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The map label for this gene is yfeW [H]

Identifier: 138894950

GI number: 138894950

Start: 1368023

End: 1369732

Strand: Direct

Name: yfeW [H]

Synonym: GTNG_1288

Alternate gene names: 138894950

Gene position: 1368023-1369732 (Clockwise)

Preceding gene: 138894949

Following gene: 138894951

Centisome position: 38.53

GC content: 47.43

Gene sequence:

>1710_bases
ATGGATAAGCGGCCTGTTTTTATGATCTTGTCGTCGATTTTGTTCGGCTCCGTTCTTTTTTGTTCACCGGTCGCCGCCAC
ATCCCACCATGATCCAACCCCTACAATCGAGTCAGCCGAAATAAAAGCGTATAAAACGAGTCAGTCTCACAGGAAAGCCT
CTTTTTCTTGGGATCAGAAAGGATCGATTTCCGCGGTTATTCATCCTGGAACACCTCAAGCTGCTGGCATGAGAGAAGCT
CCTTTACGAAAAATTGATGAAGTCATAACGCAAGCCATGCGCGACAACGTCATTTCGGGGGCGGTCGTTTACATTGTGCG
GCGCGGAATGATTGTGAAACAGAAAGCGTATGGATATGCCAAACAGTATGAGGACGATACGTTTACACAATCTAAACAGC
CGATTCCGATGCGAATGGACACAATGTTTGATTTGGCATCCATCAGCAAACTGTTCACAACAACAGCGGCGATGAAGCTA
TACGAACAAGGAAAATTTTCGCTAGACGATCCTGTTGCGAAGTACATACCGGAATTTGCCCAAAACGGAAAAGAAAATGT
AACGATCCGTCAACTGATGACCCATACGTCTGGGCTGGCGGCGTGGATCCCCCTGTATACAATGGGAACGAATCGCGACG
ATCGTTTGCAAATTGTATTTGCCCAGCCGCTTGAGCATCCCCCGGGAACAACGTATGTATACAGTGATTTGAACATGATT
ACTTTAGGTGCATTGGTCGAACGTTTATCGGGCGTACGTCTTGATCAGTTTGTGTATCGGTATATTACGAAGCCGTTAGG
CATGAACAATACGATGTATAATCCCCCGTTGCTAAAAAAGAGGAGAATCGCTGCTACGGAATATCAGCCATGGACGGGAA
GAGGAATGGTTTGGGGGGAAGTGCATGATGAAAACGCATGGGCGTTAGATGGGGTGGCCGGACATGCGGGATTGTTTTCA
ACTGCTAGGGATTTGGCTATTTTTGCTTCCATGTTTTTGCAAAATGGAACATATGGCGGCAAGCGGATTTTACAGCCGGA
AACGGTTCAGCTGCTCATGGAAAATCAAATTCCGCAGTTTCCTGGATACGATCATGGGCTCGGATGGGAACTCGCACAAG
GATGGTATATGGATGCATTGTCTGAACATACATCGTTTGGCCATACAGGGTATACGGGAACATCCATCGTTGTAAACCCG
AACAATGATGTGATCGCTATTTTATTAACTAATCGCGTTCACCCTACACGCAATACGCCATCCATCAATCCGTTGCGCAG
GCAAGTTTCCCGTCTAACGGCAGACGCCATTCCCGTGGCCATTCCCGGGAAAAAAGCAGCTTGGTTTGCGGGATATGGAG
ATCATTTGAATGCGATACTGTCGACAAAGGTAGTGGCTCGTAAACAGCTCACATTAACGTTTGATACATGGTACCGAATG
GAGCCGGATGTTGATTTCGGTGTTGTCGAAGTATCACAAGATGGAGAACATTGGAGGCAAGTTGGGGAACAGCTGACAGG
CAGCAGTGACTGGACAACGAAAACGGTGCCTATTCCGGCTCATACGGTTGCCATTCGGTTTCGCTACTGTACCGATTCGT
CCGTTAACGGGCGTGGCTGGTATGTCACAAATATTCGCCTTGTCGACGATGATGGGAAAGAGTTAGAGACATTATGGGAA
AGCCATGATTGGGAACGGCGCACGTTTTAA

Upstream 100 bases:

>100_bases
AAGTGGTATATACAACTATACCAAAAAATTTGTATGATAACGATAGAAAGCGCTATCATTGTTTTGCGGGAGATCTTAAT
CGGATAAAGGGGGCTATTTT

Downstream 100 bases:

>100_bases
ACAAACCATATAAGGGGGAACGGGGATGTCATTTTATTGGAAAACAGCTGTTTTCATGACTGTGATCACCTTTTTCATTT
CGTGGGCCTCGCCACAGGTT

Product: beta-lactamase

Products: substituted beta-amino acid

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MDKRPVFMILSSILFGSVLFCSPVAATSHHDPTPTIESAEIKAYKTSQSHRKASFSWDQKGSISAVIHPGTPQAAGMREA
PLRKIDEVITQAMRDNVISGAVVYIVRRGMIVKQKAYGYAKQYEDDTFTQSKQPIPMRMDTMFDLASISKLFTTTAAMKL
YEQGKFSLDDPVAKYIPEFAQNGKENVTIRQLMTHTSGLAAWIPLYTMGTNRDDRLQIVFAQPLEHPPGTTYVYSDLNMI
TLGALVERLSGVRLDQFVYRYITKPLGMNNTMYNPPLLKKRRIAATEYQPWTGRGMVWGEVHDENAWALDGVAGHAGLFS
TARDLAIFASMFLQNGTYGGKRILQPETVQLLMENQIPQFPGYDHGLGWELAQGWYMDALSEHTSFGHTGYTGTSIVVNP
NNDVIAILLTNRVHPTRNTPSINPLRRQVSRLTADAIPVAIPGKKAAWFAGYGDHLNAILSTKVVARKQLTLTFDTWYRM
EPDVDFGVVEVSQDGEHWRQVGEQLTGSSDWTTKTVPIPAHTVAIRFRYCTDSSVNGRGWYVTNIRLVDDDGKELETLWE
SHDWERRTF

Sequences:

>Translated_569_residues
MDKRPVFMILSSILFGSVLFCSPVAATSHHDPTPTIESAEIKAYKTSQSHRKASFSWDQKGSISAVIHPGTPQAAGMREA
PLRKIDEVITQAMRDNVISGAVVYIVRRGMIVKQKAYGYAKQYEDDTFTQSKQPIPMRMDTMFDLASISKLFTTTAAMKL
YEQGKFSLDDPVAKYIPEFAQNGKENVTIRQLMTHTSGLAAWIPLYTMGTNRDDRLQIVFAQPLEHPPGTTYVYSDLNMI
TLGALVERLSGVRLDQFVYRYITKPLGMNNTMYNPPLLKKRRIAATEYQPWTGRGMVWGEVHDENAWALDGVAGHAGLFS
TARDLAIFASMFLQNGTYGGKRILQPETVQLLMENQIPQFPGYDHGLGWELAQGWYMDALSEHTSFGHTGYTGTSIVVNP
NNDVIAILLTNRVHPTRNTPSINPLRRQVSRLTADAIPVAIPGKKAAWFAGYGDHLNAILSTKVVARKQLTLTFDTWYRM
EPDVDFGVVEVSQDGEHWRQVGEQLTGSSDWTTKTVPIPAHTVAIRFRYCTDSSVNGRGWYVTNIRLVDDDGKELETLWE
SHDWERRTF
>Mature_569_residues
MDKRPVFMILSSILFGSVLFCSPVAATSHHDPTPTIESAEIKAYKTSQSHRKASFSWDQKGSISAVIHPGTPQAAGMREA
PLRKIDEVITQAMRDNVISGAVVYIVRRGMIVKQKAYGYAKQYEDDTFTQSKQPIPMRMDTMFDLASISKLFTTTAAMKL
YEQGKFSLDDPVAKYIPEFAQNGKENVTIRQLMTHTSGLAAWIPLYTMGTNRDDRLQIVFAQPLEHPPGTTYVYSDLNMI
TLGALVERLSGVRLDQFVYRYITKPLGMNNTMYNPPLLKKRRIAATEYQPWTGRGMVWGEVHDENAWALDGVAGHAGLFS
TARDLAIFASMFLQNGTYGGKRILQPETVQLLMENQIPQFPGYDHGLGWELAQGWYMDALSEHTSFGHTGYTGTSIVVNP
NNDVIAILLTNRVHPTRNTPSINPLRRQVSRLTADAIPVAIPGKKAAWFAGYGDHLNAILSTKVVARKQLTLTFDTWYRM
EPDVDFGVVEVSQDGEHWRQVGEQLTGSSDWTTKTVPIPAHTVAIRFRYCTDSSVNGRGWYVTNIRLVDDDGKELETLWE
SHDWERRTF

Specific function: Unknown

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0214 family [H]

Homologues:

Organism=Escherichia coli, GI87082101, Length=399, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1786574, Length=324, Percent_Identity=27.4691358024691, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790593, Length=289, Percent_Identity=26.9896193771626, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=373, Percent_Identity=26.5415549597855, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550934, Length=209, Percent_Identity=25.8373205741627, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR022849 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6

Molecular weight: Translated: 63955; Mature: 63955

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRPVFMILSSILFGSVLFCSPVAATSHHDPTPTIESAEIKAYKTSQSHRKASFSWDQK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCCCCCCC
GSISAVIHPGTPQAAGMREAPLRKIDEVITQAMRDNVISGAVVYIVRRGMIVKQKAYGYA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEHHHHCHH
KQYEDDTFTQSKQPIPMRMDTMFDLASISKLFTTTAAMKLYEQGKFSLDDPVAKYIPEFA
HHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QNGKENVTIRQLMTHTSGLAAWIPLYTMGTNRDDRLQIVFAQPLEHPPGTTYVYSDLNMI
HCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEECCCCHH
TLGALVERLSGVRLDQFVYRYITKPLGMNNTMYNPPLLKKRRIAATEYQPWTGRGMVWGE
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
VHDENAWALDGVAGHAGLFSTARDLAIFASMFLQNGTYGGKRILQPETVQLLMENQIPQF
EECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
PGYDHGLGWELAQGWYMDALSEHTSFGHTGYTGTSIVVNPNNDVIAILLTNRVHPTRNTP
CCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCC
SINPLRRQVSRLTADAIPVAIPGKKAAWFAGYGDHLNAILSTKVVARKQLTLTFDTWYRM
CCCHHHHHHHHHHHCCCEEEECCCCCEEECCCCHHHHHHHHHHHHEEEEEEEEEECEEEE
EPDVDFGVVEVSQDGEHWRQVGEQLTGSSDWTTKTVPIPAHTVAIRFRYCTDSSVNGRGW
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEEECCCCCCCCEE
YVTNIRLVDDDGKELETLWESHDWERRTF
EEEEEEEECCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDKRPVFMILSSILFGSVLFCSPVAATSHHDPTPTIESAEIKAYKTSQSHRKASFSWDQK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCCCCCCC
GSISAVIHPGTPQAAGMREAPLRKIDEVITQAMRDNVISGAVVYIVRRGMIVKQKAYGYA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEHHHHCHH
KQYEDDTFTQSKQPIPMRMDTMFDLASISKLFTTTAAMKLYEQGKFSLDDPVAKYIPEFA
HHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
QNGKENVTIRQLMTHTSGLAAWIPLYTMGTNRDDRLQIVFAQPLEHPPGTTYVYSDLNMI
HCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEECCCCHH
TLGALVERLSGVRLDQFVYRYITKPLGMNNTMYNPPLLKKRRIAATEYQPWTGRGMVWGE
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
VHDENAWALDGVAGHAGLFSTARDLAIFASMFLQNGTYGGKRILQPETVQLLMENQIPQF
EECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
PGYDHGLGWELAQGWYMDALSEHTSFGHTGYTGTSIVVNPNNDVIAILLTNRVHPTRNTP
CCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCC
SINPLRRQVSRLTADAIPVAIPGKKAAWFAGYGDHLNAILSTKVVARKQLTLTFDTWYRM
CCCHHHHHHHHHHHCCCEEEECCCCCEEECCCCHHHHHHHHHHHHEEEEEEEEEECEEEE
EPDVDFGVVEVSQDGEHWRQVGEQLTGSSDWTTKTVPIPAHTVAIRFRYCTDSSVNGRGW
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEEECCCCCCCCEE
YVTNIRLVDDDGKELETLWESHDWERRTF
EEEEEEEECCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: beta-lactam; H2O

Specific reaction: A beta-lactam + H2O = a substituted beta-amino acid

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]