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The map label for this gene is gltT [H]

Identifier: 138896106

GI number: 138896106

Start: 2573636

End: 2574766

Strand: Reverse

Name: gltT [H]

Synonym: GTNG_2469

Alternate gene names: 138896106

Gene position: 2574766-2573636 (Counterclockwise)

Preceding gene: 138896107

Following gene: 138896105

Centisome position: 72.52

GC content: 47.3

Gene sequence:

>1131_bases
ATGATCGTCATTCCGATTGTCGTCTCGAGTTTAATTGTAGGCGTCGCCAATGTCGGTGATGTGAAAAAGCTCGGGAAATT
GGGCGGAAAAACGATTATTTATTTTGAGATCATCACGACGATTGCAATTGTCGTCGGCCTCTTGGCAGCGAATATGTTCC
AGCCAGGCGCTGGTGTCAATATGAAGTCGCTCGAGAAAACAGATATTCAATCATACATTGATACGGCAAACGAAGTGCAG
CACCACTCGATGGTGGAAACGTTTGTTAACATTGTGCCGAAAAACTTGTTTGAGGAACTATCGAACGGCAATATACTGCC
GATCATTTTCTTCTCGGTCATGTTCGGGTTGGGCGTGGCAGCGATCGGCGAAAAAGGAAAGCCGGTGCTTCACTTTTTCC
GGGGGCACCGCGGAAGCGATGTTTTACGTGACAAACCAAGTGATGAAGTTTCGCGCCCGTTCGGTGTTTTTGCGCTCATC
GGTGTGACGGTATTGAAGTTTGGGGTCGCTTCACTTTTTCCGCTCAGCAAACTCGTCGTGCTCGTTTATGGAGTTATGGC
ATTTTTTGTGCTTGTTGTGCTCGGTGGCGTGGCAAAATTGATGGGCATAAATATTTTTCATATTATTAAAATTTTGAAAA
ATGAACTCGTATTGGCGTATAGCACGTCGAGCTCCGAAACGGTGCTGCCAAAAATCATAGAAAAAATGGAGAGATTCGGA
TGTTCGAAAGCCATTACGTCGTTTGTTGTACCAACTGGTTATTCGTTTAATTTAGACGGCTCGACGCTGTACCAGGCGTT
GGCAGCTGTTTTTATCGCCCAGCTGTATGGCATCGACATGCCGATTTCACAGCAAATTTCGCTCGTGCTTGTTTTGATGG
TCACCTCAAAAGGCATTGCCGGCGTTCCGGGCGTTTCATTCGTCGTCTTGCTGGCGACGCTTGGCACGGTCGGCATTCCA
GTTGAAGGGCTGGCGTTTATCGCTGGTATTGACCGCATTTTAGATATGGCGCGCACAGCTGTGAACGTTGTCGGCAACGC
GCTAGCAGCTGTCATTATGTCGAAATGGGAAGGGCAATATGATGAAGAGCAAGGAAAACAATATTTGGAAGAGTTGCGGC
AAAGCGCCTAA

Upstream 100 bases:

>100_bases
CCTTATTCTCGGGATTGTCGTCGGAGCTATTTTTTACGGAAATCCTAAAGTAGCGACGTATTTGCAGCCGATCGGAGATA
TTTTTCTCCGTTTAATTAAG

Downstream 100 bases:

>100_bases
CTGAAAAAGCGGCTGAATGGGGAGCCGCTTTTTTTGTTTCTTTTCAAAAAACGGTGATAAGGAAAAAATAGTTGCCGTTT
TGAAGACTGTCCGCTATATT

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MIVIPIVVSSLIVGVANVGDVKKLGKLGGKTIIYFEIITTIAIVVGLLAANMFQPGAGVNMKSLEKTDIQSYIDTANEVQ
HHSMVETFVNIVPKNLFEELSNGNILPIIFFSVMFGLGVAAIGEKGKPVLHFFRGHRGSDVLRDKPSDEVSRPFGVFALI
GVTVLKFGVASLFPLSKLVVLVYGVMAFFVLVVLGGVAKLMGINIFHIIKILKNELVLAYSTSSSETVLPKIIEKMERFG
CSKAITSFVVPTGYSFNLDGSTLYQALAAVFIAQLYGIDMPISQQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIP
VEGLAFIAGIDRILDMARTAVNVVGNALAAVIMSKWEGQYDEEQGKQYLEELRQSA

Sequences:

>Translated_376_residues
MIVIPIVVSSLIVGVANVGDVKKLGKLGGKTIIYFEIITTIAIVVGLLAANMFQPGAGVNMKSLEKTDIQSYIDTANEVQ
HHSMVETFVNIVPKNLFEELSNGNILPIIFFSVMFGLGVAAIGEKGKPVLHFFRGHRGSDVLRDKPSDEVSRPFGVFALI
GVTVLKFGVASLFPLSKLVVLVYGVMAFFVLVVLGGVAKLMGINIFHIIKILKNELVLAYSTSSSETVLPKIIEKMERFG
CSKAITSFVVPTGYSFNLDGSTLYQALAAVFIAQLYGIDMPISQQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIP
VEGLAFIAGIDRILDMARTAVNVVGNALAAVIMSKWEGQYDEEQGKQYLEELRQSA
>Mature_376_residues
MIVIPIVVSSLIVGVANVGDVKKLGKLGGKTIIYFEIITTIAIVVGLLAANMFQPGAGVNMKSLEKTDIQSYIDTANEVQ
HHSMVETFVNIVPKNLFEELSNGNILPIIFFSVMFGLGVAAIGEKGKPVLHFFRGHRGSDVLRDKPSDEVSRPFGVFALI
GVTVLKFGVASLFPLSKLVVLVYGVMAFFVLVVLGGVAKLMGINIFHIIKILKNELVLAYSTSSSETVLPKIIEKMERFG
CSKAITSFVVPTGYSFNLDGSTLYQALAAVFIAQLYGIDMPISQQISLVLVLMVTSKGIAGVPGVSFVVLLATLGTVGIP
VEGLAFIAGIDRILDMARTAVNVVGNALAAVIMSKWEGQYDEEQGKQYLEELRQSA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=457, Percent_Identity=27.3522975929978, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI21314632, Length=423, Percent_Identity=26.7139479905437, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI169790839, Length=441, Percent_Identity=27.891156462585, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI66773030, Length=430, Percent_Identity=28.1395348837209, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI40254478, Length=444, Percent_Identity=25, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI5032093, Length=415, Percent_Identity=26.7469879518072, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI194239697, Length=285, Percent_Identity=29.8245614035088, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI223468566, Length=296, Percent_Identity=27.027027027027, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223468564, Length=290, Percent_Identity=27.2413793103448, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI301601644, Length=146, Percent_Identity=35.6164383561644, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262359914, Length=362, Percent_Identity=26.5193370165746, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1790514, Length=376, Percent_Identity=60.1063829787234, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1789947, Length=369, Percent_Identity=38.4823848238482, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI1788024, Length=387, Percent_Identity=26.8733850129199, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537407, Length=385, Percent_Identity=27.5324675324675, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=423, Percent_Identity=26.7139479905437, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=416, Percent_Identity=26.9230769230769, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193206505, Length=422, Percent_Identity=27.4881516587678, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=427, Percent_Identity=27.1662763466042, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=418, Percent_Identity=24.6411483253589, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=416, Percent_Identity=23.7980769230769, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583025, Length=392, Percent_Identity=23.9795918367347, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17137668, Length=392, Percent_Identity=23.9795918367347, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583023, Length=392, Percent_Identity=23.9795918367347, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281360481, Length=416, Percent_Identity=23.7980769230769, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281360483, Length=416, Percent_Identity=23.7980769230769, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137666, Length=416, Percent_Identity=23.7980769230769, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 40344; Mature: 40344

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIPIVVSSLIVGVANVGDVKKLGKLGGKTIIYFEIITTIAIVVGLLAANMFQPGAGVN
CEEHHHHHHHHHHHHHCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MKSLEKTDIQSYIDTANEVQHHSMVETFVNIVPKNLFEELSNGNILPIIFFSVMFGLGVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AIGEKGKPVLHFFRGHRGSDVLRDKPSDEVSRPFGVFALIGVTVLKFGVASLFPLSKLVV
HHCCCCCHHHHHHHCCCCCCHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVYGVMAFFVLVVLGGVAKLMGINIFHIIKILKNELVLAYSTSSSETVLPKIIEKMERFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHC
CSKAITSFVVPTGYSFNLDGSTLYQALAAVFIAQLYGIDMPISQQISLVLVLMVTSKGIA
HHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
GVPGVSFVVLLATLGTVGIPVEGLAFIAGIDRILDMARTAVNVVGNALAAVIMSKWEGQY
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEEQGKQYLEELRQSA
CHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVIPIVVSSLIVGVANVGDVKKLGKLGGKTIIYFEIITTIAIVVGLLAANMFQPGAGVN
CEEHHHHHHHHHHHHHCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MKSLEKTDIQSYIDTANEVQHHSMVETFVNIVPKNLFEELSNGNILPIIFFSVMFGLGVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AIGEKGKPVLHFFRGHRGSDVLRDKPSDEVSRPFGVFALIGVTVLKFGVASLFPLSKLVV
HHCCCCCHHHHHHHCCCCCCHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVYGVMAFFVLVVLGGVAKLMGINIFHIIKILKNELVLAYSTSSSETVLPKIIEKMERFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHC
CSKAITSFVVPTGYSFNLDGSTLYQALAAVFIAQLYGIDMPISQQISLVLVLMVTSKGIA
HHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
GVPGVSFVVLLATLGTVGIPVEGLAFIAGIDRILDMARTAVNVVGNALAAVIMSKWEGQY
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEEQGKQYLEELRQSA
CHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]