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The map label for this gene is iolC

Identifier: 138895459

GI number: 138895459

Start: 1917116

End: 1918129

Strand: Reverse

Name: iolC

Synonym: GTNG_1807

Alternate gene names: 138895459

Gene position: 1918129-1917116 (Counterclockwise)

Preceding gene: 138895460

Following gene: 138895458

Centisome position: 54.03

GC content: 46.15

Gene sequence:

>1014_bases
ATGAATTTACTCCCATTTGACGAGCAAAAACCGTTGGATTTTATCGCTGTCGGCCGACTATGCATCGATTTAAATGCCAA
TGAGATTCACCGGCCGATGGAAGAAACGGTGACGTTTACGAAATATGTCGGCGGATCTCCGGCGAATATTGCCATCGGCA
TGGCCCGGCTTGGCATGAAAACAGGGTTTATCGGCCGAGTGGCCGACGACCAAATGGGCCGATTTATCGTTCAATACTTA
AAAAACAATGGCATTGATACATCCCATGTCATTACCGACAAGTCCGGCAGTGTAACAGGCTTGGCGTTCACCGAGATTAA
GAGTCCGACCGACTGCAGCATCCTCATGTATCGCGATAATGTCGCTGATTTGAAACTGGAACCGAACGACATTCATGAAG
ACTATATTCGGCAGGCAAAATGCTTATTGATTTCCGGGACGGCTTTGGCGAAAAGCCCGTCAAGAGAAGCGGTGTTTTTA
GCGTTGGAATATGCAAGACGCCATGGAGTCGTTGTCTTTTTCGATTTGGATTATCGCCCTTATACGTGGCAATCCAAAGA
GGAAACGGCGATTTATTACAACTTGGCCGCCGAAAAATGCGACGTGATCATCGGCACGAGAGAAGAATTTGACATGATGG
AGCAGTTTGCTGTTCATCAGCATGATGACGAGAAAACGGCGCAAAAATGGTTTGATTATCACGCGAAAATCGTCGTCATT
AAACATGGCAAAGATGGATCGATCGCCTATACGAAAACAGGGGAAACGTTTGTCGGTACGATTTTTCCGGCGAATATTGT
CAAAACGTTTGGAGCAGGCGATTCTTACGCTGCTGGGTTTATCTACGGATTAATGAATGGATGGCCGATTCCAAAGGCGA
TGGAATATGGTGCAGCTGCTGCTTCGATTGTCATCTCGAGCCATAGTTGTTCCGATGCAATGCCGACGTTAGATCAAATT
GAACAGTTCATTCAACACATAAAAGCAGCTCGACCGCTGCAAAATCATAAATGA

Upstream 100 bases:

>100_bases
TTCCGCAATGATCCGGACCATGAGTGGGTGATGGAAAGCAAACTCGCGGCCAAACAGAAGTAGAAACGATCTAAAAAGAC
GACAGGAAAGAGGCGGTTCG

Downstream 100 bases:

>100_bases
AAGGGGATCGACGAACATGACAATGACAACGGGAGTACAAACTTTAAAAAACTATATTGGTGGGCAATGGGTGGAATCTC
GTTCTGCGAAGACAGAAGCG

Product: myo-inositol catabolism protein iolC/5-dehydro-2-deoxygluconokinase

Products: NA

Alternate protein names: 2-deoxy-5-keto-D-gluconate kinase; DKG kinase

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MNLLPFDEQKPLDFIAVGRLCIDLNANEIHRPMEETVTFTKYVGGSPANIAIGMARLGMKTGFIGRVADDQMGRFIVQYL
KNNGIDTSHVITDKSGSVTGLAFTEIKSPTDCSILMYRDNVADLKLEPNDIHEDYIRQAKCLLISGTALAKSPSREAVFL
ALEYARRHGVVVFFDLDYRPYTWQSKEETAIYYNLAAEKCDVIIGTREEFDMMEQFAVHQHDDEKTAQKWFDYHAKIVVI
KHGKDGSIAYTKTGETFVGTIFPANIVKTFGAGDSYAAGFIYGLMNGWPIPKAMEYGAAAASIVISSHSCSDAMPTLDQI
EQFIQHIKAARPLQNHK

Sequences:

>Translated_337_residues
MNLLPFDEQKPLDFIAVGRLCIDLNANEIHRPMEETVTFTKYVGGSPANIAIGMARLGMKTGFIGRVADDQMGRFIVQYL
KNNGIDTSHVITDKSGSVTGLAFTEIKSPTDCSILMYRDNVADLKLEPNDIHEDYIRQAKCLLISGTALAKSPSREAVFL
ALEYARRHGVVVFFDLDYRPYTWQSKEETAIYYNLAAEKCDVIIGTREEFDMMEQFAVHQHDDEKTAQKWFDYHAKIVVI
KHGKDGSIAYTKTGETFVGTIFPANIVKTFGAGDSYAAGFIYGLMNGWPIPKAMEYGAAAASIVISSHSCSDAMPTLDQI
EQFIQHIKAARPLQNHK
>Mature_337_residues
MNLLPFDEQKPLDFIAVGRLCIDLNANEIHRPMEETVTFTKYVGGSPANIAIGMARLGMKTGFIGRVADDQMGRFIVQYL
KNNGIDTSHVITDKSGSVTGLAFTEIKSPTDCSILMYRDNVADLKLEPNDIHEDYIRQAKCLLISGTALAKSPSREAVFL
ALEYARRHGVVVFFDLDYRPYTWQSKEETAIYYNLAAEKCDVIIGTREEFDMMEQFAVHQHDDEKTAQKWFDYHAKIVVI
KHGKDGSIAYTKTGETFVGTIFPANIVKTFGAGDSYAAGFIYGLMNGWPIPKAMEYGAAAASIVISSHSCSDAMPTLDQI
EQFIQHIKAARPLQNHK

Specific function: Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family

Homologues:

Organism=Escherichia coli, GI87082281, Length=290, Percent_Identity=26.8965517241379, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790193, Length=295, Percent_Identity=26.4406779661017, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532905, Length=296, Percent_Identity=26.0135135135135, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IOLC_GEOTN (A4IPB3)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125912.1
- ProteinModelPortal:   A4IPB3
- SMR:   A4IPB3
- STRING:   A4IPB3
- GeneID:   4966740
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1807
- NMPDR:   fig|420246.5.peg.1739
- eggNOG:   COG0524
- HOGENOM:   HBG466006
- OMA:   REECEMA
- PhylomeDB:   A4IPB3
- ProtClustDB:   CLSK873289
- BioCyc:   GTHE420246:GTNG_1807-MONOMER
- HAMAP:   MF_01668
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR022841

Pfam domain/function: PF00294 PfkB

EC number: =2.7.1.92

Molecular weight: Translated: 37581; Mature: 37581

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLPFDEQKPLDFIAVGRLCIDLNANEIHRPMEETVTFTKYVGGSPANIAIGMARLGMK
CCCCCCCCCCCCHHEEECEEEEECCHHHHHCCHHHHHHHHHHCCCCCCCEEEEHHHHCCC
TGFIGRVADDQMGRFIVQYLKNNGIDTSHVITDKSGSVTGLAFTEIKSPTDCSILMYRDN
CCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECCCCCCCEEEEEECC
VADLKLEPNDIHEDYIRQAKCLLISGTALAKSPSREAVFLALEYARRHGVVVFFDLDYRP
CEEEEECCCCHHHHHHHCCEEEEEECCHHCCCCCCCEEEEEEEHHHHCCEEEEEECCCCC
YTWQSKEETAIYYNLAAEKCDVIIGTREEFDMMEQFAVHQHDDEKTAQKWFDYHAKIVVI
CCCCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEE
KHGKDGSIAYTKTGETFVGTIFPANIVKTFGAGDSYAAGFIYGLMNGWPIPKAMEYGAAA
EECCCCCEEEEECCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCE
ASIVISSHSCSDAMPTLDQIEQFIQHIKAARPLQNHK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNLLPFDEQKPLDFIAVGRLCIDLNANEIHRPMEETVTFTKYVGGSPANIAIGMARLGMK
CCCCCCCCCCCCHHEEECEEEEECCHHHHHCCHHHHHHHHHHCCCCCCCEEEEHHHHCCC
TGFIGRVADDQMGRFIVQYLKNNGIDTSHVITDKSGSVTGLAFTEIKSPTDCSILMYRDN
CCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECCCCCCCEEEEEECC
VADLKLEPNDIHEDYIRQAKCLLISGTALAKSPSREAVFLALEYARRHGVVVFFDLDYRP
CEEEEECCCCHHHHHHHCCEEEEEECCHHCCCCCCCEEEEEEEHHHHCCEEEEEECCCCC
YTWQSKEETAIYYNLAAEKCDVIIGTREEFDMMEQFAVHQHDDEKTAQKWFDYHAKIVVI
CCCCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEE
KHGKDGSIAYTKTGETFVGTIFPANIVKTFGAGDSYAAGFIYGLMNGWPIPKAMEYGAAA
EECCCCCEEEEECCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCE
ASIVISSHSCSDAMPTLDQIEQFIQHIKAARPLQNHK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA