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The map label for this gene is dtd

Identifier: 138896145

GI number: 138896145

Start: 2611873

End: 2612331

Strand: Reverse

Name: dtd

Synonym: GTNG_2508

Alternate gene names: 138896145

Gene position: 2612331-2611873 (Counterclockwise)

Preceding gene: 138896146

Following gene: 138896144

Centisome position: 73.58

GC content: 55.56

Gene sequence:

>459_bases
ATGAAAGCGGTCATCCAGCGGGCGAAGCAGGCGAGCGTCACCGTCAACGGCGAGGTCGTTGGAGCGATCGATGCGGGGCT
TGTCGTGCTTCTTGGCGTCACGCACGAGGATACGGAGGCCGACGCCGCCTATTTAGCGGAGAAAATTGCTCATTTGCGCA
TCTTTGAAGATGAAAATGGAAAAATGAACCGTTCGTTGCTTGAAGTCGGCGGGGCGGTGCTGTCGGTGTCGCAGTTTACC
CTTTACGGCGACTGTCGGAAAGGACGGCGGCCGAACTTTATGGCAGCAGCGAAACCGGATCGCGCCTTGCCGCTTTATGA
GGCATTCAACACCTTCTTGCGCGGAAAAGGCATCCATGTCGAAACAGGAGTGTTCGGCGCAATGATGGACGTTTCGCTCA
CAAACGATGGACCAGTCACCTTGATTATCGACAGCGGTGACAAACCGGGAAACGAATGA

Upstream 100 bases:

>100_bases
AGCCATTTGCAAAAAGTAGTGGAACGAATTAAACAAATTCCTGACATTTATTCAGTTCAGCGGCTGATGAACAACTAGGG
GTGTCGAAAGGAGGGACACA

Downstream 100 bases:

>100_bases
TGTTTCCCGGTTTTTTTATTTTCAGCGAAAAATGGGAAAGATGAAAACGAACCGGCGGCATAGAAAGGAGGAAAGGCGAT
GCGGCAAACGGGCAGAAGCA

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MKAVIQRAKQASVTVNGEVVGAIDAGLVVLLGVTHEDTEADAAYLAEKIAHLRIFEDENGKMNRSLLEVGGAVLSVSQFT
LYGDCRKGRRPNFMAAAKPDRALPLYEAFNTFLRGKGIHVETGVFGAMMDVSLTNDGPVTLIIDSGDKPGNE

Sequences:

>Translated_152_residues
MKAVIQRAKQASVTVNGEVVGAIDAGLVVLLGVTHEDTEADAAYLAEKIAHLRIFEDENGKMNRSLLEVGGAVLSVSQFT
LYGDCRKGRRPNFMAAAKPDRALPLYEAFNTFLRGKGIHVETGVFGAMMDVSLTNDGPVTLIIDSGDKPGNE
>Mature_152_residues
MKAVIQRAKQASVTVNGEVVGAIDAGLVVLLGVTHEDTEADAAYLAEKIAHLRIFEDENGKMNRSLLEVGGAVLSVSQFT
LYGDCRKGRRPNFMAAAKPDRALPLYEAFNTFLRGKGIHVETGVFGAMMDVSLTNDGPVTLIIDSGDKPGNE

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=149, Percent_Identity=43.6241610738255, Blast_Score=114, Evalue=4e-26,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=51.7482517482517, Blast_Score=140, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=44.3708609271523, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=44.5945945945946, Blast_Score=124, Evalue=8e-30,
Organism=Drosophila melanogaster, GI281361569, Length=153, Percent_Identity=43.7908496732026, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_GEOTN (A4IR99)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001126598.1
- ProteinModelPortal:   A4IR99
- SMR:   A4IR99
- STRING:   A4IR99
- GeneID:   4967434
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_2508
- NMPDR:   fig|420246.5.peg.2415
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   A4IR99
- ProtClustDB:   PRK05273
- BioCyc:   GTHE420246:GTNG_2508-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16263; Mature: 16263

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIQRAKQASVTVNGEVVGAIDAGLVVLLGVTHEDTEADAAYLAEKIAHLRIFEDENG
CCHHHHHHHHCEEEECCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHEEEEECCCC
KMNRSLLEVGGAVLSVSQFTLYGDCRKGRRPNFMAAAKPDRALPLYEAFNTFLRGKGIHV
CCHHHHHHHCCCEEEEEEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEE
ETGVFGAMMDVSLTNDGPVTLIIDSGDKPGNE
ECCCCEEEEEEEECCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKAVIQRAKQASVTVNGEVVGAIDAGLVVLLGVTHEDTEADAAYLAEKIAHLRIFEDENG
CCHHHHHHHHCEEEECCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHEEEEECCCC
KMNRSLLEVGGAVLSVSQFTLYGDCRKGRRPNFMAAAKPDRALPLYEAFNTFLRGKGIHV
CCHHHHHHHCCCEEEEEEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEE
ETGVFGAMMDVSLTNDGPVTLIIDSGDKPGNE
ECCCCEEEEEEEECCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA