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The map label for this gene is mccB [H]

Identifier: 138896110

GI number: 138896110

Start: 2577260

End: 2578393

Strand: Reverse

Name: mccB [H]

Synonym: GTNG_2473

Alternate gene names: 138896110

Gene position: 2578393-2577260 (Counterclockwise)

Preceding gene: 138896111

Following gene: 138896109

Centisome position: 72.62

GC content: 54.59

Gene sequence:

>1134_bases
ATGAGACGAAAAACGTTGCTCATTCATGGCGGCATTCCGGGTGACCCGCATACAGGGGCGGTGTCGGTGCCGATTTATCA
AGTGAGTACGTACAAGCAAGAAGAAGTTGGAAAGCATAAAGGATTTGAATACTCGCGTACCGGCAACCCGACGCGTGCAG
CGCTCGAAAAACTGATTGCTGACCTCGAAGGCGGCGAGGCCGGGTTCGCGTTCGCTTCCGGAATGGCGGCGATTACGGCC
GTCATGATGCTGTTTGACAGCGGGGATCATATTGTGCTCACCGATGACGTTTACGGCGGCACGTATCGAGTGATGGCGAA
CGTGTTAAACCGATTCGGATTGGAATCGACGTTCGTCGATACGAGCGACATCGCCAACATAGAGGCGCACATTCGTCCAA
ATACGAAAGCCATTTACATTGAGACACCGACGAATCCGTTGTTGAAAATCACGGATTTGAAGGCCGCCGCCGCCATTGCC
CGTGCGCACGGGCTGCTATTGATCGTCGATAACACGTTTTCGACACCGTACTTTCAAACGCCGCTTGAGCTTGGCGCTGA
TATCGTCATCCATAGCGCGACGAAATATTTAGGCGGTCATAGTGACGTCGTCGCCGGACTGGCTGTTGTCCGCACCGCCG
AGCTCGCCGAGCGGCTTCATTACGTGCAAAATTCGACGGGCGGCATCCTTGGACCGCAAGATTCGTGGCTGCTTATGCGC
GGGATGAAAACGCTTGGCGTGCGGATGGAAGAGCATGAACAAAATGCGCGGGCAATTGCCGCCTTTTTGGCGGAGCATCA
GGCGGTTACCCGCGTGTATTATCCTGGGCTTCCGGAGCATCCGAACCATGAGCTGGCGAAAGCACAAATGCGTGGGTTCG
GCGGCATGATTTCGTTCGATGTCGGCAGCCTTGAGCGCGCTGAAACGGTGCTGTCGCGTGTCCGCTACTTTACGCTAGCT
GAAAGTTTAGGGGCAGTCGAAAGCTTAATTTCATTGCCAGGGAAAATGACACATGCGTCGATCCCGAAAGAGCGGCGTGA
ACAGCTCGGCATTACTGATGGGCTCATCCGTCTATCGGTCGGCCTTGAAGACGTCAATGATTTGATTGACGATTTGGCGC
AAGCGCTTGGTTGA

Upstream 100 bases:

>100_bases
AGGCTGAGAAGGCGAAGCCGGGGACAAACATCGTCGTCATTTTCCCTGACGGGAGCGAGCGGTATTTAAGCAAAAACATT
TACGAAGGTGGAGGATCCTC

Downstream 100 bases:

>100_bases
AATTGCCGCTCCTCCTTTTTCGCCCTTTATGGTAAAGTGAGGGCGAGAGGAGGAATTGGCAGTGAATGAACAACAACGGA
ACGTGCTGCGCACGAAGGCG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRRKTLLIHGGIPGDPHTGAVSVPIYQVSTYKQEEVGKHKGFEYSRTGNPTRAALEKLIADLEGGEAGFAFASGMAAITA
VMMLFDSGDHIVLTDDVYGGTYRVMANVLNRFGLESTFVDTSDIANIEAHIRPNTKAIYIETPTNPLLKITDLKAAAAIA
RAHGLLLIVDNTFSTPYFQTPLELGADIVIHSATKYLGGHSDVVAGLAVVRTAELAERLHYVQNSTGGILGPQDSWLLMR
GMKTLGVRMEEHEQNARAIAAFLAEHQAVTRVYYPGLPEHPNHELAKAQMRGFGGMISFDVGSLERAETVLSRVRYFTLA
ESLGAVESLISLPGKMTHASIPKERREQLGITDGLIRLSVGLEDVNDLIDDLAQALG

Sequences:

>Translated_377_residues
MRRKTLLIHGGIPGDPHTGAVSVPIYQVSTYKQEEVGKHKGFEYSRTGNPTRAALEKLIADLEGGEAGFAFASGMAAITA
VMMLFDSGDHIVLTDDVYGGTYRVMANVLNRFGLESTFVDTSDIANIEAHIRPNTKAIYIETPTNPLLKITDLKAAAAIA
RAHGLLLIVDNTFSTPYFQTPLELGADIVIHSATKYLGGHSDVVAGLAVVRTAELAERLHYVQNSTGGILGPQDSWLLMR
GMKTLGVRMEEHEQNARAIAAFLAEHQAVTRVYYPGLPEHPNHELAKAQMRGFGGMISFDVGSLERAETVLSRVRYFTLA
ESLGAVESLISLPGKMTHASIPKERREQLGITDGLIRLSVGLEDVNDLIDDLAQALG
>Mature_377_residues
MRRKTLLIHGGIPGDPHTGAVSVPIYQVSTYKQEEVGKHKGFEYSRTGNPTRAALEKLIADLEGGEAGFAFASGMAAITA
VMMLFDSGDHIVLTDDVYGGTYRVMANVLNRFGLESTFVDTSDIANIEAHIRPNTKAIYIETPTNPLLKITDLKAAAAIA
RAHGLLLIVDNTFSTPYFQTPLELGADIVIHSATKYLGGHSDVVAGLAVVRTAELAERLHYVQNSTGGILGPQDSWLLMR
GMKTLGVRMEEHEQNARAIAAFLAEHQAVTRVYYPGLPEHPNHELAKAQMRGFGGMISFDVGSLERAETVLSRVRYFTLA
ESLGAVESLISLPGKMTHASIPKERREQLGITDGLIRLSVGLEDVNDLIDDLAQALG

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=359, Percent_Identity=53.7604456824513, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI299473759, Length=375, Percent_Identity=48.2666666666667, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI25453487, Length=374, Percent_Identity=46.7914438502674, Blast_Score=295, Evalue=6e-80,
Organism=Escherichia coli, GI1790375, Length=373, Percent_Identity=41.2868632707775, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789383, Length=383, Percent_Identity=31.5926892950392, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17560056, Length=357, Percent_Identity=50.140056022409, Blast_Score=353, Evalue=8e-98,
Organism=Caenorhabditis elegans, GI17538055, Length=377, Percent_Identity=48.0106100795756, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=42.5068119891008, Blast_Score=290, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6319307, Length=382, Percent_Identity=46.3350785340314, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6321254, Length=401, Percent_Identity=34.6633416458853, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323333, Length=430, Percent_Identity=33.7209302325581, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321170, Length=289, Percent_Identity=34.9480968858132, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=30.9462915601023, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323557, Length=405, Percent_Identity=23.9506172839506, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322970, Length=367, Percent_Identity=24.2506811989101, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322590, Length=303, Percent_Identity=24.4224422442244, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922554, Length=375, Percent_Identity=48.2666666666667, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 40846; Mature: 40846

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRKTLLIHGGIPGDPHTGAVSVPIYQVSTYKQEEVGKHKGFEYSRTGNPTRAALEKLIA
CCCEEEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DLEGGEAGFAFASGMAAITAVMMLFDSGDHIVLTDDVYGGTYRVMANVLNRFGLESTFVD
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
TSDIANIEAHIRPNTKAIYIETPTNPLLKITDLKAAAAIARAHGLLLIVDNTFSTPYFQT
CHHCCCEEEEECCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLELGADIVIHSATKYLGGHSDVVAGLAVVRTAELAERLHYVQNSTGGILGPQDSWLLMR
HHHCCCCEEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GMKTLGVRMEEHEQNARAIAAFLAEHQAVTRVYYPGLPEHPNHELAKAQMRGFGGMISFD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCEEEEC
VGSLERAETVLSRVRYFTLAESLGAVESLISLPGKMTHASIPKERREQLGITDGLIRLSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEC
GLEDVNDLIDDLAQALG
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRKTLLIHGGIPGDPHTGAVSVPIYQVSTYKQEEVGKHKGFEYSRTGNPTRAALEKLIA
CCCEEEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DLEGGEAGFAFASGMAAITAVMMLFDSGDHIVLTDDVYGGTYRVMANVLNRFGLESTFVD
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
TSDIANIEAHIRPNTKAIYIETPTNPLLKITDLKAAAAIARAHGLLLIVDNTFSTPYFQT
CHHCCCEEEEECCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLELGADIVIHSATKYLGGHSDVVAGLAVVRTAELAERLHYVQNSTGGILGPQDSWLLMR
HHHCCCCEEEECHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
GMKTLGVRMEEHEQNARAIAAFLAEHQAVTRVYYPGLPEHPNHELAKAQMRGFGGMISFD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCEEEEC
VGSLERAETVLSRVRYFTLAESLGAVESLISLPGKMTHASIPKERREQLGITDGLIRLSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEC
GLEDVNDLIDDLAQALG
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]