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The map label for this gene is proA [H]

Identifier: 138895580

GI number: 138895580

Start: 2057643

End: 2058887

Strand: Direct

Name: proA [H]

Synonym: GTNG_1933

Alternate gene names: 138895580

Gene position: 2057643-2058887 (Clockwise)

Preceding gene: 138895579

Following gene: 138895583

Centisome position: 57.96

GC content: 56.47

Gene sequence:

>1245_bases
ATGAACGAATTGCTCGAAAAAGCCGAACGGTTGAAAACGGCGTCACAAACGTTGGCCATGCTGTCGACAGAAGAAAAAAA
CGCGGCATTAGAACAGATTGCCAAAGCCATCGACCGCAAACGCGCCGTCATTTTAGCGGAAAACGAAAAGGATATGGCCG
CCGGCCGCTCGCAAGGGCTGTCACCGGCTTTGCTTGACCGGCTGCAGCTCACGAATGAACGGATCGATCAAATCATCAGC
GGCGTCCGCCAAGTCGCCTCATTGCCGGATCCGGTTGGAGACATCATCGAGGAGTGGACGCGGCCAAACGGCCTTCGCAT
CCAAACAGTGCGCGTGCCGCTTGGGGTGATCGGTATGGTATATGAAGCGCGCCCGAACGTGACAGTTGACGCTGTCAGCC
TTTGTCTGAAAACAGGCAACGCCGTCCTGCTCCGCGGCAGCTCATCGGCGCTTCATTCCAACAAAGCACTTGTCAGCGTC
ATGAAAGAGGCGCTTCGCACAACGGCCATCCCGGAAACAGCCATTGAGCTGCTCGAAGACACGAGCCGGGAAACAGCCCA
GCGCATGTTCCGCCTAAACGATTATCTCGATGTCCTCATTCCGCGCGGCGGAGCGGGGCTCATTCGCTCGGTCGTCGAAA
ACGCCACCGTACCGGTGCTTGAGACCGGTGTCGGCAACTGCCATATTTTCGTTGATGAATCGGCCGAACGATCGATGGCG
ATCGATATCGTCTTAAACGCTAAATTGCAGCGTCCATCTGTCTGCAACGCCATCGAAACCGTGCTCATTCATGAGCGGTG
GCCGTACGTCGGCGAACTGCTTGAGGCACTTCATGCTCGCGGTGTTGAGCTTCGCGGCGACCGACGCCTTGCCGCCGCCT
ATCCGTTCGTCACCGAAGCGACGGAAGAAGACTGGCATACAGAATATTTGGCGCCGATTTTAGCGATCAAACTCGTCACT
GATGTCGATGAAGCGATTCAACATATCCACCGCTACGGAACGAAACATTCCGAAGCGATCATCACGGAAAACGAAGCGCA
TGTCCGCCGCTTTTTCCAAGCGGTCGACGCGGCGGTGTTGTACCATAACGCATCCACCCGCTTCACCGATGGCGAACAGT
TCGGCTACGGGGCGGAAATCGGAATCAGCACGCAAAAACTGCACGCGCGCGGACCGATGGGGCTTGTTGCCATCACCACA
ACGAAATCGCTCGTATACGGGACGGGGCAAATCCGAACGGTTTGA

Upstream 100 bases:

>100_bases
GGCGGCCGAGCGAAGAAGCGCGGCAATACTCTTACCTTCACCGCCCGGAAGTCATCCACCGCGACAATTGGGTCACTTTG
CGAAAGGAGCGTGTCAAAAG

Downstream 100 bases:

>100_bases
CCGGGACGGGAAGCGGAACAATCCGCTTCCCCGTCCTTTTGATGTATACCATCGCGAAAAGATCCGACATACCGTTGATG
GATTTTCGCAGCTATGAACA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNELLEKAERLKTASQTLAMLSTEEKNAALEQIAKAIDRKRAVILAENEKDMAAGRSQGLSPALLDRLQLTNERIDQIIS
GVRQVASLPDPVGDIIEEWTRPNGLRIQTVRVPLGVIGMVYEARPNVTVDAVSLCLKTGNAVLLRGSSSALHSNKALVSV
MKEALRTTAIPETAIELLEDTSRETAQRMFRLNDYLDVLIPRGGAGLIRSVVENATVPVLETGVGNCHIFVDESAERSMA
IDIVLNAKLQRPSVCNAIETVLIHERWPYVGELLEALHARGVELRGDRRLAAAYPFVTEATEEDWHTEYLAPILAIKLVT
DVDEAIQHIHRYGTKHSEAIITENEAHVRRFFQAVDAAVLYHNASTRFTDGEQFGYGAEIGISTQKLHARGPMGLVAITT
TKSLVYGTGQIRTV

Sequences:

>Translated_414_residues
MNELLEKAERLKTASQTLAMLSTEEKNAALEQIAKAIDRKRAVILAENEKDMAAGRSQGLSPALLDRLQLTNERIDQIIS
GVRQVASLPDPVGDIIEEWTRPNGLRIQTVRVPLGVIGMVYEARPNVTVDAVSLCLKTGNAVLLRGSSSALHSNKALVSV
MKEALRTTAIPETAIELLEDTSRETAQRMFRLNDYLDVLIPRGGAGLIRSVVENATVPVLETGVGNCHIFVDESAERSMA
IDIVLNAKLQRPSVCNAIETVLIHERWPYVGELLEALHARGVELRGDRRLAAAYPFVTEATEEDWHTEYLAPILAIKLVT
DVDEAIQHIHRYGTKHSEAIITENEAHVRRFFQAVDAAVLYHNASTRFTDGEQFGYGAEIGISTQKLHARGPMGLVAITT
TKSLVYGTGQIRTV
>Mature_414_residues
MNELLEKAERLKTASQTLAMLSTEEKNAALEQIAKAIDRKRAVILAENEKDMAAGRSQGLSPALLDRLQLTNERIDQIIS
GVRQVASLPDPVGDIIEEWTRPNGLRIQTVRVPLGVIGMVYEARPNVTVDAVSLCLKTGNAVLLRGSSSALHSNKALVSV
MKEALRTTAIPETAIELLEDTSRETAQRMFRLNDYLDVLIPRGGAGLIRSVVENATVPVLETGVGNCHIFVDESAERSMA
IDIVLNAKLQRPSVCNAIETVLIHERWPYVGELLEALHARGVELRGDRRLAAAYPFVTEATEEDWHTEYLAPILAIKLVT
DVDEAIQHIHRYGTKHSEAIITENEAHVRRFFQAVDAAVLYHNASTRFTDGEQFGYGAEIGISTQKLHARGPMGLVAITT
TKSLVYGTGQIRTV

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=413, Percent_Identity=35.1089588377724, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI21361368, Length=413, Percent_Identity=35.1089588377724, Blast_Score=258, Evalue=7e-69,
Organism=Escherichia coli, GI1786438, Length=407, Percent_Identity=46.9287469287469, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17569969, Length=412, Percent_Identity=38.5922330097087, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17569967, Length=412, Percent_Identity=38.5922330097087, Blast_Score=283, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6324899, Length=426, Percent_Identity=33.3333333333333, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI21357643, Length=405, Percent_Identity=36.2962962962963, Blast_Score=269, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45510; Mature: 45510

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELLEKAERLKTASQTLAMLSTEEKNAALEQIAKAIDRKRAVILAENEKDMAAGRSQGL
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCC
SPALLDRLQLTNERIDQIISGVRQVASLPDPVGDIIEEWTRPNGLRIQTVRVPLGVIGMV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
YEARPNVTVDAVSLCLKTGNAVLLRGSSSALHSNKALVSVMKEALRTTAIPETAIELLED
EECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
TSRETAQRMFRLNDYLDVLIPRGGAGLIRSVVENATVPVLETGVGNCHIFVDESAERSMA
CCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCEEECCCCEEEEEEECCCCCCEE
IDIVLNAKLQRPSVCNAIETVLIHERWPYVGELLEALHARGVELRGDRRLAAAYPFVTEA
EEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCCEEEHHCCCHHCC
TEEDWHTEYLAPILAIKLVTDVDEAIQHIHRYGTKHSEAIITENEAHVRRFFQAVDAAVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHE
YHNASTRFTDGEQFGYGAEIGISTQKLHARGPMGLVAITTTKSLVYGTGQIRTV
EECCCCCCCCCCCCCCCCEECCCHHHHHCCCCCEEEEEEECCEEEEECCCEEEC
>Mature Secondary Structure
MNELLEKAERLKTASQTLAMLSTEEKNAALEQIAKAIDRKRAVILAENEKDMAAGRSQGL
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCC
SPALLDRLQLTNERIDQIISGVRQVASLPDPVGDIIEEWTRPNGLRIQTVRVPLGVIGMV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
YEARPNVTVDAVSLCLKTGNAVLLRGSSSALHSNKALVSVMKEALRTTAIPETAIELLED
EECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
TSRETAQRMFRLNDYLDVLIPRGGAGLIRSVVENATVPVLETGVGNCHIFVDESAERSMA
CCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCEEECCCCEEEEEEECCCCCCEE
IDIVLNAKLQRPSVCNAIETVLIHERWPYVGELLEALHARGVELRGDRRLAAAYPFVTEA
EEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCCEEEHHCCCHHCC
TEEDWHTEYLAPILAIKLVTDVDEAIQHIHRYGTKHSEAIITENEAHVRRFFQAVDAAVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHE
YHNASTRFTDGEQFGYGAEIGISTQKLHARGPMGLVAITTTKSLVYGTGQIRTV
EECCCCCCCCCCCCCCCCEECCCHHHHHCCCCCEEEEEEECCEEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA