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The map label for this gene is dapA [H]

Identifier: 138894797

GI number: 138894797

Start: 1193892

End: 1194776

Strand: Direct

Name: dapA [H]

Synonym: GTNG_1131

Alternate gene names: 138894797

Gene position: 1193892-1194776 (Clockwise)

Preceding gene: 138894796

Following gene: 138894798

Centisome position: 33.63

GC content: 55.82

Gene sequence:

>885_bases
GTGAAAACAGTGGCTCAGTTCGGAAACATTGTAACGGCGATGGTGACACCATTTGACCGGAAAGGAAATCTCGATTTAGC
GAAAACGACGGAGCTCGTCAACTATTTGCTCGATAACGGCACTGATGCGCTCGTTGTCGCCGGCACGACCGGCGAATCGC
CGACCTTAACGGCAGAGGAAAAAGTCGCGTTGTTCCGTCACGTCGTTAATGTCGTCAACGGCCGTGTGCCGGTCATTGCC
GGGACGGGAACGAACGATACGCGCGCGTCGATCGAACTGACGAAGCGGGCAGAAGAGACGGGGGTTGACGCCGTCATGCT
CGTTGCGCCGTATTATAATAAGCCAAACCAAGAAGGGCTGTATCAGCATTTTAAAGCAATTGCCGAAAGTACGTCGCTGC
CGGTCATGCTTTATAATGTGCCGGGACGTACGTCGGTCAATCTCGCTCCTGAGACCGTTATTCGGCTCGCTGCGATTCCA
AACATTGTCGCTGTCAAAGAAGCGGGCGGCAACTTGGATGCGATGGCGGAAATCATTGAGCAAACTCCGGACGATTTCCT
GCTGTATAGTGGAGATGACAGCTTGACGCTTCCGGTGTTGGCGATCGGCGGCGCCGGCGTCGTCTCGGTCGCTTCGCACA
TCATCGGAAATGAGATGCAGCAAATGATCCGCGCCTTCCAAGCGGGTGATCACCAAAAAGCGGCGGCGCTGCACCGGAAA
TGGGTGCCGCTTATGAAAGGGCTGTTTGCTGCACCAAGTCCGGTGCCGGTGAAAACTGCGCTTCAGTTGCGCGGATTGGA
TGTCGGTCCGGTGCGTCTTCCGCTCGTTCCGCTCACTGAGCAAGAACGGAGCGAGCTCAGCCGTCTGCTCAGTGCGTTGT
CATAA

Upstream 100 bases:

>100_bases
TGCTTGTGAAACAGGATGATATGGAAAAAGCGGTTAACGCCTTGCATGACGCCTTTTGTCTGTCTGAGGAAGGCGGATAT
GAAGCGATTTGGAACGAGGA

Downstream 100 bases:

>100_bases
CATCGACACTGTAGGAACAGCTCACCCCCAACGCTGCTGTTTGCGCGTTGGGGCGTTTTTTTGCCTTCATGGCAAAATCG
TCTGCCCGATTATAACAATC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS; Vegetative protein 81; VEG81 [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKTVAQFGNIVTAMVTPFDRKGNLDLAKTTELVNYLLDNGTDALVVAGTTGESPTLTAEEKVALFRHVVNVVNGRVPVIA
GTGTNDTRASIELTKRAEETGVDAVMLVAPYYNKPNQEGLYQHFKAIAESTSLPVMLYNVPGRTSVNLAPETVIRLAAIP
NIVAVKEAGGNLDAMAEIIEQTPDDFLLYSGDDSLTLPVLAIGGAGVVSVASHIIGNEMQQMIRAFQAGDHQKAAALHRK
WVPLMKGLFAAPSPVPVKTALQLRGLDVGPVRLPLVPLTEQERSELSRLLSALS

Sequences:

>Translated_294_residues
MKTVAQFGNIVTAMVTPFDRKGNLDLAKTTELVNYLLDNGTDALVVAGTTGESPTLTAEEKVALFRHVVNVVNGRVPVIA
GTGTNDTRASIELTKRAEETGVDAVMLVAPYYNKPNQEGLYQHFKAIAESTSLPVMLYNVPGRTSVNLAPETVIRLAAIP
NIVAVKEAGGNLDAMAEIIEQTPDDFLLYSGDDSLTLPVLAIGGAGVVSVASHIIGNEMQQMIRAFQAGDHQKAAALHRK
WVPLMKGLFAAPSPVPVKTALQLRGLDVGPVRLPLVPLTEQERSELSRLLSALS
>Mature_294_residues
MKTVAQFGNIVTAMVTPFDRKGNLDLAKTTELVNYLLDNGTDALVVAGTTGESPTLTAEEKVALFRHVVNVVNGRVPVIA
GTGTNDTRASIELTKRAEETGVDAVMLVAPYYNKPNQEGLYQHFKAIAESTSLPVMLYNVPGRTSVNLAPETVIRLAAIP
NIVAVKEAGGNLDAMAEIIEQTPDDFLLYSGDDSLTLPVLAIGGAGVVSVASHIIGNEMQQMIRAFQAGDHQKAAALHRK
WVPLMKGLFAAPSPVPVKTALQLRGLDVGPVRLPLVPLTEQERSELSRLLSALS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=284, Percent_Identity=28.8732394366197, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI13540533, Length=277, Percent_Identity=26.3537906137184, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1788823, Length=278, Percent_Identity=45.3237410071942, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI87082415, Length=294, Percent_Identity=31.2925170068027, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786463, Length=291, Percent_Identity=32.6460481099656, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1789620, Length=288, Percent_Identity=30.5555555555556, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31371; Mature: 31371

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVAQFGNIVTAMVTPFDRKGNLDLAKTTELVNYLLDNGTDALVVAGTTGESPTLTAEE
CCCHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
KVALFRHVVNVVNGRVPVIAGTGTNDTRASIELTKRAEETGVDAVMLVAPYYNKPNQEGL
HHHHHHHHHHHHCCCEEEEEECCCCCCEEHEEEHHHHHHCCCCEEEEEECCCCCCCCCHH
YQHFKAIAESTSLPVMLYNVPGRTSVNLAPETVIRLAAIPNIVAVKEAGGNLDAMAEIIE
HHHHHHHHCCCCCCEEEEECCCCCEECCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
QTPDDFLLYSGDDSLTLPVLAIGGAGVVSVASHIIGNEMQQMIRAFQAGDHQKAAALHRK
CCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
WVPLMKGLFAAPSPVPVKTALQLRGLDVGPVRLPLVPLTEQERSELSRLLSALS
HHHHHHHHHCCCCCCCHHHHHEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTVAQFGNIVTAMVTPFDRKGNLDLAKTTELVNYLLDNGTDALVVAGTTGESPTLTAEE
CCCHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
KVALFRHVVNVVNGRVPVIAGTGTNDTRASIELTKRAEETGVDAVMLVAPYYNKPNQEGL
HHHHHHHHHHHHCCCEEEEEECCCCCCEEHEEEHHHHHHCCCCEEEEEECCCCCCCCCHH
YQHFKAIAESTSLPVMLYNVPGRTSVNLAPETVIRLAAIPNIVAVKEAGGNLDAMAEIIE
HHHHHHHHCCCCCCEEEEECCCCCEECCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
QTPDDFLLYSGDDSLTLPVLAIGGAGVVSVASHIIGNEMQQMIRAFQAGDHQKAAALHRK
CCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
WVPLMKGLFAAPSPVPVKTALQLRGLDVGPVRLPLVPLTEQERSELSRLLSALS
HHHHHHHHHCCCCCCCHHHHHEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8098035; 9384377; 9298659 [H]