Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 138894880

GI number: 138894880

Start: 1283820

End: 1285319

Strand: Direct

Name: glpK [H]

Synonym: GTNG_1216

Alternate gene names: 138894880

Gene position: 1283820-1285319 (Clockwise)

Preceding gene: 138894879

Following gene: 138894881

Centisome position: 36.16

GC content: 54.73

Gene sequence:

>1500_bases
ATGTTCATGACAGATCAATATATTTTAGCGATTGACCAAGGCACAACAAGCTCGCGCGCCATTTTGTTCAACCGTGGTGG
AGAAATTGTTCATATGGCGCAAAAAGAATTTACGCAATATTTCCCACAGCCCGGCTGGGTTGAGCATAATGCGAACGAAA
TTTGGGGCTCGGTGCTTGCGGTCATTGCCAGTGTCTTGTCTGAGGCGCAAGTGAAGCCGGAACAAGTGGCGGCGATCGGC
ATTACGAACCAGCGGGAAACGACCGTTGTCTGGGAAAAAGAGAGCGGCAATCCGATTTACAACGCCATCGTTTGGCAATC
GCGGCAAACGGCTGATATTTGCGACGAGTTGAAAGCGAAAGGGTATGATCCGCTGTTTCGCGAAAAAACGGGGCTGCTCA
TTGACGCTTATTTTTCGGGAACGAAAGTGAAATGGATTTTAGATCATGTCGACGGAGCGCGTGAACGGGCGGAGCGCGGC
GAGCTGCTGTTTGGCACGATCGACACGTGGCTTATTTGGAAGCTGTCCGGCGGCCGCGCTCATGTGACTGATTACTCGAA
TGCGTCGCGTACATTGATGTTTAACATTCATACGCTTGAATGGGACGATGAGTTGCTTGCAATTTTAAACGTGCCAAAGG
CGATGCTCCCTGAGGTGCGGCCGTCCTCGGAAGTATATGCGAAAACCGTTCCGCATCATTTCTTCGGCGTGGAAGTGCCG
ATCGCTGGGGCGGCGGGTGACCAGCAGGCAGCCTTGTTCGGACAGGCGTGCTTTGCTGAAGGGATGGCGAAGAATACATA
CGGCACCGGCTGCTTTATGCTCATGAACACCGGAGAAAAAGCGGTGCAGTCAAAACACGGGCTGTTGACAACAATTGCTT
GGGGCATCGATGGCAAAGTCGAATATGCGCTTGAAGGCAGCATCTTCGTCGCCGGTTCGGCCATTCAATGGCTGCGCGAC
GGCTTGCGGATGATCAAAACGGCGGCTGACAGCGAAACGTACGCCGAAAAAGTCGAGTCAACGGACGGGGTGTACGTTGT
CCCGGCGTTCGTCGGTCTCGGCACGCCGTATTGGGACAGCGAGGTGCGTGGAGCGGTGTTTGGCCTCACGCGCGGCACGA
CGAAAGAACATTTCATCCGTGCGACATTGGAATCGCTCGCCTACCAGACAAAGGACGTGCTCGCCGCTATGGAAGCGGAT
GCCGGCTTGCCGCTGACGACATTGCGCGTCGACGGAGGAGCGGTGAAAAACAACTTGCTCATGCAGTTTCAAAGCGATTT
GCTCGCTGTGCCGGTCGAGCGGCCGATGATTAGCGAGACGACCGCGCTTGGAGCGGCGTACTTAGCTGGGCTGGCGGTCG
GCTATTGGGGCAGTCGTGAAGATATTGCTGCCCAGTGGCAGCTTGAGCACCGCTTTGAGCCGCAGATGACTGACGATAAG
CGAACGGCACTCTATGAAGGCTGGAAAAAAGCAGTGCGGGCGGCGATGATGTTTAAATAA

Upstream 100 bases:

>100_bases
AGGGGCGGGCTCGGCGGTAGCGGATCGCCGTTCAGTTTGATAGGAGGCCCGGTGTTTGCGGCGGTGTCATTGAGCTGAAA
AAATCAAGTAGGAGAGGAGA

Downstream 100 bases:

>100_bases
CGGGAAGAAAACGGATACCCTTGGCTGAGGGTGTCCGTTTTTTGGTGGTTCAAAACAGGAGCAAAGCTGATGGCTAGCGA
AGGGCAGGGATGTCAGCGCA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MFMTDQYILAIDQGTTSSRAILFNRGGEIVHMAQKEFTQYFPQPGWVEHNANEIWGSVLAVIASVLSEAQVKPEQVAAIG
ITNQRETTVVWEKESGNPIYNAIVWQSRQTADICDELKAKGYDPLFREKTGLLIDAYFSGTKVKWILDHVDGARERAERG
ELLFGTIDTWLIWKLSGGRAHVTDYSNASRTLMFNIHTLEWDDELLAILNVPKAMLPEVRPSSEVYAKTVPHHFFGVEVP
IAGAAGDQQAALFGQACFAEGMAKNTYGTGCFMLMNTGEKAVQSKHGLLTTIAWGIDGKVEYALEGSIFVAGSAIQWLRD
GLRMIKTAADSETYAEKVESTDGVYVVPAFVGLGTPYWDSEVRGAVFGLTRGTTKEHFIRATLESLAYQTKDVLAAMEAD
AGLPLTTLRVDGGAVKNNLLMQFQSDLLAVPVERPMISETTALGAAYLAGLAVGYWGSREDIAAQWQLEHRFEPQMTDDK
RTALYEGWKKAVRAAMMFK

Sequences:

>Translated_499_residues
MFMTDQYILAIDQGTTSSRAILFNRGGEIVHMAQKEFTQYFPQPGWVEHNANEIWGSVLAVIASVLSEAQVKPEQVAAIG
ITNQRETTVVWEKESGNPIYNAIVWQSRQTADICDELKAKGYDPLFREKTGLLIDAYFSGTKVKWILDHVDGARERAERG
ELLFGTIDTWLIWKLSGGRAHVTDYSNASRTLMFNIHTLEWDDELLAILNVPKAMLPEVRPSSEVYAKTVPHHFFGVEVP
IAGAAGDQQAALFGQACFAEGMAKNTYGTGCFMLMNTGEKAVQSKHGLLTTIAWGIDGKVEYALEGSIFVAGSAIQWLRD
GLRMIKTAADSETYAEKVESTDGVYVVPAFVGLGTPYWDSEVRGAVFGLTRGTTKEHFIRATLESLAYQTKDVLAAMEAD
AGLPLTTLRVDGGAVKNNLLMQFQSDLLAVPVERPMISETTALGAAYLAGLAVGYWGSREDIAAQWQLEHRFEPQMTDDK
RTALYEGWKKAVRAAMMFK
>Mature_499_residues
MFMTDQYILAIDQGTTSSRAILFNRGGEIVHMAQKEFTQYFPQPGWVEHNANEIWGSVLAVIASVLSEAQVKPEQVAAIG
ITNQRETTVVWEKESGNPIYNAIVWQSRQTADICDELKAKGYDPLFREKTGLLIDAYFSGTKVKWILDHVDGARERAERG
ELLFGTIDTWLIWKLSGGRAHVTDYSNASRTLMFNIHTLEWDDELLAILNVPKAMLPEVRPSSEVYAKTVPHHFFGVEVP
IAGAAGDQQAALFGQACFAEGMAKNTYGTGCFMLMNTGEKAVQSKHGLLTTIAWGIDGKVEYALEGSIFVAGSAIQWLRD
GLRMIKTAADSETYAEKVESTDGVYVVPAFVGLGTPYWDSEVRGAVFGLTRGTTKEHFIRATLESLAYQTKDVLAAMEAD
AGLPLTTLRVDGGAVKNNLLMQFQSDLLAVPVERPMISETTALGAAYLAGLAVGYWGSREDIAAQWQLEHRFEPQMTDDK
RTALYEGWKKAVRAAMMFK

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=501, Percent_Identity=46.3073852295409, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI4504007, Length=501, Percent_Identity=46.3073852295409, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI42794763, Length=505, Percent_Identity=45.9405940594059, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI41393575, Length=500, Percent_Identity=45.8, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI88196792, Length=506, Percent_Identity=33.00395256917, Blast_Score=313, Evalue=3e-85,
Organism=Escherichia coli, GI1790361, Length=494, Percent_Identity=62.9554655870445, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=23.6947791164659, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1789987, Length=500, Percent_Identity=24, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787789, Length=514, Percent_Identity=23.7354085603113, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789168, Length=491, Percent_Identity=23.8289205702648, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17535599, Length=498, Percent_Identity=42.1686746987952, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71986140, Length=521, Percent_Identity=24.7600767754319, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71986147, Length=299, Percent_Identity=29.7658862876254, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6321755, Length=486, Percent_Identity=38.0658436213992, Blast_Score=311, Evalue=2e-85,
Organism=Drosophila melanogaster, GI17864214, Length=509, Percent_Identity=42.6326129666012, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24654573, Length=436, Percent_Identity=44.4954128440367, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655555, Length=479, Percent_Identity=39.2484342379958, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655560, Length=479, Percent_Identity=39.2484342379958, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655570, Length=479, Percent_Identity=39.2484342379958, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655574, Length=479, Percent_Identity=39.2484342379958, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655565, Length=479, Percent_Identity=39.2484342379958, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19922058, Length=527, Percent_Identity=30.7400379506641, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24652871, Length=494, Percent_Identity=31.3765182186235, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24656367, Length=490, Percent_Identity=28.1632653061224, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21357867, Length=505, Percent_Identity=27.3267326732673, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24656372, Length=337, Percent_Identity=29.3768545994065, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI45552909, Length=302, Percent_Identity=26.4900662251656, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55118; Mature: 55118

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMTDQYILAIDQGTTSSRAILFNRGGEIVHMAQKEFTQYFPQPGWVEHNANEIWGSVLA
CCCCCCEEEEEECCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VIASVLSEAQVKPEQVAAIGITNQRETTVVWEKESGNPIYNAIVWQSRQTADICDELKAK
HHHHHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHC
GYDPLFREKTGLLIDAYFSGTKVKWILDHVDGARERAERGELLFGTIDTWLIWKLSGGRA
CCCCHHHCCCCCEEEEEECCCEEEEEEECCCCHHHHHHCCCEEEEEECEEEEEEECCCEE
HVTDYSNASRTLMFNIHTLEWDDELLAILNVPKAMLPEVRPSSEVYAKTVPHHFFGVEVP
EEECCCCCCEEEEEEEEEECCCHHHHHHHCCCHHHCCCCCCCCHHHHHHCCCHHEEEEEE
IAGAAGDQQAALFGQACFAEGMAKNTYGTGCFMLMNTGEKAVQSKHGLLTTIAWGIDGKV
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCEEEEEEECCCCEE
EYALEGSIFVAGSAIQWLRDGLRMIKTAADSETYAEKVESTDGVYVVPAFVGLGTPYWDS
EEEECCCEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEHHHCCCCCCCC
EVRGAVFGLTRGTTKEHFIRATLESLAYQTKDVLAAMEADAGLPLTTLRVDGGAVKNNLL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
MQFQSDLLAVPVERPMISETTALGAAYLAGLAVGYWGSREDIAAQWQLEHRFEPQMTDDK
HHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCH
RTALYEGWKKAVRAAMMFK
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFMTDQYILAIDQGTTSSRAILFNRGGEIVHMAQKEFTQYFPQPGWVEHNANEIWGSVLA
CCCCCCEEEEEECCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VIASVLSEAQVKPEQVAAIGITNQRETTVVWEKESGNPIYNAIVWQSRQTADICDELKAK
HHHHHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHC
GYDPLFREKTGLLIDAYFSGTKVKWILDHVDGARERAERGELLFGTIDTWLIWKLSGGRA
CCCCHHHCCCCCEEEEEECCCEEEEEEECCCCHHHHHHCCCEEEEEECEEEEEEECCCEE
HVTDYSNASRTLMFNIHTLEWDDELLAILNVPKAMLPEVRPSSEVYAKTVPHHFFGVEVP
EEECCCCCCEEEEEEEEEECCCHHHHHHHCCCHHHCCCCCCCCHHHHHHCCCHHEEEEEE
IAGAAGDQQAALFGQACFAEGMAKNTYGTGCFMLMNTGEKAVQSKHGLLTTIAWGIDGKV
ECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCEEEEEEECCCCEE
EYALEGSIFVAGSAIQWLRDGLRMIKTAADSETYAEKVESTDGVYVVPAFVGLGTPYWDS
EEEECCCEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEHHHCCCCCCCC
EVRGAVFGLTRGTTKEHFIRATLESLAYQTKDVLAAMEADAGLPLTTLRVDGGAVKNNLL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
MQFQSDLLAVPVERPMISETTALGAAYLAGLAVGYWGSREDIAAQWQLEHRFEPQMTDDK
HHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCH
RTALYEGWKKAVRAAMMFK
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA