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The map label for this gene is hbd [H]

Identifier: 138894838

GI number: 138894838

Start: 1244733

End: 1245578

Strand: Direct

Name: hbd [H]

Synonym: GTNG_1174

Alternate gene names: 138894838

Gene position: 1244733-1245578 (Clockwise)

Preceding gene: 138894837

Following gene: 138894839

Centisome position: 35.06

GC content: 55.44

Gene sequence:

>846_bases
ATGGCTGAAACGATCGCAGTGATCGGATCTGGGGTGATGGGAAGCGGCATCGCGCAAACAGCGGCGATGGCGGGAAAAAC
GGTGTATCTATATGATGTGTCCGAAGCGGCCTTGCAAAACGGGCTCACTTCGGCTGAAAAAAGCTTGCGCCGCTTTGTCC
AATCCGGCCGCATGTCCGAACAAGAAGCACAGGCGGCGCGTGGCCGTCTCCGTCCTACGACGGATTTGGCAGAAGCGGTC
CGTGAAGCGGACGTTGTCATTGAAGCGGTGCCGGAAAACTTGGCATTGAAAAAAGAGGTGTTTCAAAAGCTTGATGAATT
GGCAAAGCCAAGCGCCATTTTGGCGACGAACACATCAGAGTTGAGCGTTACCGCGCTTGCGGCCGCGACCAATCGGCCGG
AGAACGTCATCGGTATGCATTGGTTCAATCCAGCACCGGTGATGAAGCTAATTGAAATTGTTAAAGGTGAAACGACGGCT
GACGAAACGGTCGACGCCATCCGCCGCCTGTCCACAGAGCTTGGCAAAGAGACGGTTGTTGTCAAAGACCGTCAAGGATT
TGTGACGACGCGGGCGATCGCCGCCCACATGATTGAATGCATCCGCATGTACGAAGAAGGAATCGCTTCTGCCGAGGATA
TCGATAAAGCGGTGCGGCTCGGTCTCAATTACCCGATGGGGCCGTTGGAGCTCGCCGACATGGTCGGGCTTGATACGCTC
TTGTTTGTGAGTGAAAACATGACCGAGGCGTACGGCGACCGCTTCCGGGCACCGCAGCTGCTGCGCAAGCTCGTCGAAGC
CGGACATTTAGGACGGAAGACCGGGAAAGGCTTTTATACGTATTGA

Upstream 100 bases:

>100_bases
ATTCCAAAAACGAGCGTTGGCAAGTTTTTGAAGAGGAAACTACGCGATGAGATGGCGGCGCGCTATGCCGATGCGGCAAC
AGAATAAAGGGGGAGACGTT

Downstream 100 bases:

>100_bases
CACCCATTCGTCGCCTTGAAGGGCGGCGTTTAACGAAAGGGATAGTTGTTGTGAGGCGGATAACGGGAAAAGGAGCAATG
ACGAAGCGAAGCAGAAGGAG

Product: 3-hydroxybutyryl-CoA dehydrogenase-like protein

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MAETIAVIGSGVMGSGIAQTAAMAGKTVYLYDVSEAALQNGLTSAEKSLRRFVQSGRMSEQEAQAARGRLRPTTDLAEAV
READVVIEAVPENLALKKEVFQKLDELAKPSAILATNTSELSVTALAAATNRPENVIGMHWFNPAPVMKLIEIVKGETTA
DETVDAIRRLSTELGKETVVVKDRQGFVTTRAIAAHMIECIRMYEEGIASAEDIDKAVRLGLNYPMGPLELADMVGLDTL
LFVSENMTEAYGDRFRAPQLLRKLVEAGHLGRKTGKGFYTY

Sequences:

>Translated_281_residues
MAETIAVIGSGVMGSGIAQTAAMAGKTVYLYDVSEAALQNGLTSAEKSLRRFVQSGRMSEQEAQAARGRLRPTTDLAEAV
READVVIEAVPENLALKKEVFQKLDELAKPSAILATNTSELSVTALAAATNRPENVIGMHWFNPAPVMKLIEIVKGETTA
DETVDAIRRLSTELGKETVVVKDRQGFVTTRAIAAHMIECIRMYEEGIASAEDIDKAVRLGLNYPMGPLELADMVGLDTL
LFVSENMTEAYGDRFRAPQLLRKLVEAGHLGRKTGKGFYTY
>Mature_280_residues
AETIAVIGSGVMGSGIAQTAAMAGKTVYLYDVSEAALQNGLTSAEKSLRRFVQSGRMSEQEAQAARGRLRPTTDLAEAVR
EADVVIEAVPENLALKKEVFQKLDELAKPSAILATNTSELSVTALAAATNRPENVIGMHWFNPAPVMKLIEIVKGETTAD
ETVDAIRRLSTELGKETVVVKDRQGFVTTRAIAAHMIECIRMYEEGIASAEDIDKAVRLGLNYPMGPLELADMVGLDTLL
FVSENMTEAYGDRFRAPQLLRKLVEAGHLGRKTGKGFYTY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=41.3194444444444, Blast_Score=231, Evalue=6e-61,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=39.0163934426229, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI20127408, Length=279, Percent_Identity=37.2759856630824, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI261878539, Length=298, Percent_Identity=33.2214765100671, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=33.5593220338983, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI115430219, Length=263, Percent_Identity=32.319391634981, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=41.6370106761566, Blast_Score=214, Evalue=4e-57,
Organism=Escherichia coli, GI1790281, Length=263, Percent_Identity=32.6996197718631, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=33.8403041825095, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=284, Percent_Identity=39.7887323943662, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=38.4615384615385, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=40.418118466899, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=39.0681003584229, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17508951, Length=279, Percent_Identity=39.0681003584229, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=39.0681003584229, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17558304, Length=279, Percent_Identity=38.3512544802867, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=32.8571428571429, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=29.4326241134752, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193203623, Length=198, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115533614, Length=198, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583077, Length=281, Percent_Identity=35.9430604982206, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24583079, Length=281, Percent_Identity=35.9430604982206, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19921000, Length=281, Percent_Identity=35.9430604982206, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20129993, Length=246, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45549573, Length=237, Percent_Identity=32.0675105485232, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30493; Mature: 30362

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETIAVIGSGVMGSGIAQTAAMAGKTVYLYDVSEAALQNGLTSAEKSLRRFVQSGRMSE
CCCHHHHHCCCCCCCHHHHHHHHCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHHCCCCH
QEAQAARGRLRPTTDLAEAVREADVVIEAVPENLALKKEVFQKLDELAKPSAILATNTSE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCH
LSVTALAAATNRPENVIGMHWFNPAPVMKLIEIVKGETTADETVDAIRRLSTELGKETVV
HHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
VKDRQGFVTTRAIAAHMIECIRMYEEGIASAEDIDKAVRLGLNYPMGPLELADMVGLDTL
EECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LFVSENMTEAYGDRFRAPQLLRKLVEAGHLGRKTGKGFYTY
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AETIAVIGSGVMGSGIAQTAAMAGKTVYLYDVSEAALQNGLTSAEKSLRRFVQSGRMSE
CCHHHHHCCCCCCCHHHHHHHHCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHHCCCCH
QEAQAARGRLRPTTDLAEAVREADVVIEAVPENLALKKEVFQKLDELAKPSAILATNTSE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCH
LSVTALAAATNRPENVIGMHWFNPAPVMKLIEIVKGETTADETVDAIRRLSTELGKETVV
HHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
VKDRQGFVTTRAIAAHMIECIRMYEEGIASAEDIDKAVRLGLNYPMGPLELADMVGLDTL
EECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LFVSENMTEAYGDRFRAPQLLRKLVEAGHLGRKTGKGFYTY
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA