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The map label for this gene is iscS1 [H]

Identifier: 138896134

GI number: 138896134

Start: 2599910

End: 2601052

Strand: Reverse

Name: iscS1 [H]

Synonym: GTNG_2497

Alternate gene names: 138896134

Gene position: 2601052-2599910 (Counterclockwise)

Preceding gene: 138896135

Following gene: 138896133

Centisome position: 73.26

GC content: 53.28

Gene sequence:

>1143_bases
TTGGAACGGATTTATTTGGACCATGCCGCCACGGCTCCCGTGCATCCAGATGTGGCAGCCGGTATGGTCCATTGGATGAC
TGAACAGTTCGGCAACCCGTCAAGCATCCATTATTTTGGTCGACAAAGCCGCCGTGCGATTGACGAAGCAAGGGCAACCA
TCGCTCGCAGCCTCGGGGCGAAAGAGACAGAAATTGTGTTTACAAGTGGCGGTACGGAAGCGGATAACTTTGCGCTCATC
GGGACGGCGATGGCCAACCGGGGGCGCGGCAATCATATTATTACGACTGCTATCGAGCATCACGCTGTGTTGCGTGCTTG
TGAATATTTGGAAAAACAAGGGTTTGACGTGACGTATTTGCCGGTTGATGAACAAGGGCTTGTGTCGGTCGATGATGTAA
AAGCTGCGCTGCGCGATGAGACGATTTTAGTGTCGGTCATGTTTGCCAACAATGAAGTTGGTACGATCCAGCCGATCCGT
GAAATCGGCGCGTTGCTTCGTGATCACCCGGCCTATTTTCACACCGACGCCGTCCAAGCGTATGGGTTGCTCTCCATCGA
TGTGAATGAATATGGGGTCGATTTGTTGTCACTCTCAAGCCATAAAATTAATGGCCCGAAAGGAAGCGGGGCATTGTATG
TTCGGGAGACGGTCCGCATTACTCCGCTGCTTTTTGGCGGTGAACAAGAGCGGAAACGGCGCGCTGGCACGGAAAACGTC
CCCGGTATCATCGGTTTGGCGCGGGCAGCGGAAATCGCCGAGCGGACGAGGGAGGAAAAGCACAAACAGTACACGGCTTG
GCGCGAGGCAATGCTTGATATTTTTCGCTCATCGGGCATTGACTATGTAGTTAACGGCAGTCAAGACGGTCTGCCGCATA
TTTTAAACGTTGCTTTTCCGGGAACGAACGTTGAATCGCTGCTTGTGAATTTGGATTTAGCCGGCATCGCCGCTTCAAGT
GGCTCGGCATGTACGGCCGGTTCGATCGACCCATCTCACGTGCTTGTTGCCATGTGTGGAAAACAGTCCGAGCGCATCCG
CTCGTCCGTTCGTTTCAGCTTCGGACTGGGCAACACGAATGAGCAAATTGAACGAGCCGCGGAAGAAACGGTAAAGATCG
TCAAACGGCTCACGAACCAGTGA

Upstream 100 bases:

>100_bases
GTGCTTGATAGCACGACATTGGAAGATTTGGCGAAGTATAACGACGGAGATGAAGGAGCATATATGTTTTATATTTAAGC
GATAGAAAGGAGAATGAGCG

Downstream 100 bases:

>100_bases
GGGGTGAAGCAGCATGAACAAAGCACCGCATGAAACGCGCGTTGTTGTTGGCATGTCCGGCGGAGTTGACTCATCTGTCG
CTGCGCTATTGTTAAAAGAG

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MERIYLDHAATAPVHPDVAAGMVHWMTEQFGNPSSIHYFGRQSRRAIDEARATIARSLGAKETEIVFTSGGTEADNFALI
GTAMANRGRGNHIITTAIEHHAVLRACEYLEKQGFDVTYLPVDEQGLVSVDDVKAALRDETILVSVMFANNEVGTIQPIR
EIGALLRDHPAYFHTDAVQAYGLLSIDVNEYGVDLLSLSSHKINGPKGSGALYVRETVRITPLLFGGEQERKRRAGTENV
PGIIGLARAAEIAERTREEKHKQYTAWREAMLDIFRSSGIDYVVNGSQDGLPHILNVAFPGTNVESLLVNLDLAGIAASS
GSACTAGSIDPSHVLVAMCGKQSERIRSSVRFSFGLGNTNEQIERAAEETVKIVKRLTNQ

Sequences:

>Translated_380_residues
MERIYLDHAATAPVHPDVAAGMVHWMTEQFGNPSSIHYFGRQSRRAIDEARATIARSLGAKETEIVFTSGGTEADNFALI
GTAMANRGRGNHIITTAIEHHAVLRACEYLEKQGFDVTYLPVDEQGLVSVDDVKAALRDETILVSVMFANNEVGTIQPIR
EIGALLRDHPAYFHTDAVQAYGLLSIDVNEYGVDLLSLSSHKINGPKGSGALYVRETVRITPLLFGGEQERKRRAGTENV
PGIIGLARAAEIAERTREEKHKQYTAWREAMLDIFRSSGIDYVVNGSQDGLPHILNVAFPGTNVESLLVNLDLAGIAASS
GSACTAGSIDPSHVLVAMCGKQSERIRSSVRFSFGLGNTNEQIERAAEETVKIVKRLTNQ
>Mature_380_residues
MERIYLDHAATAPVHPDVAAGMVHWMTEQFGNPSSIHYFGRQSRRAIDEARATIARSLGAKETEIVFTSGGTEADNFALI
GTAMANRGRGNHIITTAIEHHAVLRACEYLEKQGFDVTYLPVDEQGLVSVDDVKAALRDETILVSVMFANNEVGTIQPIR
EIGALLRDHPAYFHTDAVQAYGLLSIDVNEYGVDLLSLSSHKINGPKGSGALYVRETVRITPLLFGGEQERKRRAGTENV
PGIIGLARAAEIAERTREEKHKQYTAWREAMLDIFRSSGIDYVVNGSQDGLPHILNVAFPGTNVESLLVNLDLAGIAASS
GSACTAGSIDPSHVLVAMCGKQSERIRSSVRFSFGLGNTNEQIERAAEETVKIVKRLTNQ

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=378, Percent_Identity=42.5925925925926, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI156713448, Length=417, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=4e-54,
Organism=Escherichia coli, GI48994898, Length=381, Percent_Identity=44.0944881889764, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1787970, Length=352, Percent_Identity=26.4204545454545, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789175, Length=390, Percent_Identity=25.1282051282051, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25143064, Length=393, Percent_Identity=43.0025445292621, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=31.7901234567901, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319831, Length=382, Percent_Identity=43.979057591623, Blast_Score=293, Evalue=2e-80,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=42.0634920634921, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41395; Mature: 41395

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIYLDHAATAPVHPDVAAGMVHWMTEQFGNPSSIHYFGRQSRRAIDEARATIARSLGA
CCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCC
KETEIVFTSGGTEADNFALIGTAMANRGRGNHIITTAIEHHAVLRACEYLEKQGFDVTYL
CCEEEEEECCCCCCCCEEEEEEHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEE
PVDEQGLVSVDDVKAALRDETILVSVMFANNEVGTIQPIREIGALLRDHPAYFHTDAVQA
ECCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEECHHHHH
YGLLSIDVNEYGVDLLSLSSHKINGPKGSGALYVRETVRITPLLFGGEQERKRRAGTENV
EEEEEEECHHHCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEEECCCHHHHHCCCCCCC
PGIIGLARAAEIAERTREEKHKQYTAWREAMLDIFRSSGIDYVVNGSQDGLPHILNVAFP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECC
GTNVESLLVNLDLAGIAASSGSACTAGSIDPSHVLVAMCGKQSERIRSSVRFSFGLGNTN
CCCHHHHEEEEEHHEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHEEEECCCCCH
EQIERAAEETVKIVKRLTNQ
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERIYLDHAATAPVHPDVAAGMVHWMTEQFGNPSSIHYFGRQSRRAIDEARATIARSLGA
CCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCC
KETEIVFTSGGTEADNFALIGTAMANRGRGNHIITTAIEHHAVLRACEYLEKQGFDVTYL
CCEEEEEECCCCCCCCEEEEEEHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEE
PVDEQGLVSVDDVKAALRDETILVSVMFANNEVGTIQPIREIGALLRDHPAYFHTDAVQA
ECCCCCCEEHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEECHHHHH
YGLLSIDVNEYGVDLLSLSSHKINGPKGSGALYVRETVRITPLLFGGEQERKRRAGTENV
EEEEEEECHHHCCEEEEECCCCCCCCCCCCEEEEEEEEEEEEEEECCCHHHHHCCCCCCC
PGIIGLARAAEIAERTREEKHKQYTAWREAMLDIFRSSGIDYVVNGSQDGLPHILNVAFP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECC
GTNVESLLVNLDLAGIAASSGSACTAGSIDPSHVLVAMCGKQSERIRSSVRFSFGLGNTN
CCCHHHHEEEEEHHEEECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHEEEECCCCCH
EQIERAAEETVKIVKRLTNQ
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]