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The map label for this gene is nadC [H]

Identifier: 138896167

GI number: 138896167

Start: 2635089

End: 2635919

Strand: Reverse

Name: nadC [H]

Synonym: GTNG_2530

Alternate gene names: 138896167

Gene position: 2635919-2635089 (Counterclockwise)

Preceding gene: 138896168

Following gene: 138896166

Centisome position: 74.24

GC content: 53.07

Gene sequence:

>831_bases
ATGAATCGGTTAAAACTCGAACAGTTGTTGAGGCAGTTTTTTCTTGAAGATATCGGCGATGGGGATGTGACAAGCGACAC
GATTTTTCCGGCTAACGAACGTGCGACGGGGGTGTTTACGGCGAAAGAGGACGGGGTTGTGGCTGGCGTCGACCTTATTG
CCGCTGGCTATCAACTGCTTGATCCGCATATCGAGGTATCGATCATGAAACGGGACGGCGAACGGATTGCAGCTGGTGAA
ACGATCGCCGCCGTTTCTGGGCCTGTCCGTCCACTGTTGTCTGGTGAGCGCGTCATTTTGAATTTGCTTCAGCGTTTGAG
CGGCATTGCGACTATGACGCGGCAGGCAGTTGACCTGCTTGGTGACAGCCATACTCGCCTTTGCGATACGCGAAAAACGA
CACCGGGCTTGCGCATGTTGGAAAAATATGCGGTTACTTGCGGTGGCGGCTACAATCACCGCTTTGGCTTGTACGATGGT
GTGATGATTAAAGACAATCATATCGCCTTTTGTGGGTCGATTGCCGCCGCTGTCAAAGCGGTGAGAGAGCGGCTCGGCCA
TATGGTGAAAATCGAAGTCGAAACGGAAACGGAAGCTCAGGTGCTCGAGGCGGTCGAAGCCGGGGCTGACATTATTATGT
TTGACAATCGGACGCCGGATGAAGTGCGGTCGTTCGTCCGGCTCGTGCCGAAACCGATCATCACGGAGGCGTCCGGCGGC
ATTACGCTCGCCAATGTAGCAGCATACGGTGCGACCGGAGTCGACTACATTTCACTTGGGTTTTTAACGCATTCAGCTGC
AGCGTTGGACATTAGTTTTTATTTACAATGA

Upstream 100 bases:

>100_bases
CGCACTGGAAAGGTCGACGCCTCGTGCGGACGAAAGAAGAGTGGGAGCATGCACCAGTTGGACGGTAAAGCGGGAATAAG
ATCAAAAGGAGGATGAGGCG

Downstream 100 bases:

>100_bases
CGGAGGAGAGAATGATGAACGTACTCGAACAGTTCAAACAGCTCGATAATATGCCGGAACAGTATAAAACGATGGACAGA
GATGAGCTCGAAGCGCGCGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNRLKLEQLLRQFFLEDIGDGDVTSDTIFPANERATGVFTAKEDGVVAGVDLIAAGYQLLDPHIEVSIMKRDGERIAAGE
TIAAVSGPVRPLLSGERVILNLLQRLSGIATMTRQAVDLLGDSHTRLCDTRKTTPGLRMLEKYAVTCGGGYNHRFGLYDG
VMIKDNHIAFCGSIAAAVKAVRERLGHMVKIEVETETEAQVLEAVEAGADIIMFDNRTPDEVRSFVRLVPKPIITEASGG
ITLANVAAYGATGVDYISLGFLTHSAAALDISFYLQ

Sequences:

>Translated_276_residues
MNRLKLEQLLRQFFLEDIGDGDVTSDTIFPANERATGVFTAKEDGVVAGVDLIAAGYQLLDPHIEVSIMKRDGERIAAGE
TIAAVSGPVRPLLSGERVILNLLQRLSGIATMTRQAVDLLGDSHTRLCDTRKTTPGLRMLEKYAVTCGGGYNHRFGLYDG
VMIKDNHIAFCGSIAAAVKAVRERLGHMVKIEVETETEAQVLEAVEAGADIIMFDNRTPDEVRSFVRLVPKPIITEASGG
ITLANVAAYGATGVDYISLGFLTHSAAALDISFYLQ
>Mature_276_residues
MNRLKLEQLLRQFFLEDIGDGDVTSDTIFPANERATGVFTAKEDGVVAGVDLIAAGYQLLDPHIEVSIMKRDGERIAAGE
TIAAVSGPVRPLLSGERVILNLLQRLSGIATMTRQAVDLLGDSHTRLCDTRKTTPGLRMLEKYAVTCGGGYNHRFGLYDG
VMIKDNHIAFCGSIAAAVKAVRERLGHMVKIEVETETEAQVLEAVEAGADIIMFDNRTPDEVRSFVRLVPKPIITEASGG
ITLANVAAYGATGVDYISLGFLTHSAAALDISFYLQ

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=242, Percent_Identity=38.4297520661157, Blast_Score=151, Evalue=7e-37,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=39.4833948339483, Blast_Score=171, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=249, Percent_Identity=35.3413654618474, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29810; Mature: 29810

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLKLEQLLRQFFLEDIGDGDVTSDTIFPANERATGVFTAKEDGVVAGVDLIAAGYQLL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHCHHHC
DPHIEVSIMKRDGERIAAGETIAAVSGPVRPLLSGERVILNLLQRLSGIATMTRQAVDLL
CCCEEEEEEECCCCEEECCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
GDSHTRLCDTRKTTPGLRMLEKYAVTCGGGYNHRFGLYDGVMIKDNHIAFCGSIAAAVKA
CCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHH
VRERLGHMVKIEVETETEAQVLEAVEAGADIIMFDNRTPDEVRSFVRLVPKPIITEASGG
HHHHCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCEECCCCC
ITLANVAAYGATGVDYISLGFLTHSAAALDISFYLQ
EEEEHHHHCCCCCCHHHHHHHHHHCCEEEEEEEEEC
>Mature Secondary Structure
MNRLKLEQLLRQFFLEDIGDGDVTSDTIFPANERATGVFTAKEDGVVAGVDLIAAGYQLL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHCHHHC
DPHIEVSIMKRDGERIAAGETIAAVSGPVRPLLSGERVILNLLQRLSGIATMTRQAVDLL
CCCEEEEEEECCCCEEECCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
GDSHTRLCDTRKTTPGLRMLEKYAVTCGGGYNHRFGLYDGVMIKDNHIAFCGSIAAAVKA
CCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEHHHHHHHHHH
VRERLGHMVKIEVETETEAQVLEAVEAGADIIMFDNRTPDEVRSFVRLVPKPIITEASGG
HHHHCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCEECCCCC
ITLANVAAYGATGVDYISLGFLTHSAAALDISFYLQ
EEEEHHHHCCCCCCHHHHHHHHHHCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]