

Name: comC [H]

Synonym: GTNG_2555

Alternate gene names: 138896192

Gene position: 2656534-2655788 (Counterclockwise)

Preceding gene: 138896193

Following gene: 138896191

Centisome position: 74.83

GC content: 56.49

Gene sequence:

>747_bases
ATGGTCTTAAGCTATTTATTTATTATTTCCCTTCTCCTCGCCTCCTTTTTTAACGTCGTCGGGCTGCGGGTGCCGGTCGG
GAAGTCGATCGTCCGGCCGCGGTCGCATTGTCCGGCGTGCGGGCGGACGTTGTCGGCGAGGGAGTTGGTTCCGGTTGTGT
CGTATGTTGTGCAGCGCGGGCGGTGCAAAGGGTGCGGGGGGCGCATTTCCCCCCTTTACCCGGCGATGGAGCTCGCGACG
GCTATCTTGTTTACCGCTGCACCAACGTGGGTCGGTTGGGGTGGACGGCTTATTATCGTTTGGACGTTGATTGCGCTTTT
TGCCATTATCGTTGTTTCTGACCTTCGCTATATGCTCATCCCGGACCGGGTGCTTGTGGTATTTGCCGCCTTGTTTTTGA
TAGAACGGCTCTTCATTCCGTTTTTGCCGTGGATGGACATGCTCATTGGTGCGGCGGTGGGGTTTTTGTTGTTGCTGCTG
ATTGCCGTGCTATCAAAAGGCGGGATGGGCGGCGGCGATGTAAAACTGTTTGCCGTGCTTGGATTTGTGCTTGGCTGGAA
AATGGTGTTGCTCGCGTTTTTCTTGGCGGCATTGTATGGTACAGTGATCGGGTTGGTCGGCATGGCGCTCGGCCATGTGC
GACGCGGCGTGCCGATGCCGTTTGCGCCGGCTATTGCGCTCGGGACGCTGACAGCGTTTTTCTTTGGCGAGGCGATGGTG
CGTGCGTATCTTTCGCTTATGATGTAG

Upstream 100 bases:

>100_bases
AGAATGATAATGGAGAAGCTGTCAATGAAAATAAATTAGATCGTAAACAAGTTAGAAACAATTCATCTCAAAATCCTGAA
AATAACTCCTAATGAGGACC

Downstream 100 bases:

>100_bases
GACGGTAGAAAGGAAGCAGACAACCATGGCGTTATGGCGGCGAAAGGCAAAACAAGCGAATATTGTCATTAAAGACCATG
TCGTCCGTTGTGTGGAAGCG

Product: late competence protein ComC

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MVLSYLFIISLLLASFFNVVGLRVPVGKSIVRPRSHCPACGRTLSARELVPVVSYVVQRGRCKGCGGRISPLYPAMELAT
AILFTAAPTWVGWGGRLIIVWTLIALFAIIVVSDLRYMLIPDRVLVVFAALFLIERLFIPFLPWMDMLIGAAVGFLLLLL
IAVLSKGGMGGGDVKLFAVLGFVLGWKMVLLAFFLAALYGTVIGLVGMALGHVRRGVPMPFAPAIALGTLTAFFFGEAMV
RAYLSLMM

Sequences:

>Translated_248_residues
MVLSYLFIISLLLASFFNVVGLRVPVGKSIVRPRSHCPACGRTLSARELVPVVSYVVQRGRCKGCGGRISPLYPAMELAT
AILFTAAPTWVGWGGRLIIVWTLIALFAIIVVSDLRYMLIPDRVLVVFAALFLIERLFIPFLPWMDMLIGAAVGFLLLLL
IAVLSKGGMGGGDVKLFAVLGFVLGWKMVLLAFFLAALYGTVIGLVGMALGHVRRGVPMPFAPAIALGTLTAFFFGEAMV
RAYLSLMM
>Mature_248_residues
MVLSYLFIISLLLASFFNVVGLRVPVGKSIVRPRSHCPACGRTLSARELVPVVSYVVQRGRCKGCGGRISPLYPAMELAT
AILFTAAPTWVGWGGRLIIVWTLIALFAIIVVSDLRYMLIPDRVLVVFAALFLIERLFIPFLPWMDMLIGAAVGFLLLLL
IAVLSKGGMGGGDVKLFAVLGFVLGWKMVLLAFFLAALYGTVIGLVGMALGHVRRGVPMPFAPAIALGTLTAFFFGEAMV
RAYLSLMM

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=255, Percent_Identity=33.7254901960784, Blast_Score=81, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 26840; Mature: 26840

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSYLFIISLLLASFFNVVGLRVPVGKSIVRPRSHCPACGRTLSARELVPVVSYVVQRG
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHCC
RCKGCGGRISPLYPAMELATAILFTAAPTWVGWGGRLIIVWTLIALFAIIVVSDLRYMLI
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
PDRVLVVFAALFLIERLFIPFLPWMDMLIGAAVGFLLLLLIAVLSKGGMGGGDVKLFAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GFVLGWKMVLLAFFLAALYGTVIGLVGMALGHVRRGVPMPFAPAIALGTLTAFFFGEAMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
RAYLSLMM
HHHHHHHC
>Mature Secondary Structure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HHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]