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The map label for this gene is hemN [H]

Identifier: 138896080

GI number: 138896080

Start: 2551017

End: 2552156

Strand: Reverse

Name: hemN [H]

Synonym: GTNG_2443

Alternate gene names: 138896080

Gene position: 2552156-2551017 (Counterclockwise)

Preceding gene: 138896081

Following gene: 138896079

Centisome position: 71.89

GC content: 53.33

Gene sequence:

>1140_bases
ATGGCAACATCGGCATATTTTCACATCCCATTTTGCGCTCATATTTGTCACTATTGCGACTTTAACAAAGTGTTTGCGGC
AGGCCAGCCGATTGACGACTACTTGCAGGCGATGGACAAGGAAATGGAATGGACAGCGGCCGAGTTCGGCAGTCAGCTTA
AGACGCTGTTTATCGGAGGAGGCACGCCGACGGTGCTGGAGCCGGTGCAGCTTGGCCGTCTGCTAGAGAGCATTCATAAA
CATTTTCAGTTTCACCCGCAAACGGCCGAATTTACGGTCGAGGCCAATCCGGATGGGCTGACGAAAGAAAAACTCGCCAT
TTTGCGCGATGCTGGAGTGAATCGGTTGAGCATCGGGGTGCAGGCGTTTGATGATGAGCTCCTTCAAGCGATCGGCCGTA
CGCATCGGCGCGGTGATGCCGAGCGGGCGGTGGCGATGGCAAGGGAAGCCGGTTTTGAAAATATCAGTCTCGATCTTATG
TATGGCTTGCCGGGACAGACACTCGAGCAGTTTCTCGCCGATTTGGAAACAGCGTTTTCGCTTCATGTACCACATCTTTC
CGCCTACTCACTTATTATCGAGCCAAAGACGATTTTTTACAACGAATGGCGGAACGGTCGGCTTCGCCTTCCAGGCGAAG
AAGCGGAAGCGGTGATGTATGAAGCGGCGATGGAACGAACCGTAGCTCATGGCTATCAGCAATATGAAATTAGCAACTAC
GCGTTCCCAGGGTTTGAAAGCCAGCATAATTTGGTCTACTGGAACAACGAAGAGTATTACGGCATCGGTGCCGGGGCGCA
CAGCTATATCGATGGAGTGCGGCGTGCCAATATCGGTCCGATCCGCCACTACATCGAGAAAGTGGAACGCGGCGAATGGC
CGCATCGCGACGTGCACCGTCTGACCTTCCGTGAACAGATGGAGGAGGAGATGTTTTTAGGGTTGCGCAAGACAGAAGGC
GTATCGAAAGCACGCTTTCGGCAAAAGTTTGGCCGTGAGATGAGCGACATGTTTGGCGAGGCAATCCGCCGTGAAATCGA
AAACGGGCGCCTCGAGGAGACGGCGACTCATGTCCGCTTGACAAAACGCGGCAAGCTGCTTGGCAATGAAGTGTTTGCTG
CCTTCCTCGGAGAAATGTAA

Upstream 100 bases:

>100_bases
CTCCTTCGGGGATGGCCTTGTTTCTTTCTTACGATGCGATGTCGGCAAAAAGATGAAGGTGCCATGCACCGTTGCGCCGG
CAGCCGAAAGGAGGAGAGCC

Downstream 100 bases:

>100_bases
AGATTGACATTTACCGGGCGATTTGCTACCCTAATAGTAGATTTAGCACTCGAATTGTTTGAGTGCTAACAGAGGTGAGA
AACGTGTTAACGGACCGCCA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MATSAYFHIPFCAHICHYCDFNKVFAAGQPIDDYLQAMDKEMEWTAAEFGSQLKTLFIGGGTPTVLEPVQLGRLLESIHK
HFQFHPQTAEFTVEANPDGLTKEKLAILRDAGVNRLSIGVQAFDDELLQAIGRTHRRGDAERAVAMAREAGFENISLDLM
YGLPGQTLEQFLADLETAFSLHVPHLSAYSLIIEPKTIFYNEWRNGRLRLPGEEAEAVMYEAAMERTVAHGYQQYEISNY
AFPGFESQHNLVYWNNEEYYGIGAGAHSYIDGVRRANIGPIRHYIEKVERGEWPHRDVHRLTFREQMEEEMFLGLRKTEG
VSKARFRQKFGREMSDMFGEAIRREIENGRLEETATHVRLTKRGKLLGNEVFAAFLGEM

Sequences:

>Translated_379_residues
MATSAYFHIPFCAHICHYCDFNKVFAAGQPIDDYLQAMDKEMEWTAAEFGSQLKTLFIGGGTPTVLEPVQLGRLLESIHK
HFQFHPQTAEFTVEANPDGLTKEKLAILRDAGVNRLSIGVQAFDDELLQAIGRTHRRGDAERAVAMAREAGFENISLDLM
YGLPGQTLEQFLADLETAFSLHVPHLSAYSLIIEPKTIFYNEWRNGRLRLPGEEAEAVMYEAAMERTVAHGYQQYEISNY
AFPGFESQHNLVYWNNEEYYGIGAGAHSYIDGVRRANIGPIRHYIEKVERGEWPHRDVHRLTFREQMEEEMFLGLRKTEG
VSKARFRQKFGREMSDMFGEAIRREIENGRLEETATHVRLTKRGKLLGNEVFAAFLGEM
>Mature_378_residues
ATSAYFHIPFCAHICHYCDFNKVFAAGQPIDDYLQAMDKEMEWTAAEFGSQLKTLFIGGGTPTVLEPVQLGRLLESIHKH
FQFHPQTAEFTVEANPDGLTKEKLAILRDAGVNRLSIGVQAFDDELLQAIGRTHRRGDAERAVAMAREAGFENISLDLMY
GLPGQTLEQFLADLETAFSLHVPHLSAYSLIIEPKTIFYNEWRNGRLRLPGEEAEAVMYEAAMERTVAHGYQQYEISNYA
FPGFESQHNLVYWNNEEYYGIGAGAHSYIDGVRRANIGPIRHYIEKVERGEWPHRDVHRLTFREQMEEEMFLGLRKTEGV
SKARFRQKFGREMSDMFGEAIRREIENGRLEETATHVRLTKRGKLLGNEVFAAFLGEM

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=263, Percent_Identity=36.8821292775665, Blast_Score=165, Evalue=6e-41,
Organism=Escherichia coli, GI1789325, Length=383, Percent_Identity=37.597911227154, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI87082341, Length=393, Percent_Identity=29.0076335877863, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43306; Mature: 43174

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSAYFHIPFCAHICHYCDFNKVFAAGQPIDDYLQAMDKEMEWTAAEFGSQLKTLFIGG
CCCCCEEECHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GTPTVLEPVQLGRLLESIHKHFQFHPQTAEFTVEANPDGLTKEKLAILRDAGVNRLSIGV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEHHH
QAFDDELLQAIGRTHRRGDAERAVAMAREAGFENISLDLMYGLPGQTLEQFLADLETAFS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
LHVPHLSAYSLIIEPKTIFYNEWRNGRLRLPGEEAEAVMYEAAMERTVAHGYQQYEISNY
CCCCCCCEEEEEECCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHEEECCC
AFPGFESQHNLVYWNNEEYYGIGAGAHSYIDGVRRANIGPIRHYIEKVERGEWPHRDVHR
CCCCCCCCCCEEEECCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
LTFREQMEEEMFLGLRKTEGVSKARFRQKFGREMSDMFGEAIRREIENGRLEETATHVRL
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TKRGKLLGNEVFAAFLGEM
HHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATSAYFHIPFCAHICHYCDFNKVFAAGQPIDDYLQAMDKEMEWTAAEFGSQLKTLFIGG
CCCCEEECHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GTPTVLEPVQLGRLLESIHKHFQFHPQTAEFTVEANPDGLTKEKLAILRDAGVNRLSIGV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEHHH
QAFDDELLQAIGRTHRRGDAERAVAMAREAGFENISLDLMYGLPGQTLEQFLADLETAFS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
LHVPHLSAYSLIIEPKTIFYNEWRNGRLRLPGEEAEAVMYEAAMERTVAHGYQQYEISNY
CCCCCCCEEEEEECCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHEEECCC
AFPGFESQHNLVYWNNEEYYGIGAGAHSYIDGVRRANIGPIRHYIEKVERGEWPHRDVHR
CCCCCCCCCCEEEECCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
LTFREQMEEEMFLGLRKTEGVSKARFRQKFGREMSDMFGEAIRREIENGRLEETATHVRL
HHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TKRGKLLGNEVFAAFLGEM
HHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]