Click here to switch to the map view.

The map label for this gene is metC [H]

Identifier: 138894418

GI number: 138894418

Start: 814530

End: 815708

Strand: Direct

Name: metC [H]

Synonym: GTNG_0746

Alternate gene names: 138894418

Gene position: 814530-815708 (Clockwise)

Preceding gene: 138894417

Following gene: 138894421

Centisome position: 22.94

GC content: 54.71

Gene sequence:

>1179_bases
ATGGAACGGGAATGGTCGTTTTCGACGAAATTGCTCCATAACAAATGGAAAGTCGATCGACATACAGGGGCGGTGAGCGT
GCCGATCCAGCATGCATCCACGTTCCATCAGTTCGATTTCGACTCATTCGGCAAATACGACTACAGCCGCTCCGGCAATC
CGACGCGCGAGGCGCTTGAAGAAACGATTGCCGCATTGGAAGGCGGTGTGCGCGGGTTTGCATTTGCTTCTGGCATGGCT
GCCATTTCCACAGCATTTTTGCTCCTGTCAAAGGGCGACCATGTGCTCGTGACGGAAGATGTCTACGGCGGCACATACCG
GATGATTACCGAGGTGCTTAATCGCTTTGGTATCGAATATACGTTCGTTGACATGACGGACCTTGAAGCAGTGGCGGAAA
ACATCCGGCCGAACACAAAGGTCATTTATATGGAAACGCCGTCCAATCCGCTCTTAAAAGTGACCGACATTCGCGGTGTC
GTCAAGTTGGCGAAAGCGCATGGCTGTTTAACTTTTCTGGACAATACGTTCATGACCCCAGCGTTGCAGCGGCCGTTGGA
TCTCGGCGTCGATGTTGTGCTTCATAGTGCGACGAAGTTTTTAGCCGGCCATAGCGACGTCGTTGCCGGGTTGGCGGTCG
TAAAAGACGAGGAGCTCGGCAAACAGCTATACAAATTGCAAAACGCCTTTGGCGCTGTCCTTGGCGTCCAAGATGCTTGG
CTTGTGCTGCGCGGTGTAAAAACACTCCATGTCCGGCTGAAACAGTCGTCTGAATCAGCGGCCGCCCTTGCTGCCTATTT
GACGCGCCATCCCAAAGTAGAGGAAGTGTACTATCCAGGATTGTCGCACCACCCGGGCCATGCGATCCAGCGCAATCAAG
CGGCTGGGTTCGGCGCTGTGCTGTCGTTCCGCCTGGCGGATGAAGAAGCGGCCCGGACGTTCGTCCGAAACGTTCGCTTA
CCGGTGTTCGCCGTCAGTCTTGGCGCTGTTGAATCGATTTTATCGTATCCAGCGAAAATGTCACATGCCGCCATGCCGAA
AGACGAGCGGCTGCGACGCGGCATTACCGACGGACTGTTGCGGTTGAGCGTCGGGCTTGAGGATCTCAACGATTTGATCG
CCGATTTTGAGCAGGCGCTATCATTTGTCAACGAGCGCTCGTCGATTCCGGCGCGATGA

Upstream 100 bases:

>100_bases
TTGCAACCGTCTACTCCGTTTCTCGGTCGGTATCGAGCATGCCGACGATTTGATCGCTGATTTAGCGCAGGCATTGAAAA
ACATGAAAGAGGTGTGAGCG

Downstream 100 bases:

>100_bases
AAGAAAGTAAAAAAATGGCTATGCTGTAACAGCATAGCCGTTTTTCATTGTTTGATAAGGTATGTGAGGTTTCGGCGGAT
GCATACCTTATACTCTTTGT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MEREWSFSTKLLHNKWKVDRHTGAVSVPIQHASTFHQFDFDSFGKYDYSRSGNPTREALEETIAALEGGVRGFAFASGMA
AISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLNRFGIEYTFVDMTDLEAVAENIRPNTKVIYMETPSNPLLKVTDIRGV
VKLAKAHGCLTFLDNTFMTPALQRPLDLGVDVVLHSATKFLAGHSDVVAGLAVVKDEELGKQLYKLQNAFGAVLGVQDAW
LVLRGVKTLHVRLKQSSESAAALAAYLTRHPKVEEVYYPGLSHHPGHAIQRNQAAGFGAVLSFRLADEEAARTFVRNVRL
PVFAVSLGAVESILSYPAKMSHAAMPKDERLRRGITDGLLRLSVGLEDLNDLIADFEQALSFVNERSSIPAR

Sequences:

>Translated_392_residues
MEREWSFSTKLLHNKWKVDRHTGAVSVPIQHASTFHQFDFDSFGKYDYSRSGNPTREALEETIAALEGGVRGFAFASGMA
AISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLNRFGIEYTFVDMTDLEAVAENIRPNTKVIYMETPSNPLLKVTDIRGV
VKLAKAHGCLTFLDNTFMTPALQRPLDLGVDVVLHSATKFLAGHSDVVAGLAVVKDEELGKQLYKLQNAFGAVLGVQDAW
LVLRGVKTLHVRLKQSSESAAALAAYLTRHPKVEEVYYPGLSHHPGHAIQRNQAAGFGAVLSFRLADEEAARTFVRNVRL
PVFAVSLGAVESILSYPAKMSHAAMPKDERLRRGITDGLLRLSVGLEDLNDLIADFEQALSFVNERSSIPAR
>Mature_392_residues
MEREWSFSTKLLHNKWKVDRHTGAVSVPIQHASTFHQFDFDSFGKYDYSRSGNPTREALEETIAALEGGVRGFAFASGMA
AISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLNRFGIEYTFVDMTDLEAVAENIRPNTKVIYMETPSNPLLKVTDIRGV
VKLAKAHGCLTFLDNTFMTPALQRPLDLGVDVVLHSATKFLAGHSDVVAGLAVVKDEELGKQLYKLQNAFGAVLGVQDAW
LVLRGVKTLHVRLKQSSESAAALAAYLTRHPKVEEVYYPGLSHHPGHAIQRNQAAGFGAVLSFRLADEEAARTFVRNVRL
PVFAVSLGAVESILSYPAKMSHAAMPKDERLRRGITDGLLRLSVGLEDLNDLIADFEQALSFVNERSSIPAR

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=377, Percent_Identity=43.5013262599469, Blast_Score=295, Evalue=4e-80,
Organism=Homo sapiens, GI299473759, Length=377, Percent_Identity=38.9920424403183, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI25453487, Length=376, Percent_Identity=38.8297872340425, Blast_Score=232, Evalue=6e-61,
Organism=Escherichia coli, GI1790375, Length=371, Percent_Identity=41.7789757412399, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789383, Length=376, Percent_Identity=31.3829787234043, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=385, Percent_Identity=43.1168831168831, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17538055, Length=385, Percent_Identity=42.8571428571429, Blast_Score=298, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=41.6893732970027, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI193202265, Length=89, Percent_Identity=42.6966292134831, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319307, Length=392, Percent_Identity=43.3673469387755, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6321254, Length=393, Percent_Identity=34.8600508905852, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6321170, Length=293, Percent_Identity=35.4948805460751, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=32.3671497584541, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=392, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323557, Length=345, Percent_Identity=25.2173913043478, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322970, Length=349, Percent_Identity=24.9283667621776, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322590, Length=349, Percent_Identity=24.9283667621776, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19922554, Length=385, Percent_Identity=43.3766233766234, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43173; Mature: 43173

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEREWSFSTKLLHNKWKVDRHTGAVSVPIQHASTFHQFDFDSFGKYDYSRSGNPTREALE
CCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHCHHHHCCCCCCCCCCCCCCCCCHHHHHHH
ETIAALEGGVRGFAFASGMAAISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLNRFGIEY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHHCCEE
TFVDMTDLEAVAENIRPNTKVIYMETPSNPLLKVTDIRGVVKLAKAHGCLTFLDNTFMTP
EEEEHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHCCHHHHHHCCCCCH
ALQRPLDLGVDVVLHSATKFLAGHSDVVAGLAVVKDEELGKQLYKLQNAFGAVLGVQDAW
HHCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHH
LVLRGVKTLHVRLKQSSESAAALAAYLTRHPKVEEVYYPGLSHHPGHAIQRNQAAGFGAV
HHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCHHEECCCCCCCCCCHHCCCCCCCCHHH
LSFRLADEEAARTFVRNVRLPVFAVSLGAVESILSYPAKMSHAAMPKDERLRRGITDGLL
HEEEECCHHHHHHHHHHCCCHHEEHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCHHHHHH
RLSVGLEDLNDLIADFEQALSFVNERSSIPAR
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEREWSFSTKLLHNKWKVDRHTGAVSVPIQHASTFHQFDFDSFGKYDYSRSGNPTREALE
CCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHCHHHHCCCCCCCCCCCCCCCCCHHHHHHH
ETIAALEGGVRGFAFASGMAAISTAFLLLSKGDHVLVTEDVYGGTYRMITEVLNRFGIEY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHHCCEE
TFVDMTDLEAVAENIRPNTKVIYMETPSNPLLKVTDIRGVVKLAKAHGCLTFLDNTFMTP
EEEEHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHCCHHHHHHCCCCCH
ALQRPLDLGVDVVLHSATKFLAGHSDVVAGLAVVKDEELGKQLYKLQNAFGAVLGVQDAW
HHCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHHH
LVLRGVKTLHVRLKQSSESAAALAAYLTRHPKVEEVYYPGLSHHPGHAIQRNQAAGFGAV
HHHHHHHHHEEEECCCCCHHHHHHHHHHCCCCCHHEECCCCCCCCCCHHCCCCCCCCHHH
LSFRLADEEAARTFVRNVRLPVFAVSLGAVESILSYPAKMSHAAMPKDERLRRGITDGLL
HEEEECCHHHHHHHHHHCCCHHEEHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCHHHHHH
RLSVGLEDLNDLIADFEQALSFVNERSSIPAR
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]