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The map label for this gene is hutU [H]

Identifier: 138894889

GI number: 138894889

Start: 1290668

End: 1292329

Strand: Direct

Name: hutU [H]

Synonym: GTNG_1225

Alternate gene names: 138894889

Gene position: 1290668-1292329 (Clockwise)

Preceding gene: 138894888

Following gene: 138894890

Centisome position: 36.35

GC content: 55.35

Gene sequence:

>1662_bases
ATGACGATGGGAAATAAACGGATGGTTCAAGCGCTTTCAGGAACAACGCGGCAAGCGAAAGGATGGATTCAGGAAGCAGC
GCTCCGCATGTTAAACAACAACTTGCATCCGGATGTCGCCGAACGACCGGATGAATTGATCGTCTACGGCGGCATCGGTA
AAGCGGCGCGCAACTGGGAATGTTATGAGGCGATTGTGGACACTCTTCTTCGTTTAGAAAACGATGAGACATTGCTCATT
CAATCGGGGAAGCCGGTCGCGGTGTTTCGCACCCATCCGAACGCGCCGCGCGTGCTCATCGCCAACTCTAACCTCGTGCC
GGCATGGGCGACGTGGGACCATTTCCATGAACTCGACAAAAAAGGATTGATCATGTACGGGCAAATGACGGCCGGCAGCT
GGATTTACATCGGAAGCCAAGGCATCGTTCAAGGGACGTACGAAACGTTCGCCGAAGTGGCGCGCCAGCACTTTGGCGGC
ACGCTGGCGGGAACGATCACGGTCACGGCTGGCCTTGGCGGCATGGGTGGGGCGCAGCCGTTGGCAGTGACGATGAACGG
CGGCGTCTGTATTGCTATCGAAGTCGACCCGGCTCGCATCCAGCGCCGTCTTGACACGAAATATCTTGACACGATGACTG
ACAGCCTAGACGTCGCGCTTCAAATGGCAAAACAAGCGAAAGAAGAGAAAAAAGCGCTGTCGATCGGTCTTGTCGGCAAT
GCGGCCGAAGTGCTGCCGCAGCTCGTTGACATAGGCTTTATTCCTGACGTTTTGACCGATCAAACGTCCGCTCATGATCC
GTTAAATGGCTACATTCCTGCTCGTTTGACACTCGAGGAAGCCGCCGAGCTGCGGGTTCGCGATCCGAAGCAGTATGTTG
CTCGTGCCAAACAATCGATCGCTGAGCACGTAAGGGCGATGCTTGTGATGCAAAAACAAGGGGCAGTGACGTTTGATTAC
GGCAACAACATTCGTCAAGTGGCGAAAGACGAAGGAGTCGAGGATGCCTTCTCCTTCCCGGGGTTTGTGCCAGCTTACAT
CCGCCCGCTCTTTTGCGAAGGAAAAGGCCCGTTCCGTTGGGTGGCGCTCTCCGGCGACCCAGAAGACATTTATAAGACGG
ATGAAGTCATTTTGCGCGAATTCAGCGATAATGAACGCCTTTGCCATTGGATTCGCATGGCGCAAAAACAAATCAAGTTT
CAAGGGCTGCCGGCGCGCATTTGCTGGCTCGGTTACGGCGAACGGGCGAAGTTCGGGAAAATCATTAACGACATGGTTGC
TCGCGGCGAATTGAAGGCGCCGATCGTCATCGGCCGCGATCATTTAGATTCGGGATCTGTCGCCTCGCCGAACCGAGAAA
CGGAAGGAATGAAAGATGGAAGTGACGCCATTGCCGACTGGCCGATTTTAAACGCGCTATTGAATGCGGTCGGCGGTGCG
AGCTGGGTGTCGGTTCACCATGGCGGCGGCGTCGGTATGGGCTATTCGCTTCATGCTGGCATGGTTATTGTCGCCGATGG
CACGAAAGAGGCGGAAGAACGGTTGGCGCGTGTGTTGACGACCGATCCGGGACTTGGTGTCGTCCGCCACGCTGACGCGG
GGTATGAGCTCGCCATTCGCACGGCGAAAGAAAAAGGTATTGATATGCCAATGCTGAAGTAG

Upstream 100 bases:

>100_bases
ATGAAATTTCTAAAAAAACGGATCAACTTTAAAAGAAGAGCATCTATCTCCCTCCTCTTGGCTTCCTTCATAATAAAAAG
CAAAGAGGAAAAAGAGGGGG

Downstream 100 bases:

>100_bases
AAAAGGGGAGATAAGATGCGCCCACTCTTTATCCGCCGCGCTCGCCAACTCGTCACGCTGGCGGGAAGCTCCGCGGCTCC
GCTTGTCAGAGAAAAGATGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTMGNKRMVQALSGTTRQAKGWIQEAALRMLNNNLHPDVAERPDELIVYGGIGKAARNWECYEAIVDTLLRLENDETLLI
QSGKPVAVFRTHPNAPRVLIANSNLVPAWATWDHFHELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAEVARQHFGG
TLAGTITVTAGLGGMGGAQPLAVTMNGGVCIAIEVDPARIQRRLDTKYLDTMTDSLDVALQMAKQAKEEKKALSIGLVGN
AAEVLPQLVDIGFIPDVLTDQTSAHDPLNGYIPARLTLEEAAELRVRDPKQYVARAKQSIAEHVRAMLVMQKQGAVTFDY
GNNIRQVAKDEGVEDAFSFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFSDNERLCHWIRMAQKQIKF
QGLPARICWLGYGERAKFGKIINDMVARGELKAPIVIGRDHLDSGSVASPNRETEGMKDGSDAIADWPILNALLNAVGGA
SWVSVHHGGGVGMGYSLHAGMVIVADGTKEAEERLARVLTTDPGLGVVRHADAGYELAIRTAKEKGIDMPMLK

Sequences:

>Translated_553_residues
MTMGNKRMVQALSGTTRQAKGWIQEAALRMLNNNLHPDVAERPDELIVYGGIGKAARNWECYEAIVDTLLRLENDETLLI
QSGKPVAVFRTHPNAPRVLIANSNLVPAWATWDHFHELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAEVARQHFGG
TLAGTITVTAGLGGMGGAQPLAVTMNGGVCIAIEVDPARIQRRLDTKYLDTMTDSLDVALQMAKQAKEEKKALSIGLVGN
AAEVLPQLVDIGFIPDVLTDQTSAHDPLNGYIPARLTLEEAAELRVRDPKQYVARAKQSIAEHVRAMLVMQKQGAVTFDY
GNNIRQVAKDEGVEDAFSFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFSDNERLCHWIRMAQKQIKF
QGLPARICWLGYGERAKFGKIINDMVARGELKAPIVIGRDHLDSGSVASPNRETEGMKDGSDAIADWPILNALLNAVGGA
SWVSVHHGGGVGMGYSLHAGMVIVADGTKEAEERLARVLTTDPGLGVVRHADAGYELAIRTAKEKGIDMPMLK
>Mature_552_residues
TMGNKRMVQALSGTTRQAKGWIQEAALRMLNNNLHPDVAERPDELIVYGGIGKAARNWECYEAIVDTLLRLENDETLLIQ
SGKPVAVFRTHPNAPRVLIANSNLVPAWATWDHFHELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAEVARQHFGGT
LAGTITVTAGLGGMGGAQPLAVTMNGGVCIAIEVDPARIQRRLDTKYLDTMTDSLDVALQMAKQAKEEKKALSIGLVGNA
AEVLPQLVDIGFIPDVLTDQTSAHDPLNGYIPARLTLEEAAELRVRDPKQYVARAKQSIAEHVRAMLVMQKQGAVTFDYG
NNIRQVAKDEGVEDAFSFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFSDNERLCHWIRMAQKQIKFQ
GLPARICWLGYGERAKFGKIINDMVARGELKAPIVIGRDHLDSGSVASPNRETEGMKDGSDAIADWPILNALLNAVGGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTKEAEERLARVLTTDPGLGVVRHADAGYELAIRTAKEKGIDMPMLK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=558, Percent_Identity=36.0215053763441, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI260306182, Length=357, Percent_Identity=33.6134453781513, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71997891, Length=559, Percent_Identity=33.8103756708408, Blast_Score=311, Evalue=4e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60383; Mature: 60252

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMGNKRMVQALSGTTRQAKGWIQEAALRMLNNNLHPDVAERPDELIVYGGIGKAARNWE
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEEECCCCCCCCCCH
CYEAIVDTLLRLENDETLLIQSGKPVAVFRTHPNAPRVLIANSNLVPAWATWDHFHELDK
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHCC
KGLIMYGQMTAGSWIYIGSQGIVQGTYETFAEVARQHFGGTLAGTITVTAGLGGMGGAQP
CCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCC
LAVTMNGGVCIAIEVDPARIQRRLDTKYLDTMTDSLDVALQMAKQAKEEKKALSIGLVGN
EEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC
AAEVLPQLVDIGFIPDVLTDQTSAHDPLNGYIPARLTLEEAAELRVRDPKQYVARAKQSI
HHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCHHHHHHHHHHHH
AEHVRAMLVMQKQGAVTFDYGNNIRQVAKDEGVEDAFSFPGFVPAYIRPLFCEGKGPFRW
HHHHHHHHHEECCCCEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHCEEEECCCCCEEE
VALSGDPEDIYKTDEVILREFSDNERLCHWIRMAQKQIKFQGLPARICWLGYGERAKFGK
EEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
IINDMVARGELKAPIVIGRDHLDSGSVASPNRETEGMKDGSDAIADWPILNALLNAVGGA
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
SWVSVHHGGGVGMGYSLHAGMVIVADGTKEAEERLARVLTTDPGLGVVRHADAGYELAIR
EEEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEE
TAKEKGIDMPMLK
EHHHCCCCCCCCC
>Mature Secondary Structure 
TMGNKRMVQALSGTTRQAKGWIQEAALRMLNNNLHPDVAERPDELIVYGGIGKAARNWE
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEEECCCCCCCCCCH
CYEAIVDTLLRLENDETLLIQSGKPVAVFRTHPNAPRVLIANSNLVPAWATWDHFHELDK
HHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHCC
KGLIMYGQMTAGSWIYIGSQGIVQGTYETFAEVARQHFGGTLAGTITVTAGLGGMGGAQP
CCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCC
LAVTMNGGVCIAIEVDPARIQRRLDTKYLDTMTDSLDVALQMAKQAKEEKKALSIGLVGN
EEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECC
AAEVLPQLVDIGFIPDVLTDQTSAHDPLNGYIPARLTLEEAAELRVRDPKQYVARAKQSI
HHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCHHHHHHHHHHHH
AEHVRAMLVMQKQGAVTFDYGNNIRQVAKDEGVEDAFSFPGFVPAYIRPLFCEGKGPFRW
HHHHHHHHHEECCCCEEEECCCCHHHHHHHCCCHHHHCCCCCCHHHHCEEEECCCCCEEE
VALSGDPEDIYKTDEVILREFSDNERLCHWIRMAQKQIKFQGLPARICWLGYGERAKFGK
EEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
IINDMVARGELKAPIVIGRDHLDSGSVASPNRETEGMKDGSDAIADWPILNALLNAVGGA
HHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
SWVSVHHGGGVGMGYSLHAGMVIVADGTKEAEERLARVLTTDPGLGVVRHADAGYELAIR
EEEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEE
TAKEKGIDMPMLK
EHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA