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The map label for this gene is hutI

Identifier: 138894890

GI number: 138894890

Start: 1292345

End: 1293619

Strand: Direct

Name: hutI

Synonym: GTNG_1226

Alternate gene names: 138894890

Gene position: 1292345-1293619 (Clockwise)

Preceding gene: 138894889

Following gene: 138894891

Centisome position: 36.4

GC content: 57.57

Gene sequence:

>1275_bases
ATGCGCCCACTCTTTATCCGCCGCGCTCGCCAACTCGTCACGCTGGCGGGAAGCTCCGCGGCTCCGCTTGTCAGAGAAAA
GATGAACGACCTTCAAATCATTGAAAACGGAAGCGTCTGGATCGAGCGGGGGGTGATCATTGCCGTTGGTCCGGACGATG
AACTGGCTCACCGATTTGCCGATCGGATCGGTGAGGCGGATGTGATTGACGCCCGCGGCAAAACGGTCACTCCTGGACTC
ATCGACCCCCACACTCATCTCGTGTACGCCGGCAGCCGTGAACATGAATGGACGATGCGTCTCCGTGGGGCGACGTATAT
GGAGATCATGAACGCTGGCGGCGGCATTCATGCGACGACAAAAGCGACACGCGAGGCGTCGGAAGAAATGCTGTATGAGG
AAAGCAAGCGGCGGCTGGATCTGTTTTTGCTTCATGGTGTCACAACCGTTGAGGCGAAAAGCGGCTACGGTTTAAGCTTT
GAAGGCGAAATCAAGCAGCTCGAAGTTGCCAAGAGGCTTCATGACACCCACCCGGTTGATGTCGTTTCCACTTTTCTTGG
TGCTCATGCCGTCCCGCCGGAGTGGAAGGACGATCGGGATGGATACATCCGCTTGATCATGGAAGTAATGATTCCTGAGG
TCAGCCGTCGAGGCTTGGCCGAGTTCAACGATGTTTTCTGTGAGCGTGGTGTGTTTACCCCTGATGAGGCGCGCCGCATC
CTCGAAGCGGGCAAGGCGCACGGCTTGACGCCGAAAATCCACGCCGATGAAATCGAACCGTACGGCGGTGCCGAACTGGC
TGCTGAGGTTGGGGCGATTTCGGCCGACCACTTGCTCCGTGCGTCTGATGAAGGCCTCCGCCGCATGGCGGAGCGCGGCG
TGATCGGCGTTCTTTTGCCAGGTACGGCATTTTTCTTAATGACCCAGGCCGCTGACGCCCGCCGCTTGATCGACAACGGC
GTTCCTGTCGCCCTAGCGACTGACTGCAATCCTGGTTCATCGCCGACCGTTTCACTGCCGCTTGTCATGAGCCTTGCCTG
TTTGCATATGCGCATGACCCCGGCTGAGGCGCTCGCCGCCGCCACAATCAACGCCGCCCACGCCATCGGCCGCTCTCACG
TGATCGGTAGCCTTGAACCGGGCAAGAAAGCGGATTTGGCCATTTTCAACGCCGCAAACTATATGCAAATCATGTACTAT
TACGGCGTCAACCATACGGAGATGGTGATTAAGGGTGGGAAGATCGTGGTGAATGAAGGCAAGGTATGCATCTGA

Upstream 100 bases:

>100_bases
TGTCGTCCGCCACGCTGACGCGGGGTATGAGCTCGCCATTCGCACGGCGAAAGAAAAAGGTATTGATATGCCAATGCTGA
AGTAGAAAAGGGGAGATAAG

Downstream 100 bases:

>100_bases
AGGGGAATAGTCTTCCGTGGAGGTGTTTGGCGACCGGGAGCGGGATGCTTCCGGTTGCATCGTCTTGTGTAAGAAGAACA
ATGGGGGTGGAGGAAAATGA

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MRPLFIRRARQLVTLAGSSAAPLVREKMNDLQIIENGSVWIERGVIIAVGPDDELAHRFADRIGEADVIDARGKTVTPGL
IDPHTHLVYAGSREHEWTMRLRGATYMEIMNAGGGIHATTKATREASEEMLYEESKRRLDLFLLHGVTTVEAKSGYGLSF
EGEIKQLEVAKRLHDTHPVDVVSTFLGAHAVPPEWKDDRDGYIRLIMEVMIPEVSRRGLAEFNDVFCERGVFTPDEARRI
LEAGKAHGLTPKIHADEIEPYGGAELAAEVGAISADHLLRASDEGLRRMAERGVIGVLLPGTAFFLMTQAADARRLIDNG
VPVALATDCNPGSSPTVSLPLVMSLACLHMRMTPAEALAAATINAAHAIGRSHVIGSLEPGKKADLAIFNAANYMQIMYY
YGVNHTEMVIKGGKIVVNEGKVCI

Sequences:

>Translated_424_residues
MRPLFIRRARQLVTLAGSSAAPLVREKMNDLQIIENGSVWIERGVIIAVGPDDELAHRFADRIGEADVIDARGKTVTPGL
IDPHTHLVYAGSREHEWTMRLRGATYMEIMNAGGGIHATTKATREASEEMLYEESKRRLDLFLLHGVTTVEAKSGYGLSF
EGEIKQLEVAKRLHDTHPVDVVSTFLGAHAVPPEWKDDRDGYIRLIMEVMIPEVSRRGLAEFNDVFCERGVFTPDEARRI
LEAGKAHGLTPKIHADEIEPYGGAELAAEVGAISADHLLRASDEGLRRMAERGVIGVLLPGTAFFLMTQAADARRLIDNG
VPVALATDCNPGSSPTVSLPLVMSLACLHMRMTPAEALAAATINAAHAIGRSHVIGSLEPGKKADLAIFNAANYMQIMYY
YGVNHTEMVIKGGKIVVNEGKVCI
>Mature_424_residues
MRPLFIRRARQLVTLAGSSAAPLVREKMNDLQIIENGSVWIERGVIIAVGPDDELAHRFADRIGEADVIDARGKTVTPGL
IDPHTHLVYAGSREHEWTMRLRGATYMEIMNAGGGIHATTKATREASEEMLYEESKRRLDLFLLHGVTTVEAKSGYGLSF
EGEIKQLEVAKRLHDTHPVDVVSTFLGAHAVPPEWKDDRDGYIRLIMEVMIPEVSRRGLAEFNDVFCERGVFTPDEARRI
LEAGKAHGLTPKIHADEIEPYGGAELAAEVGAISADHLLRASDEGLRRMAERGVIGVLLPGTAFFLMTQAADARRLIDNG
VPVALATDCNPGSSPTVSLPLVMSLACLHMRMTPAEALAAATINAAHAIGRSHVIGSLEPGKKADLAIFNAANYMQIMYY
YGVNHTEMVIKGGKIVVNEGKVCI

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=426, Percent_Identity=43.1924882629108, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17555004, Length=446, Percent_Identity=36.322869955157, Blast_Score=272, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_GEOTN (A4IMP4)

Other databases:

- EMBL:   CP000557
- RefSeq:   YP_001125343.1
- ProteinModelPortal:   A4IMP4
- SMR:   A4IMP4
- STRING:   A4IMP4
- GeneID:   4966166
- GenomeReviews:   CP000557_GR
- KEGG:   gtn:GTNG_1226
- NMPDR:   fig|420246.5.peg.1194
- eggNOG:   COG1228
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   GTHE420246:GTNG_1226-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 46229; Mature: 46229

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: BINDING 93-93 BINDING 106-106 BINDING 156-156 BINDING 189-189 BINDING 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLFIRRARQLVTLAGSSAAPLVREKMNDLQIIENGSVWIERGVIIAVGPDDELAHRFA
CCCHHHHHHHHHHEECCCCCCHHHHHHCCCEEEEECCCEEEECCEEEEECCCHHHHHHHH
DRIGEADVIDARGKTVTPGLIDPHTHLVYAGSREHEWTMRLRGATYMEIMNAGGGIHATT
HHCCCCCEEECCCCEECCCCCCCCCEEEEECCCCCEEEEEECCCCEEHHHHCCCCEEECH
KATREASEEMLYEESKRRLDLFLLHGVTTVEAKSGYGLSFEGEIKQLEVAKRLHDTHPVD
HHHHHHHHHHHHHHHHHCEEEEEEECEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHH
VVSTFLGAHAVPPEWKDDRDGYIRLIMEVMIPEVSRRGLAEFNDVFCERGVFTPDEARRI
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
LEAGKAHGLTPKIHADEIEPYGGAELAAEVGAISADHLLRASDEGLRRMAERGVIGVLLP
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCEEEEEEC
GTAFFLMTQAADARRLIDNGVPVALATDCNPGSSPTVSLPLVMSLACLHMRMTPAEALAA
CCEEEHHHHCHHHHHHHHCCCCEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHH
ATINAAHAIGRSHVIGSLEPGKKADLAIFNAANYMQIMYYYGVNHTEMVIKGGKIVVNEG
HHHHHHHHHCHHHEECCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEECCEEEEECC
KVCI
CEEC
>Mature Secondary Structure
MRPLFIRRARQLVTLAGSSAAPLVREKMNDLQIIENGSVWIERGVIIAVGPDDELAHRFA
CCCHHHHHHHHHHEECCCCCCHHHHHHCCCEEEEECCCEEEECCEEEEECCCHHHHHHHH
DRIGEADVIDARGKTVTPGLIDPHTHLVYAGSREHEWTMRLRGATYMEIMNAGGGIHATT
HHCCCCCEEECCCCEECCCCCCCCCEEEEECCCCCEEEEEECCCCEEHHHHCCCCEEECH
KATREASEEMLYEESKRRLDLFLLHGVTTVEAKSGYGLSFEGEIKQLEVAKRLHDTHPVD
HHHHHHHHHHHHHHHHHCEEEEEEECEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHH
VVSTFLGAHAVPPEWKDDRDGYIRLIMEVMIPEVSRRGLAEFNDVFCERGVFTPDEARRI
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHH
LEAGKAHGLTPKIHADEIEPYGGAELAAEVGAISADHLLRASDEGLRRMAERGVIGVLLP
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCEEEEEEC
GTAFFLMTQAADARRLIDNGVPVALATDCNPGSSPTVSLPLVMSLACLHMRMTPAEALAA
CCEEEHHHHCHHHHHHHHCCCCEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHH
ATINAAHAIGRSHVIGSLEPGKKADLAIFNAANYMQIMYYYGVNHTEMVIKGGKIVVNEG
HHHHHHHHHCHHHEECCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEECCEEEEECC
KVCI
CEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA